|
|
(5-L-glutamyl)-peptide + amino_acid <=> alpha-(5-L-glutamyl)-amino_acid + peptide + H+
|
2.3.2.2
gamma-glutamyltransferase
|
–
|
|
|
BRENDA:
BR44110;
BS374959
KEGG:
R04159
MetaCyc:
GAMMA-GLUTAMYLTRANSFERASE-RXN
|
|
|
|
protein + H2O <=> peptide + H+
|
3.4.11
3.4.17.B1
3.4.21
3.4.21.10
acrosin
3.4.21.100
sedolisin
3.4.21.102
C-terminal processing peptidase
3.4.21.103
physarolisin
3.4.21.106
hepsin
3.4.21.107
peptidase Do
3.4.21.108
HtrA2 peptidase
3.4.21.109
matriptase
3.4.21.112
site-1 protease
3.4.21.117
stratum corneum chymotryptic enzyme
3.4.21.118
kallikrein 8
3.4.21.12
alpha-lytic endopeptidase
3.4.21.19
glutamyl endopeptidase
3.4.21.20
cathepsin G
3.4.21.25
cucumisin
3.4.21.26
prolyl oligopeptidase
3.4.21.34
plasma kallikrein
3.4.21.35
tissue kallikrein
3.4.21.36
pancreatic elastase
3.4.21.37
leukocyte elastase
3.4.21.39
chymase
3.4.21.48
cerevisin
3.4.21.49
hypodermin C
3.4.21.50
lysyl endopeptidase
3.4.21.53
endopeptidase La
3.4.21.57
leucyl endopeptidase
3.4.21.59
tryptase
3.4.21.61
kexin
3.4.21.62
subtilisin
3.4.21.63
oryzin
3.4.21.64
peptidase K
3.4.21.65
thermomycolin
3.4.21.66
thermitase
3.4.21.67
endopeptidase So
3.4.21.70
pancreatic endopeptidase E
3.4.21.71
pancreatic elastase II
3.4.21.76
myeloblastin
3.4.21.78
granzyme A
3.4.21.79
granzyme B
3.4.21.80
streptogrisin A
3.4.21.81
streptogrisin B
3.4.21.82
glutamyl endopeptidase II
3.4.21.90
togavirin
3.4.21.91
flavivirin
3.4.21.93
proprotein convertase 1
3.4.21.94
proprotein convertase 2
3.4.21.96
lactocepin
3.4.21.97
assemblin
3.4.21.99
spermosin
3.4.22.1
cathepsin B
3.4.22.10
streptopain
3.4.22.15
cathepsin L
3.4.22.16
cathepsin H
3.4.22.2
papain
3.4.22.25
glycyl endopeptidase
3.4.22.27
cathepsin S
3.4.22.3
ficain
3.4.22.30
caricain
3.4.22.31
ananain
3.4.22.32
stem bromelain
3.4.22.33
fruit bromelain
3.4.22.34
legumain
3.4.22.35
histolysain
3.4.22.37
gingipain R
3.4.22.38
cathepsin K
3.4.22.39
adenain
3.4.22.41
cathepsin F
3.4.22.42
cathepsin O
3.4.22.43
cathepsin V
3.4.22.44
nuclear-inclusion-a endopeptidase
3.4.22.46
L-peptidase
3.4.22.48
staphopain
3.4.22.50
V-cath endopeptidase
3.4.22.51
cruzipain
3.4.22.52
calpain-1
3.4.22.6
chymopapain
3.4.22.67
zingipain
3.4.22.7
asclepain
3.4.22.8
clostripain
3.4.23.1
pepsin A
3.4.23.12
nepenthesin
3.4.23.16
HIV-1 retropepsin
3.4.23.18
aspergillopepsin I
3.4.23.19
aspergillopepsin II
3.4.23.2
pepsin B
3.4.23.20
penicillopepsin
3.4.23.21
rhizopuspepsin
3.4.23.22
endothiapepsin
3.4.23.23
mucorpepsin
3.4.23.24
candidapepsin
3.4.23.25
saccharopepsin
3.4.23.26
rhodotorulapepsin
3.4.23.28
acrocylindropepsin
3.4.23.29
polyporopepsin
3.4.23.3
gastricsin
3.4.23.30
pycnoporopepsin
3.4.23.31
scytalidopepsin A
3.4.23.32
scytalidopepsin B
3.4.23.34
cathepsin E
3.4.23.40
phytepsin
3.4.23.41
yapsin 1
3.4.23.42
thermopsin
3.4.23.44
nodavirus endopeptidase
3.4.23.47
HIV-2 retropepsin
3.4.23.49
omptin
3.4.23.5
cathepsin D
3.4.24
3.4.24.1
atrolysin A
3.4.24.11
neprilysin
3.4.24.12
envelysin
3.4.24.15
thimet oligopeptidase
3.4.24.17
stromelysin 1
3.4.24.18
meprin A
3.4.24.20
peptidyl-Lys metalloendopeptidase
3.4.24.21
astacin
3.4.24.22
stromelysin 2
3.4.24.23
matrilysin
3.4.24.24
gelatinase A
3.4.24.25
vibriolysin
3.4.24.27
thermolysin
3.4.24.28
bacillolysin
3.4.24.29
aureolysin
3.4.24.30
coccolysin
3.4.24.31
mycolysin
3.4.24.33
peptidyl-Asp metalloendopeptidase
3.4.24.34
neutrophil collagenase
3.4.24.35
gelatinase B
3.4.24.36
leishmanolysin
3.4.24.37
saccharolysin
3.4.24.38
gametolysin
3.4.24.39
