|
|
L-glutamate + L-cysteine + ATP <=> gamma-Glu-L-Cys + ADP + phosphate + H+
|
6.3.2.2
glutamate---cysteine ligase
|
–
|
BMK
|
|
BRENDA:
BR112
KEGG:
R00894
MetaCyc:
GLUTCYSLIG-RXN
SABIO-RK:
1217
|
|
|
|
L-cystathionine + H2O <=> L-cysteine + 2-oxobutyrate + NH3
|
2.5.1.48
cystathionine gamma-synthase
4.4.1.1
cystathionine gamma-lyase
|
–
–
|
BMK
|
|
BRENDA:
BR3435
KEGG:
R01001
MetaCyc:
RXN-15130
SABIO-RK:
1294
|
|
|
|
H+ + sulfite + L-cysteine <=> Sulfide + L-cysteic_acid
|
4.4.1.10
cysteine lyase
|
–
|
BK
|
|
BRENDA:
BR3436
KEGG:
R00901
MetaCyc:
CYSTEINE-LYASE-RXN
|
|
|
|
L-cysteine + cyanide <=> H+ + Sulfide + Beta-cyanoalanine
|
2.5.1.47
cysteine synthase
2.8.1.1
thiosulfate sulfurtransferase
4.4.1.9
L-3-cyanoalanine synthase
|
–
–
–
|
MK
|
|
BRENDA:
BR3447
KEGG:
R02846;
R03524
MetaCyc:
L-3-CYANOALANINE-SYNTHASE-RXN
SABIO-RK:
3312;
8566
|
|
|
|
L-cystine + glutathione <=> GSSG + L-cysteine
|
1.8.1.6
cystine reductase
1.8.4.4
glutathione---cystine transhydrogenase
1.8.4.9
adenylyl-sulfate reductase (glutathione)
|
–
–
–
|
BK
|
|
BRENDA:
BR37026
KEGG:
R01109;
R01113
MetaCyc:
1.8.4.4-RXN
|
|
|
|
H2O + O2 + an_S-prenyl-L-cysteine <=> 3-methylbut-2-enal + H2O2 + L-cysteine
|
1.8.3.5
prenylcysteine oxidase
|
–
|
|
|
BRENDA:
BR40347
KEGG:
R07360
MetaCyc:
1.8.3.5-RXN;
RXN-18932
|
|
|
|
O2 + L-cysteine <=> H+ + L-cysteine_sulfinic_acid
|
1.13.11.20
cysteine dioxygenase
1.14.99.52
L-cysteinyl-L-histidinylsulfoxide synthase
|
–
–
|
BMK
|
|
BRENDA:
BR40484
KEGG:
R00893
MetaCyc:
CYSTEINE-DIOXYGENASE-RXN
SABIO-RK:
1216;
14729
|
|
|
|
L-2-aminoadipate + L-cysteine + L-valine + ATP + H2O <=> H+ + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
MK
|
|
BRENDA:
BR40508
KEGG:
R04870
MetaCyc:
6.3.2.26-RXN
|
|
|
|
L-cysteine + NAD+ <=> H+ + L-cystine + NADH
|
1.8.1.6
cystine reductase
|
–
|
BK
|
|
BRENDA:
BR40533
KEGG:
R00892
MetaCyc:
CYSTINE-REDUCTASE-NADH-RXN
|
|
|
|
tRNAMet + L-cysteine + ATP <=> L-cysteinyl-[tRNACys] + diphosphate + AMP
|
6.1.1.15
proline---tRNA ligase
6.1.1.16
cysteine---tRNA ligase
|
–
–
|
BMK
|
|
BRENDA:
BR46
KEGG:
R03650
MetaCyc:
CYSTEINE--TRNA-LIGASE-RXN
SABIO-RK:
405
|
|
|
|
O-acetyl-L-serine + Sulfide <=> L-cysteine + acetate + H+
|
2.5.1.47
cysteine synthase
2.5.1.49
O-acetylhomoserine aminocarboxypropyltransferase
2.5.1.65
O-phosphoserine sulfhydrylase
4.2.1.22
cystathionine beta-synthase
4.2.1.50
pyrazolylalanine synthase
4.4.1.9
L-3-cyanoalanine synthase
|
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR47463;
BS370451
KEGG:
R00897
MetaCyc:
ACSERLY-RXN
SABIO-RK:
1220;
9651
|
|
|
|
O-succinyl-L-homoserine + L-cysteine <=> L-cystathionine + succinate + H+
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
BMK
|
|
BRENDA:
BR47465
KEGG:
R02508;
R03260
MetaCyc:
O-SUCCHOMOSERLYASE-RXN
SABIO-RK:
3081
|
|
|
|
L-cysteine + 2-oxoglutarate <=> 3-Mercaptopyruvate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.3
cysteine transaminase
2.6.1.5
tyrosine transaminase
|
–
–
–
|
BMK
|
|
BRENDA:
BR47681
KEGG:
R00895;
R00896
MetaCyc:
CYSTEINE-AMINOTRANSFERASE-RXN
|
|
|
|
(R)-4''-phosphopantothenate + L-cysteine + CTP <=> H+ + (R)-4''-phosphopantothenoyl-L-cysteine + diphosphate + CMP
|
6.3.2.5
phosphopantothenate---cysteine ligase (CTP)
|
–
|
BMK
|
|
BRENDA:
BR48388
KEGG:
R04231
MetaCyc:
P-PANTOCYSLIG-RXN
SABIO-RK:
3942
|
|
|
|
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP <=> H+ + desacetylmycothiol + AMP + diphosphate
|
6.3.1.13
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
|
–
|
M
|
|
BRENDA:
BR48477
KEGG:
R09591
MetaCyc:
RXN1G-121
|
|
|
|
O-phospho-L-serine + Sulfide <=> L-cysteine + phosphate
|
2.5.1.47
cysteine synthase
2.5.1.65
O-phosphoserine sulfhydrylase
|
–
–
|
BMK
|
|
BRENDA:
BR48518
KEGG:
R07274
MetaCyc:
2.5.1.65-RXN
SABIO-RK:
7293
|
|
|
|
