|
|
H+ + H2O + guanine <=> NH3 + xanthine
|
3.5.4.3
guanine deaminase
|
–
|
BMK
|
|
BRENDA:
BR22740
KEGG:
R01676
MetaCyc:
GUANINE-DEAMINASE-RXN
SABIO-RK:
127
|
|
|
|
XMP + diphosphate <=> xanthine + 5-phospho-alpha-D-ribose_1-diphosphate
|
2.4.2.22
xanthine phosphoribosyltransferase
2.4.2.7
adenine phosphoribosyltransferase
2.4.2.8
hypoxanthine phosphoribosyltransferase
|
–
–
–
|
BMK
|
|
BRENDA:
BR47505
KEGG:
R02142
MetaCyc:
XANPRIBOSYLTRAN-RXN
SABIO-RK:
194
|
|
|
|
xanthine + NAD+ + H2O <=> Urate + NADH + H+
|
1.17.1.4
xanthine dehydrogenase
1.17.3.2
xanthine oxidase
|
–
–
|
BMK
|
|
BRENDA:
BR48027
KEGG:
R02103
MetaCyc:
RXN0-901
SABIO-RK:
196
|
|
|
|
xanthine + O2 + H2O <=> Urate + H2O2
|
1.17.3.2
xanthine oxidase
1.2.3.1
aldehyde oxidase
|
–
–
|
MK
|
|
BRENDA:
BR48028
KEGG:
R02107
MetaCyc:
XANTHINE-OXIDASE-RXN
SABIO-RK:
192
|
|
|
|
7-methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
BMK
|
|
BRENDA:
BR49432
KEGG:
R07966
MetaCyc:
RXN-11518
|
|
|
|
7-methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
K
|
|
BRENDA:
BR49432-a
KEGG:
R07965
MetaCyc:
RXN-11518_WOP
|
|
|
|
3-Methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O
|
1.14.13.179
methylxanthine N3-demethylase
|
–
|
MK
|
|
BRENDA:
BR50581
KEGG:
R07968
MetaCyc:
RXN-13109
|
|
|
|
3-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.179
methylxanthine N3-demethylase
|
–
–
|
K
|
|
BRENDA:
BR50581-a
KEGG:
R07967
MetaCyc:
RXN-13109_WOP
|
|
|
|
xanthine + 2-oxoglutarate + O2 <=> Urate + succinate + CO2
|
1.14.11.48
xanthine dioxygenase
|
–
|
|
|
BRENDA:
BR51293
KEGG:
R10920
MetaCyc:
RXN-15841
|
|
|
|
H+ + 6-Amino-2-hydroxypurine + H2O <=> xanthine + NH3
|
3.5.4.2
adenine deaminase
|
–
|
|
|
BRENDA:
BS116418
MetaCyc:
RXN0-6708
|
|
|
|
Xanthosine + H2O <=> D-ribose + xanthine
|
3.2.2.1
purine nucleosidase
3.2.2.2
inosine nucleosidase
3.2.2.3
uridine nucleosidase
3.2.2.8
ribosylpyrimidine nucleosidase
|
–
–
–
–
|
BMK
|
|
BRENDA:
BS214506
KEGG:
R02143
MetaCyc:
RXN0-363
|
|
|
|
Xanthosine + phosphate <=> xanthine + alpha-D-ribose_1-phosphate
|
2.4.2
2.4.2.1
purine-nucleoside phosphorylase
|
–
–
|
BMK
|
|
BRENDA:
BS323174
KEGG:
R02297
MetaCyc:
XANTHOSINEPHOSPHORY-RXN
|
|
|
|
hypoxanthine + NAD+ + H2O <=> xanthine + NADH + H+
|
1.17.1.4
xanthine dehydrogenase
1.17.3.2
xanthine oxidase
|
–
–
|
BMK
|
|
BRENDA:
BS359314
KEGG:
R01768
MetaCyc:
RXN-7682
SABIO-RK:
323
|
|
|
|
1-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O
|
1.14.13.178
methylxanthine N1-demethylase
|
–
|
K
|
|
BRENDA:
BS422267
KEGG:
R07969
MetaCyc:
RXN-13111_WOP
|
|
|
|
hypoxanthine + O2 + H2O <=> xanthine + H2O2
|
1.17.1.4
xanthine dehydrogenase
1.17.3.2
xanthine oxidase
1.2.3.1
aldehyde oxidase
|
–
–
–
|
K
|
|
BRENDA:
BS258274
KEGG:
R01769
|
|
|
|
xanthine + H2O <=> H+ + 5-ureido-4-imidazole_carboxylate
|
3.5.2
|
–
|
MK
|
|
KEGG:
R02141
MetaCyc:
R127-RXN
|
|
|
|
1-Methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O
|
1.14.13.178
methylxanthine N1-demethylase
|
–
|
MK
|
|
KEGG:
R07970
MetaCyc:
RXN-13111