deuterolysin
3.4.24.40
serralysin
3.4.24.41
atrolysin B
3.4.24.42
atrolysin C
3.4.24.43
atroxase
3.4.24.44
atrolysin E
3.4.24.45
atrolysin F
3.4.24.46
adamalysin
3.4.24.47
horrilysin
3.4.24.48
ruberlysin
3.4.24.49
bothropasin
3.4.24.50
bothrolysin
3.4.24.51
ophiolysin
3.4.24.52
trimerelysin I
3.4.24.53
trimerelysin II
3.4.24.54
mucrolysin
3.4.24.55
pitrilysin
3.4.24.6
leucolysin
3.4.24.60
dactylysin
3.4.24.61
nardilysin
3.4.24.62
magnolysin
3.4.24.63
meprin B
3.4.24.65
macrophage elastase
3.4.24.66
choriolysin L
3.4.24.67
choriolysin H
3.4.24.69
bontoxilysin
3.4.24.72
fibrolase
3.4.24.73
jararhagin
3.4.24.74
fragilysin
3.4.24.76
flavastacin
3.4.24.77
snapalysin
3.4.24.78
gpr endopeptidase
3.4.24.81
ADAM10 endopeptidase
3.4.24.83
anthrax lethal factor endopeptidase
3.4.24.85
S2P endopeptidase
3.4.24.B10
3.4.24.B14
3.4.24.B15
3.4.24.B16
3.4.24.B17
3.4.24.B18
3.4.24.B19
3.4.24.B2
3.4.24.B20
3.4.24.B3
3.4.24.B4
3.4.24.B5
3.4.25.1
proteasome endopeptidase complex
|
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS365037
MetaCyc:
3.4.21.10-RXN;
3.4.21.100-RXN;
3.4.21.102-RXN;
3.4.21.106-RXN;
3.4.21.107-RXN;
3.4.21.108-RXN;
3.4.21.109-RXN;
3.4.21.112-RXN;
3.4.21.117-RXN;
3.4.21.118-RXN;
3.4.21.12-RXN;
3.4.21.19-RXN;
3.4.21.20-RXN;
3.4.21.25-RXN;
3.4.21.26-RXN;
3.4.21.34-RXN;
3.4.21.35-RXN;
3.4.21.36-RXN;
3.4.21.37-RXN;
3.4.21.39-RXN;
3.4.21.48-RXN;
3.4.21.49-RXN;
3.4.21.50-RXN;
3.4.21.53-RXN;
3.4.21.57-RXN;
3.4.21.59-RXN;
3.4.21.61-RXN;
3.4.21.62-RXN;
3.4.21.63-RXN;
3.4.21.64-RXN;
3.4.21.65-RXN;
3.4.21.66-RXN;
3.4.21.67-RXN;
3.4.21.70-RXN;
3.4.21.71-RXN;
3.4.21.76-RXN;
3.4.21.78-RXN;
3.4.21.79-RXN;
3.4.21.80-RXN;
3.4.21.81-RXN;
3.4.21.82-RXN;
3.4.21.87-RXN;
3.4.21.90-RXN;
3.4.21.91-RXN;
3.4.21.93-RXN;
3.4.21.94-RXN;
3.4.21.96-RXN;
3.4.21.97-RXN;
3.4.21.99-RXN;
3.4.22.1-RXN;
3.4.22.10-RXN;
3.4.22.15-RXN;
3.4.22.16-RXN;
3.4.22.17-RXN;
3.4.22.2-RXN;
3.4.22.27-RXN;
3.4.22.3-RXN;
3.4.22.30-RXN;
3.4.22.31-RXN;
3.4.22.32-RXN;
3.4.22.33-RXN;
3.4.22.34-RXN;
3.4.22.35-RXN;
3.4.22.37-RXN;
3.4.22.38-RXN;
3.4.22.39-RXN;
3.4.22.41-RXN;
3.4.22.42-RXN;
3.4.22.43-RXN;
3.4.22.44-RXN;
3.4.22.46-RXN;
3.4.22.50-RXN;
3.4.22.51-RXN;
3.4.22.6-RXN;
3.4.22.67-RXN;
3.4.22.7-RXN;
3.4.22.8-RXN;
3.4.23.1-RXN;
3.4.23.12-RXN;
3.4.23.16-RXN;
3.4.23.18-RXN;
3.4.23.19-RXN;
3.4.23.2-RXN;
3.4.23.20-RXN;
3.4.23.21-RXN;
3.4.23.22-RXN;
3.4.23.23-RXN;
3.4.23.24-RXN;
3.4.23.25-RXN;
3.4.23.26-RXN;
3.4.23.27-RXN;
3.4.23.28-RXN;
3.4.23.29-RXN;
3.4.23.3-RXN;
3.4.23.30-RXN;
3.4.23.31-RXN;
3.4.23.32-RXN;
3.4.23.34-RXN;
3.4.23.40-RXN;
3.4.23.41-RXN;
3.4.23.42-RXN;
3.4.23.44-RXN;
3.4.23.5-RXN;
3.4.24.1-RXN;
3.4.24.11-RXN;
3.4.24.12-RXN;
3.4.24.15-RXN;
3.4.24.17-RXN;
3.4.24.18-RXN;
3.4.24.20-RXN;
3.4.24.21-RXN;
3.4.24.22-RXN;
3.4.24.23-RXN;
3.4.24.24-RXN;
3.4.24.25-RXN;
3.4.24.27-RXN;
3.4.24.28-RXN;
3.4.24.29-RXN;
3.4.24.30-RXN;
3.4.24.31-RXN;
3.4.24.33-RXN;
3.4.24.34-RXN;
3.4.24.35-RXN;
3.4.24.36-RXN;
3.4.24.37-RXN;
3.4.24.38-RXN;
3.4.24.39-RXN;
3.4.24.40-RXN;
3.4.24.41-RXN;
3.4.24.42-RXN;
3.4.24.43-RXN;
3.4.24.44-RXN;
3.4.24.45-RXN;
3.4.24.46-RXN;
3.4.24.47-RXN;
3.4.24.48-RXN;
3.4.24.49-RXN;
3.4.24.50-RXN;
3.4.24.51-RXN;
3.4.24.52-RXN;
3.4.24.53-RXN;
3.4.24.54-RXN;
3.4.24.55-RXN;
3.4.24.6-RXN;
3.4.24.60-RXN;
3.4.24.61-RXN;
3.4.24.62-RXN;
3.4.24.63-RXN;
3.4.24.65-RXN;
3.4.24.66-RXN;
3.4.24.67-RXN;
3.4.24.69-RXN;
3.4.24.72-RXN;
3.4.24.73-RXN;
3.4.24.74-RXN;
3.4.24.76-RXN;
3.4.24.77-RXN;
3.4.24.83-RXN;
3.4.25.1-RXN;
RXN-11694;
RXN-11699;
