|
|
H2O + L-phenylalanine + ATP <=> H+ + D-Phe + diphosphate + AMP
|
5.1.1.11
phenylalanine racemase (ATP-hydrolysing)
|
–
|
BK
|
|
BRENDA:
BR164
KEGG:
R00686
MetaCyc:
5.1.1.11-RXN
|
|
|
|
H+ + L-phenylalanine <=> 2-Phenylethylamine + CO2
|
4.1.1.14
valine decarboxylase
4.1.1.19
arginine decarboxylase
4.1.1.25
tyrosine decarboxylase
4.1.1.28
aromatic-L-amino-acid decarboxylase
4.1.1.53
phenylalanine decarboxylase
|
–
–
–
–
–
|
MK
|
|
BRENDA:
BR313
KEGG:
R00699
MetaCyc:
PHENYLALANINE-DECARBOXYLASE-RXN
|
|
|
|
L-phenylalanine + NAD+ + H2O <=> phenylpyruvate + NH3 + NADH + H+
|
1.4.1.1
alanine dehydrogenase
1.4.1.19
tryptophan dehydrogenase
1.4.1.20
phenylalanine dehydrogenase
1.4.1.5
L-amino-acid dehydrogenase
1.4.1.8
valine dehydrogenase (NADP+)
1.4.1.9
leucine dehydrogenase
|
–
–
–
–
–
–
|
K
|
|
BRENDA:
BR33796
KEGG:
R00688
MetaCyc:
PHENYLALANINE-DEHYDROGENASE-RXN
SABIO-RK:
1068
|
|
|
|
L-phenylalanine <=> Cinnamic_acid + NH3
|
4.3.1.1
aspartate ammonia-lyase
4.3.1.23
tyrosine ammonia-lyase
4.3.1.24
phenylalanine ammonia-lyase
4.3.1.25
phenylalanine/tyrosine ammonia-lyase
4.3.1.31
L-tryptophan ammonia lyase
4.3.1.5
phenylalanine ammonia-lyase
|
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR3427;
BS445625
KEGG:
R00697
MetaCyc:
PHENYLALANINE-AMMONIA-LYASE-RXN
SABIO-RK:
1076
|
|
|
|
L-phenylalanine + O2 <=> phenylacetamide + CO2 + H2O
|
1.11.1.21
catalase-peroxidase
1.13.12.3
tryptophan 2-monooxygenase
1.13.12.9
phenylalanine 2-monooxygenase
|
–
–
–
|
K
|
|
BRENDA:
BR40461
KEGG:
R00690;
R00698
MetaCyc:
PHENYLALANINE-2-MONOOXYGENASE-RXN
SABIO-RK:
1070
|
|
|
|
L-phenylalanine + acetyl-CoA <=> H+ + N-acetyl-L-phenylalanine + CoA
|
2.3.1.53
phenylalanine N-acetyltransferase
|
–
|
K
|
|
BRENDA:
BR44055
KEGG:
R00693
MetaCyc:
PHENYLALANINE-N-ACETYLTRANSFERASE-RXN
|
|
|
|
L-phenylalanine + pyruvate <=> phenylpyruvate + L-alanine
|
2.6.1.12
alanine---oxo-acid transaminase
2.6.1.15
glutamine---pyruvate transaminase
2.6.1.44
alanine---glyoxylate transaminase
2.6.1.51
serine---pyruvate transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.58
phenylalanine(histidine) transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
|
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR47420
KEGG:
R00692
MetaCyc:
2.6.1.58-RXN
SABIO-RK:
1072
|
|
|
|
L-tryptophan + phenylpyruvate <=> 3-Indole-2-oxopropanoate + L-phenylalanine
|
2.6.1.28
tryptophan---phenylpyruvate transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.70
aspartate---phenylpyruvate transaminase
2.6.1.99
L-tryptophan---pyruvate aminotransferase
|
–
–
–
–
–
|
BM
|
|
BRENDA:
BR47679
KEGG:
R01376
MetaCyc:
2.6.1.28-RXN
|
|
|
|
L-glutamine + phenylpyruvate <=> 2-Oxoglutaramate + L-phenylalanine
|
2.6.1.14
asparagine---oxo-acid transaminase
2.6.1.15
glutamine---pyruvate transaminase
2.6.1.51
serine---pyruvate transaminase
2.6.1.58
phenylalanine(histidine) transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
|
–
–
–
–
–
|
|
|
BRENDA:
BR47702
KEGG:
R01375
MetaCyc:
2.6.1.64-RXN
SABIO-RK:
1577
|
|
|
|
phenylpyruvate + L-aspartate <=> L-phenylalanine + oxaloacetate
|
2.6.1.27
tryptophan transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.70
aspartate---phenylpyruvate transaminase
2.6.1.78
aspartate---prephenate aminotransferase
|
–
–
–
–
|
|
|
BRENDA:
BR47706
KEGG:
R00695
MetaCyc:
2.6.1.70-RXN
SABIO-RK:
1075
|
|
|
|
H+ + L-arogenate <=> CO2 + H2O + L-phenylalanine
|
4.2.1.51
prephenate dehydratase
4.2.1.91
arogenate dehydratase
|
–
–
|
BMK
|
|
BRENDA:
BR48340
KEGG:
R00691
MetaCyc:
CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN
SABIO-RK:
1071
|
|
|
|
angiotensin_II + H2O <=> angiotensin-(1-7) + L-phenylalanine
|
3.4.17.15
