|
|
steroid + reduced_adrenodoxin + O2 + H+ <=> an_11beta-hydroxysteroid + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BR29152
KEGG:
R02726
MetaCyc:
STEROID-11-BETA-MONOOXYGENASE-RXN
|
|
|
|
cholesterol + O2 + reduced_adrenodoxin + H+ <=> pregnenolone + 4-Methylpentanal + H2O + oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
B
|
|
BRENDA:
BR29153;
BS386399
KEGG:
R02724
MetaCyc:
1.14.15.6-RXN
SABIO-RK:
2614
|
|
|
|
corticosterone + O2 + reduced_adrenodoxin + H+ <=> 18-hydroxycorticosterone + H2O + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
1.14.15.5
corticosterone 18-monooxygenase
|
–
–
|
MK
|
|
BRENDA:
BR40407;
BS186781
KEGG:
R03262
MetaCyc:
RXN66-360
|
|
|
|
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced_adrenodoxin + H+ + O2 <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic_acid + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BR40435
KEGG:
R11142
MetaCyc:
RXN-13690
|
|
|
|
25-hydroxyvitamin_D3 + reduced_adrenodoxin + O2 + H+ <=> 1alpha,25-dihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.18
calcidiol 1-monooxygenase
|
–
|
MK
|
|
BRENDA:
BR40512
KEGG:
R03610
MetaCyc:
CALCIDIOL-1-MONOOXYGENASE-RXN
|
|
|
|
1alpha,25-dihydroxyvitamin_D3 + reduced_adrenodoxin + O2 + H+ <=> 1alpha,24R,25-trihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
K
|
|
BRENDA:
BR49597
KEGG:
R09515
MetaCyc:
RXN-9830
|
|
|
|
25-hydroxyvitamin_D3 + reduced_adrenodoxin + H+ + O2 <=> secalciferol + oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
K
|
|
BRENDA:
BR49598
KEGG:
R09516
MetaCyc:
RXN-12069
|
|
|
|
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced_adrenodoxin + H+ + O2 <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
BMK
|
|
BRENDA:
BR50217;
BS288576
KEGG:
R04807
MetaCyc:
CHOLESTANETRIOL-26-MONOOXYGENASE-RXN
|
|
|
|
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + O2 + reduced_adrenodoxin + H+ <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + oxidized_ferredoxin
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
BM
|
|
BRENDA:
BR50218;
BS257109
KEGG:
R03507
MetaCyc:
CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN
|
|
|
|
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + reduced_adrenodoxin + O2 + H+ <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic_acid + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
1.2.1.40
3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase
|
–
–
|
BMK
|
|
BRENDA:
BR50219;
BS387400
KEGG:
R08761
MetaCyc:
1.2.1.40-RXN
|
|
|
|
reduced_adrenodoxin + NADP+ + H+ <=> oxidized_ferredoxin + NADPH
|
1.18.1.2
ferredoxin---NADP+ reductase
1.18.1.6
adrenodoxin-NADP+ reductase
|
–
–
|
|
|
BRENDA:
BR50227
KEGG:
R10159
MetaCyc:
RXN-13685
|
|
|
|
cholesterol + O2 + reduced_adrenodoxin + H+ <=> (22R)-22-hydroxycholesterol + H2O + oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
MK
|
|
BRENDA:
BR50360
KEGG:
R02723
MetaCyc:
RXN-7875
|
|
|
|
(22R)-22-hydroxycholesterol + O2 + reduced_adrenodoxin + H+ <=> (20R,22R)-20,22-dihydroxy-cholesterol + H2O + oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
MK
|
|
BRENDA:
BR50361
KEGG:
R04855
MetaCyc:
RXN66-338
|
|
|
|
(20R,22R)-20,22-dihydroxy-cholesterol + O2 + reduced_adrenodoxin + H+ <=> pregnenolone + 4-Methylpentanal + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
MK
|
|
BRENDA:
BR50362
KEGG:
R03933
MetaCyc:
RXN66-339
|
|
|
|
all-trans-retinol + O2 + reduced_adrenodoxin + H+ <=> 3,4-didehydroretinol + H2O + oxidized_ferredoxin
|
1.14.19.53
all-trans-retinol 3,4-desaturase
|
–
|
K
|
|
BRENDA:
BR52311
KEGG:
R11952
MetaCyc:
RXN-18778
|
|
|
|
11-deoxycortisol + reduced_adrenodoxin + O2 + H+ <=> H2O + cortisol + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
M
|
|
BRENDA:
BS186773;
BS425303
MetaCyc:
RXN66-357
|
|
|
|
11-deoxycorticosterone + reduced_adrenodoxin + O2 + H+ <=> corticosterone + H2O + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
M
|
|
BRENDA:
BS186779;
BS424445
MetaCyc:
RXN66-359
|
|
|
|
18-hydroxycorticosterone + reduced_adrenodoxin + H+ + O2 <=> H2O + aldosterone + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
1.14.15.5
corticosterone 18-monooxygenase
|
–
–
|
MK
|
|
BRENDA:
BS186783;
BS424454
KEGG:
R03263
MetaCyc:
RXN66-361
|
|
|
|