RXN-12014;
RXN-12015;
RXN-12018;
RXN0-3182;
RXN0-3221;
RXN0-5103;
RXN0-5195
|
|
|
|
casein + H2O <=> peptide + H+
|
3.4.21.101
xanthomonalisin
3.4.21.83
oligopeptidase B
3.4.24.16
neurolysin
3.4.24.70
oligopeptidase A
3.4.24.B17
|
–
–
–
–
–
|
|
|
BRENDA:
BS367602
MetaCyc:
3.4.21.101-RXN;
3.4.21.83-RXN;
3.4.24.16-RXN;
3.4.24.70-RXN
|
|
|
|
Insulin_B-chain + H2O <=> peptide + H+
|
3.4.24.32
beta-lytic metalloendopeptidase
3.4.24.B9
|
–
–
|
|
|
BRENDA:
BS367745
MetaCyc:
RXN-12866
|
|
|
|
ATP + peptide <=> ADP + phosphopeptide
|
2.7.11.1
non-specific serine/threonine protein kinase
2.7.11.12
cGMP-dependent protein kinase
2.7.11.13
protein kinase C
2.7.11.14
rhodopsin kinase
2.7.11.15
beta-adrenergic-receptor kinase
2.7.11.17
Ca2+/calmodulin-dependent protein kinase
|
–
–
–
–
–
–
|
|
|
BRENDA:
BS357153
SABIO-RK:
13445
|
|
|
|
peptide + H2O <=> L-proline + peptide
|
3.4.11.5
prolyl aminopeptidase
|
–
|
K
|
|
KEGG:
R00135
|
|
|
|
D-glutamate + peptide <=> D-glutamyl-peptide
|
not assigned
|
–
|
|
|
KEGG:
R01578
|
|
|
|
(5-L-glutamyl)-peptide + taurine <=> peptide + 5-L-glutamyl-taurine
|
2.3.2.2
gamma-glutamyltransferase
|
–
|
K
|
|
KEGG:
R01687
|
|
|
|
epsilon-N-biotinyl-L-lysine + 2 peptide <=> biotin-carboxyl-carrier_protein + 2 H2O
|
3.4
|
–
|
K
|
|
KEGG:
R04869
|
|
|
|
(5-L-glutamyl)-peptide + Se-methyl-L-selenocysteine <=> peptide + gamma-Glutamyl-Se-methylselenocysteine
|
2.3.2.2
gamma-glutamyltransferase
|
–
|
|
|
KEGG:
R04935
|
|
|
|
S-farnesyl_protein + H2O <=> protein_C-terminal_S-farnesyl-L-cysteine + peptide
|
3.4.22
3.4.24.84
Ste24 endopeptidase
|
–
–
|
K
|
|
KEGG:
R09845
|
|
|
|
peptide_with_an_N-terminal_L-leucine + H2O <=> L-leucine + peptide
|
3.4.11.10
bacterial leucyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.10-RXN
|
|
|
|
peptide_with_an_N-terminal_L-amino_acid + H2O <=> proteinogenic_amino_acid + peptide
|
3.4.11.13
clostridial aminopeptidase
3.4.11.22
aminopeptidase I
|
–
–
|
|
|
MetaCyc:
3.4.11.13-RXN
|
|
|
|
peptide_with_an_N-terminal_L-tryptophan + H2O <=> L-tryptophan + peptide
|
3.4.11.17
tryptophanyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.17-RXN
|
|
|
|
peptide_with_an_N-terminal_L-methionine + H2O <=> L-methionine + peptide
|
3.4.11.18
methionyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.18-RXN
|
|
|
|
peptide_with_an_N-terminal_D-amino_acid + H2O <=> a_D-amino_acid + peptide
|
3.4.11.19
D-stereospecific aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.19-RXN
|
|
|
|
peptide_with_an_N-terminal_L-alanine + H2O <=> L-alanine + peptide
|
3.4.11.14
cytosol alanyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
|
–
–
|
|
|
MetaCyc:
3.4.11.2-RXN
|
|
|
|
aminopeptidase_Ey_substrate + H2O <=> proteinogenic_amino_acid + peptide
|
3.4.11.20
aminopeptidase Ey
|
–
|
|
|
MetaCyc:
3.4.11.20-RXN
|
|
|
|
peptide_with_an_N-terminal_L-aspartate + H2O <=> L-aspartate + peptide
|
3.4.11.21
aspartyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.21-RXN
|
|
|
|
aminopeptidase_S_substrate + H2O <=> proteinogenic_amino_acid + peptide
|
3.4.11.24
aminopeptidase S
|
–
|
|
|
MetaCyc:
3.4.11.24-RXN
|
|
|
|
peptide_with_an_N-terminal_L-cysteine + H2O <=> L-cysteine + peptide
|
3.4.11.3
cystinyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.3-RXN
|
|
|
|
peptide_with_an_N-terminal_L-proline + H2O <=> L-proline + peptide
|
3.4.11.5
prolyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.5-RXN
|
|
|
|
peptide_with_an_N-terminal_L-arginine + H2O <=> L-arginine + peptide