carboxypeptidase A2
3.4.17.23
angiotensin-converting enzyme 2
3.4.21.26
prolyl oligopeptidase
|
–
–
–
|
|
|
BRENDA:
BR48643
KEGG:
R09535
MetaCyc:
RXN-11112
SABIO-RK:
13097
|
|
|
|
L-phenylalanine <=> (S)-beta-phenylalanine
|
5.4.3.10
phenylalanine aminomutase (L-beta-phenylalanine forming)
5.4.3.11
phenylalanine aminomutase (D-beta-phenylalanine forming)
|
–
–
|
BM
|
|
BRENDA:
BR50482;
BR52647
KEGG:
R10286;
R10287
MetaCyc:
RXN-13484;
RXN-13649
|
|
|
|
S-adenosyl-L-methionine + ATP + anthranilate + L-phenylalanine <=> cyclopeptine + AMP + diphosphate + S-adenosyl-L-homocysteine + H+
|
6.3.2.40
cyclopeptine synthase
|
–
|
BM
|
|
BRENDA:
BR50555
KEGG:
R10495
MetaCyc:
RXN-13989
|
|
|
|
H+ + L-phenylalanine + O2 + H2O <=> phenylacetaldehyde + NH3 + H2O2 + CO2
|
4.1.1.109
phenylacetaldehyde synthase
|
–
|
MK
|
|
BRENDA:
BR52269
KEGG:
R11918
MetaCyc:
RXN-8990
|
|
|
|
L-phenylalanine + O2 + H2O <=> phenylpyruvate + NH3 + H2O2 + H+
|
1.13.12.9
phenylalanine 2-monooxygenase
1.4.3.14
L-lysine oxidase
1.4.3.2
L-amino-acid oxidase
|
–
–
–
|
K
|
|
BRENDA:
BS258989
KEGG:
R00689
MetaCyc:
RXN-17130
SABIO-RK:
1069
|
|
|
|
L-phenylalanine + 2-oxoglutarate <=> phenylpyruvate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.24
diiodotyrosine transaminase
2.6.1.27
tryptophan transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.60
aromatic-amino-acid---glyoxylate transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
2.6.1.70
aspartate---phenylpyruvate transaminase
2.6.1.79
glutamate---prephenate aminotransferase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BS353519
KEGG:
R00694
MetaCyc:
RXN-10814
SABIO-RK:
1074
|
|
|
|
L-methionine + phenylpyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-phenylalanine
|
2.6.1.14
asparagine---oxo-acid transaminase
2.6.1.15
glutamine---pyruvate transaminase
2.6.1.28
tryptophan---phenylpyruvate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.51
serine---pyruvate transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.58
phenylalanine(histidine) transaminase
2.6.1.60
aromatic-amino-acid---glyoxylate transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.88
methionine transaminase
|
–
–
–
–
–
–
–
–
–
–
|
BM
|
|
BRENDA:
BS353571
MetaCyc:
RXN-7708
SABIO-RK:
11201
|
|
|
|
L-tyrosine + phenylpyruvate <=> 4-hydroxyphenylpyruvate + L-phenylalanine
|
2.6.1.28
tryptophan---phenylpyruvate transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.70
aspartate---phenylpyruvate transaminase
|
–
–
–
–
–
|
M
|
|
BRENDA:
BS356435
MetaCyc:
RXN-15200
|
|
|
|
Asp-Phe + H2O <=> L-aspartate + L-phenylalanine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.16
Xaa-Trp aminopeptidase
3.4.11.23
PepB aminopeptidase
3.4.13.19
membrane dipeptidase
3.4.13.21
dipeptidase E
|
–
–
–
–
–
|
|
|
BRENDA:
BS358882
MetaCyc:
RXN-21570
|
|
|
|
L-phenylalanine + ATP + H2O <=> L-phenylalanine + ADP + phosphate + H+
|
7.4.2.1
ABC-type polar-amino-acid transporter
7.4.2.2
ABC-type nonpolar-amino-acid transporter
|
–
–
|
|
|
BRENDA:
BS394754
MetaCyc:
TRANS-RXN-312
|
|
|
|
jasmonic_acid + L-phenylalanine + ATP <=> H+ + jasmonoyl-L-phenylalanine + AMP + diphosphate
|
6.3.2.52
jasmonoyl---L-amino acid ligase
6.3.2.z
|
–
–
|
M
|
|
BRENDA:
BS443077
MetaCyc:
RXN-10438;
RXN-10456
|
|
|
|
L-phenylalanine + tetrahydropteridine + O2 <=> L-tyrosine + a_4a-hydroxy-5,6,7,8-tetrahydropteridine
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
B
|
|
BRENDA:
BR40406
KEGG:
R12540
|
|
|
|
L-phenylalanine + 2 reduced_flavodoxin + 2 O2 <=> (E)-phenylacetaldoxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.40
phenylalanine N-monooxygenase
|
–
|
K
|
|
BRENDA:
BR49589
KEGG:
R09578
|
|
|
|
