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Nicotinate and nicotinamide metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
succinate_semialdehyde + NADP+ + H2O <=> NADPH + succinate + H+ 1.1.1.21 aldose reductase
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
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6-Hydroxynicotinate + NADH + H+ + O2 <=> 2,5-dihydroxypyridine + NAD+ + CO2 + H2O 1.14.13.114 6-hydroxynicotinate 3-monooxygenase
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nicotinic_acid_mononucleotide + H2O <=> beta-D-ribosylnicotinate + phosphate 3.1.3
3.1.3.5 5'-nucleotidase
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nicotinate + glycine + ATP <=> Nicotinurate + AMP + diphosphate not assigned
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nicotinamide + alpha-D-ribose_1-phosphate + H+ <=> beta-D-ribosylnicotinamide + phosphate 2.4.2
2.4.2.1 purine-nucleoside phosphorylase
2.7.1.22 ribosylnicotinamide kinase
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N1-methylnicotinamide + O2 + H2O <=> N1-methyl-4-pyridone-3-carboxamide + H2O2 + H+ 1.2.3.1 aldehyde oxidase
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NADP+ + H2O <=> NAD+ + phosphate 3.1.3
3.1.3.1 alkaline phosphatase
3.1.3.108 nocturnin
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NH3 + ATP + deamido-NAD+ <=> H+ + AMP + diphosphate + NAD+ 6.3.1.5 NAD+ synthase
6.3.5.1 NAD+ synthase (glutamine-hydrolysing)
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(2R,3S)-dimethylmalate <=> dimethylmaleate + H2O 4.2.1.85 dimethylmaleate hydratase
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S-adenosyl-L-methionine + nicotinate <=> S-adenosyl-L-homocysteine + Trigonelline 2.1.1.7 nicotinate N-methyltransferase
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NAD+ + [alpha-tubulin]-N6-acetyl-L-lysine + H2O <=> nicotinamide + Histone-L-lysine + O-acetyl-ADP-ribose + H+ 2.3.1.286 protein acetyllysine N-acetyltransferase
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nicotine_blue_leuco_form + NADP+ <=> nicotine_blue + NADPH + H+ 1.1.1.328 nicotine blue oxidoreductase
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NAD+ + ATP <=> H+ + NADP+ + ADP 2.7.1.23 NAD+ kinase
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1,4,5,6-Tetrahydro-6-oxonicotinate + H2O <=> (S)-2-formylglutarate + NH3 3.5.2.18 enamidase
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succinate_semialdehyde + NAD+ + H2O <=> NADH + succinate + H+ 1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
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(2R,3S)-dimethylmalate <=> propionate + pyruvate 3.7.1.1 oxaloacetase
4.1.3.1 isocitrate lyase
4.1.3.32 2,3-dimethylmalate lyase
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4-methylaminobutanoate + H2O + O2 <=> succinate_semialdehyde + methylamine + H2O2 1.5.3.21 4-methylaminobutanoate oxidase (methylamine-forming)
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nicotinate + H2O + NADP+ <=> 6-Hydroxynicotinate + NADPH + H+ 1.17.1.5 nicotinate dehydrogenase
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4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP+ <=> 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ 1.2.1.83 3-succinoylsemialdehyde-pyridine dehydrogenase
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NAD+ + H2O <=> AMP + NMN + H+ 2.7.7.1 nicotinamide-nucleotide adenylyltransferase
3.1.13.3 oligonucleotidase
3.1.4.1 phosphodiesterase I
3.6.1.13 ADP-ribose diphosphatase
3.6.1.18 FAD diphosphatase
3.6.1.21 ADP-sugar diphosphatase
3.6.1.22 NAD+ diphosphatase
3.6.1.45 UDP-sugar diphosphatase
3.6.1.9 nucleotide diphosphatase
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[protein]-N6-acetyl-L-lysine + NAD+ + H2O <=> a_[protein]-L-tyrosine + 2''''-O-acetyl-ADP-ribose + nicotinamide 2.3.1.286 protein acetyllysine N-acetyltransferase
2.3.1.B43
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2 2,3,6-Trihydroxypyridine + 2 O2 <=> nicotine_blue + 2 H2O2 not assigned
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(RS)-nicotine + acceptor + H2O <=> 6-hydroxy-L-nicotine + reduced_acceptor 1.5.99.4 nicotine dehydrogenase
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1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + 2 H2O <=> 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + methylamine not assigned
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6-hydroxy-L-nicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2 1.5.3.5 (S)-6-hydroxynicotine oxidase
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beta-D-ribosylnicotinate + H2O <=> nicotinate + D-ribose 3.2.2.3 uridine nucleosidase