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O <=> (2E,6E)-farnesal + L-cysteine + H2O2
|
1.8.3.5
prenylcysteine oxidase
1.8.3.6
farnesylcysteine lyase
|
–
–
|
MK
|
|
BRENDA:
BR49439
KEGG:
R09562
MetaCyc:
RXN-11623
|
|
|
|
L-cysteine + H2O <=> pyruvate + Sulfide + NH3
|
4.4.1.1
cystathionine gamma-lyase
4.4.1.11
methionine gamma-lyase
4.4.1.13
cysteine-S-conjugate beta-lyase
4.4.1.28
L-cysteine desulfidase
4.4.1.3
dimethylpropiothetin dethiomethylase
|
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR51143
KEGG:
R00782
MetaCyc:
LCYSDESULF-RXN
SABIO-RK:
1131
|
|
|
|
L-cysteine <=> 2-aminoacrylate + Sulfide
|
4.4.1.28
L-cysteine desulfidase
|
–
|
M
|
|
BRENDA:
BR51144
MetaCyc:
RXN-15129
|
|
|
|
L-cystathionine <=> L-cysteine + 2-aminobut-2-enoate + H+
|
4.4.1.1
cystathionine gamma-lyase
|
–
|
|
|
BRENDA:
BR51158
KEGG:
R08632
MetaCyc:
RXN-14048
|
|
|
|
hercynine + L-cysteine + O2 <=> S-(hercyn-2-yl)-L-cysteine_S-oxide + H2O
|
1.14.99.51
hercynylcysteine S-oxide synthase
|
–
|
MK
|
|
BRENDA:
BR51394
KEGG:
R11014
MetaCyc:
RXN-15801
|
|
|
|
L-histidine + L-cysteine + O2 <=> S-(L-histidin-5-yl)-L-cysteine_S-oxide + H2O
|
1.14.99.52
L-cysteinyl-L-histidinylsulfoxide synthase
|
–
|
|
|
BRENDA:
BR51395
KEGG:
R11015
MetaCyc:
RXN-15802
|
|
|
|
(R)-4''-phosphopantothenate + L-cysteine + ATP <=> H+ + (R)-4''-phosphopantothenoyl-L-cysteine + diphosphate + AMP
|
6.3.2.51
phosphopantothenate---cysteine ligase (ATP)
|
–
|
MK
|
|
BRENDA:
BR52070
KEGG:
R04230
MetaCyc:
RXN66-555
|
|
|
|
L-cystathionine + H2O <=> L-cysteine + L-homoserine
|
4.4.1.1
cystathionine gamma-lyase
|
–
|
|
|
BRENDA:
BS19007
MetaCyc:
CYSTATHIONASE-RXN
|
|
|
|
L-cysteine + H2O <=> L-serine + Sulfide
|
2.5.1.47
cysteine synthase
2.5.1.49
O-acetylhomoserine aminocarboxypropyltransferase
4.2.1.22
cystathionine beta-synthase
|
–
–
–
|
MK
|
|
BRENDA:
BS1928
KEGG:
R00891
MetaCyc:
RXN-19038
SABIO-RK:
1214
|
|
|
|
L-cysteine + O-phospho-L-homoserine <=> L-cystathionine + phosphate
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
BM
|
|
BRENDA:
BS354338
MetaCyc:
CYSPH-RXN
SABIO-RK:
13007
|
|
|
|
Cys-Gly + H2O <=> L-cysteine + glycine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.23
PepB aminopeptidase
3.4.11.6
aminopeptidase B
3.4.13
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.23
cysteinylglycine-S-conjugate dipeptidase
|
–
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BS364761
KEGG:
R00899
MetaCyc:
RXN-6622
SABIO-RK:
1221
|
|
|
|
ATP + L-cysteine + H2O <=> ADP + L-cysteine + phosphate + H+
|
7.4.2
7.4.2.1
ABC-type polar-amino-acid transporter
|
–
–
|
|
|
BRENDA:
BS388056
MetaCyc:
RXN0-3
|
|
|
|
L-cysteine + L-homocysteine <=> L-cystathionine + Sulfide
|
2.5.1.47
cysteine synthase
4.2.1.22
cystathionine beta-synthase
4.4.1.1
cystathionine gamma-lyase
|
–
–
–
|
M
|
|
BRENDA:
BS409645
MetaCyc:
RXN66-562
SABIO-RK:
7280
|
|
|
|
L-cysteine <=> Lanthionine + Sulfide
|
2.5.1.47
cysteine synthase
4.2.1.22
cystathionine beta-synthase
4.4.1.1
cystathionine gamma-lyase
|
–
–
–
|
M
|
|
BRENDA:
BS412246
MetaCyc:
RXN66-534
|
|
|
|
L-cysteine + [enzyme]-cysteine <=> L-alanine + [enzyme]-S-sulfanylcysteine
|
2.8.1.7
cysteine desulfurase
|
–
|
BK
|
|
BRENDA:
BR49765
KEGG:
R07460
|
|
|
|
gamma-Glu-L-Cys <=> 5-oxoproline + L-cysteine
|
4.3.2.9
gamma-glutamylcyclotransferase
|
–
|
K
|
|
BRENDA:
BS321706
KEGG:
R02743
|
|
|
|
O-acetyl-L-homoserine + L-cysteine <=> L-cystathionine + acetate
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
K
|
|
BRENDA:
BS354336
KEGG:
R03217
|
|
|
|
L-cysteine + ''activated''_tRNA <=> L-serine + tRNA_containing_a_thionucleotide
|
2.8.1.4
tRNA uracil 4-sulfurtransferase
|
–
|
|
|
BRENDA:
BS358737
KEGG:
R03923
|
|
|
|
H+ + S-Glutathionyl-L-cysteine + NADPH <=> L-cysteine + glutathione + NADP+
|
