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Chlorocyclohexane and chlorobenzene degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
cis-4-carboxymethylenebut-2-en-4-olide + H2O <=> maleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase

(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> cis-4-carboxymethylenebut-2-en-4-olide + Cl- + H+ not assigned

3,4,6-trichlorocatechol + O2 <=> 2,3,5-Trichloro-cis,cis-muconate + H+ 1.13.11
1.13.11.M6


cis-Chlorobenzene_dihydrodiol + NAD+ <=> tetrachlorocatechol + NADH + H+ 1.3.1

cis-1,2-Dihydroxy-3,6-dichlorocyclohexa-3,5-diene + NAD+ <=> 3,6-dichlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase

2,6-dichlorohydroquinone + Cl- + GSSG + H+ <=> 2,3,5-trichlorohydroquinone + glutathione 1.21.4.5 tetrachlorohydroquinone reductive dehalogenase

2-hydroxy-1,4-benzoquinone + NADH + H+ <=> Hydroxyquinol + NAD+ 1.6.5.7 2-hydroxy-1,4-benzoquinone reductase
1.8.1.4 dihydrolipoyl dehydrogenase


3-chlorocatechol + O2 <=> 3-chloro-2-hydroxymuconic_semialdehyde + H2O 1.13.11.2 catechol 2,3-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase


2,4-dichloro-cis,cis-muconate <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + Hydrochloric_acid 5.5.1.11 dichloromuconate cycloisomerase

trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + Hydrochloric_acid <=> 2,5-dichloro-cis,cis-muconate 5.5.1.7 chloromuconate cycloisomerase

hydroquinone + O2 + NADPH <=> Hydroxyquinol + NADP+ + H2O 1.14.13
1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)



4-Chlorophenol + O2 + NADPH + H+ <=> 4-Chlorocatechol + H2O + NADP+ 1.14.13.20 2,4-dichlorophenol 6-monooxygenase
1.14.13.7 phenol 2-monooxygenase (NADPH)


Hydroxyquinol + O2 <=> H+ + maleylacetate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase


2,4-Dichlorophenoxyacetic_acid + 2-oxoglutarate + O2 <=> 2,4-Dichlorophenol + glyoxylate + succinate + CO2 1.14.11

2,4,5-trichloro-2,5-cyclohexadiene-1-ol <=> 2,5-dichlorophenol + Hydrochloric_acid not assigned

2,6-dichlorophenol + O2 + NADH + H+ <=> 2,6-dichlorohydroquinone + NAD+ + H2O 1.14.13

1,2,3,4-tetrachlorobenzene + O2 + NADH + H+ <=> cis-Chlorobenzene_dihydrodiol + NAD+ 1.14.12

2,6-dichloroquinone + NADH + H+ <=> 2,6-dichlorohydroquinone + NAD+ not assigned

2,5-Dichloro-carboxymethylenebut-2-en-4-olide + H2O <=> 2,5-dichloromaleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase

5-chloro-1,2,4-trihydroxybenzene <=> 2-hydroxy-1,4-benzoquinone + Cl- + H+ 4.5.1

2,4-Dichlorophenoxyacetic_acid + H+ + 2 e- <=> 4-Chlorophenoxyacetate + Cl- 1.97.1

4-Chlorocatechol + O2 <=> H+ + 3-chloro-cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.M6


2,6-dichlorohydroquinone + H2O <=> 6-chlorohydroxyquinol + Cl- not assigned

3-chloro-cis,cis-muconate <=> protoanemonin + Hydrochloric_acid + CO2 5.5.1.1 muconate cycloisomerase

phenol + O2 + NADH + H+ <=> catechol + H2O + NAD+ 1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)



beta-hexachlorocyclohexane + H2O <=> beta-2,3,4,5,6-Pentachlorocyclohexanol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase

cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+ <=> 3-chlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase


cis-benzene_dihydrodiol + NAD+ <=> catechol + NADH + H+ 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase






gamma-pentachlorocyclohexene <=> H+ + 1,3,4,6-tetrachloro-1,4-cyclohexadiene + Cl- 4.5.1
4.5.1.B1


delta-3,4,5,6-Tetrachlorocyclohexene <=> 5,6-Dichloro-1,3-cyclohexadiene + 2 Cl- not assigned