|
3.4.11.6
aminopeptidase B
|
–
|
|
|
MetaCyc:
3.4.11.6-RXN
|
|
|
|
[protein]_with_an_N-terminal_L-glutamate + H2O <=> L-glutamate + peptide
|
3.4.11.7
glutamyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.7-RXN
|
|
|
|
dipeptidyl-peptidase_I_substrate + H2O <=> Dipeptide + peptide + H+
|
3.4.14.1
dipeptidyl-peptidase I
|
–
|
|
|
MetaCyc:
3.4.14.1-RXN
|
|
|
|
tripeptidyl-peptidase_II_substrate + H2O <=> Tripeptide + peptide + H+
|
3.4.14.10
tripeptidyl-peptidase II
|
–
|
|
|
MetaCyc:
3.4.14.10-RXN
|
|
|
|
Xaa-Pro_dipeptidyl-peptidase_substrate + H2O <=> Xaa-Pro + peptide
|
3.4.14.11
Xaa-Pro dipeptidyl-peptidase
|
–
|
|
|
MetaCyc:
3.4.14.11-RXN
|
|
|
|
H2O + peptide_with_proline_in_the_third_position <=> tripeptide_with_proline_at_the_third_position + peptide
|
3.4.14.12
Xaa-Xaa-Pro tripeptidyl-peptidase
|
–
|
|
|
MetaCyc:
3.4.14.12-RXN
|
|
|
|
dipeptidyl-peptidase_II_substrate + H2O <=> Dipeptide + peptide + H+
|
3.4.14.2
dipeptidyl-peptidase II
|
–
|
|
|
MetaCyc:
3.4.14.2-RXN
|
|
|
|
dipeptidyl-peptidase_III_substrate + H2O <=> peptide + Dipeptide + H+
|
3.4.14.4
dipeptidyl-peptidase III
|
–
|
|
|
MetaCyc:
3.4.14.4-RXN
|
|
|
|
dipeptidyl-peptidase_IV_substrate + H2O <=> Dipeptide + peptide + H+
|
3.4.14.5
dipeptidyl-peptidase IV
|
–
|
|
|
MetaCyc:
3.4.14.5-RXN
|
|
|
|
tripeptidyl-peptidase_I_substrate + H2O <=> peptide + Tripeptide + H+
|
3.4.14.9
tripeptidyl-peptidase I
|
–
|
|
|
MetaCyc:
3.4.14.9-RXN
|
|
|
|
peptidyl-dipeptidase_A_substrate + H2O <=> Dipeptide + peptide
|
3.4.15.1
peptidyl-dipeptidase A
|
–
|
|
|
MetaCyc:
3.4.15.1-RXN
|
|
|
|
peptidyl-dipeptidase_B_substrate + H2O <=> Dipeptide + peptide
|
3.4.15.4
peptidyl-dipeptidase B
|
–
|
|
|
MetaCyc:
3.4.15.4-RXN
|
|
|
|
peptidyl-dipeptidase_Dcp_substrate + H2O <=> peptide + Dipeptide
|
3.4.15.5
peptidyl-dipeptidase Dcp
|
–
|
|
|
MetaCyc:
3.4.15.5-RXN
|
|
|
|
carboxypeptidase_C_substrate + H2O <=> peptide + proteinogenic_amino_acid
|
3.4.16.5
carboxypeptidase C
|
–
|
|
|
MetaCyc:
3.4.16.5-RXN
|
|
|
|
[peptide]-with_a_C-terminal_L-arginine + H2O <=> peptide + L-arginine
|
3.4.16.6
carboxypeptidase D
3.4.17.10
carboxypeptidase E
3.4.17.12
carboxypeptidase M
3.4.17.2
carboxypeptidase B
3.4.17.20
carboxypeptidase U
3.4.17.22
metallocarboxypeptidase D
|
–
–
–
–
–
–
|
|
|
MetaCyc:
3.4.17.12-RXN
|
|
|
|
carboxypeptidase_A2_substrate + H2O <=> peptide + an_aromatic_amino_acid
|
3.4.17.15
carboxypeptidase A2
|
–
|
|
|
MetaCyc:
3.4.17.15-RXN
|
|
|
|
carboxypeptidase_T_substrate + H2O <=> peptide + proteinogenic_amino_acid
|
3.4.17.18
carboxypeptidase T
|
–
|
|
|
MetaCyc:
3.4.17.18-RXN
|
|
|
|
carboxypeptidase_Taq_substrate + H2O <=> proteinogenic_amino_acid + peptide
|
3.4.17.19
carboxypeptidase Taq
|
–
|
|
|
MetaCyc:
3.4.17.19-RXN
|
|
|
|
[protein]_with_C-terminal_alpha-L-glutamate + H2O <=> peptide + L-glutamate
|
3.4.17.21
glutamate carboxypeptidase II
|
–
|
|
|
MetaCyc:
3.4.17.21-RXN
|
|
|
|
cathepsin_X_substrate + H2O <=> peptide + an_L-amino_acid
|
3.4.18.1
cathepsin X
|
–
|
|
|
MetaCyc:
3.4.18.1-RXN
|
|
|
|
[peptide]_with_N-terminal_beta_aspartate + H2O <=> L-aspartate + peptide
|
3.4.19.5
beta-aspartyl-peptidase
|
–
|
|
|
MetaCyc:
3.4.19.5-RXN
|
|
|
|
protein_with_an_N-terminal_N-formylmethionine + H2O <=> N-formyl-L-methionine + peptide
|
3.4.19.7
N-formylmethionyl-peptidase
|
–
|
|
|
MetaCyc:
3.4.19.7-RXN
|
|
|
|
chymotrypsin_substrate + H2O <=> peptide + peptide
|
3.4.21.1
chymotrypsin
|
–
|
|
|
MetaCyc:
