|
|
cholesterol + O2 + reduced_adrenodoxin + H+ <=> pregnenolone + 4-Methylpentanal + H2O + oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
B
|
|
BRENDA:
BR29153;
BS386399
KEGG:
R02724
MetaCyc:
1.14.15.6-RXN
SABIO-RK:
2614
|
|
|
|
(20R,22R)-20,22-dihydroxy-cholesterol + O2 + reduced_adrenodoxin + H+ <=> pregnenolone + 4-Methylpentanal + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
MK
|
|
BRENDA:
BR50362
KEGG:
R03933
MetaCyc:
RXN66-339
|
|
|
|
pregnenolone + NAD+ <=> 5-Pregnene-3,20-dione + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
|
M
|
|
BRENDA:
BS257030-a
MetaCyc:
RXN66-353
|
|
|
|
3''-phosphoadenylyl-sulfate + pregnenolone <=> adenosine_3,5''-bisphosphate + pregnenolone_sulfate + H+
|
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
–
|
K
|
|
BRENDA:
BS360202
KEGG:
R08978
MetaCyc:
RXN-20215
SABIO-RK:
15237
|
|
|
|
pregnenolone + NAD+ <=> progesterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
–
|
BK
|
|
BRENDA:
BS383305
KEGG:
R02216
MetaCyc:
RXN-9722
SABIO-RK:
2188
|
|
|
|
pregnenolone_sulfate + H2O <=> pregnenolone + sulfate
|
3.1.6.2
steryl-sulfatase
|
–
|
K
|
|
BRENDA:
BS374416
KEGG:
R08942
|
|
|
|
pregnenolone + reduced_flavodoxin + O2 <=> 17alpha-hydroxypregnenolone + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
K
|
|
BRENDA:
BS427508
KEGG:
R03783
|
|
|
|
pregnenolone + UDP-glucose <=> UDP + pregnenolone_3-beta-D-glucoside
|
2.4.1.173
sterol 3beta-glucosyltransferase
2.4.1.192
nuatigenin 3beta-glucosyltransferase
|
–
–
|
|
|
BRENDA:
BS322411
SABIO-RK:
10345
|
|
|
|
pregnenolone + reduced_flavodoxin + O2 <=> 21-hydroxypregnenolone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
K
|
|
KEGG:
R03784
|
|
|
|
pregnenolone + NADPH + H+ + O2 <=> 7alpha-hydroxypregnenolone + NADP+ + H2O
|
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
|
K
|
|
KEGG:
R08943
|
|
|
|
pregnenolone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 17alpha-hydroxypregnenolone + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN66-340
|
|
|
|
pregnenolone + reduced_adrenodoxin + O2 <=> 7beta-hydroxy-pregnenolone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS443859
|
|
|
|
pregnenolone + O2 <=> DELTA5-pregnen-3,20-dione + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
|
|
BRENDA:
BS188847
|
|
|
|
pregnenolone + O2 <=> 5-Pregnene-3,20-dione + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
|
|
BRENDA:
BS425592
|
|
|
|
DELTA5-pregnen-3,20-dione + O2 <=> pregnenolone + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
|
|
BRENDA:
BS451150
|
|
|
|
pregnenolone + reduced_acceptor + O2 <=> 17alpha-hydroxypregnenolone + oxidized_acceptor + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS415730
|
|
|
|
pregnenolone + oleoyl-CoA <=> 20-oxopregn-5-en-3beta-yl_(9Z)-octadec-9-enoate + CoA
|
2.3.1.26
sterol O-acyltransferase
|
–
|
|
|
BRENDA:
BS421216
|
|
|
|
pregnenolone + reduced_acceptor + O2 <=> 17alpha-hydroxypregnenolone + A + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
|
|
BRENDA:
BS258004
|
|
|
|
pregnenolone + NADH + O2 <=> 11-deoxycorticosterone + NAD+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS186799
|
|
|
|
pregnenolone + NADH + H+ <=> progesterone + NAD+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS426945
|
|
|
|
pregnenolone + NAD+ <=> 5-Pregnene-3,20-dione + progesterone + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS398144
|
|
|
|
acyl-CoA + pregnenolone <=> CoA + pregnenolyl_3-O-acyl_ester
|
2.3.1.26
sterol O-acyltransferase
|
–
|
|
|
BRENDA:
BS435291
|
|
|
|
20alpha-hydroxycholesterol + reduced_adrenodoxin + O2 <=> pregnenolone + 4-Methylpentanal + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS377798
|
|
|
|
cholesterol + 6 reduced_adrenodoxin_mutant_S112W + 3 O2 <=> pregnenolone + 4-Methylpentanal + 6 oxidized_adrenodoxin_mutant_S112W + 4 H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS426100
|
|
|
|
(22R)-22-hydroxycholesterol + reduced_adrenodoxin + O2 <=> pregnenolone + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS375718
|
|
|
|
20alpha-hydroxycholesterol + reduced_adrenodoxin + O2 <=> pregnenolone + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS186790
|
|
|
|
25-hydroxycholesterol + reduced_adrenodoxin + O2 <=> pregnenolone + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS375731
|
|
|
|
cholesterol + reduced_ferredoxin + O2 <=> pregnenolone + adrenal_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS394800
|
|
|
|
25-hydroxycholesterol + O2 + reduced_ferredoxin <=> pregnenolone + H2O + Ferredoxin + 4-hydroxy-4-methylpentanal
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS387234
|
|
|
|
pregnenolone <=> progesterone
|
5.3.3.1
steroid Delta-isomerase
|
–
|
|
|
BRENDA:
BS428886
|
|
|
|
pregnenolone + reduced_flavodoxin + O2 <=> dehydroepiandrosterone + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS443860
|
|
|
|
pregnenolone + NADPH <=> progesterone + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS389583
|
|
|
|
pregnenolone + NADPH <=> 5-pregnene-3beta,20beta-diol + NADP+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS188326
|
|
|
|
pregnenolone + NADPH + H+ <=> 5-Pregnene-3,20-dione + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS424967
|
|
|
|
pregnenolone + NADP+ <=> progesterone + NADPH + H+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS406431
|
|
|
|
pregnenolone + NADP+ <=> 5-Pregnene-3,20-dione + NADPH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
|
|
|
BRENDA:
BS257030
|
|
|
|
3beta,20alpha-Dihydroxypregn-5-ene + NADP+ <=> pregnenolone + NADPH
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS188346
|
|
|
|
3''-phosphoadenylylsulfate + pregnenolone <=> adenosine_3'',5''-bisphosphate + 5-pregnen-20-one_3-sulfate
|
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
|
–
–
|
|
|
BRENDA:
BS360326
|
|
|
|
NADPH + O2 + pregnenolone <=> 17alpha-hydroxypregnenolone + NADP+ + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
SABIO-RK:
7672
|
|