|
|
tryptamine + secologanin <=> strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
MK
|
|
BRENDA:
BR48360
KEGG:
R03738
MetaCyc:
STRICTOSIDINE-SYNTHASE-RXN
|
|
|
|
H+ + L-tryptophan <=> CO2 + tryptamine
|
4.1.1.105
L-tryptophan decarboxylase
4.1.1.28
aromatic-L-amino-acid decarboxylase
4.1.1.53
phenylalanine decarboxylase
|
–
–
–
|
BMK
|
|
BRENDA:
BR52265
KEGG:
R00685
MetaCyc:
AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN
SABIO-RK:
1065
|
|
|
|
tryptamine + H2O + O2 <=> NH3 + Indole-3-acetaldehyde + H2O2
|
1.4.3.10
putrescine oxidase
1.4.3.21
primary-amine oxidase
1.4.3.22
diamine oxidase
1.4.3.4
monoamine oxidase
1.4.3.5
pyridoxal 5'-phosphate synthase
1.5.3.17
non-specific polyamine oxidase
|
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BS260300
KEGG:
R02173
MetaCyc:
RXN-1401
SABIO-RK:
2147
|
|
|
|
S-adenosyl-L-methionine + tryptamine <=> S-adenosyl-L-homocysteine + N-methyltryptamine + H+
|
2.1.1.49
amine N-methyltransferase
|
–
|
K
|
|
BRENDA:
BS289589
KEGG:
R02174
MetaCyc:
RXN-19909
SABIO-RK:
2148
|
|
|
|
tryptamine + reduced_acceptor + O2 <=> 4-hydroxytryptamine + acceptor + H2O
|
1.14.99.59
tryptamine 4-monooxygenase
|
–
|
K
|
|
BRENDA:
BR52245
KEGG:
R11912
|
|
|
|
tryptamine + O2 + NADPH <=> N-Hydroxyl-tryptamine + H2O + NADP+
|
1.14.13
|
–
|
MK
|
|
KEGG:
R08604
MetaCyc:
RXN-1405
|
|
|
|
feruloyl-CoA + tryptamine <=> CoA + (2E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(1H-indol-3-yl)ethyl]prop-2-enamide
|
2.3.1.110
tyramine N-feruloyltransferase
|
–
|
|
|
BRENDA:
BS320294
SABIO-RK:
14780
|
|
|
|
acetyl-CoA + tryptamine <=> CoA + N-acetyltryptamine
|
2.3.1.5
arylamine N-acetyltransferase
2.3.1.87
aralkylamine N-acetyltransferase
|
–
–
|
|
|
BRENDA:
BS320953
SABIO-RK:
14676
|
|
|
|
caffeoyl-CoA + tryptamine <=> CoA + (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(1H-indol-3-yl)ethyl]prop-2-enamide
|
2.3.1.110
tyramine N-feruloyltransferase
|
–
|
|
|
BRENDA:
BS376443
SABIO-RK:
14779
|
|
|
|
Protoemetine + tryptamine <=> deoxytubulosine
|
not assigned
|
–
|
K
|
|
KEGG:
R05895
|
|
|
|
tryptamine <=> eserine
|
not assigned
|
–
|
K
|
|
KEGG:
R08481
|
|
|
|
tryptamine <=> harman
|
not assigned
|
–
|
|
|
KEGG:
R08482
|
|
|
|
tryptamine <=> tetrahydroharman
|
not assigned
|
–
|
|
|
KEGG:
R08483
|
|
|
|
tryptamine <=> Harmaline
|
not assigned
|
–
|
|
|
KEGG:
R08484
|
|
|
|
tryptamine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 4-hydroxytryptamine + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.99.59
tryptamine 4-monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN-19089
|
|
|
|
tryptamine + secologanate <=> (3alphaS,21S)-strictosidinate + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
MetaCyc:
RXN-19641
|
|
|
|
tryptamine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> serotonin + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14
|
–
|
M
|
|
MetaCyc:
RXN-8707
|
|
|
|
tryptamine <=> harmalol
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9316
|
|
|
|
tryptamine + FADH2 + Cl- + O2 + H+ <=> 7-chloro-L-tryptamine + FAD + H2O
|
1.14.19.9
tryptophan 7-halogenase
|
–
|
|
|
BRENDA:
BS428980
|
|
|
|
dimethylallyl_diphosphate + tryptamine <=> diphosphate + 4-(3-methylbut-2-enyl)-tryptamin
|
