|
|
Atrazine + H2O <=> H+ + 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + Cl-
|
3.8.1.8
atrazine chlorohydrolase
|
–
|
BMK
|
|
BRENDA:
BR26144
KEGG:
R05558
MetaCyc:
3.8.1.8-RXN
|
|
|
|
O2 + Cl- <=> Chlorite
|
1.13.11.49
chlorite O2-lyase
|
–
|
BM
|
|
BRENDA:
BR29131
KEGG:
R05721
MetaCyc:
1.13.11.49-RXN
SABIO-RK:
5315
|
|
|
|
4-chlorobenzoyl-CoA + Cl- + NADP+ <=> 2,4-dichlorobenzoyl-CoA + NADPH
|
1.21.1.2
2,4-dichlorobenzoyl-CoA reductase
|
–
|
K
|
|
BRENDA:
BR29442
KEGG:
R05276
MetaCyc:
1.3.1.63-RXN
|
|
|
|
4-Chlorobenzoate + H2O <=> Cl- + 4-hydroxybenzoate + H+
|
3.8.1.6
4-chlorobenzoate dehalogenase
|
–
|
|
|
BRENDA:
BR29553
KEGG:
R01307
MetaCyc:
4-CHLOROBENZOATE-DEHALOGENASE-RXN
|
|
|
|
H2O + 4-chlorobenzoyl-CoA <=> H+ + Cl- + 4-hydroxybenzoyl-CoA
|
3.8.1.7
4-chlorobenzoyl-CoA dehalogenase
|
–
|
MK
|
|
BRENDA:
BR3357
KEGG:
R04101
MetaCyc:
3.8.1.7-RXN
SABIO-RK:
3828
|
|
|
|
acceptor + Cl- + Trichloroethylene + H+ <=> reduced_acceptor + tetrachloroethene
|
1.21.99.5
tetrachloroethene reductive dehalogenase
|
–
|
M
|
|
BRENDA:
BR33799
KEGG:
R05753
MetaCyc:
1.97.1.8-RXN
|
|
|
|
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> H+ + 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + Cl-
|
4.5.1.1
DDT-dehydrochlorinase
|
–
|
K
|
|
BRENDA:
BR3448
KEGG:
R04522
MetaCyc:
DDT-DEHYDROCHLORINASE-RXN
|
|
|
|
3-chloro-D-alanine + H2O <=> pyruvate + NH3 + Cl- + H+
|
2.6.1.21
D-amino-acid transaminase
4.3.1.18
D-serine ammonia-lyase
4.4.1.15
D-cysteine desulfhydrase
4.5.1.2
3-chloro-D-alanine dehydrochlorinase
|
–
–
–
–
|
|
|
BRENDA:
BR3449
KEGG:
R01031
MetaCyc:
3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN
SABIO-RK:
1319
|
|
|
|
Pentachlorophenol + O2 + NADPH + H+ <=> tetrafluoro-1,4-benzoquinone + Cl- + NADP+ + H2O
|
1.14.13.50
pentachlorophenol monooxygenase
|
–
|
MK
|
|
BRENDA:
BR40415
KEGG:
R03982
MetaCyc:
PCP4MONO-RXN
|
|
|
|
4-chlorophenylacetate + NADH + O2 <=> 3,4-Dihydroxyphenylacetate + Cl- + NAD+
|
1.14.12.9
4-chlorophenylacetate 3,4-dioxygenase
|
–
|
K
|
|
BRENDA:
BR40438
KEGG:
R03306
MetaCyc:
1.14.12.9-RXN
|
|
|
|
2-Chlorobenzoate + O2 + NADH + H+ <=> catechol + Cl- + CO2 + NAD+
|
1.14.12.13
2-halobenzoate 1,2-dioxygenase
|
–
|
MK
|
|
BRENDA:
BR40444
KEGG:
R01033
MetaCyc:
2-CHLOROBENZOATE-12-DIOXYGENASE-RXN
|
|
|
|
Dichloromethane + H2O <=> formaldehyde + Cl- + H+
|
4.5.1.3
dichloromethane dehalogenase
|
–
|
K
|
|
BRENDA:
BR48363
KEGG:
R00603
MetaCyc:
DICHLOROMETHANE-DEHALOGENASE-RXN
|
|
|
|
H2O + L-2-amino-4-chloro-4-pentenoate <=> 2-oxopent-4-enoate + NH3 + Cl- + H+
|
4.5.1.4
L-2-amino-4-chloropent-4-enoate dehydrochlorinase
|
–
|
|
|
BRENDA:
BR48364
KEGG:
R02605
MetaCyc:
4.5.1.4-RXN
|
|
|
|
beta-chloro-L-alanine + thioglycolic_acid <=> H+ + S-carboxymethyl-L-cysteine + Cl-
