|
|
tobramycin + O-carbamoyladenylate <=> nebramycin_5'' + AMP + H+
|
6.1.2.2
nebramycin 5' synthase
|
–
|
|
|
BRENDA:
BR50756
KEGG:
R10543
MetaCyc:
RXN-13168
|
|
|
|
Carbamoyl_phosphate + tobramycin + ATP + H2O <=> nebramycin_5'' + AMP + diphosphate + phosphate + H+
|
6.1.2.2
nebramycin 5' synthase
|
–
|
K
|
|
BRENDA:
BR51037
KEGG:
R10767
MetaCyc:
RXN-15284
|
|
|
|
GTP + tobramycin <=> tobramycin_2''''-phosphate + GDP + H+
|
2.7.1.190
aminoglycoside 2''-phosphotransferase
|
–
|
|
|
BRENDA:
BS433798
MetaCyc:
RXN-16732
|
|
|
|
acetyl-CoA + tobramycin <=> CoA + N2''-acetyltobramycin
|
2.3.1.59
gentamicin 2'-N-acetyltransferase
2.3.1.60
gentamicin 3-N-acetyltransferase
|
–
–
|
|
|
BRENDA:
BS321113
SABIO-RK:
11471
|
|
|
|
acetyl-CoA + tobramycin <=> CoA + N3''-acetyltobramycin
|
2.3.1.60
gentamicin 3-N-acetyltransferase
2.3.1.81
aminoglycoside 3-N-acetyltransferase
|
–
–
|
|
|
BRENDA:
BS321397
SABIO-RK:
11472
|
|
|
|
acetyl-CoA + tobramycin <=> CoA + N6''-acetyltobramycin
|
2.3.1.82
aminoglycoside 6'-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS353889
SABIO-RK:
11225
|
|
|
|
UDP-alpha-D-kanosamine + nebramine <=> UDP + tobramycin
|
2.4.1
|
–
|
K
|
|
KEGG:
R11278
|
|
|
|
dATP + tobramycin <=> diphosphate + 2''''-deoxyadenylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS452391
|
|
|
|
dATP + tobramycin <=> diphosphate + 2''''-adenylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359905
|
|
|
|
dTTP + tobramycin <=> diphosphate + 2''''-deoxythymidylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS452394
|
|
|
|
dTTP + tobramycin <=> diphosphate + 2''''-adenylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359908
|
|
|
|
dCTP + tobramycin <=> diphosphate + 2''''-deoxycytosylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS452392
|
|
|
|
dCTP + tobramycin <=> diphosphate + 2''''-adenylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359907
|
|
|
|
dGTP + tobramycin <=> diphosphate + 2''''-deoxyguanosylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS452393
|
|
|
|
dGTP + tobramycin <=> diphosphate + 2''''-adenylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359906
|
|
|
|
butyryl-CoA + tobramycin <=> CoA + N6''-butyryltobramycin
|
2.3.1.82
aminoglycoside 6'-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS353907
|
|
|
|
acetyl-CoA + tobramycin <=> CoA + N6''-acetylnebramycin_factor_6
|
2.3.1.82
aminoglycoside 6'-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS353888
|
|
|
|
acetyl-CoA + tobramycin <=> CoA + 6''-N-acetyltobramicin
|
2.3.1.82
aminoglycoside 6'-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS455229
|
|
|
|
propionyl-CoA + tobramycin <=> CoA + N6''-propionyltobramycin
|
2.3.1.82
aminoglycoside 6'-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS353905
|
|
|
|
propionyl-CoA + tobramycin <=> CoA + N3''-propionyl-tobramycin
|
2.3.1.81
aminoglycoside 3-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS409951
|
|
|
|
GTP + tobramycin <=> diphosphate + 2''''-adenylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359904
|
|
|
|
CTP + tobramycin <=> diphosphate + 2''''-cytosylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS452390
|
|
|
|
CTP + tobramycin <=> diphosphate + 2''''-adenylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359903
|
|
|
|
N-acetyl-D-glucosamine + tobramycin <=> D-glucosamine + N2''-acetyltobramycin
|
2.3.1.59
gentamicin 2'-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS321115
|
|
|
|
UTP + tobramycin <=> UDP + tobramycin_2''''-phosphate
|
2.7.1.190
aminoglycoside 2''-phosphotransferase
|
–
|
|
|
BRENDA:
BS434459
|
|
|
|
ATP + tobramycin <=> diphosphate + 2''''-(adenosine-5''-phosphoryl)-tobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359909
|
|
|
|
ATP + tobramycin <=> diphosphate + 2''''-adenylyltobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359902
|
|
|
|
malonyl-CoA + tobramycin <=> CoA + N6''-malonyltobramycin
|
2.3.1.82
aminoglycoside 6'-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS353906
|
|
|
|
adenosine_5''-mono-O-phosphorothiolate + tobramycin <=> diphosphate + 2''''-(adenosine-5''-thiophosphoryl)-tobramycin
|
2.7.7.46
gentamicin 2''-nucleotidyltransferase
|
–
|
|
|
BRENDA:
BS359910
|
|
|
|
tobramycin + ATP + H2O <=> tobramycin + ADP + phosphate
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
|
BRENDA:
BS141512
|
|
|
|
ATP + tobramycin <=> ADP + tobramycin_2''''-phosphate
|
2.7.1.190
aminoglycoside 2''-phosphotransferase
|
–
|
|
|
BRENDA:
BS433488
|
|