5,6-Dichloro-1,3-cyclohexadiene <=> chlorobenzene + Cl- + H+ not assigned

2,3,5-Trichlorodienelactone + H2O <=> 2,3,5-trichloromaleylacetate 3.1.1.45 carboxymethylenebutenolidase

2,4,5-T + O2 + NADH <=> 2,4,5-Trichlorophenol + glyoxylate + H2O + NAD+ 1.14.13

chlorobenzene + O2 + NADH + H+ <=> cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+ 1.14.12.26 chlorobenzene dioxygenase

4-hydroxymuconic_acid_semialdehyde + NAD+ + H2O <=> maleylacetate + NADH + H+ 1.2.1.61 4-hydroxymuconic-semialdehyde dehydrogenase

tetrachlorohydroquinone + NAD+ + H+ <=> tetrafluoro-1,4-benzoquinone + NADH 1.1.1.404 tetrachlorobenzoquinone reductase

2,3,5-trichloromaleylacetate + 2 NADPH + 2 H+ <=> 2,4-dichloro-3-oxohexanedioic_acid + 2 NADP+ + Hydrochloric_acid 1.3.1.32 maleylacetate reductase

cis,cis-tetrachloromuconic_acid <=> 2,3,5-Trichlorodienelactone + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase

3,4,6-Trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ <=> 3,4,6-trichlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase

1,4-dichlorobenzene <=> chlorobenzene not assigned

cis-Chlorobenzene_dihydrodiol + NADP+ <=> tetrachlorocatechol + NADPH + H+ 1.3.1

2,5-Dichloro-p-benzoquinone + NADH + H+ <=> 2,5-dichlorohydroquinone + NAD+ not assigned

hexachlorocyclohexane <=> gamma-pentachlorocyclohexene + Cl- + H+ 4.5.1
4.5.1.B1


3,5-dichlorocatechol + O2 <=> 2,4-dichloro-cis,cis-muconate + H+ 1.13.11
1.13.11.1 catechol 1,2-dioxygenase
1.13.11.M6



1,2,4-trichlorobenzene <=> 1,4-dichlorobenzene not assigned

cis-4-carboxymethylenebut-2-en-4-olide + H2O <=> maleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase

Benzene + NADH + O2 <=> phenol + NAD+ + H2O 1.14.13.236 toluene 4-monooxygenase
1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.25 methane monooxygenase (soluble)



4-chloroaniline + O2 + 2 H+ <=> 4-Chlorocatechol + NH3 1.14

1,3,4,6-tetrachloro-1,4-cyclohexadiene + H2O <=> 2,4,5-trichloro-2,5-cyclohexadiene-1-ol + Cl- 3.8.1.5 haloalkane dehalogenase

2,4,5-trichloro-2,5-cyclohexadiene-1-ol + H2O <=> 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase

2,5-dichloro-p-quinol + glutathione <=> H+ + chlorohydroquinone + GSSG + Cl- 2.5.1

2,5-dichloromaleylacetate + NADH <=> 2-chloro-3-oxohexanedioic_acid + NAD+ + Cl- 1.3.1.32 maleylacetate reductase

5,6-Dichloro-1,3-cyclohexadiene <=> Benzene + 2 Cl- not assigned

2,4-Dichlorophenol + O2 + NADPH + H+ <=> 3,5-dichlorocatechol + H2O + NADP+ 1.14.13.20 2,4-dichlorophenol 6-monooxygenase

4-Chlorophenoxyacetate + 2-oxoglutarate + O2 <=> 4-Chlorophenol + glyoxylate + succinate + CO2 1.14.11

2,4-dichloroaniline + 2 H+ <=> 4-chloroaniline + Hydrochloric_acid 1.97.1

1,2,4-trichlorobenzene + O2 + NADH + H+ <=> 3,4,6-Trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ 1.14.12.26 chlorobenzene dioxygenase

tetrachlorocatechol + O2 <=> cis,cis-tetrachloromuconic_acid 1.13.11.1 catechol 1,2-dioxygenase

4-Chlorocatechol + O2 <=> 5-chloro-2-hydroxymuconic-6-semialdehyde 1.13.11.2 catechol 2,3-dioxygenase

2,3,5-Trichloro-cis,cis-muconate <=> 2,5-Dichloro-carboxymethylenebut-2-en-4-olide + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase

Cl- + hydroquinone + GSSG + H+ <=> chlorohydroquinone + glutathione 2.5.1

trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + H2O <=> 2-chloromaleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase

2,4-dichloro-3-oxohexanedioic_acid <=> CO2 not assigned

(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H+ 5.5.1.1 muconate cycloisomerase
5.5.1.7 chloromuconate cycloisomerase


2,5-dichloro-p-quinol + O2 + FADH2 <=> 5-chloro-2-hydroxy-[1,4]-benzoquinone + Cl- + H2O + FAD + H+ 1.14.14

1,3,4,6-tetrachloro-1,4-cyclohexadiene <=> H+ + Cl- + 1,2,4-trichlorobenzene not assigned

1,4-dichlorobenzene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-3,6-dichlorocyclohexa-3,5-diene + NAD+ 1.14.12.26 chlorobenzene dioxygenase

2-chloro-3-oxohexanedioic_acid <=> Chloroacetate + succinate not assigned

2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ <=> 2,5-dichlorohydroquinone + NADH + H+ 1.3.1

2,6-dichlorohydroquinone + O2 + H2O <=> H+ + 2-chloromaleylacetate + Cl- 1.13.11
1.13.11.66 hydroquinone 1,2-dioxygenase


2,3,5-trichloromaleylacetate + NADH <=> 2,4-dichloro-3-oxohexanedioic_acid + NAD+ + Cl- 1.3.1.32 maleylacetate reductase

5-chloro-2-hydroxy-[1,4]-benzoquinone + NADH <=> 5-chloro-1,2,4-trihydroxybenzene + NAD+ 1.6.5.7 2-hydroxy-1,4-benzoquinone reductase

2-chloromaleylacetate + NADH <=> maleylacetate + Cl- + NAD+ 1.3.1.32 maleylacetate reductase

5-chloro-2-hydroxymuconic-6-semialdehyde + H+ <=> 2-hydroxymuconate-6-semialdehyde + Cl- 1.97.1

2-chloro-cis,cis-muconate <=> trans-4-Carboxymethylenebut-2-en-4-olide + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase

2,4,5-Trichlorophenol + O2 + FADH2 <=> 2,5-dichlorohydroquinone + Cl- + H2O + FAD + H+ 1.14.14

3,6-dichlorocatechol + O2 <=> 2,5-dichloro-cis,cis-muconate + H+ 1.13.11
1.13.11.M6


Pentachlorophenol + O2 + NADPH + H+ <=> tetrafluoro-1,4-benzoquinone + Cl- + NADP+ + H2O 1.14.13.50 pentachlorophenol monooxygenase

protoanemonin + H2O <=> cis-acetylacrylate 3.1.1.45 carboxymethylenebutenolidase

H+ + O2 + NADH + Benzene <=> NAD+ + cis-benzene_dihydrodiol 1.14.12.11 toluene dioxygenase
1.14.12.3 benzene 1,2-dioxygenase


beta-2,3,4,5,6-Pentachlorocyclohexanol + H2O <=> beta-2,3,5,6-Tetrachloro-1,4-cyclohexanediol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase

Chloroacetate + H2O <=> H+ + glycolate + Cl- 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)
3.8.1.2 (S)-2-haloacid dehalogenase
3.8.1.3 haloacetate dehalogenase
3.8.1.5 haloalkane dehalogenase
3.8.1.9 (R)-2-haloacid dehalogenase





beta-hexachlorocyclohexane <=> delta-3,4,5,6-Tetrachlorocyclohexene + 2 Cl- not assigned

2,3,5-trichlorohydroquinone + Cl- + GSSG <=> tetrachlorohydroquinone + glutathione 1.21.4.5 tetrachlorohydroquinone reductive dehalogenase

cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide 5.2.1.10 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase

2,4,6-Trichlorophenol + O2 + FADH2 <=> 2,6-dichloroquinone + Cl- + H2O + FAD + H+ 1.14.14.173 2,4,6-trichlorophenol monooxygenase

3-chlorocatechol + O2 <=> H+ + 2-chloro-cis,cis-muconate 1.13.11
1.13.11.1 catechol 1,2-dioxygenase
1.13.11.M6



hydroquinone + O2 <=> 4-hydroxymuconic_acid_semialdehyde + H+ 1.13.11.66 hydroquinone 1,2-dioxygenase

1,2,3,4-tetrachlorobenzene + O2 + NADPH + H+ <=> cis-Chlorobenzene_dihydrodiol + NADP+ 1.14.12

Visualization of the pathway