|
|
heme + ATP + H2O <=> heme + ADP + phosphate + H+
|
7.6.2.5
ABC-type heme transporter
|
–
|
|
|
BRENDA:
BR29543
MetaCyc:
3.6.3.41-RXN;
TRANS-RXN-397;
TRANS-RXN0-162
|
|
|
|
heme + H+ <=> protoporphyrin_IX + Fe2+
|
4.99.1.1
protoporphyrin ferrochelatase
4.99.1.9
coproporphyrin ferrochelatase
|
–
–
|
BMK
|
|
BRENDA:
BR3454
KEGG:
R00310
MetaCyc:
PROTOHEMEFERROCHELAT-RXN
SABIO-RK:
802
|
|
|
|
heme <=> beta-hematin
|
4.99.1.8
heme ligase
|
–
|
M
|
|
BRENDA:
BR49097
MetaCyc:
RXN-10785
|
|
|
|
heme + reduced_acceptor + O2 + H+ <=> 5-oxo-delta-bilirubin + Fe2+ + formaldehyde + acceptor + H2O
|
1.14.99.48
heme oxygenase (staphylobilin-producing)
|
–
|
MK
|
|
BRENDA:
BR50750
KEGG:
R10468
MetaCyc:
RXN-14696
|
|
|
|
heme + reduced_acceptor + O2 + H+ <=> 15-oxo-beta-bilirubin + Fe2+ + formaldehyde + acceptor + H2O
|
1.14.99.48
heme oxygenase (staphylobilin-producing)
|
–
|
M
|
|
BRENDA:
BR50751
KEGG:
R10510
MetaCyc:
RXN-14697
|
|
|
|
heme + (2E,6E)-farnesyl_diphosphate + H2O <=> ferroheme_o + diphosphate
|
2.5.1.141
heme o synthase
|
–
|
M
|
|
BRENDA:
BR51122
MetaCyc:
HEMEOSYN-RXN
|
|
|
|
heme + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> Biliverdin + Fe2+ + CO + oxidized_ferredoxin + H2O
|
1.14.15.20
heme oxygenase (biliverdin-producing, ferredoxin)
|
–
|
MK
|
|
BRENDA:
BR51703
KEGG:
R11579
MetaCyc:
RXN-17523
|
|
|
|
heme + reduced_acceptor + O2 + H+ <=> mycobilin_a + Fe2+ + acceptor + H2O
|
1.14.99.57
heme oxygenase (mycobilin-producing)
|
–
|
M
|
|
BRENDA:
BR52044
KEGG:
R11741
MetaCyc:
RXN-18346
|
|
|
|
heme + reduced_acceptor + O2 + H+ <=> mycobilin_b + Fe2+ + acceptor + H2O
|
1.14.99.57
heme oxygenase (mycobilin-producing)
|
–
|
M
|
|
BRENDA:
BR52045
KEGG:
R11742
MetaCyc:
RXN-18347
|
|
|
|
S-adenosyl-L-methionine + heme + reduced_flavodoxin <=> anaerobilin + L-methionine + 5''-deoxyadenosine + S-adenosyl-L-homocysteine + Fe2+ + flavin
|
2.1.1.342
anaerobilin synthase
|
–
|
M
|
|
BRENDA:
BR52055
KEGG:
R11700
MetaCyc:
RXN-18337
|
|
|
|
heme + O2 + reduced_acceptor + H+ <=> biliverdin-IX-delta + Fe2+ + CO + acceptor + H2O
|
1.14.99.58
heme oxygenase (biliverdin-IX-beta and delta-forming)
|
–
|
MK
|
|
BRENDA:
BR52152
KEGG:
R11816
MetaCyc:
RXN-18339
|
|
|
|
heme + O2 + reduced_acceptor + H+ <=> biliverdin_IXbeta + Fe2+ + CO + acceptor + H2O
|
1.14.99.58
heme oxygenase (biliverdin-IX-beta and delta-forming)
|
–
|
MK
|
|
BRENDA:
BR52153
KEGG:
R11817
MetaCyc:
RXN-18338
|
|
|
|
S-adenosyl-L-methionine + Fe-coproporphyrin_III <=> heme + CO2 + 5''-deoxyadenosine + L-methionine
|
1.3.98.6
AdoMet-dependent heme synthase
|
–
|
MK
|
|
BRENDA:
BR52577
KEGG:
R12002
MetaCyc:
RXN-15808
|
|
|
|
Fe-coproporphyrin_III + H2O2 + H+ <=> heme + CO2 + H2O
|
1.3.98.5
hydrogen peroxide-dependent heme synthase
|
–
|
BK
|
|
BRENDA:
BR52578
KEGG:
R11522
MetaCyc:
RXN-17519
|
|
|
|
harderoheme_III + H2O2 + H+ <=> heme + CO2 + H2O
|
1.3.98.5
hydrogen peroxide-dependent heme synthase
|
–
|
M
|
|
BRENDA:
BR52580
KEGG:
R12455
MetaCyc:
RXN-19756
|
|
|
|
Holocytochrome_c <=> apocytochrome_c + heme
|
4.4.1.17
holocytochrome-c synthase
4.4.1.B1
|
–
–
|
K
|
|
BRENDA:
BR11631
KEGG:
R02480
|
|
|
|
heme + 3 reduced_flavodoxin + 3 O2 <=> Biliverdin + Fe2+ + CO + 3 flavin + 3 H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
