|
|
dUTP + H2O <=> H+ + dUMP + diphosphate
|
3.6.1
3.6.1.23
dUTP diphosphatase
3.6.1.8
ATP diphosphatase
3.6.1.9
nucleotide diphosphatase
|
–
–
–
–
|
BMK
|
|
BRENDA:
BR22764
KEGG:
R02100
MetaCyc:
DUTP-PYROP-RXN
SABIO-RK:
365
|
|
|
|
H+ + dCMP + H2O <=> NH3 + dUMP
|
3.5.4.12
dCMP deaminase
|
–
|
BMK
|
|
BRENDA:
BR29523
KEGG:
R01663
MetaCyc:
DCMP-DEAMINASE-RXN
SABIO-RK:
363
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate
|
2.1.1.45
thymidylate synthase
|
–
|
BMK
|
|
BRENDA:
BR43900;
BS319728
KEGG:
R02101
MetaCyc:
THYMIDYLATESYN-RXN
SABIO-RK:
88
|
|
|
|
dCTP + H2O <=> dUMP + diphosphate + NH3
|
3.5.4.30
dCTP deaminase (dUMP-forming)
|
–
|
BMK
|
|
BRENDA:
BR48302
KEGG:
R07307
MetaCyc:
3.5.4.30-RXN
SABIO-RK:
7649
|
|
|
|
dUDP + H2O <=> dUMP + phosphate + H+
|
3.6.1.23
dUTP diphosphatase
|
–
|
|
|
BRENDA:
BS141301
MetaCyc:
RXN-14220
SABIO-RK:
10888
|
|
|
|
2''-deoxyuridine + ATP <=> H+ + dUMP + ADP
|
2.7.1.145
deoxynucleoside kinase
2.7.1.21
thymidine kinase
2.7.1.74
deoxycytidine kinase
2.7.1.76
2'-deoxyadenosine kinase
|
–
–
–
–
|
BMK
|
|
BRENDA:
BS353774
KEGG:
R02099
MetaCyc:
DURIDKI-RXN
SABIO-RK:
500
|
|
|
|
ATP + dUMP <=> ADP + dUDP
|
2.7.4.13
(deoxy)nucleoside-phosphate kinase
2.7.4.14
UMP/CMP kinase
2.7.4.22
UMP kinase
2.7.4.25
(d)CMP kinase
2.7.4.4
nucleoside-phosphate kinase
2.7.4.9
dTMP kinase
2.7.4.B1
|
–
–
–
–
–
–
–
|
K
|
|
BRENDA:
BS359746
KEGG:
R02098
MetaCyc:
RXN-14122
SABIO-RK:
499
|
|
|
|
dUTP + H2O <=> dUMP + phosphate + H+
|
3.5.4.13
dCTP deaminase
3.6.1.5
apyrase
|
–
–
|
|
|
BRENDA:
BS367865
MetaCyc:
RXN-14199
|
|
|
|
dUMP + H2O <=> 2''-deoxyuridine + phosphate
|
3.1.3.2
acid phosphatase
3.1.3.31
nucleotidase
3.1.3.34
deoxynucleotide 3'-phosphatase
3.1.3.35
thymidylate 5'-phosphatase
3.1.3.5
5'-nucleotidase
3.1.3.89
5'-deoxynucleotidase
|
–
–
–
–
–
–
|
K
|
|
BRENDA:
BS390579
KEGG:
R02102
MetaCyc:
RXN-14143
SABIO-RK:
501
|
|
|
|
dUMP + 5,10-methylenetetrahydrofolate + NADPH + H+ <=> dTMP + tetrahydrofolate + NADP+
|
1.5.1.3
dihydrofolate reductase
2.1.1.148
thymidylate synthase (FAD)
|
–
–
|
MK
|
|
BRENDA:
BR47450
KEGG:
R06613
MetaCyc:
RXN-8850
SABIO-RK:
7840
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FADH2 + O2 <=> dTMP + tetrahydrofolate + FAD + H2O2
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
|
|
BRENDA:
BS398698
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FADH2 <=> dTMP + tetrahydrofolate + FAD
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
B
|
|
BRENDA:
BS354165
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP <=> tetrahydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS375949
|
|
|
|
UMP + thioredoxin <=> dUMP + thioredoxin_disulfide + H2O
|
1.17.4.2
ribonucleoside-triphosphate reductase (thioredoxin)
|
–
|
|
|
BRENDA:
BS287794
|
|
|
|
dUTPalphaS + H2O <=> dUMP + thiodiphosphate
|
3.6.1.23
dUTP diphosphatase
|
–
|
|
|
BRENDA:
BS141299
|
|
|
|
dUMP + acceptor <=> dNMP + Uracil
|
2.4.2.6
nucleoside deoxyribosyltransferase
|
–
|
|
|
BRENDA:
BS388636
|
|
|
|
methylenetetrahydropteroylglutamate + dUMP <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS451873
|
|
|
|
5,10-methenyltetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS399200
|
|
|
|
dUMP_DNA + H2O <=> dUMP + DNA
|
3.2.2.27
uracil-DNA glycosylase
|
–
|
|
|
BRENDA:
BS412017
|
|
|
|
[6R]methylenetetrahydropteroylpentaglutamate + dUMP <=> dihydropteroylpentaglutamate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS451867
|
|
|
|
[6R]methylenetetrahydropteroylheptaglutamate + dUMP <=> 7,8-dihydropteroylheptaglutamate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS451865
|
|
|
|
[6R]methylenetetrahydropteroylhexaglutamate + dUMP <=> 7,8-dihydropteroylhexaglutamate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS451866
|
|
|
|
[6R]methylenetetrahydropteroyltriglutamate + dUMP <=> 7,8-dihydropteroyltriglutamate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS451869
|
|
|
|
[6R]methylenetetrahydropteroyldiglutamate + dUMP <=> 7,8-dihydropteroyldiglutamate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS451864
|
|
|
|
[6R]methylenetetrahydropteroyltetraglutamate + dUMP <=> 7,8-dihydropteroyltetraglutamate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS451868
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FMNH2 <=> dTMP + tetrahydrofolate + FMN
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
|
|
BRENDA:
BS354166
|
|
|
|
alpha,beta-imido-dUTP + H2O <=> dUMP + amino-diphosphate
|
3.6.1.23
dUTP diphosphatase
|
–
|
|
|
BRENDA:
BS433402
|
|
|
|
NTP + deoxyuridine <=> NDP + dUMP
|
2.7.1.74
deoxycytidine kinase
|
–
|
|
|
BRENDA:
BS357769
|
|
|
|
Phenyl_phosphate + deoxyuridine <=> dUMP + phenol
|
2.7.1.77
nucleoside phosphotransferase
|
–
|
|
|
BRENDA:
BS357814
|
|