3.4.21.1-RXN
|
|
|
|
egg_glycoprotein_Gp43 + H2O <=> egg_glycoprotein_Gp41 + peptide
|
3.4.21.120
oviductin
|
–
|
|
|
MetaCyc:
3.4.21.120-RXN
|
|
|
|
chymotrypsin_C_substrate + H2O <=> peptide + peptide
|
3.4.21.2
chymotrypsin C
|
–
|
|
|
MetaCyc:
3.4.21.2-RXN
|
|
|
|
metridin_substrate + H2O <=> peptide + peptide
|
3.4.21.3
metridin
|
–
|
|
|
MetaCyc:
3.4.21.3-RXN
|
|
|
|
brachyurin_substrate + H2O <=> peptide + H+
|
3.4.21.32
brachyurin
|
–
|
|
|
MetaCyc:
3.4.21.32-RXN
|
|
|
|
trypsin_substrate + H2O <=> peptide + peptide
|
3.4.21.4
trypsin
|
–
|
|
|
MetaCyc:
3.4.21.4-RXN
|
|
|
|
H2O + prothrombin <=> peptide + thrombin + peptide
|
3.4.21.6
coagulation factor Xa
|
–
|
|
|
MetaCyc:
3.4.21.6-RXN
|
|
|
|
prothrombin + H2O <=> peptide + thrombin + peptide
|
3.4.21.60
scutelarin
|
–
|
|
|
MetaCyc:
3.4.21.60-RXN
|
|
|
|
H2O + Factor_Va <=> peptide + H+
|
3.4.21.69
protein C (activated)
|
–
|
|
|
MetaCyc:
3.4.21.69-RXN
|
|
|
|
Fibrin + H2O <=> peptide + peptide
|
3.4.21.7
plasmin
|
–
|
|
|
MetaCyc:
3.4.21.7-RXN
|
|
|
|
H2O + Protein_precursor <=> mature_protein + peptide
|
3.4.21.75
furin
|
–
|
|
|
MetaCyc:
3.4.21.75-RXN
|
|
|
|
Limulus_clotting_factor_B + H2O <=> activated_factor_B + peptide
|
3.4.21.84
limulus clotting factor _overbar_C_
|
–
|
|
|
MetaCyc:
3.4.21.84-RXN
|
|
|
|
Coagulogen + H2O <=> coagulin + peptide
|
3.4.21.86
limulus clotting enzyme
|
–
|
|
|
MetaCyc:
3.4.21.86-RXN
|
|
|
|
peptide_with_a_leader_sequence + H2O <=> peptide + leader_sequence
|
3.4.21.89
signal peptidase I
|
–
|
|
|
MetaCyc:
3.4.21.89-RXN
|
|
|
|
protein + ATP + H2O <=> peptide + ADP + phosphate + H+
|
3.4.21.92
endopeptidase Clp
|
–
|
|
|
MetaCyc:
3.4.21.92-RXN
|
|
|
|
peptide_with_an_internal_glycine + H2O <=> peptide_with_a_C-terminal_glycine + peptide
|
3.4.22.25
glycyl endopeptidase
|
–
|
|
|
MetaCyc:
3.4.22.25-RXN
|
|
|
|
HC-Pro + H2O <=> cleaved_helper_component_proteinase + peptide
|
3.4.22.45
helper-component proteinase
|
–
|
|
|
MetaCyc:
3.4.22.45-RXN
|
|
|
|
peptide_containing_an_internal_L-lysine + H2O <=> [peptide]_with_a_C-terminal_L-lysine + peptide
|
3.4.22.47
gingipain K
|
–
|
|
|
MetaCyc:
3.4.22.47-RXN
|
|
|
|
calpain-1_substrate + H2O <=> peptide + H+
|
3.4.22.52
calpain-1
|
–
|
|
|
MetaCyc:
3.4.22.52-RXN
|
|
|
|
calpain-2_substrate + H2O <=> peptide + H+
|
3.4.22.53
calpain-2
|
–
|
|
|
MetaCyc:
3.4.22.53-RXN
|
|
|
|
calpain-3_substrate + H2O <=> peptide + H+
|
3.4.22.54
calpain-3
|
–
|
|
|
MetaCyc:
3.4.22.54-RXN
|
|
|
|
caspase-2_substrate + H2O <=> peptide + H+
|
3.4.22.55
caspase-2
|
–
|
|
|
MetaCyc:
3.4.22.55-RXN
|
|
|
|
caspase-3_substrate + H2O <=> peptide + H+
|
3.4.22.56
caspase-3
|
–
|
|
|
MetaCyc:
3.4.22.56-RXN
|
|
|
|
caspase-4_substrate + H2O <=> peptide + H+
|
3.4.22.57
caspase-4
|
–
|
|
|
MetaCyc:
3.4.22.57-RXN
|
|
|
|
caspase-5_substrate + H2O <=> peptide + H+
|
3.4.22.58
caspase-5
|
–
|
|
|
MetaCyc:
3.4.22.58-RXN
|
|
|
|
caspase-6_substrate + H2O <=> peptide_with_a_C-terminal_L-aspartate + peptide + H+
|
3.4.22.59
caspase-6
|
–
|
|
|
MetaCyc:
3.4.22.59-RXN
|
|
|
|
caspase-7_substrate + H2O <=> peptide + peptide_with_a_C-terminal_L-aspartate + H+
|
3.4.22.60
caspase-7
|
–
|
|
|
MetaCyc:
3.4.22.60-RXN
|
|
|
|
caspase-8_substrate + H2O <=> peptide_with_a_C-terminal_L-aspartate + peptide + H+
|
3.4.22.61
caspase-8
|
–
|
|
|
MetaCyc:
3.4.22.61-RXN
|
|
|
|
caspase-9_substrate + H2O <=> peptide + H+
|
3.4.22.62
caspase-9
|
–
|
|
|
MetaCyc:
3.4.22.62-RXN
|
|
|
|