1.8.1.10
CoA-glutathione reductase
1.8.1.9
thioredoxin-disulfide reductase
1.8.4.2
protein-disulfide reductase (glutathione)
|
–
–
–
|
K
|
|
KEGG:
R00900
MetaCyc:
GSCYSDEG-RXN
SABIO-RK:
1222
|
|
|
|
dopaquinone + L-cysteine <=> Cysteinyldopa
|
not assigned
|
–
|
MK
|
|
KEGG:
R08848
MetaCyc:
RXN-14185
|
|
|
|
molybdenum_cofactor + L-cysteine + reduced_acceptor <=> MoOS(OH)Dtpp-mP + L-alanine + H2O + acceptor
|
2.8.1.9
molybdenum cofactor sulfurtransferase
|
–
|
K
|
|
KEGG:
R11583
MetaCyc:
RXN-21548
|
|
|
|
(Z)-phenylacetaldoxime + O2 + L-cysteine + NADPH + H+ <=> S-(Phenylacetothiohydroximoyl)-L-cysteine + H2O + NADP+
|
1.14
|
–
|
|
|
KEGG:
R08653
MetaCyc:
RXN-4603
|
|
|
|
L-cysteine + acceptor <=> L-alanine + sulfhydryl_reagents
|
2.8.1.7
cysteine desulfurase
4.4.1.16
selenocysteine lyase
|
–
–
|
|
|
BRENDA:
BR48104
SABIO-RK:
12679
|
|
|
|
N-acetyl-L-cysteine + H2O <=> L-cysteine + acetate
|
3.5.1.14
N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.15
aspartoacylase
3.5.1.16
acetylornithine deacetylase
3.5.1.32
hippurate hydrolase
|
–
–
–
–
|
|
|
BRENDA:
BS116183
SABIO-RK:
8155
|
|
|
|
Lanthionine + H2O <=> L-cysteine + NH3 + pyruvate
|
4.4.1.13
cysteine-S-conjugate beta-lyase
4.4.1.3
dimethylpropiothetin dethiomethylase
|
–
–
|
|
|
BRENDA:
BS19145
SABIO-RK:
13971
|
|
|
|
L-cysteine + 2-mercaptoethanol <=> S-(2-Hydroxyethyl)-L-cysteine + Sulfide
|
4.2.1.22
cystathionine beta-synthase
|
–
|
|
|
BRENDA:
BS1929
SABIO-RK:
9652
|
|
|
|
L-cysteine + H2O + O2 <=> 3-Mercaptopyruvate + NH3 + H2O2
|
1.4.3.2
L-amino-acid oxidase
|
–
|
|
|
BRENDA:
BS259023
SABIO-RK:
10887
|
|
|
|
beta-chloro-L-alanine + Sulfide <=> L-cysteine + Cl-
|
2.5.1.47
cysteine synthase
4.4.1.9
L-3-cyanoalanine synthase
|
–
–
|
|
|
BRENDA:
BS354309
SABIO-RK:
10508
|
|
|
|
L-glutamine + 3-Mercaptopyruvate <=> 2-Oxoglutaramate + L-cysteine
|
2.6.1.15
glutamine---pyruvate transaminase
|
–
|
|
|
BRENDA:
BS356348
SABIO-RK:
10380
|
|
|
|
Cys-Leu + H2O <=> L-cysteine + L-leucine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.23
PepB aminopeptidase
|
–
–
|
|
|
BRENDA:
BS358915
SABIO-RK:
15395
|
|
|
|
Leu-Cys + H2O <=> L-leucine + L-cysteine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.23
PepB aminopeptidase
|
–
–
|
|
|
BRENDA:
BS358931
SABIO-RK:
15396
|
|
|
|
L-cystine + NADPH + H+ <=> 2 L-cysteine + NADP+
|
1.8.1.9
thioredoxin-disulfide reductase
|
–
|
|
|
BRENDA:
BS441244
SABIO-RK:
696
|
|
|
|
(E,Z)-indolyl-3-acetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Indolylmethylthiohydroximoyl)-L-cysteine + NADP+ + 2 H2O
|
1.14.14.43
(methylsulfanyl)alkanaldoxime N-monooxygenase
1.14.14.45
aromatic aldoxime N-monooxygenase
|
–
–
|
K
|
|
KEGG:
R08168
SABIO-RK:
14613
|
|
|
|
L-cysteine <=> D-cysteine
|
5.1.1.10
amino-acid racemase
|
–
|
K
|
|
KEGG:
R00903
|
|
|
|
L-cystine + sulfate <=> S-sulfocysteine + L-cysteine
|
1.8.4.3
glutathione---CoA-glutathione transhydrogenase
|
–
|
K
|
|
KEGG:
R02409
|
|
|
|
L-serine <=> L-cysteine
|
not assigned
|
–
|
|
|
KEGG:
R02818
|
|
|
|
O-acetyl-L-serine + thiosulfate + thioredoxin + H+ <=> L-cysteine + sulfite + thioredoxin_disulfide + acetate
|
2.5.1.47
cysteine synthase
2.5.1.49
O-acetylhomoserine aminocarboxypropyltransferase
|
–
–
|
|
|
KEGG:
R04859
|
|
|
|
1-aci-nitro-2-indolyl-ethane + L-cysteine <=> S-(Indolylmethylthiohydroximoyl)-L-cysteine + H2O
|
not assigned
|
–
|
|
|
KEGG:
R08608
|
|
|
|
p-hydroxyphenylacetaldoxime + O2 + NADPH + L-cysteine + H+ <=> S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O
|
1.14
|
–
|
|
|
KEGG:
R08659
|
|
|
|
4-methylthiobutanaldoxime + L-cysteine + reduced_flavodoxin + O2 <=> S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine + flavin + 2 H2O
|
1.14.14.43
(methylsulfanyl)alkanaldoxime N-monooxygenase
|
–
|
K
|
|
KEGG:
R08666