L-phenylalanine + reduced_flavodoxin + O2 <=> N-hydroxy-L-phenylalanine + flavin + H2O
|
1.14.14.40
phenylalanine N-monooxygenase
|
–
|
K
|
|
BRENDA:
BR49590
KEGG:
R09579
|
|
|
|
L-phenylalanine + tetrahydropteridine + O2 <=> L-m-Tyr + a_4a-hydroxy-5,6,7,8-tetrahydropteridine
|
1.14.16.7
phenylalanine 3-monooxygenase
|
–
|
|
|
BRENDA:
BR50848
KEGG:
R12543
|
|
|
|
ATP + L-phenylalanine + tRNAMet <=> AMP + diphosphate + L-phenylalanyl-tRNAPhe
|
6.1.1.20
phenylalanine---tRNA ligase
|
–
|
BK
|
|
BRENDA:
BR51
KEGG:
R03660
SABIO-RK:
409
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + dihydrobiopterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
1.14.16.4
tryptophan 5-monooxygenase
|
–
–
|
K
|
|
BRENDA:
BS288214
KEGG:
R01795
SABIO-RK:
1884
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + 4a-hydroxytetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
K
|
|
BRENDA:
BS386541
KEGG:
R07211
SABIO-RK:
8496
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-m-Tyr + 4a-hydroxytetrahydrobiopterin
|
1.14.16.7
phenylalanine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS424873
KEGG:
R10729
|
|
|
|
3-[(2S,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate + L-phenylalanine <=> L-dihydroanticapsin + phenylpyruvate
|
2.6.1
|
–
|
MK
|
|
KEGG:
R11068
MetaCyc:
RXN-16297
|
|
|
|
N-acetyl-L-phenylalanine + H2O <=> acetate + L-phenylalanine
|
3.5.1.114
N-acyl-aromatic-L-amino acid amidohydrolase
3.5.1.14
N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.15
aspartoacylase
3.5.1.87
N-carbamoyl-L-amino-acid hydrolase
|
–
–
–
–
|
|
|
BRENDA:
BS140317
SABIO-RK:
8120
|
|
|
|
L-Phe-4-nitroanilide + H2O <=> L-phenylalanine + 4-nitroaniline
|
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.20
aminopeptidase Ey
3.4.11.22
aminopeptidase I
3.4.11.24
aminopeptidase S
3.4.13.20
beta-Ala-His dipeptidase
3.4.14.5
dipeptidyl-peptidase IV
3.4.21.26
prolyl oligopeptidase
3.4.22.40
bleomycin hydrolase
|
–
–
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS14576
SABIO-RK:
13319
|
|
|
|
Phe-Gly + H2O <=> L-phenylalanine + glycine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.14
cytosol alanyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.22
aminopeptidase I
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.19
membrane dipeptidase
|
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS14602
SABIO-RK:
10574
|
|
|
|
Benzyloxycarbonyl-Gly-Phe + H2O <=> Benzyloxycarbonyl-Gly + L-phenylalanine
|
3.4.16.5
carboxypeptidase C
3.4.17.1
carboxypeptidase A
3.4.17.15
carboxypeptidase A2
3.4.17.19
carboxypeptidase Taq
3.4.17.4
Gly-Xaa carboxypeptidase
3.4.22.33
fruit bromelain
3.4.23.26
rhodotorulapepsin
3.4.24.77
snapalysin
|
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS15047
SABIO-RK:
11624
|
|
|
|
L-phenylalanine_ethyl_ester + H2O <=> L-phenylalanine + ethanol
|
3.1.1.1
carboxylesterase
3.1.1.43
alpha-amino-acid esterase
3.4.22.32
stem bromelain
|
–
–
–
|
|
|
BRENDA:
BS16087
SABIO-RK:
12436
|
|
|
|
L-phenylalanine + 6-Methyl-5,6,7,8-tetrahydropterin + O2 <=> L-tyrosine + 6-methyldihydropterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
1.14.16.2
tyrosine 3-monooxygenase
1.14.16.4
tryptophan 5-monooxygenase
|
–
–
–
|
|
|
BRENDA:
BS288230
SABIO-RK:
8067
|
|
|
|
L-Dopa + phenylpyruvate <=> 3,4-Dihydroxyphenylpyruvate + L-phenylalanine
|
2.6.1.49
dihydroxyphenylalanine transaminase
|
–
|
|
|
BRENDA:
BS353597
SABIO-RK:
12100
|
|
|
|
L-phenylalanine + glyoxylate <=> phenylpyruvate + glycine
|
2.6.1.15
glutamine---pyruvate transaminase
2.6.1.44
alanine---glyoxylate transaminase
2.6.1.51
serine---pyruvate transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.60
aromatic-amino-acid---glyoxylate transaminase