2.5.1.34
4-dimethylallyltryptophan synthase
|
–
|
|
|
BRENDA:
BS388578
|
|
|
|
dimethylallyl_diphosphate + tryptamine <=> diphosphate + 7-(3-methylbut-2-enyl)-tryptamine
|
2.5.1.80
7-dimethylallyltryptophan synthase
|
–
|
|
|
BRENDA:
BS397072
|
|
|
|
tryptamine + H2O + 2,6-dichlorophenolindophenol <=> 4H-indol-3-yl-acetaldehyde + NH3 + reduced_2,6-dichlorophenolindophenol
|
1.4.9.2
aralkylamine dehydrogenase (azurin)
|
–
|
|
|
BRENDA:
BS374785
|
|
|
|
N-Phosphopyridoxyl_tryptamine + H2O + O2 <=> pyridoxal_5''-phosphate + tryptamine + H2O2
|
1.4.3.5
pyridoxal 5'-phosphate synthase
|
–
|
|
|
BRENDA:
BS259095
|
|
|
|
4-coumaroyl-CoA + tryptamine <=> CoA + N-(4-coumaroyl)tryptamine
|
2.3.1.110
tyramine N-feruloyltransferase
|
–
|
|
|
BRENDA:
BS420046
|
|
|
|
tryptamine + acceptor + H2O <=> Indole-3-acetaldehyde + NH3 + reduced_acceptor
|
1.4.9.2
aralkylamine dehydrogenase (azurin)
|
–
|
|
|
BRENDA:
BS261195
|
|
|
|
L-typtophan <=> tryptamine + CO2
|
4.1.1.28
aromatic-L-amino-acid decarboxylase
|
–
|
|
|
BRENDA:
BS442450
|
|
|
|
methyl_(2R,4S)-2-(2-methylpropoxy)-4-(2-oxoethyl)-3,4-dihydro-2H-pyran-5-carboxylate + tryptamine <=> methyl_(2R,4S)-2-(2-methylpropoxy)-4-[(1S)-2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl]-3,4-dihydro-2H-pyran-5-carboxylate + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS409868
|
|
|
|
methyl_(2R,4S)-2-(cyclohexyloxy)-4-(2-oxoethyl)-3,4-dihydro-2H-pyran-5-carboxylate + tryptamine <=> methyl_(2R,4S)-2-(cyclohexyloxy)-4-[(1S)-2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl]-3,4-dihydro-2H-pyran-5-carboxylate + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS409869
|
|
|
|
methyl_(2R,4S)-2-ethoxy-4-(2-oxoethyl)-3,4-dihydro-2H-pyran-5-carboxylate + tryptamine <=> methyl_(2R,4S)-2-ethoxy-4-[(1S)-2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl]-3,4-dihydro-2H-pyran-5-carboxylate + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS409870
|
|
|
|
methyl_(2R,4S)-2-tert-butoxy-4-(2-oxoethyl)-3,4-dihydro-2H-pyran-5-carboxylate + tryptamine <=> methyl_(2R,4S)-2-tert-butoxy-4-[(1S)-2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl]-3,4-dihydro-2H-pyran-5-carboxylate + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS409871
|
|
|
|
methyl_(2S,4S)-2-(2-methylpropoxy)-4-(2-oxoethyl)-3,4-dihydro-2H-pyran-5-carboxylate + tryptamine <=> methyl_(2S,4S)-2-(2-methylpropoxy)-4-[(1S)-2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl]-3,4-dihydro-2H-pyran-5-carboxylate + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS409872
|
|
|
|
methyl_(2S,4S)-2-ethoxy-4-(2-oxoethyl)-3,4-dihydro-2H-pyran-5-carboxylate + tryptamine <=> methyl_(2S,4S)-2-ethoxy-4-[(1S)-2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl]-3,4-dihydro-2H-pyran-5-carboxylate + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS409873
|
|
|
|
methyl_(2S,4S)-2-tert-butoxy-4-(2-oxoethyl)-3,4-dihydro-2H-pyran-5-carboxylate + tryptamine <=> methyl_(2S,4S)-2-tert-butoxy-4-[(1S)-2,3,4,9-tetrahydro-1H-beta-carbolin-1-ylmethyl]-3,4-dihydro-2H-pyran-5-carboxylate + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS409874
|
|
|
|
tryptamine + benzoyl-CoA <=> N-[2-(1H-indol-3-yl)ethyl]benzamide + CoA
|
not assigned
|
–
|
|
|
SABIO-RK:
14778
|
|