1.14.99.58
heme oxygenase (biliverdin-IX-beta and delta-forming)
|
–
–
|
BK
|
|
BRENDA:
BR40384
KEGG:
R00311
|
|
|
|
heme + (2E,6E)-farnesyl_diphosphate + H2O <=> heme_O + diphosphate
|
2.5.1.141
heme o synthase
|
–
|
K
|
|
BRENDA:
BS427516
KEGG:
R07411
|
|
|
|
heme + 2 NADPH + 2 H+ + 2 O2 <=> Biliverdin + Fe2+ + CO + 2 NADP+ + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS370238
SABIO-RK:
13063
|
|
|
|
heme + 2 NADH + 2 H+ + 2 O2 <=> Biliverdin + Fe2+ + CO + 2 NAD+ + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS370239
SABIO-RK:
13093
|
|
|
|
heme <=> cytochrome_a
|
not assigned
|
–
|
K
|
|
KEGG:
R00312
|
|
|
|
heme <=> catalase
|
not assigned
|
–
|
K
|
|
KEGG:
R00313
|
|
|
|
heme <=> Peroxidase
|
not assigned
|
–
|
K
|
|
KEGG:
R00314
|
|
|
|
hemoglobin <=> Globin + heme
|
not assigned
|
–
|
K
|
|
KEGG:
R03684
|
|
|
|
myoglobin <=> Globin + heme
|
not assigned
|
–
|
K
|
|
KEGG:
R04977
|
|
|
|
H2O + hemoglobin <=> globin_fragment + heme
|
3.4.23.38
plasmepsin I
|
–
|
M
|
|
MetaCyc:
3.4.23.38-RXN
|
|
|
|
hemoglobin + H2O <=> globin_fragment + heme
|
3.4.23.39
plasmepsin II
|
–
|
M
|
|
MetaCyc:
3.4.23.39-RXN
|
|
|
|
heme + O2 + reduced_[NADPH-hemoprotein_reductase] + H+ <=> Biliverdin + Fe2+ + CO + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
M
|
|
MetaCyc:
HEME-OXYGENASE-DECYCLIZING-RXN
|
|
|
|
cytochrome_c <=> heme + apo-[c-type_cytochrome]_with_reduced_L-cysteine_residues
|
4.4.1.17
holocytochrome-c synthase
|
–
|
M
|
|
MetaCyc:
HOLOCYTOCHROME-C-SYNTHASE-RXN
|
|
|
|
heme + H2O2 + O2 + H+ + acceptor <=> hematinic_acid + a_tripyrrole + CO + Fe3+ + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17522
|
|
|
|
heme + O2 + reduced_[NADPH-hemoprotein_reductase] <=> alpha-hydroxyheme + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-18341
|
|
|
|
heme + geranylgeranyl_diphosphate + H2O <=> ferroheme_oP2 + diphosphate
|
2.5.1.141
heme o synthase
|
–
|
|
|
MetaCyc:
RXN-20645
|
|
|
|
heme + CcmCDE_complex + acceptor + H+ <=> heme(III)-bound_CcmCDE_complex + AH
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-21407
|
|
|
|
heme + H2O2 <=> heme_d
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-8073
|
|
|
|
harderoheme_IV + H2O2 <=> heme + CO2 + H2O
|
1.3.98.5
hydrogen peroxide-dependent heme synthase
|
–
|
|
|
BRENDA:
BS446281
|
|
|
|
heme + electron_donor + O2 <=> Biliverdin + Fe2+ + CO + oxidized_electron_donor + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS409569
|
|
|
|
heme + electron_donor + O2 <=> Biliverdin + Fe2+ + CO + oxidized_eletron_donor + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
1.14.99.58
heme oxygenase (biliverdin-IX-beta and delta-forming)
|
–
–
|
|
|
BRENDA:
BS287919
|
|
|
|
heme + [reduced_cytochrome_P450_reductase] + O2 <=> Biliverdin + Fe2+ + CO + [oxidized_cytochrome_P450_reductase] + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS443866
|
|
|
|
heme + reduced_flavodoxin + O2 <=> biliverdin_IXbeta + biliverdin_IXdelta + Fe2+ + CO + flavin + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS443867
|
|
|
|
heme + Ferredoxin + O2 <=> Biliverdin + Fe2+ + CO + A + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS409570
|
|
|
|