|
4.5.1.5
S-carboxymethylcysteine synthase
|
–
|
|
|
BRENDA:
BR48365
KEGG:
R04003
MetaCyc:
S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN
|
|
|
|
L-tryptophan + FADH2 + Cl- + O2 <=> 7-chloro-L-tryptophan + FAD + H2O
|
1.14.19.9
tryptophan 7-halogenase
|
–
|
MK
|
|
BRENDA:
BR48866
KEGG:
R09570
MetaCyc:
RXN-10842
SABIO-RK:
14708
|
|
|
|
S-adenosyl-L-methionine + Cl- <=> 5''-chloro-5''-deoxyadenosine + L-methionine
|
2.5.1.63
adenosyl-fluoride synthase
2.5.1.94
adenosyl-chloride synthase
|
–
–
|
M
|
|
BRENDA:
BR49404
KEGG:
R09639
MetaCyc:
RXN-11714
|
|
|
|
Cl- + H2O2 + H+ <=> HOCl + H2O
|
1.11.1.7
peroxidase
1.11.1.B2
1.11.2.2
myeloperoxidase
|
–
–
–
|
|
|
BRENDA:
BR49413
KEGG:
R09564
MetaCyc:
RXN-11818
|
|
|
|
7-chloro-L-tryptophan + FADH2 + Cl- + O2 <=> 6,7-dichloro-L-tryptophan + FAD + H2O
|
1.14.19.60
7-chloro-L-tryptophan 6-halogenase
|
–
|
|
|
BRENDA:
BR51090
KEGG:
R12034
MetaCyc:
RXN-19122
|
|
|
|
L-tryptophan + O2 + Cl- + FADH2 <=> 6-chlorotryptophan + FAD + H2O
|
1.14.19.59
tryptophan 6-halogenase
1.14.19.60
7-chloro-L-tryptophan 6-halogenase
|
–
–
|
|
|
BRENDA:
BR51091
KEGG:
R12032
MetaCyc:
RXN-19121
|
|
|
|
D-tryptophan + O2 + Cl- + FADH2 <=> 6-chloro-D-tryptophan + FAD + H2O
|
1.14.19.59
tryptophan 6-halogenase
|
–
|
|
|
BRENDA:
BR51092
KEGG:
R12033
MetaCyc:
RXN-19634
|
|
|
|
L-tryptophan + O2 + Cl- + FADH2 <=> 5-chloro-L-tryptophan + FAD + H2O
|
1.14.19.58
tryptophan 5-halogenase
|
–
|
|
|
BRENDA:
BR51093
KEGG:
R12031
MetaCyc:
RXN-11104
|
|
|
|
tetracycline + O2 + Cl- + FADH2 <=> 7-chlorotetracycline + H2O + FAD + H+
|
1.14.19.49
tetracycline 7-halogenase
|
–
|
MK
|
|
BRENDA:
BR51837
KEGG:
R11478
MetaCyc:
RXN-17996
|
|
|
|
hapalindole_U + 2-oxoglutarate + O2 + Cl- + H+ <=> hapalindole_G + succinate + CO2 + H2O
|
1.14.20.14
hapalindole-type alkaloid chlorinase
|
–
|
|
|
BRENDA:
BR52471
KEGG:
R12165
MetaCyc:
RXN-19285
|
|
|
|
12-epi-fischerindole_U + 2-oxoglutarate + O2 + Cl- + H+ <=> 12-epi-fischerindole_G + succinate + CO2 + H2O
|
1.14.20.14
hapalindole-type alkaloid chlorinase
|
–
|
M
|
|
BRENDA:
BR52472
KEGG:
R12166
MetaCyc:
RXN-19283
|
|
|
|
an_L-threonyl-[L-threonyl-carrier_protein] + 2-oxoglutarate + O2 + Cl- + H+ <=> a_4-chloro-L-threonyl-[L-threonyl-carrier_protein] + succinate + CO2 + H2O
|
1.14.20.15
L-threonyl-[L-threonyl-carrier protein] 4-chlorinase
|
–
|
|
|
BRENDA:
BR52473
KEGG:
R12176
MetaCyc:
RXN-19538
|
|
|
|
2,6-dichlorohydroquinone + Cl- + GSSG + H+ <=> 2,3,5-trichlorohydroquinone + glutathione
|
1.21.4.5
tetrachlorohydroquinone reductive dehalogenase
|
–
|
K
|
|
BRENDA:
BR52571
KEGG:
R05403
MetaCyc:
TECH2REDHAL-RXN
|
|
|
|
2,3,5-trichlorohydroquinone + Cl- + GSSG <=> tetrachlorohydroquinone + glutathione
|
1.21.4.5
tetrachlorohydroquinone reductive dehalogenase