|
|
|
|
xanthine + 3-acetylpyridine_adenine_dinucleotide + H2O <=> Urate + reduced_acetylpyridine_adenine_dinucleotide
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359224
SABIO-RK:
12908
|
|
|
|
hypoxanthine + NADP+ + H2O <=> xanthine + NADPH
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359322
SABIO-RK:
6745
|
|
|
|
xanthine + nitrite <=> Urate + NO
|
1.17.3.2
xanthine oxidase
|
–
|
|
|
BRENDA:
BS359361
SABIO-RK:
10986
|
|
|
|
xanthine + 2 S-adenosyl-L-methionine <=> theophylline + 2 S-adenosyl-L-homocysteine
|
not assigned
|
–
|
|
|
KEGG:
R08410
|
|
|
|
3-Methylxanthine + demethylated_methyl_donor <=> xanthine + alkane
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-11546
|
|
|
|
hypoxanthine + acceptor + H2O <=> xanthine + reduced_acceptor
|
1.17.99.M4
|
–
|
M
|
|
MetaCyc:
RXN-21065
|
|
|
|
xanthine + H+ <=> xanthine + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-5076
|
|
|
|
S-adenosyl-L-methionine + xanthine <=> H+ + 3-Methylxanthine + S-adenosyl-L-homocysteine
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-7602
|
|
|
|
xanthine + H+ <=> xanthine + H+
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN-206
|
|
|
|
xanthine <=> xanthine
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN0-561
|
|
|
|
xanthine + 5-phospho-alpha-D-ribose_1-diphosphate <=> 3-ribosylxanthine_5''-phosphate + diphosphate
|
2.4.2.20
dioxotetrahydropyrimidine phosphoribosyltransferase
|
–
|
|
|
BRENDA:
BS354614
|
|
|
|
xanthine + FAD + H2O <=> Urate + FADH2
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359292
|
|
|
|
Inosine + xanthine <=> hypoxanthine + Xanthosine
|
2.4.2.5
nucleoside ribosyltransferase
|
–
|
|
|
BRENDA:
BS356214
|
|
|
|
2,6-diaminopurine + H2O <=> xanthine + NH3
|
3.5.4.3
guanine deaminase
|
–
|
|
|
BRENDA:
BS403389
|
|
|
|
hypoxanthine + methylene_blue + H2O <=> xanthine + reduced_methylene_blue
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359233
|
|
|
|
hypoxanthine + O2 + H2O <=> xanthine + O2-
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS376982
|
|
|
|
hypoxanthine + ferricyanide <=> xanthine + ferrocyanide
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359254
|
|
|
|
Inosine + H2O <=> D-ribose + xanthine
|
3.2.2.3
uridine nucleosidase
|
–
|
|
|
BRENDA:
BS431966
|
|
|
|
alkylated_DNA + H2O <=> 7-Methyladenine + 7-methylguanine + 3-Methyladenine + 3-Methylguanine + purine + 6-Chloropurine + xanthine + DNA
|
3.2.2.21
DNA-3-methyladenine glycosylase II
|
–
|
|
|
BRENDA:
BS430869
|
|
|
|
xanthine + 1,4-benzoquinone + H2O <=> hypoxanthine + hydroquinone
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359241
|
|
|
|
hypoxanthine + thio-NAD+ + H2O <=> xanthine + thio-NADH
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359248
|
|
|
|
2'-deoxyadenosine + xanthine <=> adenine + 2'-deoxyxanthosine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS354852
|
|
|
|
hypoxanthine + methyl_viologen + H2O <=> xanthine + reduced_methyl_viologen
