|
|
methylmalonyl-CoA + [acyl-carrier_protein] <=> CoA + a_methylmalonyl-[acyl-carrier_protein]
|
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
2.3.1.B32
|
–
–
|
|
|
BRENDA:
BR51683;
BS435627;
BS456004
SABIO-RK:
14636
|
|
|
|
acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H+ + [acyl-carrier_protein] <=> Multi-methyl-branched_acyl-[acp] + (n+1)_CoA + n CO2 + 2n NADP+ + n H2O
|
2.3.1.111
mycocerosate synthase
2.3.1.252
mycolipanoate synthase
|
–
–
|
|
|
KEGG:
R05189
|
|
|
|
malonyl-CoA + 6 methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 8,8a-deoxyoleandolide + 7 CoA + 7 CO2 + H2O + 6 NADP+
|
not assigned
|
–
|
K
|
|
KEGG:
R06453
|
|
|
|
2-methylbutanoyl-CoA + 5 methylmalonyl-CoA + 7 malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''2a''''_aglycone + 12 CO2 + 13 CoA + 5 H2O + 9 NADP+
|
not assigned
|
–
|
K
|
|
KEGG:
R06480
|
|
|
|
2-methylbutanoyl-CoA + 5 methylmalonyl-CoA + 7 malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''1a''''_aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
|
not assigned
|
–
|
K
|
|
KEGG:
R06481
|
|
|
|
isobutyryl-CoA + 5 methylmalonyl-CoA + 7 malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''2b''''_aglycone + 12 CO2 + 13 CoA + 5 H2O + 9 NADP+
|
not assigned
|
–
|
K
|
|
KEGG:
R06482
|
|
|
|
isobutyryl-CoA + 5 methylmalonyl-CoA + 7 malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''1b''''_aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
|
not assigned
|
–
|
K
|
|
KEGG:
R06483
|
|
|
|
arachidoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ + [acyl-carrier_protein] <=> C32-Mycocerosyl-[acp] + 5 CoA + 4 CO2 + 8 NADP+ + 4 H2O
|
2.3.1.111
mycocerosate synthase
|
–
|
|
|
KEGG:
R11450
|
|
|
|
stearoyl-CoA + 3 methylmalonyl-CoA + 6 NADPH + 6 H+ + [acyl-carrier_protein] <=> C27-Mycolipanoyl-[acp] + 4 CoA + 3 CO2 + 6 NADP+ + 3 H2O
|
2.3.1.252
mycolipanoate synthase
|
–
|
|
|
KEGG:
R11451
|
|
|
|
acetoacetyl-CoA + methylmalonyl-CoA <=> 3,6-dimethyl-4-hydroxy-2-pyrone + CoA + CO2 + H2O
|
2.3.1.233
1,3,6,8-tetrahydroxynaphthalene synthase
|
–
|
|
|
BRENDA:
BS429860
|
|
|
|
methylmalonyl-CoA + (2S,5S)-5-carboxymethylproline + CO2 <=> CoA + (2S,5S,6R)-6-methyl-5-carboxymethylproline
|
2.3.1.226
carboxymethylproline synthase
|
–
|
|
|
BRENDA:
BS423852
|
|
|
|
methylmalonyl-CoA + (2S,5S)-5-carboxymethylproline + CO2 <=> CoA + (2S,5S,6S)-6-methyl-5-carboxymethylproline
|
2.3.1.226
carboxymethylproline synthase
|
–
|
|
|
BRENDA:
BS423853
|
|
|
|
benzoyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-3,5-dimethyl-6-phenyl-pyran-2-one + 4-hydroxy-3,5-dimethyl-6-(1-methyl-2-oxo-2-phenyl-ethyl)-pyran-2-one + CoA + CO2
|
2.3.1.74
chalcone synthase
|
–
|
|
|
BRENDA:
BS379544
|
|
|
|
hexanoyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-3,5-dimethyl-6-pentyl-pyran-2-one + CoA + CO2
|
2.3.1.74
chalcone synthase
|
–
|
|
|
BRENDA:
BS379948
|
|
|
|
methylmalonyl-CoA + hexanoyl-CoA <=> triketide_lactone + 6-ethyl-4-hydroxy-3,5-dimethyl-2-pyrone
|
2.3.1.74
chalcone synthase
|
–
|
|
|
BRENDA:
BS454742
|
|
|
|
4-coumaroyl-CoA + methylmalonyl-CoA + H2O <=> 2 CoA + 1-(4-hydroxyphenyl)pent-1-en-3-one + 2 CO2
|
2.3.1.212
benzalacetone synthase
|
–
|
|
|
BRENDA:
BS422574
|
|
|
|
4-coumaroyl-CoA + methylmalonyl-CoA <=> 1-(4-hydroxyphenyl)pent-1-en-3-one
|
2.3.1.74
chalcone synthase
|
–
|
|
|
BRENDA:
BS455040
|
|
|
|
methylmalonyl-CoA + [acyl-carrier_protein] <=> CoA + a_methalmalonyl-[acyl-carrier_protein]
|
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
|
–
|
|
|
BRENDA:
BS456003
|
|
|
|
methylmalonyl-CoA + Glutarate <=> methylmalonate + glutaryl-CoA
|
2.8.3.13