|
|
|
|
an_aliphatic_aldoxime + NADPH + O2 + L-cysteine + H+ <=> S-Alkyl-thiohydroximate + NADP+ + 2 H2O
|
1.14
|
–
|
|
|
KEGG:
R08685
|
|
|
|
S-sulfocysteine + thioredoxin <=> L-cysteine + sulfite + thioredoxin_disulfide
|
not assigned
|
–
|
K
|
|
KEGG:
R10409
|
|
|
|
(E)-phenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Phenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O
|
1.14.14.45
aromatic aldoxime N-monooxygenase
|
–
|
K
|
|
KEGG:
R10670
|
|
|
|
p-hydroxyphenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O
|
1.14.14.45
aromatic aldoxime N-monooxygenase
|
–
|
K
|
|
KEGG:
R10672
|
|
|
|
(5R)-carbapen-2-em-3-carboxylate + L-cysteine <=> C20817 + CO2
|
not assigned
|
–
|
K
|
|
KEGG:
R10736
|
|
|
|
[Sulfur-carrier_protein]-Gly-Gly-L-Cys + H2O <=> L-cysteine + Sulfur-carrier_protein
|
3.13.1.6
[CysO sulfur-carrier protein]-S-L-cysteine hydrolase
|
–
|
|
|
KEGG:
R11524
|
|
|
|
L-cysteine + protein <=> L-alanine + a_[protein]-S-sulfanyl-L-cysteine
|
2.8.1.7
cysteine desulfurase
|
–
|
|
|
KEGG:
R11528
|
|
|
|
peptide_with_an_N-terminal_L-cysteine + H2O <=> L-cysteine + peptide
|
3.4.11.3
cystinyl aminopeptidase
|
–
|
|
|
MetaCyc:
3.4.11.3-RXN
|
|
|
|
2-sulfoacetaldehyde + L-cysteine <=> H+ + 2-(sulfomethyl)thiazolidine-4-carboxylate + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
R232-RXN
|
|
|
|
(5-hydroxy-1H-indol-3-yl)acetaldehyde + L-cysteine <=> 5-hydroxyindole_thiazolidine_carboxylate + H2O + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10779
|
|
|
|
S-adenosyl-L-methionine + (2-hydroxybenzoyl)adenylate + L-cysteine + malonyl-CoA + NADPH + H+ <=> yersiniabactin + CoA + S-adenosyl-L-homocysteine + NADP+ + H2O + AMP
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN-11105
|
|
|
|
S-adenosyl-L-methionine + salicylate + L-cysteine + NADPH <=> pyochelin + S-adenosyl-L-homocysteine + NADP+ + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-11114
|
|
|
|
L-cysteine + ATP + H+ <=> (L-cysteinyl)adenylate + diphosphate
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-11115
|
|
|
|
4-(2-aminoethyl)-1,2-benzoquinone + L-cysteine <=> 5-S-cysteinyl_dopamine
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-11446
|
|
|
|
L-cysteine + unsulfurated_[sulfur_carrier] <=> L-alanine + sulfurated_[sulfur_carrier]
|
2.8.1.7
cysteine desulfurase
|
–
|
|
|
MetaCyc:
RXN-12588
|
|
|
|
L-cysteine + [cysteine_desulfurase]-S-sulfanyl-[disordered-form_scaffold_protein]_complex <=> L-alanine + S-sulfanyl-[cysteine_desulfurase]-S-sulfanyl-[disordered-form_scaffold_protein]_complex
|
2.8.1.7
cysteine desulfurase
|
–
|
M
|
|
MetaCyc:
RXN-14385
|
|
|
|
[CysO_sulfur-carrier_protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O <=> [CysO_sulfur-carrier_protein]-Gly-Gly + L-cysteine + H+
|
3.13.1.6
[CysO sulfur-carrier protein]-S-L-cysteine hydrolase
|
–
|
M
|
|
MetaCyc:
RXN-14567
|
|
|
|
L-cysteine + H+ <=> L-cysteine + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-14647
|
|
|
|
L-cysteine + [L-cysteine_desulfurase] <=> L-alanine + S-sulfanyl-[L-cysteine_desulfurase]
|
2.8.1.7
cysteine desulfurase
|
–
|
M
|
|
MetaCyc:
RXN-15881
|
|
|
|
L-cysteinyl-[tRNACys] + H2O <=> L-cysteine + tRNAMet + H+
|
3.1.1.29
aminoacyl-tRNA hydrolase
|
–
|
M
|
|
MetaCyc:
RXN-16637
|
|
|
|
HlmE_non-ribosomal_peptide_synthetase + L-cysteine + ATP <=> L-cysteinyl-[HlmE_non-ribosomal_peptide_synthetase] + AMP + diphosphate
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-16874
|
|
|
|
(2E)-2-amino-3-sulfanylprop-2-enoyl-[HlmE_non-ribosomal_peptide_synthetase] + L-cysteine + acceptor + ATP <=> (2E)-2-[(2E)-2-azanidyl-3-sulfanylprop-2-enamido]-3-[HlmE_non-ribosomal_peptide_synthetase] + reduced_acceptor + AMP + diphosphate + H+
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-16876