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beta-D-ribosylnicotinamide + ATP <=> H+ + NMN + ADP 2.7.1.173 nicotinate riboside kinase
2.7.1.22 ribosylnicotinamide kinase
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Maleate <=> fumarate 5.2.1.1 maleate isomerase
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ATP + deamido-NAD+ + L-glutamine + H2O <=> H+ + L-glutamate + AMP + diphosphate + NAD+ 6.3.1.5 NAD+ synthase
6.3.5.1 NAD+ synthase (glutamine-hydrolysing)
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H+ + 2,6-Dihydroxypyridine + O2 + NADH <=> H2O + NAD+ + 2,3,6-Trihydroxypyridine 1.14.13.10 2,6-dihydroxypyridine 3-monooxygenase
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2-hydroxymethylglutarate <=> 2-Methyleneglutarate + H2O not assigned
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1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O <=> 2,6-Dihydroxypyridine + 4-methylaminobutanoate + H+ 3.7.1.19 2,6-dihydroxypseudooxynicotine hydrolase
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N-methylmyosmine + H2O <=> 4-(methylamino)-1-(pyridin-3-yl)butan-1-one 1.5.3
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4-methylaminobutanoate + O2 + H2O <=> 4-aminobutanoate + formaldehyde + H2O2 1.5.3.19 4-methylaminobutanoate oxidase (formaldehyde-forming)
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S-adenosyl-L-methionine + nicotinamide <=> S-adenosyl-L-homocysteine + N1-methylnicotinamide 2.1.1.1 nicotinamide N-methyltransferase
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2,3,6-Trihydroxypyridine + O2 + H+ <=> Maleamate + 2 H+ + CO2 not assigned
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NADP+ + nicotinate <=> nicotinate-adenine_dinucleotide_phosphate + nicotinamide 2.4.99.20 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
3.2.2.5 NAD+ glycohydrolase
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2-Methyleneglutarate <=> (R)-3-methylitaconate 5.4.99.4 2-methyleneglutarate mutase
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nicotinic_acid_mononucleotide + ATP + H+ <=> deamido-NAD+ + diphosphate 2.7.7.1 nicotinamide-nucleotide adenylyltransferase
2.7.7.18 nicotinate-nucleotide adenylyltransferase
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(R)-3-methylitaconate <=> dimethylmaleate 5.3.3.6 methylitaconate Delta-isomerase
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beta-D-ribosylnicotinate + phosphate <=> nicotinate + alpha-D-ribose_1-phosphate + H+ 2.4.2.1 purine-nucleoside phosphorylase
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deamido-NAD+ + H2O <=> nicotinic_acid_mononucleotide + AMP 3.6.1.22 NAD+ diphosphatase
3.6.1.9 nucleotide diphosphatase
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4-(methylamino)-1-(pyridin-3-yl)butan-1-one + O2 + H2O <=> 4-oxo-4-(pyridin-3-yl)butanal + methylamine + H2O2 1.4.3.24 pseudooxynicotine oxidase
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NMN + diphosphate <=> nicotinamide + 5-phospho-alpha-D-ribose_1-diphosphate + H+ 2.4.2.12 nicotinamide phosphoribosyltransferase
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L-aspartate + NAD+ <=> iminosuccinate + NADH + H+ 1.4.1.21 aspartate dehydrogenase
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1,4,5,6-Tetrahydro-6-oxonicotinate + oxidized_ferredoxin <=> 6-Hydroxynicotinate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.1 6-hydroxynicotinate reductase
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NMN + H2O <=> beta-D-ribosylnicotinamide + phosphate 3.1.3
3.1.3.2 acid phosphatase
3.1.3.5 5'-nucleotidase
3.6.1.22 NAD+ diphosphatase
3.6.1.45 UDP-sugar diphosphatase
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L-aspartate + NADP+ <=> iminosuccinate + NADPH + H+ 1.4.1.21 aspartate dehydrogenase
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Maleamate + H2O <=> Maleate + NH3 3.5.1.107 maleamate amidohydrolase
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1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O + acceptor <=> 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced_acceptor 1.5.99.14 6-hydroxypseudooxynicotine dehydrogenase
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H+ + NMN + ATP <=> NAD+ + diphosphate 2.7.1.22 ribosylnicotinamide kinase
2.7.7.1 nicotinamide-nucleotide adenylyltransferase
2.7.7.18 nicotinate-nucleotide adenylyltransferase
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nicotinic_acid_mononucleotide + diphosphate + CO2 <=> 5-phospho-alpha-D-ribose_1-diphosphate + quinolinic_acid + H+ 2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating)
