|
|
H+ + pyruvate <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + CO2
|
2.2.1.6
acetolactate synthase
4.1.1.1
pyruvate decarboxylase
|
–
–
|
| |
BRENDA:
BR37100;
BS386675
KEGG:
R00006;
R00226
MetaCyc:
ACETOLACTSYN-RXN
SABIO-RK:
6473;
749
|
|
|
|
2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate
|
4.2.1.33
3-isopropylmalate dehydratase
|
–
|
| |
BRENDA:
BR413;
BR49521;
BS1964
KEGG:
R03968;
R04001
MetaCyc:
3-ISOPROPYLMALISOM-RXN;
RXN-8991
SABIO-RK:
3704;
3736
|
|
|
|
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid + NADPH + H+
|
1.1.1.86
ketol-acid reductoisomerase (NADP+)
|
–
|
| |
KEGG:
R04440
SABIO-RK:
8850
|
|
|
|
(S)-2-Hydroxy-2-methyl-3-oxobutanoate <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid
|
1.1.1.86
ketol-acid reductoisomerase (NADP+)
5.4.99.3
2-acetolactate mutase
|
–
–
|
| |
BRENDA:
BR250
KEGG:
R03052;
R05071
MetaCyc:
2-ACETOLACTATE-MUTASE-RXN
SABIO-RK:
2898
|
|
|
|
L-threonine <=> 2-oxobutyrate + NH3
|
4.2.3.1
threonine synthase
4.3.1.17
L-serine ammonia-lyase
4.3.1.19
threonine ammonia-lyase
|
–
–
–
|
| |
BRENDA:
BR22834
KEGG:
R00996
MetaCyc:
THREDEHYD-RXN
SABIO-RK:
1290
|
|
|
|
acetyl-CoA + pyruvate + H2O <=> H+ + (R)-citramalate + CoA
|
2.3.1.182
(R)-citramalate synthase
2.3.3.13
2-isopropylmalate synthase
|
–
–
|
| |
BRENDA:
BR48833
KEGG:
R07399
MetaCyc:
RXN-7743
SABIO-RK:
9043
|
|
|
|
L-isoleucine + H2O + NAD+ <=> NH3 + (S)-3-methyl-2-oxopentanoate + NADH + H+
|
1.4.1.1
alanine dehydrogenase
1.4.1.2
glutamate dehydrogenase
1.4.1.20
phenylalanine dehydrogenase
1.4.1.23
valine dehydrogenase (NAD+)
1.4.1.5
L-amino-acid dehydrogenase
1.4.1.8
valine dehydrogenase (NADP+)
1.4.1.9
leucine dehydrogenase
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BS232308
KEGG:
R02196
MetaCyc:
ILEDEAMINE-RXN
SABIO-RK:
7740
|
|
|
|
(S)-2-hydroxy-2-ethyl-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate
|
1.1.1.86
ketol-acid reductoisomerase (NADP+)
5.4.99.3
2-acetolactate mutase
|
–
–
|
| |
KEGG:
R05069
MetaCyc:
RXN-14106
|
|
|
|
2R,3R-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O
|
4.2.1.9
dihydroxy-acid dehydratase
|
–
|
| |
BRENDA:
BS453486
KEGG:
R05070
MetaCyc:
DIHYDROXYMETVALDEHYDRAT-RXN
|
|
|
|
L-leucine + NAD+ + H2O <=> H+ + NH3 + NADH + 4-methyl-2-oxopentanoate
|
1.4.1.1
alanine dehydrogenase
1.4.1.20
phenylalanine dehydrogenase
1.4.1.23
valine dehydrogenase (NAD+)
1.4.1.8
valine dehydrogenase (NADP+)
1.4.1.9
leucine dehydrogenase
|
–
–
–
–
–
|
| |
BRENDA:
BR33798
KEGG:
R01088
MetaCyc:
LEUCINE-DEHYDROGENASE-RXN
SABIO-RK:
1350
|
|
|
|
H+ + pyruvate + 2-oxobutyrate <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + CO2
|
2.2.1.6
acetolactate synthase
|
–
|
| |
BRENDA:
BS386670;
BS454179
KEGG:
R08648
MetaCyc:
ACETOOHBUTSYN-RXN
SABIO-RK:
6688
|
|
|
|
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate
|
2.6.1.1
aspartate transaminase
2.6.1.2
alanine transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.6
leucine transaminase
2.6.1.67
2-aminohexanoate transaminase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR47691
KEGG:
R01090
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERLEU-RXN