5beta-cholestane-3alpha,7alpha-diol + reduced_adrenodoxin + O2 <=> 5beta-cholestane-3alpha,7alpha,26-triol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
BK
|
|
BRENDA:
BS386164
KEGG:
R04806
|
|
|
|
cholesterol + reduced_adrenodoxin + H+ + O2 <=> 27-Hydroxycholesterol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
K
|
|
BRENDA:
BS386397
KEGG:
R08505
|
|
|
|
secalciferol + reduced_adrenodoxin + H+ + O2 <=> 1alpha,24R,25-trihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.18
calcidiol 1-monooxygenase
|
–
|
|
|
KEGG:
R11324
MetaCyc:
RXN-18233
|
|
|
|
5beta-cholestane-3alpha,7alpha-diol + reduced_adrenodoxin + H+ + O2 <=> (25R)-3alpha,7alpha-dihydroxy-5-beta-cholestanate + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
MetaCyc:
RXN-13713
|
|
|
|
1alpha,24R,25-trihydroxyvitamin_D3 + reduced_adrenodoxin + H+ + O2 <=> (1S)-1,25-dihydroxy-24-oxocalciol + oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
MetaCyc:
RXN-14052
|
|
|
|
(1S)-1,25-dihydroxy-24-oxocalciol + reduced_adrenodoxin + O2 + H+ <=> (1S)-1,23,25-trihydroxy-24-oxocalciol + oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
MetaCyc:
RXN-14053
|
|
|
|
2,22-dideoxyecdysone + reduced_adrenodoxin + O2 + H+ <=> 2-deoxyecdysone + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN-14678
|
|
|
|
2-deoxyecdysone + reduced_adrenodoxin + O2 + H+ <=> ecdysone + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN-14679
|
|
|
|
2,22-Dideoxy-3-dehydroecdysone + reduced_adrenodoxin + O2 + H+ <=> 3-dehydro-2-deoxyecdysone + oxidized_ferredoxin + H2O
|
1.14.15.M6
|
–
|
M
|
|
MetaCyc:
RXN-14681
|
|
|
|
3-dehydro-2-deoxyecdysone + reduced_adrenodoxin + O2 + H+ <=> 3-Dehydroecdysone + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN-14682
|
|
|
|
ecdysone + reduced_adrenodoxin + O2 + H+ <=> 20-hydroxyecdysone + oxidized_ferredoxin + H2O
|
1.14.99.22
ecdysone 20-monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN-18799
|
|
|
|
5beta-cholestane-3alpha,7alpha-diol + reduced_adrenodoxin + H+ + O2 <=> (25R)-5beta-cholestane-3alpha,7alpha,26-triol + oxidized_ferredoxin + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9842
|
|
|
|
(25R)-5beta-cholestane-3alpha,7alpha,26-triol + reduced_adrenodoxin + H+ + O2 <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-al + oxidized_ferredoxin + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9843
|
|
|
|
(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-al + reduced_adrenodoxin + O2 + H+ <=> (25R)-3alpha,7alpha-dihydroxy-5-beta-cholestanate + oxidized_ferredoxin + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9844
|
|
|
|
17alpha-hydroxyprogesterone + reduced_adrenodoxin + O2 + H+ <=> 11-deoxycortisol + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN66-356
|
|
|
|
progesterone + reduced_adrenodoxin + O2 + H+ <=> 11-deoxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN66-358
|
|
|
|
17,20-dihydroxyvitamin_D2 + reduced_adrenodoxin + O2 <=> 17,20,24-trihydroxyvitamin_D2 + oxidized_ferredoxin + O2
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS407774
|
|
|
|
20-hydroxyvitamin_D2 + reduced_adrenodoxin + O2 <=> 17,20,24-trihydroxyvitamin_D2 + oxidized_ferredoxin + O2
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS407913
|
|
|
|
23-oxo-24,25,26,27-tetranor-1alpha-hydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> calcitroic_acid + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434526
|
|
|
|
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + reduced_adrenodoxin + O2 <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic_acid + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS385999
|
|
|
|
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced_adrenodoxin + O2 <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic_acid + oxidzed_adrenodoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS386162
|
|
|
|
testosterone + reduced_adrenodoxin + O2 <=> 11-hydroxytestosterone + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS427105
|
|
|
|
abietic_acid + reduced_adrenodoxin + O2 <=> 12-hydroxyabietic_acid + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS425864
|
|
|
|