succinate---hydroxymethylglutarate CoA-transferase
|
–
|
|
|
BRENDA:
BS358786
|
|
|
|
succinyl-CoA + methylmalonate <=> succinate + methylmalonyl-CoA
|
2.8.3.13
succinate---hydroxymethylglutarate CoA-transferase
|
–
|
|
|
BRENDA:
BS358776
|
|
|
|
6 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+ <=> 6-Deoxyerythronolide_b + 7 CoA + 6 CO2 + H2O + 6 NADP+
|
2.3.1.94
6-deoxyerythronolide-B synthase
|
–
|
|
|
BRENDA:
BS321497
|
|
|
|
arachidoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ <=> tetramethyl-branched_mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O
|
2.3.1.111
mycocerosate synthase
|
–
|
|
|
BRENDA:
BS320304
|
|
|
|
a_long-chain_acyl-[mycocerosic_acid_synthase] + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ <=> a_tetramethylated-mycocerosoyl-[mycocerosate_synthase] + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O
|
2.3.1.111
mycocerosate synthase
|
–
|
|
|
BRENDA:
BR51596
|
|
|
|
a_long-chain_acyl-[mycocerosic_acid_synthase] + 3 methylmalonyl-CoA + 6 NADPH + 6 H+ <=> a_trimethylated-mycocerosoyl-[mycocerosate_synthase] + 3 CoA + 3 CO2 + 6 NADP+ + 3 H2O
|
2.3.1.111
mycocerosate synthase
|
–
|
|
|
BRENDA:
BR43976
|
|
|
|
methylmalonyl-CoA + cyanidin_3-O-beta-D-glucoside <=> CoA + cyanidin_3-O-(6-O-methylmalonyl-beta-D-glucoside)
|
2.3.1.171
anthocyanin 6''-O-malonyltransferase
|
–
|
|
|
BRENDA:
BS373843
|
|
|
|
methylmalonyl-CoA + neomycin <=> CoA + N3-methylmalonylneomycin_B
|
2.3.1.81
aminoglycoside 3-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS409893
|
|
|
|
methylmalonyl-CoA + adipate <=> methylmalonate + adipyl-CoA
|
2.8.3.13
succinate---hydroxymethylglutarate CoA-transferase
|
–
|
|
|
BRENDA:
BS358787
|
|
|
|
methylmalonyl-CoA + L-pyrroline-5-carboxylate + H2O <=> CoA + (2S,5S)-6-methyl-5-carboxymethylproline + CO2
|
2.3.1.226
carboxymethylproline synthase
|
–
|
|
|
BRENDA:
BS423854
|
|
|
|
methylmalonyl-CoA + 3'-dephospho-CoA <=> CoA + methylmalonyl-dephospho-CoA
|
2.3.1.187
acetyl-S-ACP:malonate ACP transferase
|
–
|
|
|
BRENDA:
BS397769
|
|
|
|
methylmalonyl-CoA + shisonin <=> CoA + methylmalonylshisonin
|
2.3.1.172
anthocyanin 5-O-glucoside 6'''-O-malonyltransferase
|
–
|
|
|
BRENDA:
BS373845
|
|
|
|
methylmalonyl-CoA + pelargonidin_3-O-beta-D-glucoside <=> CoA + pelargonidin_3-O-(6-O-methylmalonyl-beta-D-glucoside)
|
2.3.1.171
anthocyanin 6''-O-malonyltransferase
|
–
|
|
|
BRENDA:
BS373844
|
|
|
|
methylmalonyl-CoA + (S)-2-amino-6-oxohexanoate <=> CoA + (2S,6S,7R)-7-methyl-carboxymethylpipecolic_acid
|
2.3.1.226
carboxymethylproline synthase
|
–
|
|
|
BRENDA:
BS423855
|
|
|
|
methylmalonyl-CoA + (S)-2-amino-6-oxohexanoate <=> CoA + (2S,6S,7S)-7-methyl-carboxymethylpipecolic_acid
|
2.3.1.226
carboxymethylproline synthase
|
–
|
|
|
BRENDA:
BS423856
|
|
|
|
methylmalonyl-CoA + glycine <=> CoA + N-methylmalonylglycine
|
2.3.1.71
glycine N-benzoyltransferase
|
–
|
|
|
BRENDA:
BS321260
|
|
|
|
malonyl-CoA + methylmalonate <=> malonate + methylmalonyl-CoA
|
2.8.3.13
succinate---hydroxymethylglutarate CoA-transferase
2.8.3.3
malonate CoA-transferase
|
–
–
|
|
|
BRENDA:
BS358782
|
|
|
|
cinnamoyl_diketide-N-methylanthraniloyl-CoA + methylmalonyl-CoA <=> styrylpyrone
|
2.3.1.74
chalcone synthase
|
–
|
|
|
BRENDA:
BS455464
|
|
|
|
ATP + propionyl-CoA + HCO3- <=> ADP + phosphate + methylmalonyl-CoA
|
6.4.1.2
acetyl-CoA carboxylase
6.4.1.3
propionyl-CoA carboxylase
|
–
–
|
|
|
BRENDA:
BS37528
|
|
|
|
methylmalonyl-CoA + 3-hydroxy-3-methylglutarate <=> methylmalonate + 3-hydroxy-3-methylglutaryl-CoA
|
2.8.3.13
succinate---hydroxymethylglutarate CoA-transferase
|
–
|
|
|
BRENDA:
BS358785
|
|