|
|
|
|
S-adenosyl-L-methionine + quinoxaline-2-carboxyl-D-seryl-L-alanyl-[non-ribosomal_peptide_synthase] + L-cysteine + L-valine + ATP <=> triostin_A_dithiol + non-ribosomal_peptide_synthase + AMP + diphosphate + H+ + S-adenosyl-L-homocysteine
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-17157
|
|
|
|
3-hydroxyquinaldyl-[aryl-carrier_protein] + L-cysteine + glycine + non-ribosomal_peptide_synthase + ATP <=> 3-hydroxyquinaldyl-D-cysteinyl-glycyl-[non-ribosomal_peptide_synthase] + aryl-carrier_protein + AMP + diphosphate + H+
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-17172
|
|
|
|
S-adenosyl-L-methionine + 3-hydroxyquinaldyl-D-cysteinyl-glycyl-[non-ribosomal_peptide_synthase] + (S-methyl-L-cysteinyl)adenylate + L-cysteine + ATP <=> thiocoraline_dithiol + non-ribosomal_peptide_synthase + AMP + diphosphate + S-adenosyl-L-homocysteine + H+
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-17173
|
|
|
|
S-sulfocysteine + reduced_glutaredoxin <=> L-cysteine + sulfite + thioredoxin_disulfide + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18586
|
|
|
|
2-cyano-6-hydroxybenzothiazole + L-cysteine + acceptor <=> L-luciferin + NH3 + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18839
|
|
|
|
2-amino-3-[(2,5-dihydroxyphenyl)sulfanyl]propanoate + L-cysteine + acceptor <=> L-luciferin + CO2 + H2O + H+ + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18843
|
|
|
|
1,4-benzoquinone + L-cysteine <=> 2-amino-3-[(2,5-dihydroxyphenyl)sulfanyl]propanoate
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18844
|
|
|
|
dopaquinone + L-cysteine <=> 2-S-cysteinyldopa
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18899
|
|
|
|
L-cysteine + holo-[L-cysteinyl-carrier_protein] + ATP <=> L-cysteinyl-[L-cysteinyl-carrier_protein] + AMP + diphosphate
|
6.2.1.aa
|
–
|
|
|
MetaCyc:
RXN-19464
|
|
|
|
L-cysteine + [PchE_non-ribosomal_peptide_synthase] + ATP <=> L-cysteinyl-[PchE_non-ribosomal_peptide_synthase] + AMP + diphosphate
|
6.2.1.aa
|
–
|
|
|
MetaCyc:
RXN-19465
|
|
|
|
L-cysteine + [PchF_non-ribosomal_peptide_synthase_protein] + ATP <=> L-cysteinyl-[PchF_non-ribosomal_peptide_synthase] + AMP + diphosphate
|
6.2.1.aa
|
–
|
|
|
MetaCyc:
RXN-19468
|
|
|
|
glutathione + S-sulfocysteine <=> GSSG + L-cysteine + sulfite + H+
|
1.8.4.2
protein-disulfide reductase (glutathione)
|
–
|
|
|
MetaCyc:
RXN-19629
|
|
|
|
L-cysteine + adenylyl-[ThiS] + reduced_acceptor <=> thiocarboxylated-[ThiS_sulfur-carrier_protein] + L-alanine + AMP + acceptor + H+
|
2.8.1.7
cysteine desulfurase
|
–
|
|
|
MetaCyc:
RXN-20037
|
|
|
|
L-cysteinyl-[tRNAPro] + H2O <=> tRNAMet + L-cysteine + H+
|
4.2.99.M2
|
–
|
|
|
MetaCyc:
RXN-21077
|
|
|
|
ATP + L-cysteine + holo_[ClbJ_non-ribosomal_peptide_synthase] <=> AMP + diphosphate + L-cysteinyl-[ClbJ_non-ribosomal_peptide_synthase]
|
6.2.1.aa
|
–
|
|
|
MetaCyc:
RXN-21149
|
|
|
|
ATP + L-cysteine + holo_[ClbK_polyketide_synthase] <=> AMP + diphosphate + L-cysteinyl-[ClbK_polyketide_synthase]
|
6.2.1.aa
|
–
|
|
|
MetaCyc:
RXN-21150
|
|
|
|
L-cysteine + [cytidylyl_molybdenum_cofactor_chaperone]-cytidylyl_molybdenum_cofactor + reduced_acceptor <=> L-alanine + [cytidylyl_molybdenum_cofactor_chaperone]-cytidylyl_molybdenum_cofactor_(sulfo-dioxo) + H2O + acceptor
|
2.8.1.7
cysteine desulfurase
|
–
|
M
|
|
MetaCyc:
RXN-21560
|
|
|
|
L-cysteine + [bis(guanylyl_molybdopterin)_cofactor_chaperone]-L-cysteine <=> L-alanine + [bis(guanylyl_molybdopterin)_cofactor_chaperone]-S-sulfanyl-L-cysteine
|
2.8.1.7
cysteine desulfurase
|
–
|
|
|
MetaCyc:
RXN-21566
|
|
|
|
(E)-4-(methylsulfanyl)butanal_oxime + NADPH + O2 + L-cysteine + H+ <=> S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine + NADP+ + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-2207
|
|
