|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol
|
5.4.99.17
squalene---hopene cyclase
5.4.99.7
lanosterol synthase
|
–
–
|
BMK
|
|
BRENDA:
BR254
KEGG:
R03199
MetaCyc:
LANOSTEROL-SYNTHASE-RXN
SABIO-RK:
3027
|
|
|
|
24,25-dihydrolanosterol + NADP+ <=> lanosterol + NADPH + H+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
MK
|
|
BRENDA:
BS189402
KEGG:
R03689
MetaCyc:
RXN66-10
|
|
|
|
oleoyl-CoA + lanosterol <=> lanosteryl_oleate + CoA
|
2.3.1.26
sterol O-acyltransferase
|
–
|
M
|
|
BRENDA:
BS320763
MetaCyc:
RXN-15132
|
|
|
|
lanosterol + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> hydroxylanosterol + oxidized_ferredoxin + H2O
|
1.14.15.36
sterol 14alpha-demethylase (ferredoxin)
|
–
|
M
|
|
BRENDA:
BS447679
MetaCyc:
RXN-20127
|
|
|
|
lanosterol + reduced_flavodoxin + O2 <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + flavin + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
BK
|
|
BRENDA:
BS186735
KEGG:
R05640
|
|
|
|
lanosterol + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized_ferredoxin + H2O
|
1.14.15.36
sterol 14alpha-demethylase (ferredoxin)
|
–
|
K
|
|
KEGG:
R12323
MetaCyc:
RXN-20130
|
|
|
|
lanosterol + S-adenosyl-L-methionine <=> 24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine
|
2.1.1.142
cycloartenol 24-C-methyltransferase
2.1.1.41
sterol 24-C-methyltransferase
|
–
–
|
|
|
BRENDA:
BS319698
SABIO-RK:
12323
|
|
|
|
lanosteryl_oleate + H2O <=> lanosterol + oleic_acid + H+
|
3.1.1.13
sterol esterase
|
–
|
M
|
|
MetaCyc:
RXN-15133
|
|
|
|
lanosterol + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
|
|
MetaCyc:
RXN3O-130
|
|
|
|
lanosterol + reduced_[NADPH-hemoprotein_reductase] + O2 <=> hydroxylanosterol + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN66-303
|
|
|
|
lanosterol + reduced_flavodoxin + O2 <=> 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + formate + flavin + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
|
|
BRENDA:
BS386554
|
|
|
|
lanosterol + reduced_flavodoxin + O2 <=> 4,4-dimethylcholesta-8,14,24-trienol + formate + flavin + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
|
|
BRENDA:
BS386553
|
|
|
|
lanosterol + 6 reduced_ferredoxin_[iron-sulfur]_cluster + 6 H+ + 3 O2 <=> 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + formate + 6 oxidized_ferredoxin + 4 H2O
|
1.14.15.36
sterol 14alpha-demethylase (ferredoxin)
|
–
|
|
|
BRENDA:
BS447680
|
|
|
|
lanosterol + ferricytochrome_b5 + O2 + H+ <=> lanosta-5,8,24-trien-3beta-ol + ferricyctochrome_b5 + H2O
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
|
|
BRENDA:
BS433899
|
|
|
|
lanosterol + reduced_flavodoxin + O2 <=> 4,4-dimethylcholesta-8,14,24-trienol + flavin + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
|
|
BRENDA:
BS427474
|
|
|
|
lanosterol + O2 <=> Lanosta-8,24-dien-3-one + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
|
|
BRENDA:
BS188849
|
|
|
|
lanosterol + O2 <=> Lanosta-8,24-dien-3-one
|
1.1.3.6
cholesterol oxidase
|
–
|
|
|
BRENDA:
BS373689
|
|
|
|
lanosterol + S-adenosyl-L-methionine <=> 24beta-methyllanosta-8,25(27)-enol + 24(28)-methylenelanosterol + S-adenosyl-L-homocysteine
|
2.1.1.41
sterol 24-C-methyltransferase
|
–
|
|
|
BRENDA:
BS433897
|
|
|
|
S-adenosyl-L-methionine + lanosterol <=> S-adenosyl-L-homocysteine + 24beta-methyl_lanosta-8,25(27)-enol + 24(28)-methylenelanosterol