7-dehydrocholesterol + 4 reduced_adrenodoxin + 2 H+ + 2 O2 <=> 25-hydroxy-7-dehydrocholesterol + 26/27-hydroxy-7-dehydrocholesterol + 4 oxidzed_adrenodoxin + 2 H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS425838
|
|
|
|
3-epi-1alpha,25-dihydroxy-24-oxo-vitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-1alpha,23,25-trihydroxy-24-oxo-vitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434541
|
|
|
|
3-epi-1alpha,23,25-trihydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-1alpha,25-dihydroxy-23-oxo-vitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434538
|
|
|
|
3-epi-1alpha,23-dihydroxy-24,25,26,27-tetranor-vitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epicalcitroic_acid + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434539
|
|
|
|
24,25,26,27-tetranor-1alpha,23-dihydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 23-oxo-24,25,26,27-tetranor-1alpha-hydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434527
|
|
|
|
24-oxo-1alpha,23,25-trihydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 24,25,26,27-tetranor-1alpha,23-dihydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434528
|
|
|
|
ergosterol + reduced_adrenodoxin + O2 <=> 24-hydroxyergosterol + 26-hydroxyergosterol + 28-hydroxyergosterol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS435479
|
|
|
|
24-oxo-1alpha,25-dihydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 24-oxo-1alpha,23,25-trihydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434529
|
|
|
|
1alpha,24R,25-trihydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 24-oxo-1alpha,25-dihydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434626
|
|
|
|
sitosterol + reduced_adrenodoxin + O2 <=> 26-hydroxy-beta-sitosterol + 29-hydroxy-beta-sitosterol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS435360
|
|
|
|
1alpha,25-dihydroxy-3-epi-vitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-1alpha,23,25-trihydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434542
|
|
|
|
3-epi-1alpha,23,25-trihydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-1alpha,23,26-trihydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434537
|
|
|
|
3-epi-1alpha,23,25-trihydroxy-24-oxo-vitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-1alpha,23-dihydroxy-24,25,26,27-tetranor-vitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434536
|
|
|
|
1alpha,25-dihydroxy-3-epi-vitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-1alpha,24,25-trihydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434543
|
|
|
|
3-epi-1alpha,24,25-trihydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-1alpha,25-dihydroxy-24-oxo-vitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434540
|
|
|
|
3-epi-25,26,27-trinor-23-ene-1alpha-hydroxyvitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-25,26,27-trinor-23,24-epoxide-1alpha-hydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434545
|
|
|
|
1alpha,25-dihydroxy-3-epi-vitamin_D3 + 2 reduced_adrenodoxin + 2 H+ + O2 <=> 3-epi-25,26,27-trinor-23-ene-1alpha-hydroxyvitamin_D3 + 2 oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
|
BRENDA:
BS434544
|
|
|
|
all-trans-retinal + 2 reduced_adrenodoxin + 2 H+ + O2 <=> all-trans-3,4-didehydroretinal + 2 oxidized_ferredoxin + 2 H2O
|
1.14.19.53
all-trans-retinol 3,4-desaturase
|
–
|
|
|
BRENDA:
BS443029
|
|
|
|
retinoic_acid + 2 reduced_adrenodoxin + 2 H+ + O2 <=> all-trans-3,4-didehydroretinoic_acid + 2 oxidized_ferredoxin + 2 H2O
|
1.14.19.53
all-trans-retinol 3,4-desaturase
|
–
|
|
|
BRENDA:
BS443030
|
|
|
|
cortisone + reduced_adrenodoxin + O2 <=> 15beta-hydroxycortisone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS443403
|
|
|
|
pregnenolone + reduced_adrenodoxin + O2 <=> 7beta-hydroxy-pregnenolone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS443859
|
|
|
|
H2O + reduced_adrenodoxin + O2 <=> 1alpha,25-dihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS288580
|
|
|
|
11-deoxycorticosterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxy-11-deoxycorticosterone + 7beta,15beta-dihydroxy-11-deoxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS442714
|
|
|
|
11-deoxycorticosterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxy-11-deoxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS404979
|
|
|
|