|
|
MoO3-molybdopterin_cofactor + L-cysteine + reduced_acceptor <=> Mo(O)2(S)-molybdopterin_cofactor + L-alanine + H2O + acceptor
|
2.8.1.9
molybdenum cofactor sulfurtransferase
|
–
|
M
|
|
MetaCyc:
RXN-8351
|
|
|
|
L-cysteine + [ThiI_sulfur-carrier_protein]-L-cysteine <=> L-alanine + [ThiI_sulfur-carrier_protein]-S-sulfanyl-L-cysteine
|
2.8.1.7
cysteine desulfurase
|
–
|
|
|
MetaCyc:
RXN-9787
|
|
|
|
L-cysteine <=> L-cysteine
|
not assigned
|
–
|
|
|
MetaCyc:
RXN0-1924
|
|
|
|
L-cysteine + [L-cysteine_desulfurase]-L-cysteine <=> L-alanine + [L-cysteine_desulfurase]-S-sulfanyl-L-cysteine
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN0-308
|
|
|
|
Indole-3-aldehyde + L-cysteine <=> S-indole-L-cysteine
|
not assigned
|
–
|
|
|
MetaCyc:
RXN1F-13
|
|
|
|
ATP + (S)-malyl_alpha-D-glucosaminide + L-cysteine <=> ADP + phosphate + bacillithiol + H+
|
6.3.1.M5
|
–
|
M
|
|
MetaCyc:
RXN8J2-3
|
|
|
|
H+ + (E)-5-(methylsulfanyl)pentanal_oxime + NADPH + O2 + L-cysteine <=> (E)-1-(L-cystein-S-yl)-N-hydroxy-omega-(methylsulfanyl)pentan-1-imine + NADP+ + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXNQT-4314
|
|
|
|
H+ + 6-Methylthiohexanaldoxime + NADPH + O2 + L-cysteine <=> (E)-1-(L-cystein-S-yl)-N-hydroxy-omega-(methylsulfanyl)hexan-1-imine + NADP+ + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXNQT-4315
|
|
|
|
H+ + 4-methylthioheptanaldoxime + NADPH + O2 + L-cysteine <=> (E)-1-(L-cystein-S-yl)-N-hydroxy-omega-(methylsulfanyl)heptan-1-imine + NADP+ + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXNQT-4316
|
|
|
|
H+ + 4-methylthiooctanaldoxime + NADPH + O2 + L-cysteine <=> (E)-1-(L-cystein-S-yl)-N-hydroxy-omega-(methylsulfanyl)octan-1-imine + NADP+ + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXNQT-4317
|
|
|
|
H+ + 4-methylthiononanaldoxime + NADPH + O2 + L-cysteine <=> (E)-1-(L-cystein-S-yl)-N-hydroxy-omega-(methylsulfanyl)nonan-1-imine + NADP+ + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXNQT-4318
|
|
|
|
indole-3-methanol + L-cysteine <=> indol-3-ylmethyl-L-cysteine + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXNQT-4357
|
|
|
|
2-fluorohistidine + L-cysteine + O2 <=> S-(2-fluoro-L-histidin-5-yl)-L-cysteine_S-oxide + H2O
|
1.14.99.52
L-cysteinyl-L-histidinylsulfoxide synthase
|
–
|
|
|
BRENDA:
BS433195
|
|
|
|
D-histidine + L-cysteine + O2 <=> S-(D-histidin-5-yl)-L-cysteine_S-oxide + S-(D-histidin-2-yl)-L-cysteine_S-oxide + H2O
|
1.14.99.52
L-cysteinyl-L-histidinylsulfoxide synthase
|
–
|
|
|
BRENDA:
BS433609
|
|
|
|
histamine + L-cysteine + O2 <=> S-(histamin-5-yl)-L-cysteine_S-oxide + H2O
|
1.14.99.52
L-cysteinyl-L-histidinylsulfoxide synthase
|
–
|
|
|
BRENDA:
BS433814
|
|
|
|
L-histidinamide + L-cysteine + O2 <=> S-(L-histidinamide-5-yl)-L-cysteine_S-oxide + H2O
|
1.14.99.52
L-cysteinyl-L-histidinylsulfoxide synthase
|
–
|
|
|
BRENDA:
BS433874
|
|
|
|
D-allocystathionine + H2O <=> L-cysteine + NH3 + 2-oxobutyrate
|
4.4.1.1
cystathionine gamma-lyase
|
–
|
|
|
BRENDA:
BS368478
|
|
|
|
DL-cystathionine + H2O <=> L-cysteine + NH3 + 2-oxobutyrate
|
4.4.1.1
cystathionine gamma-lyase
|
–
|
|
|
BRENDA:
BS368531
|
|
|
|
p-hydroxyphenylacetaldoxime + reduced_flavodoxin + L-cysteine + O2 <=> S-(benzohydroximoyl)-L-cysteine + flavin + 2 H2O
|
1.14.14.45
aromatic aldoxime N-monooxygenase
|
–
|
|
|
BRENDA:
BS439806
|
|
|
|
geranylgeranylcysteine + O2 + H2O <=> geranylgeranal + L-cysteine + H2O2
|
1.8.3.5
prenylcysteine oxidase
|
–
|
|
|
BRENDA:
BS287638
|
|
|
|
L-cysteine + O2 <=> L-cystine + H2O2
|
1.8.3.2
thiol oxidase
1.8.3.3
glutathione oxidase
|
–
–
|
|
|
BRENDA:
BS376588
|
|
|
|
N-carbamoyl-L-cysteine + H2O <=> L-cysteine + CO2 + NH3
|
3.5.1.87
N-carbamoyl-L-amino-acid hydrolase
|
–
|
|
|
BRENDA:
BS386589
|
|
|
|
L-cysteine + 2-oxoglutarate <=> pyruvate + L-glutamate