2.6.1.63
kynurenine---glyoxylate transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS354012
SABIO-RK:
11204
|
|
|
|
Tyr-Phe + H2O <=> L-tyrosine + L-phenylalanine
|
3.4.11.16
Xaa-Trp aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.22
aminopeptidase I
3.4.13.19
membrane dipeptidase
3.4.19.1
acylaminoacyl-peptidase
|
–
–
–
–
–
|
|
|
BRENDA:
BS358889
SABIO-RK:
10583
|
|
|
|
Phe-Tyr + H2O <=> L-phenylalanine + L-tyrosine
|
3.4.11.16
Xaa-Trp aminopeptidase
3.4.11.22
aminopeptidase I
3.4.13.19
membrane dipeptidase
|
–
–
–
|
|
|
BRENDA:
BS358893
SABIO-RK:
10585
|
|
|
|
Phe-7-amido-4-methylcoumarin <=> L-phenylalanine + 7-amino-4-methylcoumarin
|
3.3.2.6
leukotriene-A4 hydrolase
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.14
cytosol alanyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.22
aminopeptidase I
3.4.11.3
cystinyl aminopeptidase
3.4.11.6
aminopeptidase B
3.4.11.7
glutamyl aminopeptidase
3.4.11.B7
3.4.21.117
stratum corneum chymotryptic enzyme
|
–
–
–
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS361358
SABIO-RK:
14399
|
|
|
|
benzyloxycarbonyl-Gly-Gly-Phe + H2O <=> benzyloxycarbonyl-Gly-Gly + L-phenylalanine
|
3.4.16.5
carboxypeptidase C
3.4.17.1
carboxypeptidase A
3.4.17.15
carboxypeptidase A2
|
–
–
–
|
|
|
BRENDA:
BS361662
SABIO-RK:
11620
|
|
|
|
Phe-Gly-Gly + H2O <=> L-phenylalanine + Gly-Gly
|
3.4.11.13
clostridial aminopeptidase
3.4.11.4
tripeptide aminopeptidase
|
–
–
|
|
|
BRENDA:
BS36278
SABIO-RK:
10722
|
|
|
|
Pro-Phe + H2O <=> L-proline + L-phenylalanine
|
3.4.11.13
clostridial aminopeptidase
3.4.11.5
prolyl aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
–
|
|
|
BRENDA:
BS36298
SABIO-RK:
10587
|
|
|
|
Phe-Pro + H2O <=> L-phenylalanine + L-proline
|
3.4.11.9
Xaa-Pro aminopeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
|
|
|
BRENDA:
BS36384
SABIO-RK:
11277
|
|
|
|
Ala-Phe + H2O <=> L-alanine + L-phenylalanine
|
3.4.11.14
cytosol alanyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.13.19
membrane dipeptidase
3.4.13.9
Xaa-Pro dipeptidase
|
–
–
–
–
|
|
|
BRENDA:
BS36449
SABIO-RK:
9735
|
|
|
|
Gly-Phe + H2O <=> glycine + L-phenylalanine
|
3.4.11.1
leucyl aminopeptidase
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.19
membrane dipeptidase
3.4.22.40
bleomycin hydrolase
|
–
–
–
–
|
|
|
BRENDA:
BS37026
SABIO-RK:
10588
|
|
|
|
Arg-Phe + H2O <=> L-arginine + L-phenylalanine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.22
aminopeptidase I
3.4.11.6
aminopeptidase B
3.4.13.19
membrane dipeptidase
|
–
–
–
–
–
–
|
|
|
BRENDA:
BS382107
SABIO-RK:
9826
|
|
|
|
Met-Phe + H2O <=> L-methionine + L-phenylalanine
|
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.20
aminopeptidase Ey
3.4.11.22
aminopeptidase I
3.4.13.18
cytosol nonspecific dipeptidase
|
–
–
–
–
|
|
|
BRENDA:
BS382150
SABIO-RK:
10570
|
|
|
|
Phe-Met + H2O <=> L-phenylalanine + L-methionine
|
3.4.11.22
aminopeptidase I
3.4.13.18
cytosol nonspecific dipeptidase
|
–
–
|
|
|
BRENDA:
BS382157
SABIO-RK:
10572
|
|
|
|
Phe-Phe + H2O <=> L-phenylalanine + L-phenylalanine
|
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.16
Xaa-Trp aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.22
aminopeptidase I
|
–
–
–
–
|
|
|
BRENDA:
BS382160
SABIO-RK:
8154;
9723
|
|
|
|
3''-L-phenylalanyl-gemcitabine + H2O <=> L-phenylalanine + gemcitabine
|
3.1.1.1
carboxylesterase
|
–
|
|
|
BRENDA:
BS383868
SABIO-RK:
12424
|
|
|
|
5''-L-phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole + H2O <=> L-phenylalanine + 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole
|
3.1.1.1
carboxylesterase
3.1.1.43
alpha-amino-acid esterase
|
–
–
|
|
|
BRENDA:
BS383970