SABIO-RK:
1352
|
|
|
|
L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate
|
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.6
leucine transaminase
2.6.1.66
valine---pyruvate transaminase
|
–
–
–
–
|
| |
BRENDA:
BS356553
KEGG:
R01214
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERVAL-RXN
SABIO-RK:
1446
|
|
|
|
2R,3R-2,3-dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate + NADPH + H+
|
1.1.1.86
ketol-acid reductoisomerase (NADP+)
|
–
|
| |
KEGG:
R05068
|
|
|
|
L-isoleucine + 2-oxoglutarate <=> L-glutamate + (S)-3-methyl-2-oxopentanoate
|
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.67
2-aminohexanoate transaminase
|
–
–
|
| |
BRENDA:
BS356522;
BS452227
KEGG:
R02199
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERILEU-RXN
SABIO-RK:
2171;
9086
|
|
|
|
(R)-2,3-dihydroxy-3-methylbutanoate <=> 2-oxoisovalerate + H2O
|
4.2.1.9
dihydroxy-acid dehydratase
|
–
|
| |
KEGG:
R04441
MetaCyc:
DIHYDROXYISOVALDEHYDRAT-RXN
|
|
|
|
D-erythro-3-Methylmalate + NAD+ <=> 2-oxobutyrate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
| |
KEGG:
R00994
MetaCyc:
RXN-7745
|
|
|
|
(R)-citramalate <=> citraconate + H2O
|
4.2.1.31
maleate hydratase
4.2.1.35
(R)-2-methylmalate dehydratase
|
–
–
|
| |
BRENDA:
BR415
KEGG:
R03896
MetaCyc:
R-2-METHYLMALATE-DEHYDRATASE-RXN
SABIO-RK:
3641
|
|
|
|
H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2
|
0.0.0.0
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
| |
BRENDA:
BR52894
KEGG:
R01652
MetaCyc:
RXN-7800
|
|
|
|
2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA
|
2.3.3.13
2-isopropylmalate synthase
2.3.3.17
methylthioalkylmalate synthase
|
–
–
|
| |
BRENDA:
BR47381;
BS353415;
BS375022;
BS438748
KEGG:
R01213
MetaCyc:
2-ISOPROPYLMALATESYN-RXN
SABIO-RK:
545
|
|
|
|
pyruvate + L-valine <=> L-alanine + 2-oxoisovalerate
|
2.6.1.12
alanine---oxo-acid transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.51
serine---pyruvate transaminase
2.6.1.66
valine---pyruvate transaminase
|
–
–
–
–
|
| |
BRENDA:
BR47703
KEGG:
R01215
MetaCyc:
VALINE-PYRUVATE-AMINOTRANSFER-RXN
|
|
|
|
2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate
|
4.2.1.33
3-isopropylmalate dehydratase
|
–
|
| |
BRENDA:
BR413;
BR49521;
BS1964
KEGG:
R03968;
R04001
MetaCyc:
3-ISOPROPYLMALISOM-RXN;
RXN-8991
SABIO-RK:
3704;
3736
|
|
|
|
L-valine + H2O + NAD+ <=> 2-oxoisovalerate + NH3 + NADH + H+
|
1.4.1.1
alanine dehydrogenase
1.4.1.2
glutamate dehydrogenase
1.4.1.20
phenylalanine dehydrogenase
1.4.1.23
valine dehydrogenase (NAD+)
1.4.1.5
L-amino-acid dehydrogenase
1.4.1.8
valine dehydrogenase (NADP+)
1.4.1.9
leucine dehydrogenase
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BR50099;
BS408366;
BS451572
KEGG:
R01434
MetaCyc:
RXN-13184
SABIO-RK:
1619
|
|
|
|
citraconate + H2O <=> D-erythro-3-Methylmalate
|
4.2.1.35
(R)-2-methylmalate dehydratase
|
–
|
| |
KEGG:
R03898
MetaCyc:
RXN-7744
|
|
|
|
(2R,3S)-3-isopropylmalate + NAD+ <=> (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
|
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
|
| |
BRENDA:
BR47597;
BS373119
KEGG:
R04426
MetaCyc:
3-ISOPROPYLMALDEHYDROG-RXN
|
|