|
2.6.1.1
aspartate transaminase
|
–
|
|
|
BRENDA:
BS356303
|
|
|
|
S-adenosyl-L-methionine + L-cysteine <=> S-adenosyl-L-homocysteine + S-methyl-L-cysteine
|
2.1.1.10
homocysteine S-methyltransferase
2.1.1.280
selenocysteine Se-methyltransferase
|
–
–
|
|
|
BRENDA:
BS389722
|
|
|
|
GTP + L-glutamate + L-cysteine <=> GDP + phosphate + gamma-Glu-L-Cys
|
6.3.2.2
glutamate---cysteine ligase
|
–
|
|
|
BRENDA:
BS505
|
|
|
|
UTP + L-glutamate + L-cysteine <=> UDP + phosphate + gamma-Glu-L-Cys
|
6.3.2.2
glutamate---cysteine ligase
|
–
|
|
|
BRENDA:
BS506
|
|
|
|
L-cysteine + 2-oxoglutarate <=> 2-oxo-3-thiobutyrate + L-glutamate
|
2.6.1.42
branched-chain-amino-acid transaminase
|
–
|
|
|
BRENDA:
BS356594
|
|
|
|
L-cysteine + pyruvate + NADH <=> N2-(D-1-Carboxyethyl)-L-Cys + NAD+
|
1.5.1.28
opine dehydrogenase
|
–
|
|
|
BRENDA:
BS73121
|
|
|
|
L-cysteine + H2O + NAD+ <=> 3-Mercaptopyruvate + NH3 + NADH
|
1.4.1.5
L-amino-acid dehydrogenase
1.4.1.8
valine dehydrogenase (NADP+)
|
–
–
|
|
|
BRENDA:
BS258953
|
|
|
|
L-cysteine + pyruvate + NADH + H+ <=> N-(1-carboxyethyl)-L-Cys + NAD+ + H2O
|
1.5.1.22
strombine dehydrogenase
|
–
|
|
|
BRENDA:
BS397566
|
|
|
|
L-cysteine + dithiothreitol <=> Beta-cyanoalanine + Sulfide
|
2.5.1.47
cysteine synthase
|
–
|
|
|
BRENDA:
BS423732
|
|
|
|
L-cysteine + dithiothreitol <=> S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + Sulfide
|
2.5.1.47
cysteine synthase
2.5.1.65
O-phosphoserine sulfhydrylase
|
–
–
|
|
|
BRENDA:
BS354314
|
|
|
|
CTP + (R)-4''-phosphopantothenate + L-cysteine <=> (R)-4''-phosphopantothenoyl-L-cysteine + CDP + phosphate
|
6.3.2.5
phosphopantothenate---cysteine ligase (CTP)
|
–
|
|
|
BRENDA:
BS363663
|
|
|
|
L-cysteine + pyruvate + NADPH <=> N2-(D-1-Carboxyethyl)-L-Cys + NADP+ + H2O
|
1.5.1.11
D-octopine dehydrogenase
|
–
|
|
|
BRENDA:
BS6368
|
|
|
|
4beta-(S-cysteinyl)-epicatechin + NADPH + H+ <=> epicatechin + L-cysteine + NADP+
|
1.17.1.3
leucoanthocyanidin reductase
|
–
|
|
|
BRENDA:
BS442214
|
|
|
|
L-cysteine + NADPH <=> L-cystine + NADP+
|
1.8.1.9
thioredoxin-disulfide reductase
|
–
|
|
|
BRENDA:
BS260491
|
|
|
|
glycyl-L-cysteine + H2O <=> glycine + L-cysteine
|
3.4.11.19
D-stereospecific aminopeptidase
|
–
|
|
|
BRENDA:
BS431911
|
|
|
|
N-carbobenzoxy-L-cysteine + H2O <=> benzyl_alcohol + CO2 + L-cysteine
|
3.5.1.64
Nalpha-benzyloxycarbonylleucine hydrolase
|
–
|
|
|
BRENDA:
BS116367
|
|
|
|
L-Cys-7-amido-4-methylcoumarin + H2O <=> L-cysteine + 7-amino-4-methylcoumarin
|
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.6
aminopeptidase B
|
–
–
–
|
|
|
BRENDA:
BS364754
|
|
|
|
3''-phosphoadenylylsulfate + L-cysteine <=> adenosine_3'',5''-bisphosphate + 2-amino-3-sulfosulfanyl-propionic_acid
|
2.8.2.16
thiol sulfotransferase
|
–
|
|
|
BRENDA:
BS360238
|
|
|
|
L-cysteine + adenosine <=> S-adenosyl-L-homocysteine
|
3.3.1.1
adenosylhomocysteinase
|
–
|
|
|
BRENDA:
BS94878
|
|
|
|
L-cysteine + KCN <=> Beta-cyanoalanine + K2S
|
4.4.1.9
L-3-cyanoalanine synthase
|
–
|
|
|
BRENDA:
BS453561
|
|
|
|
D-glutamine + L-cysteine <=> D-Glu-L-Cys + NH3
|
2.3.2.2
gamma-glutamyltransferase
|
–
|
|
|
BRENDA:
BS376617
|
|
|
|
2-oxosuccinamic_acid + L-cysteine <=> L-asparagine + 3-Mercaptopyruvate
|
2.6.1.14
asparagine---oxo-acid transaminase
|
–
|
|
|
BRENDA:
BS354196
|
|
|
|
ubiquitin-Cys + H2O <=> ubiquitin + L-cysteine
|
3.4.19.12
ubiquitinyl hydrolase 1
|
–
|
|
|
BRENDA:
BS36818
|
|
|
|
L-cysteine + L-homocystine <=> L-cystine + 2 L-homocysteine
|
1.8.4.1
glutathione---homocystine transhydrogenase
|
–
|
|
|
BRENDA:
BS441243
|
|
|
|
psychosine_sulfate + L-cysteine <=> L-cystathionine + malonate
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
BRENDA:
BS354369
|
|
|
|
O-acetyl-L-serine + Thiophenol <=> L-cysteine + Benzyl_acetate