SABIO-RK:
12434
|
|
|
|
5''-L-phenylalanyl-gemcitabine + H2O <=> L-phenylalanine + gemcitabine
|
3.1.1.1
carboxylesterase
|
–
|
|
|
BRENDA:
BS383971
SABIO-RK:
12426
|
|
|
|
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + H2O <=> Arg-Pro-Pro-Gly-Phe-Ser-Pro + L-phenylalanine
|
3.4.17.23
angiotensin-converting enzyme 2
|
–
|
|
|
BRENDA:
BS384587
SABIO-RK:
13314
|
|
|
|
Lys-Phe + H2O <=> L-lysine + L-phenylalanine
|
3.4.11.15
aminopeptidase Y
3.4.11.2
membrane alanyl aminopeptidase
|
–
–
|
|
|
BRENDA:
BS405614
SABIO-RK:
9768
|
|
|
|
Val-Phe + H2O <=> L-valine + L-phenylalanine
|
3.4.11.10
bacterial leucyl aminopeptidase
|
–
|
|
|
BRENDA:
BS452869
SABIO-RK:
10573
|
|
|
|
L-phenylalanine <=> tropate
|
not assigned
|
–
|
K
|
|
KEGG:
R06744
|
|
|
|
L-phenylalanine <=> D-Cathinone
|
not assigned
|
–
|
|
|
KEGG:
R08463
|
|
|
|
L-phenylalanine + 2 O2 + 2 reduced_flavodoxin <=> (Z)-phenylacetaldoxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.40
phenylalanine N-monooxygenase
|
–
|
|
|
KEGG:
R08652
|
|
|
|
L-phenylalanine <=> L-homophenylalanine
|
not assigned
|
–
|
K
|
|
KEGG:
R08690
|
|
|
|
L-phenylalanine + a_2-oxo_carboxylate <=> phenylpyruvate + an_L-amino_acid
|
2.6.1
|
–
|
K
|
|
KEGG:
R10499
|
|
|
|
L-tryptophan + L-phenylalanine <=> cyclo-L-Trp-L-Phe
|
6.3.2
|
–
|
K
|
|
KEGG:
R12413
|
|
|
|
tRNAMet + L-phenylalanine + ATP <=> L-phenylalanyl-[tRNAPhe] + diphosphate + AMP
|
6.1.1.20
phenylalanine---tRNA ligase
|
–
|
M
|
|
MetaCyc:
PHENYLALANINE--TRNA-LIGASE-RXN
|
|
|
|
lysergate + L-alanine + L-phenylalanine + L-proline + H+ + acceptor <=> ergotamine + H2O + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-11399
|
|
|
|
L-phenylalanine + O2 + reduced_[NADPH-hemoprotein_reductase] <=> N-hydroxy-L-phenylalanine + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-12066
|
|
|
|
L-phenylalanine + tetrahydropteridine + O2 <=> L-m-Tyr + 4a-hydroxytetrahydropteridine
|
1.14.16.7
phenylalanine 3-monooxygenase
|
–
|
|
|
MetaCyc:
RXN-13555
|
|
|
|
L-phenylalanine + 10-formyltetrahydrofolate + O2 <=> 4a-hydroxy-N10-formyltetrahydrofolate + L-tyrosine
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN-13907
|
|
|
|
L-phenylalanine + H+ <=> L-phenylalanine + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-14646
|
|
|
|
L-phenylalanine + L-serine + ATP <=> cyclo(L-phenylalanyl-L-seryl) + ADP + phosphate + H+
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-15678
|
|
|
|
R-2-hydroxy-3-methylpentanoyl-methylvalyl-[acp] + ATP + L-phenylalanine <=> R-2-hydroxy-3-methylpentanoate-methylvaline-phenylalanyl-[acp] + AMP + diphosphate + H+
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-16639
|
|
|
|
S-adenosyl-L-methionine + R-2-hydroxy-3-methylpentanoate-methylvaline-phenylalanyl-[acp] + ATP + L-phenylalanine <=> R-2-hydroxy-3-methylpentanoate-methylvaline-phenylalanine-methylphenylalanyl-[acp] + AMP + diphosphate + H+ + S-adenosyl-L-homocysteine
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-16640
|
|
|
|
D-pipecolyl-[acp] + L-2-aminooctanedioate + 9-N-methoxy-tryptophan + L-phenylalanine + ATP <=> apicidin_F-[acp] + AMP + diphosphate + H+
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-16675
|
|
|
|
ochratoxin_A + H2O <=> ochratoxin_alpha + L-phenylalanine
|
3.5.1
|
–
|
|
|
MetaCyc:
RXN-21094
|
|
|
|
ATP + L-phenylalanine + holo-[L-phenylalanyl-carrier_protein] <=> phenylalanyl-[L-phenylalanyl-carrier_protein] + AMP + diphosphate
|
6.2.1
|
–
|
|
|
MetaCyc:
RXN-21099
|
|
|
|
7-carboxymellein + L-phenylalanine + ATP <=> ochratoxin_B + ADP + phosphate + H+
|
6.3.1.M6
|
–
|
M
|
|
MetaCyc:
RXN-21100
|
|
|
|