|
2.1.1.142
cycloartenol 24-C-methyltransferase
2.1.1.143
24-methylenesterol C-methyltransferase
2.1.1.41
sterol 24-C-methyltransferase
|
–
–
–
|
|
|
BRENDA:
BS456556
|
|
|
|
S-adenosyl-L-methionine + lanosterol <=> S-adenosyl-L-homocysteine + 24(28)-methylene-24,25-dihydrolanosterol
|
2.1.1.142
cycloartenol 24-C-methyltransferase
|
–
|
|
|
BRENDA:
BS419584
|
|
|
|
lanosterol + NADH + H+ + O2 <=> 4beta-28-hydroxylanosterol + 4alpha-28-hydroxylanosterol + NAD+ + H2O
|
1.14.13.246
4beta-methylsterol monooxygenase
|
–
|
|
|
BRENDA:
BS447682
|
|
|
|
lanosterol + NAD+ <=> lanosterone + NADH + CO2 + H+
|
1.1.1.417
3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
|
BRENDA:
BS446299-a
|
|
|
|
lanosterol + O2 + NADPH + H+ <=> 4,4-dimethylcholesta-8,14,24-trienol + formate + NADP+ + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
|
|
BRENDA:
BS394903
|
|
|
|
lanosterol + NADPH <=> 24-dihydrolanosterol + NADP+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
|
|
BRENDA:
BS371022
|
|
|
|
lanosterol + NADPH + O2 <=> 4,4-dimethylcholesta-8,14,24-trienol + NADP+ + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
|
|
BRENDA:
BS409746
|
|
|
|
lanosterol + NADP+ <=> lanosterone + NADPH + CO2 + H+
|
1.1.1.417
3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
|
BRENDA:
BS446299
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + achilleol_A + (13alphaH)-isomalabarica-14(26),17E,21-trien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427770
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + achilleol_A
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427769
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> Cycloartenol + lanosterol + parkeol
|
5.4.99.47
parkeol synthase
|
–
|
|
|
BRENDA:
BS415887
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + (13alphaH)-isomalabarica-14(26),17E,21-trien-3beta-ol + protosta-16,24-dien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427768
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + (13alphaH)-isomalabarica-14(26),17E,21-trien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427767
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> achilleol_A + protosta-12,24-dien-3beta-ol + lanosterol + parkeol
|
5.4.99.47
parkeol synthase
|
–
|
|
|
BRENDA:
BS415884
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
|
5.4.99.47
parkeol synthase
|
–
|
|
|
BRENDA:
BS415942
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + parkeol + 9beta-lanosta-7,24-dien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427771
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + parkeol
|
5.4.99.47
parkeol synthase
|
–
|
|
|
BRENDA:
BS415888
|
|
|
|
ergosterol + ferricytochrome_b5 + O2 + H+ <=> lanosterol + ferricyctochrome_b5 + H2O
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
|
|
BRENDA:
BS433716
|
|
|
|
2,3-monoepoxysqualene <=> lanosterol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS378378
|
|
|
|
lanosterol + 6 [2Fe-2S]-center + 3 O2 <=> lanosterol-26-oate + 6 [2Fe-2S]-center + 4 H2O
|
1.14.15.28
cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
|
–
|
|
|
BRENDA:
BS443705
|
|
|
|
S-adenosyl-L-methionine + lanosterol <=> S-adenosyl-L-homocysteine_S-adenosyl-L-homocysteine + 24(28)-methylene-24,25-dihydrolanosterol
|
2.1.1.142
cycloartenol 24-C-methyltransferase
|
–
|
|
|
BRENDA:
BS456557
|
|