heme + reduced_acceptor + O2 <=> Biliverdin + Fe2+ + CO + A + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
1.14.99.58
heme oxygenase (biliverdin-IX-beta and delta-forming)
|
–
–
|
|
|
BRENDA:
BS394867
|
|
|
|
heme + 4 reduced_acceptor + 4 O2 <=> 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
|
1.14.99.48
heme oxygenase (staphylobilin-producing)
|
–
|
|
|
BRENDA:
BS424975
|
|
|
|
heme + 4 reduced_acceptor + 4 O2 <=> 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O
|
1.14.99.48
heme oxygenase (staphylobilin-producing)
|
–
|
|
|
BRENDA:
BS424976
|
|
|
|
heme + 3 ascorbate + 3 O2 <=> Biliverdin + Fe2+ + CO + 3 dehydroascorbate + 3 H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS428677
|
|
|
|
heme + reduced_ferredoxin_[iron-sulfur]_cluster + H2O2 + H+ <=> verdoheme + Fe2+ + CO + oxidized_ferredoxin + H2O
|
1.14.15.20
heme oxygenase (biliverdin-producing, ferredoxin)
|
–
|
|
|
BRENDA:
BS437851
|
|
|
|
heme + electron_donor + O2 <=> alpha-biliverdin + beta-biliverdin + delta-biliverdin + Fe2+ + CO + oxidized_eletron_donor + H2O
|
1.14.99.58
heme oxygenase (biliverdin-IX-beta and delta-forming)
|
–
|
|
|
BRENDA:
BS379946
|
|
|
|
apo-iso-1_cytochrome_c + heme <=> Holocytochrome_c
|
4.4.1.17
holocytochrome-c synthase
|
–
|
|
|
BRENDA:
BS416580
|
|
|
|
heme + H+ <=> mesoporphyrin_IX + Zn2+
|
4.99.1.1
protoporphyrin ferrochelatase
|
–
|
|
|
BRENDA:
BS417085
|
|
|
|
mesoporphyrin_IX + Fe2+ <=> heme + H+
|
4.99.1.1
protoporphyrin ferrochelatase
|
–
|
|
|
BRENDA:
BS392581
|
|
|
|
porphyrin + Fe2+ <=> heme + H+
|
4.99.1.1
protoporphyrin ferrochelatase
|
–
|
|
|
BRENDA:
BS393296
|
|
|
|
deuteroporphyrin_IX + Fe2+ <=> heme + H+
|
4.99.1.1
protoporphyrin ferrochelatase
|
–
|
|
|
BRENDA:
BS381787
|
|
|
|
heme + Zn2+ <=> zinc_protoporphyrin + H+
|
4.99.1.1
protoporphyrin ferrochelatase
|
–
|
|
|
BRENDA:
BS417084
|
|
|
|
protoporphyrin_IX + FeCl3 <=> heme + Cl-
|
4.99.1.1
protoporphyrin ferrochelatase
|
–
|
|
|
BRENDA:
BS382679
|
|
|
|
heme + NADPH + O2 <=> biliverdin_IXdelta + Biliverdin + Fe2+ + CO + NADP+ + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS376937
|
|
|
|
heme + reduced_acceptor + O2 <=> alpha-meso-hydroxyhemin_IX + CO + acceptor + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS376938
|
|
|
|
heme + reduced_acceptor + O2 + Fe2+ <=> Biliverdin + CO + Fe3+ + acceptor + H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
|
–
|
|
|
BRENDA:
BS440381
|
|
|
|
apo-MccA + heme <=> holo-MccA
|
4.4.1.17
holocytochrome-c synthase
|
–
|
|
|
BRENDA:
BS391297
|
|
|
|
heme + H2O2 <=> hematinic_acid + a_tripyrrole + Fe3+
|
1.14.14.B10
|
–
|
|
|
BRENDA:
BR52494
|
|
|
|
heme <=> hemozoin
|
4.99.1.8
heme ligase
|
–
|
|
|
BRENDA:
BS430241
|
|
|
|
ATP + H2O + heme-[L-alanyl-gamma-D-glutamyl-meso-diaminopimelate_periplasmic_binding_protein_MppA][side_1] <=> ADP + phosphate + heme + [L-alanyl-gamma-D-glutamyl-meso-diaminopimelate_periplasmic_binding_protein_MppA][side_1]
|
7.4.2.9
ABC-type dipeptide transporter
|
–
|
|
|
BRENDA:
BS447052
|
|
|
|
ATP + H2O + heme-[dipeptide-binding_protein_DppA][side_1] <=> ADP + phosphate + heme + [dipeptide-binding_protein_DppA][side_1]
|
7.4.2.9
ABC-type dipeptide transporter
|
–
|
|
|
BRENDA:
BS447051
|
|