|
2.5.1.47
cysteine synthase
|
–
|
|
|
BRENDA:
BS389414
|
|
|
|
L-cysteine + L-homocysteine <=> L-cystathionine + acetate
|
2.5.1.47
cysteine synthase
4.2.1.22
cystathionine beta-synthase
|
–
–
|
|
|
BRENDA:
BS445596
|
|
|
|
Sulfide + L-cysteine + ubiquinone <=> thiocysteine + ubiquinol
|
1.8.5.4
bacterial sulfide:quinone reductase
|
–
|
|
|
BRENDA:
BS437920
|
|
|
|
cysteine-glutathione + glutathione <=> L-cysteine + GSSG
|
1.8.4.3
glutathione---CoA-glutathione transhydrogenase
|
–
|
|
|
BRENDA:
BS260598
|
|
|
|
L-kynurenine + 3-Mercaptopyruvate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine
|
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
|
|
|
BRENDA:
BS377047
|
|
|
|
L-cysteine + D-homoserine <=> L-cystathionine
|
4.4.1.1
cystathionine gamma-lyase
|
–
|
|
|
BRENDA:
BS19009
|
|
|
|
O-Succinyl-L-serine + L-cysteine <=> Lanthionine + succinate
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
BRENDA:
BS354332
|
|
|
|
L-cystathionine + L-cysteine <=> L-cystathionine + L-cysteine
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
BRENDA:
BS354335
|
|
|
|
L-cysteine + H2O + 2 cytochrome_b <=> 3-Mercaptopyruvate + NH3 + 2 reduced_cytochrome_b
|
1.4.99.B3
|
–
|
|
|
BRENDA:
BS439652
|
|
|
|
L-cysteinyl_7-amido-4-carbamoylmethylcoumarin + H2O <=> L-cysteine + 7-amino-4-carbamoylmethylcoumarin
|
3.4.11.10
bacterial leucyl aminopeptidase
|
–
|
|
|
BRENDA:
BS450150
|
|
|
|
thiamine + L-cysteine <=> 4-methyl-5-(2-hydroxyethyl)-thiazole + 2-[[(4-amino-2-ethylpyrimidin-5-yl)methyl]amino]-3-mercaptopropanoic_acid
|
2.5.1.2
thiamine pyridinylase
|
–
|
|
|
BRENDA:
BS353832
|
|
|
|
L-cysteine + 1-mercapto-2-propanol <=> HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + Sulfide
|
4.2.1.22
cystathionine beta-synthase
|
–
|
|
|
BRENDA:
BS1939
|
|
|
|
O-phenyl-L-homoserine + L-cysteine <=> L-cystathionine + phenol
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
BRENDA:
BS354370
|
|
|
|
L-cysteine + DL-homocysteine <=> L-cystathionine + Sulfide
|
4.2.1.22
cystathionine beta-synthase
|
–
|
|
|
BRENDA:
BS1935
|
|
|
|
L-cysteine + NaCN <=> Beta-cyanoalanine + Na2S
|
4.4.1.9
L-3-cyanoalanine synthase
|
–
|
|
|
BRENDA:
BS392359
|
|
|
|
N-lauroyl-L-Cys + H2O <=> laurate + L-cysteine
|
3.5.1.14
N-acyl-aliphatic-L-amino acid amidohydrolase
|
–
|
|
|
BRENDA:
BS414965
|
|
|
|
[CysO_sulfur-carrier_protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O <=> [CysO_sulfur-carrier_protein]-Gly-NH-CH2-COOH + L-cysteine
|
3.13.1.6
[CysO sulfur-carrier protein]-S-L-cysteine hydrolase
|
–
|
|
|
BRENDA:
BR52191
|
|
|
|
L-Cystinyl-bis-glycine + H2O <=> L-cysteine + Gly-Gly
|
3.4.13.19
membrane dipeptidase
|
–
|
|
|
BRENDA:
BS452900
|
|
|
|
L-cysteine_methyl_ester + H2O <=> L-cysteine + methanol
|
3.1.1.43
alpha-amino-acid esterase
|
–
|
|
|
BRENDA:
BS64508
|
|
|
|
Ile-tRNAIle + L-cysteine <=> tRNAMet + isoleucylcysteine
|
6.1.1.5
isoleucine---tRNA ligase
|
–
|
|
|
BRENDA:
BS126
|
|
|
|
thiocysteine + O2 <=> L-cysteine + sulfite
|
1.13.11.18
persulfide dioxygenase
|
–
|
|
|
BRENDA:
BS441974
|
|
|
|
L-cysteine + L-serine <=> Lanthionine + H2O
|
4.2.1.22
cystathionine beta-synthase
|
–
|
|
|
BRENDA:
BS445597
|
|
|
|
L-cystinyl-p-nitroanilide + H2O <=> L-cysteine + 4-nitroaniline
|
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.3
cystinyl aminopeptidase
|
–
–
|
|
|
BRENDA:
BS364818
|
|
|
|
glyoxylate + L-cysteine <=> glycine + 3-Mercaptopyruvate
|
2.6.1.15
glutamine---pyruvate transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
|
–
–
|
|
|
BRENDA:
BS356340
|
|
|
|
L-cysteine + H2O <=> Thiophenol + pyruvate + NH3
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS445594
|
|
|
|
L-cysteine <=> Sulfide
|
4.4.1.1
cystathionine gamma-lyase
|
–
|
|
|
BRENDA:
BS381705
|
|
|
|