L-phenylalanine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> (E)-phenylacetaldoxime + oxidized_[NADPH-hemoprotein_reductase] + H2O + CO2
|
1.14.14.40
phenylalanine N-monooxygenase
|
–
|
|
|
MetaCyc:
RXN-4602
|
|
|
|
indole-3-acetic_acid + L-phenylalanine + ATP <=> H+ + (indol-3-yl)acetyl-L-phenylalanine + AMP + diphosphate
|
6.3
|
–
|
M
|
|
MetaCyc:
RXN-9084
|
|
|
|
L-phenylalanine + ATP + gramicidin-S_synthetase <=> D-phenylalanyl-[gramicidin-S_synthetase] + AMP + diphosphate
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9676
|
|
|
|
L-phenylalanine <=> L-phenylalanine
|
not assigned
|
–
|
|
|
MetaCyc:
RXN66-445
|
|
|
|
L-phenylalanine + O2 + tetrahydropteridine <=> L-tyrosine + 4a-hydroxytetrahydropteridine
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN66-569
|
|
|
|
H+ + L-phenylalanine <=> H+ + L-phenylalanine
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN-56
|
|
|
|
L-phenylalanine + 6,7-dimethyltetrahydrobiopterin + O2 <=> L-tyrosine + 6,7-dimethyl-4a-hydroxy-tetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS389056
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + L-threo-7,8-dihydrobiopterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS370246
|
|
|
|
L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + DL-m-Tyr + dihydropteridine + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS428743
|
|
|
|
L-phenylalanine + 7(R,S)-tetrahydrobiopterin + O2 <=> L-tyrosine + 4a-hydroxytetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS451334
|
|
|
|
L-phenylalanine + 6-methyl-tetrahydrobiopterin + O2 <=> L-tyrosine + 6-methyl-4a-hydroxytetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS389057
|
|
|
|
L-phenylalanine + 6,7-dimethyltetrahydropterin + O2 <=> L-tyrosine + 4a-hydroxytetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS443688
|
|
|
|
L-phenylalanine + tetrahydropteridine + O2 <=> L-tyrosine + dihydropteridine + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
1.14.16.4
tryptophan 5-monooxygenase
|
–
–
|
|
|
BRENDA:
BS288182
|
|
|
|
L-phenylalanine + 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + O2 <=> L-tyrosine + 7,8-dimethyl-6,7-dihydrobiopterin + H2O
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS377067
|
|
|
|
L-phenylalanine + (7R)-5,6,7,8-tetrahydrobiopterine + O2 <=> L-tyrosine + dihydropteridine + H2O
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS451341
|
|
|
|
L-phenylalanine + tetrahydrobiopteridine + O2 <=> L-tyrosine + dihydropteridine + H2O
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS451340
|
|
|
|
L-phenylalanine + (7R)-5,6,7,8-tetrahydrobiopterin + O2 <=> L-tyrosine + 4a-hydroxytetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS451333
|
|
|
|
L-phenylalanine + 6-Methyl-5,6,7,8-tetrahydropterin + O2 <=> L-tyrosine + 4a-hydroxy-6-methyltetrahydropterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS428740
|
|
|
|
L-phenylalanine + O2 <=> phenylpyruvate + NH3
|
1.13.12.15
3,4-dihydroxyphenylalanine oxidative deaminase
|
–
|
|
|
BRENDA:
BS397645
|
|
|
|
phenylglycinenitrile + H2O <=> L-phenylalanine + NH3
|
3.5.5.5
arylacetonitrilase
|
–
|
|
|
BRENDA:
BS385534
|
|
|
|
N-formyl-DL-phenylalanine + H2O <=> L-phenylalanine + CO2
|
3.5.1.87
N-carbamoyl-L-amino-acid hydrolase
|
–
|
|
|
BRENDA:
BS434008
|
|
|
|
N-formyl-L-phenylalanine + H2O <=> L-phenylalanine + CO2
|
3.5.1.87
N-carbamoyl-L-amino-acid hydrolase
|
–
|
|
|
BRENDA:
BS414954
|
|
|
|
benzyloxycarbonyl-Phe + H2O <=> benzyl_alcohol + CO2 + L-phenylalanine
|
3.5.1.64
Nalpha-benzyloxycarbonylleucine hydrolase
|
–
|
|
|
BRENDA:
BS116372
|
|
|
|
N-(5''-phospho-4''-pyridoxyl)-L-phenylalanine + H2O + O2 <=> pyridoxal_5''-phosphate + L-phenylalanine + H2O2
|
1.4.3.5