caspase-10_substrate + H2O <=> peptide + H+
|
3.4.22.63
caspase-10
|
–
|
|
|
MetaCyc:
3.4.22.63-RXN
|
|
|
|
peptidase_1_substrate + H2O <=> peptide + H+
|
3.4.22.65
peptidase 1 (mite)
|
–
|
|
|
MetaCyc:
3.4.22.65-RXN
|
|
|
|
prohormone + H2O <=> peptide
|
3.4.23.17
pro-opiomelanocortin converting enzyme
|
–
|
|
|
MetaCyc:
3.4.23.17-RXN
|
|
|
|
alpha_factor + H2O <=> peptide
|
3.4.23.35
barrierpepsin
|
–
|
|
|
MetaCyc:
3.4.23.35-RXN
|
|
|
|
chymosin_substrate + H2O <=> peptide + H+
|
3.4.23.4
chymosin
|
–
|
|
|
MetaCyc:
3.4.23.4-RXN
|
|
|
|
H2O + type_IV_prepilin <=> cleaved_type_IV_prepilin + peptide
|
3.4.23.43
prepilin peptidase
|
–
|
|
|
MetaCyc:
3.4.23.43-RXN
|
|
|
|
H2O + Glu-plasminogen <=> plasmin + peptide
|
3.4.23.48
plasminogen activator Pla
|
–
|
|
|
MetaCyc:
3.4.23.48-RXN
|
|
|
|
pseudolysin_substrate + H2O <=> peptide + H+
|
3.4.24.26
pseudolysin
|
–
|
|
|
MetaCyc:
3.4.24.26-RXN
|
|
|
|
H2O + Collagen <=> peptide + H+
|
3.4.24.3
microbial collagenase
|
–
|
|
|
MetaCyc:
3.4.24.3-RXN
|
|
|
|
insulysin_substrate + H2O <=> peptide + H+
|
3.4.24.56
insulysin
|
–
|
|
|
MetaCyc:
3.4.24.56-RXN
|
|
|
|
O-sialoglycoprotein + H2O <=> peptide + H+
|
3.4.24.57
O-sialoglycoprotein endopeptidase
|
–
|
|
|
MetaCyc:
3.4.24.57-RXN
|
|
|
|
mitochondrial_preprotein_including_a_mitochondrial_targeting_sequence + H2O <=> MPP-processed_mitochondrial_protein + peptide
|
3.4.24.64
mitochondrial processing peptidase
|
–
|
|
|
MetaCyc:
3.4.24.64-RXN
|
|
|
|
tentoxilysin_substrate + H2O <=> peptide + H+
|
3.4.24.68
tentoxilysin
|
–
|
|
|
MetaCyc:
3.4.24.68-RXN
|
|
|
|
H2O + Collagen <=> peptide + H+
|
3.4.24.7
interstitial collagenase
|
–
|
|
|
MetaCyc:
3.4.24.7-RXN
|
|
|
|
H2O + big_endothelin <=> Endothelin_1 + peptide
|
3.4.24.71
endothelin-converting enzyme 1
|
–
|
|
|
MetaCyc:
3.4.24.71-RXN
|
|
|
|
H2O + TNF-alpha <=> active_TNF-alpha + peptide
|
3.4.24.86
ADAM 17 endopeptidase
|
–
|
|
|
MetaCyc:
3.4.24.86-RXN
|
|
|
|
N-acylated_peptide + H2O <=> N-acyl-L-amino_acid + peptide
|
3.4.19.1
acylaminoacyl-peptidase
|
–
|
|
|
MetaCyc:
ACYLAMINOACYL-PEPTIDASE-RXN
|
|
|
|
[peptide]_with_a_C-terminal_L-alanine + H2O <=> peptide + L-alanine
|
3.4.17.6
alanine carboxypeptidase
|
–
|
|
|
MetaCyc:
ALANINE-CARBOXYPEPTIDASE-RXN
|
|
|
|
carboxypeptidase_A_substrate + H2O <=> an_L-amino_acid + peptide
|
3.4.17.1
carboxypeptidase A
|
–
|
|
|
MetaCyc:
CARBOXYPEPTIDASE-A-RXN
|
|
|
|
protein_with_a_basic_C-terminal_amino-acid + H2O <=> peptide + basic_amino_acid
|
3.4.17.3
lysine carboxypeptidase
|
–
|
|
|
MetaCyc:
LYSINEARGININE-CARBOXYPEPTIDASE-RXN
|
|
|
|
[protein]_with_an_N-terminal_5-oxo-L-proline + H2O <=> 5-oxoproline + peptide
|
3.4.19.3
pyroglutamyl-peptidase I
|
–
|
M
|
|
MetaCyc:
PYROGLUTAMYL-PEPTIDASE-I-RXN
|
|
|
|
H2O + Factor_VIIIa <=> peptide + H+
|
3.4.21.69
protein C (activated)
|
–
|
|
|
MetaCyc:
RXN-10790
|
|
|
|
protein + ATP + H2O <=> peptide + ADP + phosphate
|
3.4.25.2
HslU---HslV peptidase
|
–
|
|
|
MetaCyc:
RXN-11136
|
|
|
|
H2O + insulin-like_growth_factor-binding_protein_4 <=> peptide
|
3.4.24.79
pappalysin-1
|
–
|
|
|
MetaCyc:
RXN-11688
|
|
|
|
H2O + insulin-like_growth_factor-binding_protein_5 <=> peptide
|
3.4.24.79
pappalysin-1
|
–
|
|
|
MetaCyc:
RXN-11692
|
|
|
|
H2O + RAD21_cohesin_subunit <=> peptide
|
3.4.22.49
separase
|
–
|
|
|
MetaCyc:
RXN-11693
|
|
|
|
H2O + collagenase <=> pro-collagenase + peptide
|
3.4.24.80
membrane-type matrix metalloproteinase-1
|
–
|
|
|
MetaCyc:
RXN-11700
|
|
|
|