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359225
|
|
|
|
2'-deoxyguanosine + xanthine <=> guanine + deoxyxanthine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS354846
|
|
|
|
hypoxanthine + Urate <=> xanthine + 6,8-dihydroxypurine
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359311
|
|
|
|
Xanthosine + arsenate <=> xanthine + alpha-D-ribose_1-arsenate
|
2.4.2.1
purine-nucleoside phosphorylase
|
–
|
|
|
BRENDA:
BS323182
|
|
|
|
xanthine + 2,6-dichlorophenolindophenol + H2O <=> Urate + reduced_2,6-dichlorophenolindophenol
|
1.17.1.4
xanthine dehydrogenase
1.17.3.2
xanthine oxidase
|
–
–
|
|
|
BRENDA:
BS410641
|
|
|
|
xanthine + Ferredoxin + H2O <=> Urate + reduced_ferredoxin
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359283
|
|
|
|
xanthine + ferricyanide + H2O <=> Urate + ferrocyanide
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359272
|
|
|
|
guanosine + H2O <=> D-ribose + xanthine
|
3.2.2.1
purine nucleosidase
|
–
|
|
|
BRENDA:
BS373355
|
|
|
|
xanthine + Oxidized_benzyl_viologen + H2O <=> Urate + reduced_benzyl_viologen
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359229
|
|
|
|
xanthine + methyl_viologen + H2O <=> Urate + reduced_methyl_viologen
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359228
|
|
|
|
tRNAMet + xanthine <=> tRNAxanthine + queuine
|
2.4.2.29
tRNA-guanosine34 transglycosylase
|
–
|
|
|
BRENDA:
BS393733
|
|
|
|
thymidine + xanthine <=> thymine + Xanthosine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS354937
|
|
|
|
xanthine + 1,4-benzoquinone + H2O <=> hydroquinone + Urate
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359240
|
|
|
|
xanthine + NAD+ + O2 + H2O + H+ <=> Urate + NADH + H2O2
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359306
|
|
|
|
Theobromine + 2 O2 + 2 NADH + 2 H+ <=> xanthine + 2 NAD+ + 2 H2O + 2 formaldehyde
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
|
|
BRENDA:
BS412967
|
|
|
|
paraxanthine + 2 O2 + 2 NADH + 2 H+ <=> xanthine + 2 NAD+ + 2 H2O + 2 formaldehyde
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
|
|
BRENDA:
BS411138
|
|
|
|
Caffeine + 3 O2 + 3 NADH + 3 H+ <=> xanthine + 3 NAD+ + 3 H2O + 3 formaldehyde
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
|
|
BRENDA:
BS411829
|
|
|
|
theophylline + 2 O2 + 2 NADH + 2 H+ <=> xanthine + 2 NAD+ + 2 H2O + 2 formaldehyde
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
|
|
BRENDA:
BS412971
|
|
|
|
hypoxanthine + NAD+ + H+ + O2- + H2O <=> xanthine + NADH + H2O2
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359305
|
|
|
|
2 hypoxanthine + 2 NAD+ + 2 H2O <=> xanthine + 6,8-dihydroxypurine + 2 NADH + 2 H+
|
1.17.1.4
xanthine dehydrogenase
|
–
|
B
|
|
BRENDA:
BS359315
|
|
|
|
2 2-Hydroxypurine + 2 NAD+ + 2 H2O <=> xanthine + 2,8-dihydroxypurine + 2 NADH + 2 H+
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359313
|
|
|
|
deoxycytidine + xanthine <=> cytosine + Xanthosine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS354875
|
|
|
|
xanthine + FMN + H2O <=> Urate + FMNH2