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nicotinate + 5-phospho-alpha-D-ribose_1-diphosphate + ATP + H2O <=> nicotinic_acid_mononucleotide + diphosphate + ADP + phosphate 6.3.4.21 nicotinate phosphoribosyltransferase
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6-hydroxy-D-nicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2 1.5.3.6 (R)-6-hydroxynicotine oxidase
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nicotine_blue_leuco_form + NAD+ <=> nicotine_blue + NADH + H+ 1.1.1.328 nicotine blue oxidoreductase
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beta-D-ribosylnicotinamide + H2O <=> D-ribose + nicotinamide + H+ 3.2.2.1 purine nucleosidase
3.2.2.14 NMN nucleosidase
3.2.2.3 uridine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
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6-Hydroxynicotinate + H2O + O2 <=> 2,6-dihydroxynicotinate + H2O2 1.17.3.3 6-hydroxynicotinate dehydrogenase
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1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one <=> 2,6-Dihydroxy-N-methylmyosmine + H2O not assigned
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N-formylmaleamic_acid + H2O <=> H+ + Maleamate + formate 3.5.1.106 N-formylmaleamate deformylase
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NMN + H2O <=> D-ribose_5-phosphate + nicotinamide + H+ 3.2.2.14 NMN nucleosidase
3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
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iminosuccinate + dihydroxyacetone_phosphate <=> quinolinic_acid + H2O + phosphate 2.5.1.72 quinolinate synthase
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nicotinate + H2O + Ferrocytochrome <=> 6-Hydroxynicotinate + Ferrocytochrome + H+ 1.17.2.1 nicotinate dehydrogenase (cytochrome)
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N1-methylnicotinamide + O2 + H2O <=> N1-methyl-2-pyridone-5-carboxamide + H2O2 + H+ 1.2.3.1 aldehyde oxidase
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4-oxo-4-(pyridin-3-yl)butanoate + H2O + acceptor <=> 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + reduced_acceptor 1.5.99
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NAD+ + NADPH <=> NADH + NADP+ 1.6.1.1 NAD(P)+ transhydrogenase (Si-specific)
1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific)
1.6.1.3 NAD(P)+ transhydrogenase
7.1.1.1 proton-translocating NAD(P)+ transhydrogenase
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6-hydroxy-N-methylmyosmine + H2O <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one 1.5.3.5 (S)-6-hydroxynicotine oxidase
1.5.3.6 (R)-6-hydroxynicotine oxidase
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4-(methylamino)-1-(pyridin-3-yl)butan-1-one + H2O <=> 4-oxo-4-(pyridin-3-yl)butanoate + methylamine not assigned
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nicotinamide + H2O <=> NH3 + nicotinate 3.5.1.13 aryl-acylamidase
3.5.1.19 nicotinamidase
3.5.1.4 amidase
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2,5-dihydroxypyridine + O2 <=> H+ + N-formylmaleamic_acid 1.13.11.9 2,5-dihydroxypyridine 5,6-dioxygenase
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NMN + H2O <=> NH3 + nicotinic_acid_mononucleotide 3.5.1.42 nicotinamide-nucleotide amidase
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H2O + NAD+ <=> H+ + ADP-ribose + nicotinamide 2.4.2.30 NAD+ ADP-ribosyltransferase
3.2.2.5 NAD+ glycohydrolase
3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
3.5.1
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2,6-dihydroxynicotinate + O2 + H2O <=> H+ + Maleamate + formate + CO2 not assigned
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beta-D-ribosylnicotinate + ATP <=> H+ + nicotinic_acid_mononucleotide + ADP 2.7.1.173 nicotinate riboside kinase
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(RS)-nicotine + acceptor + H2O <=> 6-hydroxy-D-nicotine + reduced_acceptor 1.5.99.4 nicotine dehydrogenase
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2-hydroxymethylglutarate + NAD+ <=> (S)-2-formylglutarate + NADH + H+ 1.1.1.291 2-hydroxymethylglutarate dehydrogenase
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Nicotine + CO2 + H+ <=> 1-Methylpyrrolinium + nicotinate not assigned
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L-aspartate + O2 <=> H+ + iminosuccinate + H2O2 1.4.3.16 L-aspartate oxidase
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(RS)-nicotine + O2 <=> N-methylmyosmine + H2O2 1.5.3
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4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + NADH + O2 + H+ <=> 2,5-dihydroxypyridine + succinate_semialdehyde + NAD+ + H2O 1.14.13.163 6-hydroxy-3-succinoylpyridine 3-monooxygenase
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