MPP-processed_mitochondrial_protein + H2O <=> fully-processed_mitochondrial_protein + peptide
|
3.4.11.26
intermediate cleaving peptidase 55
|
–
|
|
|
MetaCyc:
RXN-12488
|
|
|
|
peptide_with_an_internal_Lys-Lys_bond + H2O <=> peptide_with_L-lysine-L-lysine_at_the_C-terminal + peptide
|
3.4.21.121
Lys-Lys/Arg-Xaa endopeptidase
|
–
|
|
|
MetaCyc:
RXN-14341
|
|
|
|
peptide_with_an_internal_L-Lys-L-Arg_motif + H2O <=> peptide_with_lysine-arginine_at_the_C-terminal + peptide
|
3.4.21.121
Lys-Lys/Arg-Xaa endopeptidase
|
–
|
|
|
MetaCyc:
RXN-14342
|
|
|
|
C5a_anaphylatoxin + H2O <=> complement_5_alpha_chain + peptide
|
3.4.21.121
Lys-Lys/Arg-Xaa endopeptidase
|
–
|
|
|
MetaCyc:
RXN-14998
|
|
|
|
signal_peptide + H2O <=> peptide
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-18678
|
|
|
|
peptide_with_an_N-terminal_L-lysine + H2O <=> L-lysine + peptide
|
3.4.11.15
aminopeptidase Y
3.4.11.6
aminopeptidase B
|
–
–
|
|
|
MetaCyc:
RXN-18719
|
|
|
|
[peptide]_with_a_C-terminal_L-lysine + H2O <=> peptide + L-lysine
|
3.4.16.6
carboxypeptidase D
3.4.17.10
carboxypeptidase E
3.4.17.12
carboxypeptidase M
3.4.17.2
carboxypeptidase B
3.4.17.20
carboxypeptidase U
3.4.17.22
metallocarboxypeptidase D
|
–
–
–
–
–
–
|
|
|
MetaCyc:
RXN-19940
|
|
|
|
patellamide_A_precursor_peptide_containing_azoline_residues + H2O <=> patellamide_A_precursor_peptide_lacking_leader_peptide + peptide
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-21193
|
|
|
|
patellamide_A_precursor_peptide_lacking_leader_peptide <=> prepatellamide_A_containing_thiazoline_residues + peptide
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-21194
|
|
|
|
patellamide_C_precursor_peptide_containing_azoline_residues + H2O <=> patellamide_C_precursor_peptide_lacking_leader_peptide + peptide
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-21197
|
|
|
|
patellamide_C_precursor_peptide_lacking_leader_peptide <=> prepatellamide_C_containing_thiazoline_residues + peptide
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-21198
|
|
|
|
microcin_B17_precursor_peptide_containing_azole_residues + H2O <=> peptide + microcin_B17
|
3.4.24
|
–
|
M
|
|
MetaCyc:
RXN-21204
|
|
|
|
protein + H2O + ATP <=> peptide + ADP + phosphate + H+
|
3.4.24
|
–
|
|
|
MetaCyc:
RXN-21299
|
|
|
|
lipoprotein_signal_peptide + H2O <=> peptide
|
3.4.21
|
–
|
M
|
|
MetaCyc:
RXN0-3201
|
|
|
|
[protein]_with_an_N-terminal_L-arginine + H2O <=> L-arginine + peptide
|
3.4.11
|
–
|
|
|
MetaCyc:
RXN0-3261
|
|
|
|
exoaminopeptidase_substrate + H2O <=> peptide + proteinogenic_amino_acid + H+
|
3.4.11
|
–
|
|
|
MetaCyc:
RXN0-5051
|
|
|
|
aminopeptidase_substrate + H2O <=> peptide + proteinogenic_amino_acid + H+
|
3.4.11
|
–
|
|
|
MetaCyc:
RXN0-5052
|
|
|
|
PepB_aminopeptidase_substrate + H2O <=> proteinogenic_amino_acid + peptide
|
3.4.11.23
PepB aminopeptidase
|
–
|
|
|
MetaCyc:
RXN0-5204
|
|
|
|
peptide + ATP + H2O <=> peptide + ADP + phosphate + H+
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN-398
|
|
|
|
polypeptide + H2O <=> peptide
|
3.4.21.117
stratum corneum chymotryptic enzyme
3.4.21.118
kallikrein 8
3.4.21.119
kallikrein 13
3.4.21.35
tissue kallikrein
3.4.21.77
semenogelase
3.4.21.B10
3.4.21.B12
3.4.21.B3
3.4.21.B39
3.4.21.B40
3.4.21.B41
3.4.21.B42
3.4.21.B43
3.4.21.B45
3.4.23.B1
|
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS361837
|
|
|
|
peptide + H2O <=> N-terminal_amino_acid + peptide(n-1)
|
3.4.11.10
bacterial leucyl aminopeptidase
|
–
|
|
|
BRENDA:
BS364746
|
|
|
|
[myelin_basic_protein]-arginine + H2O <=> L-arginine + peptide
|
3.4.11.6
aminopeptidase B
|
–
|
|
|
BRENDA:
BS36315
|
|
|
|
Trypsinogen + H2O <=> Trypsin + peptide
|
3.4.22.1
cathepsin B
|
–
|
|
|
BRENDA:
BS36967
|
|
|
|
acetyl-CoA + peptide <=> CoA + Nalpha-acetylpeptide
|
2.3.1.255
N-terminal amino-acid Nalpha-acetyltransferase NatA
2.3.1.257
N-terminal L-serine Nalpha-acetyltransferase NatD
2.3.1.258
N-terminal methionine Nalpha-acetyltransferase NatE
2.3.1.5
arylamine N-acetyltransferase
|
–
–
–
–
|
|
|
BRENDA:
BS321436
|
|
|
|
protein_N-ubiquityllysine + H2O <=> ubiquitin + peptide
|
3.4.19.12
ubiquitinyl hydrolase 1
|
–
|
|
|
BRENDA:
BS36800
|
|
|
|
peptide + H2O <=> hydrolyzed_peptide + H2O
|
3.4.21.80
streptogrisin A
3.4.22.B24
3.4.22.B25
3.4.22.B27
3.4.22.B28
3.4.22.B29
3.4.22.B30
3.4.22.B31
3.4.22.B32
3.4.22.B35
3.4.22.B36
3.4.22.B37
|
–
–
–
–
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS15687
|
|
|
|
peptide + H2O <=> amino_acid
|
3.4.22.48
staphopain
|
–
|
|
|
BRENDA:
BS358955
|
|
|
|
protein_L-glutamate + H2O <=> L-glutamate + peptide
|
3.4.11.7
glutamyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36334
|
|
|
|
apolipoprotein_A-I + H2O <=> peptide
|
3.4.24.33
peptidyl-Asp metalloendopeptidase
|
–
|
|
|
BRENDA:
BS16924
|
|
|
|
factor_IX + H2O <=> Factor_IXa + peptide
|
3.4.21.27
coagulation factor XIa
|
–
|
|
|
BRENDA:
BS36855
|
|
|
|
Factor_VIIIa + H2O <=> factor_VIII + peptide
|
3.4.21.20
cathepsin G
|
–
|
|
|
BRENDA:
BS393984
|
|
|
|
fibronectin + H2O <=> peptide
|
3.4.22.35
histolysain
|
–
|
|
|
BRENDA:
BS366842
|
|
|
|
azocasein + H2O <=> azopeptide + peptide
|
3.4.22.2
papain
|
–
|
|
|
BRENDA:
BS404444
|
|
|
|
factor_VIII + H2O <=> Factor_VIIIa + peptide
|
3.4.21.20
cathepsin G
|
–
|
|
|
BRENDA:
BS393983
|
|
|
|
Proteins + H2O <=> peptide
|
3.4.24.87
ADAMTS13 endopeptidase
3.4.24.B10
3.4.24.B11
3.4.24.B12
3.4.24.B19
3.4.24.B20
3.4.24.B6
3.4.24.B7
3.4.24.B8
3.4.24.B9
|
–
–
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS367540
|
|
|
|
von_Willebrand_factor + H2O <=> 2 peptide
|
3.4.24.87
ADAMTS13 endopeptidase
|
–
|
|
|
BRENDA:
BS367549
|
|
|
|
pro-sigmaK + H2O <=> sigmaK + peptide
|
3.4.24.B23
|
–
|
|
|
BRENDA:
BS390297
|
|
|
|
Arc-ssrA + H2O <=> peptide
|
3.4.21.92
endopeptidase Clp
|
–
|
|
|
BRENDA:
BS394241
|
|
|
|
Pancreatic_ribonuclease + H2O <=> peptide
|
3.4.24.33
peptidyl-Asp metalloendopeptidase
|
–
|
|
|
BRENDA:
BS16918
|
|
|
|
endostatin + H2O <=> peptide
|
3.4.24.B6
|
–
|
|
|
BRENDA:
BS367720
|
|
|
|
protein_sigma32 + H2O <=> peptide
|
3.4.24.B17
|
–
|
|
|
BRENDA:
BS367605
|
|
|
|
Proacrosin + H2O <=> Acrosin + peptide
|
3.4.21.10
acrosin
|
–
|
|
|
BRENDA:
BS390298
|
|
|
|
oxidized_bovine_insulin_B_chain + H2O <=> peptide + (Tyr)26
|
3.4.21.117
stratum corneum chymotryptic enzyme
|
–
|
|
|
BRENDA:
BS361872
|
|
|
|
Tyrosine_aminotransferase + H2O <=> truncated_tyrosine_aminotransferase + peptide
|
3.4.22.24
cathepsin T
|
–
|
|
|
BRENDA:
BS380774
|
|
|
|
complement_factor_C3 + H2O <=> peptide
|
3.4.22.35
histolysain
|
–
|
|
|
BRENDA:
BS366844
|
|
|
|
proproteinase_A + H2O <=> pseudo-proteinaseA + peptide
|
3.4.23.25
saccharopepsin
|
–
|
|
|
BRENDA:
BS394964
|
|
|
|
peptide + H2O <=> hydrolyzed_peptides
|
3.4.23.23
mucorpepsin
|
–
|
|
|
BRENDA:
BS16324
|
|
|
|
L-Amino_acid-peptide + H2O <=> amino_acid + peptide
|
3.4.11.1
leucyl aminopeptidase
|
–
|
|
|
BRENDA:
BS73918
|
|
|
|
L-Prolyl-peptide + H2O <=> L-proline + peptide
|
|