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359290
|
|
|
|
xanthine + iodonitrotetrazolium_chloride + H2O <=> Urate + reduced_iodonitrotetrazolium_chloride
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359289
|
|
|
|
xanthine + methylene_blue + O2 <=> Urate + reduced_methylene_blue
|
1.17.3.2
xanthine oxidase
|
–
|
|
|
BRENDA:
BS390079
|
|
|
|
xanthine + methylene_blue + H2O <=> Urate + reduced_methylene_blue
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359232
|
|
|
|
xanthine + O2 + H2O <=> Urate + O2- + 2 H+
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359307
|
|
|
|
xanthine + thio-NAD+ + H2O <=> Urate + thio-NADH
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359247
|
|
|
|
xanthine + thionine + O2 <=> Urate + reduced_thionine
|
1.17.3.2
xanthine oxidase
|
–
|
|
|
BRENDA:
BS390081
|
|
|
|
xanthine + riboflavin + H2O <=> Urate + reduced_riboflavin
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359291
|
|
|
|
xanthine + 3-pyridinealdehyde-NAD+ + H2O <=> Urate + 3-pyridinealdehyde-NAD+
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359249
|
|
|
|
xanthine + myoglobin + H2O <=> Urate + reduced_myoglobin
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359302
|
|
|
|
7-methylxanthine + O2 + NADH + H+ <=> xanthine + formaldehyde + NADP+
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
|
|
BRENDA:
BS418342-a
|
|
|
|
paraxanthine + 2 O2 + 2 NADPH + 2 H+ <=> xanthine + 2 NADP+ + 2 H2O + 2 formaldehyde
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
|
|
BRENDA:
BS411139
|
|
|
|
xanthine + NADP+ + H2O <=> Urate + NADPH
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359323
|
|
|
|
xanthine-mismatched_double-stranded_DNA + H2O <=> xanthine + double-stranded_DNA_with_abasic_site
|
3.2.2.28
double-stranded uracil-DNA glycosylase
|
–
|
|
|
BRENDA:
BS431240
|
|
|
|
xanthine-mismatched_single-stranded_DNA + H2O <=> xanthine + single-stranded_DNA_with_abasic_site
|
3.2.2.28
double-stranded uracil-DNA glycosylase
|
–
|
|
|
BRENDA:
BS431241
|
|
|
|
xanthine-containing_double-stranded_DNA + H2O <=> xanthine + double-stranded_DNA_with_abasic_site
|
3.2.2.15
DNA-deoxyinosine glycosylase
|
–
|
|
|
BRENDA:
BS448261
|
|
|
|
xanthine-containing_single-stranded_DNA + H2O <=> xanthine + single-stranded_DNA_with_abasic_site
|
3.2.2.27
uracil-DNA glycosylase
|
–
|
|
|
BRENDA:
BS448262
|
|
|
|
hypoxanthine + cytochrome_c + H2O <=> xanthine + ferricytochrome_c
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359269
|
|
|
|
xanthine + cytochrome_c + H2O <=> Urate + ferricytochrome_c
|
1.17.1.4
xanthine dehydrogenase
1.17.3.2
xanthine oxidase
|
–
–
|
|
|
BRENDA:
BS359270
|
|
|
|
thymidine + xanthine <=> Xanthosine + 7-deoxyribosylxanthine
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS354882
|
|
|
|
purine + NADP+ <=> NADPH + H+ + xanthine
|
not assigned
|
–
|
|
|
SABIO-RK:
6764
|
|
|
|
NADP+ + 2-Hydroxypurine <=> NADPH + H+ + xanthine
|
not assigned
|
–
|
|
|
SABIO-RK:
6721
|
|