pyridoxal 5'-phosphate synthase
|
–
|
|
|
BRENDA:
BS451627
|
|
|
|
5''-phospho-pyridoxyl-L-phenylalanine + H2O + O2 <=> pyridoxal_5''-phosphate + L-phenylalanine + H2O2
|
1.4.3.5
pyridoxal 5'-phosphate synthase
|
–
|
|
|
BRENDA:
BS259084
|
|
|
|
N-methyl-L-phenylalanine + O2 + H2O <=> L-phenylalanine + formaldehyde + H2O2
|
1.5.3.2
N-methyl-L-amino-acid oxidase
|
–
|
|
|
BRENDA:
BS259342
|
|
|
|
L-phenylalanine + 6-Methyl-5,6,7,8-tetrahydropterin + O2 <=> L-phenylalanine + 6-methyldihydropterin + H2O2
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS288229
|
|
|
|
Asp-Phe-NH2 + H2O <=> L-aspartate + L-phenylalanine + NH3
|
3.4.11.7
glutamyl aminopeptidase
|
–
|
|
|
BRENDA:
BS36342
|
|
|
|
L-phenylalanine + tetrahydropteridine + O2 <=> L-Dopa + dihydropteridine + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS288205
|
|
|
|
L-phenylalanine + pyridoxal_5''-phosphate <=> phenylpyruvate + pyridoxamine_5''-phosphate
|
4.4.1.14
1-aminocyclopropane-1-carboxylate synthase
|
–
|
|
|
BRENDA:
BS368522
|
|
|
|
L-Phe-NH2 + H2O <=> L-phenylalanine + NH3
|
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.17
tryptophanyl aminopeptidase
3.4.11.24
aminopeptidase S
3.5.1.57
tryptophanamidase
|
–
–
–
–
|
|
|
BRENDA:
BS140591
|
|
|
|
phenylpyruvate + 2-Aminoadipate <=> L-phenylalanine + 2-oxoglutarate
|
2.6.1.39
2-aminoadipate transaminase
|
–
|
|
|
BRENDA:
BS377509
|
|
|
|
GTP + L-phenylalanine + tRNAMet <=> GMP + diphosphate + L-phenylalanyl-tRNAPhe
|
6.1.1.20
phenylalanine---tRNA ligase
|
–
|
|
|
BRENDA:
BS368886
|
|
|
|
rac-N-(aminocarbonyl)phenylalanine + H2O <=> L-phenylalanine + CO2 + NH3
|
3.5.1.87
N-carbamoyl-L-amino-acid hydrolase
|
–
|
|
|
BRENDA:
BS190005
|
|
|
|
L-phenylalanine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate
|
2.6.1.26
thyroid-hormone transaminase
|
–
|
|
|
BRENDA:
BS356402
|
|
|
|
L-kynurenine + phenylpyruvate <=> L-phenylalanine + L-glutamate + H2O
|
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
|
|
|
BRENDA:
BS353537
|
|
|
|
Glu-Phe + H2O <=> L-glutamate + L-phenylalanine
|
3.4.11.10
bacterial leucyl aminopeptidase
|
–
|
|
|
BRENDA:
BS64783
|
|
|
|
FVNQHLCGSHLVEALYLVCGERGFFYTPKA + H2O <=> L-phenylalanine + VNQH + LCGSH + L-leucine + L-valine + L-glutamate + L-alanine + L-leucine + L-tyrosine + LVCG + ERG + L-phenylalanine + L-phenylalanine + YTPKA
|
3.4.23.21
rhizopuspepsin
|
–
|
|
|
BRENDA:
BS384742
|
|
|
|
L-phenylalanine + NADH + O2 <=> L-tyrosine + NAD+ + H2O
|
1.14.13.25
methane monooxygenase (soluble)
|
–
|
|
|
BRENDA:
BS288442-a
|
|
|
|
L-phenylalanine + pyruvate + NADH <=> N-[1-(R)-(Carboxy)ethyl]-(S)-Phe + NAD+
|
1.5.1.28
opine dehydrogenase
|
–
|
|
|
BRENDA:
BS73114
|
|
|
|
L-phenylalanine + pyridoxal_5'-phosphate <=> pyridoxamine_5'-phosphate + a_2-oxo_carboxylate
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS18641
|
|
|
|
L-phenylalanine + NADPH + O2 <=> L-tyrosine + NADP+ + H2O
|
1.14.13.25
methane monooxygenase (soluble)
|
–
|
|
|
BRENDA:
BS288442
|
|
|
|
L-phenylalanine + H2O + NADP+ <=> phenylpyruvate + NH3 + NADPH
|
1.4.1.16
diaminopimelate dehydrogenase
1.4.1.2
glutamate dehydrogenase
1.4.1.20
phenylalanine dehydrogenase
|
–
–
–
|
|
|
BRENDA:
BS232329
|
|
|
|
Phe-NH2 + H2O <=> L-phenylalanine + NH3
|
3.4.22.2
papain
3.5.1.101
L-proline amide hydrolase
3.5.1.13
aryl-acylamidase
3.5.1.3
omega-amidase
|
–
–
–
–
|
|
|
BRENDA:
BS140274
|
|
|
|
N-carbamoyl-L-phenylalanine + H2O <=> L-phenylalanine + CO2 + NH3
|
3.5.1.6
beta-ureidopropionase
3.5.1.87
N-carbamoyl-L-amino-acid hydrolase
|
–
–
|
|
|
BRENDA:
BS389256
|
|
|
|
ATP + L-phenylalanine + tRNAMet <=> diphosphate + L-phenylalanyl-tRNAPhe
|
6.1.1.20
phenylalanine---tRNA ligase
|
–
|
|
|
BRENDA:
BS453681
|
|
|
|
L-phenylalanine + 6-Methyl-5,6,7,8-tetrahydropterin + O2 <=> L-m-Tyr + 4a-hydroxy-6-methyltetrahydropterin
|
1.14.16.7
phenylalanine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS426581
|
|
|
|
L-phenylalanine + 6,7-dimethyltetrahydropterin + O2 <=> 4-(hydroxymethyl)phenylalanine + 3-methyl-L-tyrosine + H2O + 6,7-dimethyldihydropterin
|
1.14.16.1
phenylalanine 4-monooxygenase
|
–
|
|
|
BRENDA:
BS405637
|
|
|
|
L-phenylalanine_methyl_ester + H2O <=> L-phenylalanine + methanol
|
3.1.1.43
alpha-amino-acid esterase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.24
aminopeptidase S
|
–
–
–
|
|
|
BRENDA:
BS382164
|
|
|
|
L-phenylalanine + H2O + 2 cytochrome_c <=> phenylpyruvate + NH3 + 2 ferricytochrome_c
|
1.4.99.B3
|
–
|
|
|
BRENDA:
BS439683
|
|
|
|
2 ATP + 2 L-valine + L-phenylalanine <=> 2 ADP + 2 phosphate + L-Val-L-Val-L-Phe
|
6.3.2.B16
|
–
|
|
|
BRENDA:
BS429634
|
|
|
|
3 ATP + 3 L-valine + L-phenylalanine <=> 3 ADP + 3 phosphate + L-Val-L-Val-L-Val-L-Phe
|
6.3.2.B16
|
–
|
|
|
BRENDA:
BS429698
|
|
|
|
ATP + L-phenylalanine + L-asparagine <=> ADP + phosphate + L-phenylalanyl-L-asparagine
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428307
|
|
|
|
ATP + L-phenylalanine + L-glutamine <=> ADP + phosphate + L-phenylalanyl-L-glutamine
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428308
|
|
|
|
ATP + L-lysine + L-phenylalanine <=> ADP + phosphate + Lys-Phe
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408623
|
|
|
|
ATP + L-histidine + L-phenylalanine <=> ADP + phosphate + His-Phe
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408559
|
|
|
|
ATP + L-phenylalanine + L-proline <=> ADP + phosphate + Phe-Pro
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428316
|
|
|
|
ATP + L-phenylalanine + L-arginine <=> ADP + phosphate + Phe-Arg
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428306
|
|
|
|
ATP + L-phenylalanine + L-lysine <=> ADP + phosphate + Phe-Lys
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428313
|
|
|
|
ATP + L-phenylalanine + L-leucine <=> ADP + phosphate + Phe-Leu
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428312
|
|
|
|
ATP + L-tryptophan + L-phenylalanine <=> ADP + phosphate + L-Trp-L-Phe
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408713
|
|
|
|
ATP + L-alanine + L-phenylalanine <=> ADP + phosphate + Ala-Phe
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS429926
|
|
|
|
ATP + L-phenylalanine + L-tryptophan <=> ADP + phosphate + L-Phe-L-Trp
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS428319
|
|
|
|
ATP + L-phenylalanine + L-alanine <=> ADP + phosphate + Phe-Ala
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408666
|
|
|
|
ATP + L-phenylalanine + glycine <=> ADP + phosphate + Phe-Gly
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408668
|
|
|
|
ATP + L-glutamine + L-phenylalanine <=> ADP + phosphate + L-glutaminyl-L-phenylalanine
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408535
|
|
|
|
ATP + L-phenylalanine + L-phenylalanine <=> ADP + phosphate + Phe-Phe
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408671
|
|
|
|
ATP + L-asparagine + L-phenylalanine <=> ADP + phosphate + Asn-Phe
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408460
|
|
|
|
ATP + L-phenylalanine + L-methionine <=> ADP + phosphate + Phe-Met
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408670
|
|
|
|
ATP + L-arginine + L-phenylalanine <=> ADP + phosphate + Arg-Phe
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408455
|
|
|
|
ATP + L-tyrosine + L-phenylalanine <=> ADP + phosphate + Tyr-Phe
|
6.3.2.49
L-alanine---L-anticapsin ligase
|
–
|
|
|
BRENDA:
BS408723
|
|
|
|
|