20-hydroxyvitamin_D3 + reduced_adrenodoxin + O2 <=> 20,23-dihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS407915
|
|
|
|
20-hydroxyvitamin_D3 + reduced_adrenodoxin + O2 <=> 20,23-dihydroxyvitamin_D3 + 17alpha,20,23-trihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS407914
|
|
|
|
Cholesterol_sulfate + reduced_adrenodoxin + O2 <=> pregnenolone_sulfate + 17alpha-hydroxypregnenolone + dehydroepiandrosterone_3-sulfate + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS186791
|
|
|
|
cholesterol + reduced_adrenodoxin + O2 <=> 25-hydroxycholesterol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS388315
|
|
|
|
dehydroepiandrosterone + reduced_adrenodoxin + O2 <=> 7beta-hydroxydehydroepiandrosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS443452
|
|
|
|
progesterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxy-progesterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS406466
|
|
|
|
testosterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxytestosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS406748
|
|
|
|
vitamin_D2 + reduced_adrenodoxin + O2 <=> 17,20,24-trihydroxyvitamin_D2 + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS410637
|
|
|
|
imipramine + reduced_adrenodoxin + O2 <=> desipramine + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS426506
|
|
|
|
(20S)-22-thiacholesterol + reduced_adrenodoxin + O2 <=> (20S,22R)-22-thiacholesterol_S-oxide + (20S,22S)-22-thiacholesterol_S-oxide
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS186792
|
|
|
|
oxidized_ferredoxin + NADH + H+ <=> reduced_adrenodoxin + NAD+
|
1.18.1.6
adrenodoxin-NADP+ reductase
|
–
|
|
|
BRENDA:
BS421151
|
|
|
|
progesterone + reduced_adrenodoxin + O2 <=> 11beta-hydroxyprogesterone + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS426947
|
|
|
|
progesterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxy-progesterone + 11alpha-hydroxyprogesterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS443861
|
|
|
|
20alpha-hydroxycholesterol + reduced_adrenodoxin + O2 <=> pregnenolone + 4-Methylpentanal + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS377798
|
|
|
|
(22R)-22-hydroxycholesterol + reduced_adrenodoxin + O2 <=> pregnenolone + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS375718
|
|
|
|
20alpha-hydroxycholesterol + reduced_adrenodoxin + O2 <=> pregnenolone + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS186790
|
|
|
|
25-hydroxycholesterol + reduced_adrenodoxin + O2 <=> pregnenolone + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS375731
|
|
|
|
11-deoxycortisol + reduced_adrenodoxin + O2 <=> 15beta-15,17,21-trihydroxypregn-4-ene-3,20-dione + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS403302
|
|
|
|
cholesterol + reduced_adrenodoxin + O2 <=> (24S)-24-hydroxycholesterol + oxidized_ferredoxin + H2O
|
1.14.14.25
cholesterol 24-hydroxylase
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
–
|
|
|
BRENDA:
BS386396
|
|
|
|
20,23-dihydroxyvitamin_D3 + reduced_adrenodoxin + O2 <=> 17alpha,20,23-trihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS407910
|
|
|
|
vitamin_D3 + reduced_adrenodoxin + O2 <=> 20-hydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS410638
|
|
|
|
24,25-dihydroxycholecalciferol + reduced_adrenodoxin + O2 <=> 1alpha,24,25-trihydroxycholecalciferol + oxidized_ferredoxin + H2O
|
1.14.15.18
calcidiol 1-monooxygenase
|
–
|
|
|
BRENDA:
BS451322
|
|
|
|
7alpha-hydroxy-4-cholesten-3-one + reduced_adrenodoxin + O2 <=> 7alpha,27-dihydroxy-4-cholesten-3-one + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS386172
|
|
|
|
7alpha-hydroxycholesterol + reduced_adrenodoxin + O2 <=> 5-cholestene-3alpha,7alpha,26-triol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS386155
|
|
|
|
5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + reduced_adrenodoxin + O2 <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane-27-oic_acid + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
|
BRENDA:
BS387627
|
|
|
|
4-androstene-3,17-dione + reduced_adrenodoxin + O2 <=> 15beta-hydroxyandrostene-3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS442887
|
|
|
|
corticosterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS443402
|
|