|
–
|
K
|
|
BRENDA:
BR52572
KEGG:
R05402
MetaCyc:
TECH1REDHAL-RXN
|
|
|
|
3,5,6-trichloro-pyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + FAD + Cl- + H2O + H+
|
1.14.14.172
3,5,6-trichloropyridin-2-ol monooxygenase
|
–
|
M
|
|
BRENDA:
BR53067
KEGG:
R12617
MetaCyc:
RXN-20730
|
|
|
|
3,6-dichloropyridine-2,5-diol + FADH2 + O2 <=> 6-chloro-3-hydroxypyridine-2,5-dione + FAD + Cl- + H2O + H+
|
1.14.14.172
3,5,6-trichloropyridin-2-ol monooxygenase
|
–
|
M
|
|
BRENDA:
BR53068
KEGG:
R12618
MetaCyc:
RXN-20727
|
|
|
|
6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + FAD + Cl- + H2O + H+
|
1.14.14.172
3,5,6-trichloropyridin-2-ol monooxygenase
|
–
|
M
|
|
BRENDA:
BR53069
KEGG:
R12619
MetaCyc:
RXN-20729
|
|
|
|
2,4,6-Trichlorophenol + O2 + FADH2 <=> 2,6-dichloroquinone + Cl- + H2O + FAD + H+
|
1.14.14.173
2,4,6-trichlorophenol monooxygenase
|
–
|
MK
|
|
BRENDA:
BR53070
KEGG:
R05449
MetaCyc:
RXN-20721
|
|
|
|
2,6-dichlorohydroquinone + O2 + FADH2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + H2O + Cl- + FAD + H+
|
1.14.14.173
2,4,6-trichlorophenol monooxygenase
|
–
|
M
|
|
BRENDA:
BR53071
KEGG:
R12627
MetaCyc:
RXN-20723
|
|
|
|
(+)-5-chloromuconolactone <=> H+ + trans-4-Carboxymethylenebut-2-en-4-olide + Cl-
|
5.5.1.7
chloromuconate cycloisomerase
|
–
|
BM
|
|
BRENDA:
BS1280
MetaCyc:
RXN-9894
|
|
|
|
Chloroacetate + H2O <=> H+ + glycolate + Cl-
|
3.8.1.10
2-haloacid dehalogenase (configuration-inverting)
3.8.1.2
(S)-2-haloacid dehalogenase
3.8.1.3
haloacetate dehalogenase
3.8.1.5
haloalkane dehalogenase
3.8.1.9
(R)-2-haloacid dehalogenase
|
–
–
–
–
–
|
MK
|
|
BRENDA:
BS141612
KEGG:
R05287
MetaCyc:
DHLBXANAU-RXN
|
|
|
|
1,2-Dichloroethane + H2O <=> 2-Chloroethanol + Cl- + H+
|
3.8.1.5
haloalkane dehalogenase
|
–
|
MK
|
|
BRENDA:
BS165579
KEGG:
R05284
MetaCyc:
DHLAXANAU-RXN
|
|
|
|
desethylatrazine + H2O <=> H+ + 2-amino-4-hydroxy-6-(N-isopropylamino)-1,3,5-triazine + Cl-
|
3.8.1.8
atrazine chlorohydrolase
|
–
|
|
|
BRENDA:
BS165615
MetaCyc:
R463-RXN
|
|
|
|
cis-1,2-dichloroethene + Cl- + acceptor + H+ <=> Trichloroethylene + reduced_acceptor
|
1.21.99.5
tetrachloroethene reductive dehalogenase
1.21.99.M1
|
–
–
|
M
|
|
BRENDA:
BS232389
MetaCyc:
TCEREDCHLOR-RXN
|
|
|
|
1-chloro-2,4-dinitrobenzene + glutathione <=> H+ + S-(2,4-dinitrophenyl)glutathione + Cl-
|
2.5.1.18
glutathione transferase
|
–
|
|
|
BRENDA:
BS354742
MetaCyc:
GST-RXN
SABIO-RK:
6622
|
|
|
|
L-2-chloropropionate + H2O <=> D-lactate + Cl- + H+
|
3.8.1.10
2-haloacid dehalogenase (configuration-inverting)
3.8.1.2
(S)-2-haloacid dehalogenase
|
–
–
|
M
|
|
BRENDA:
BS363226
MetaCyc:
RXN-15138
|
|
|
|
Cl- + H2O + ATP <=> Cl- + phosphate + ADP + H+
|
3.6.3.11
Cl--transporting ATPase
5.6.1.6
channel-conductance-controlling ATPase
7.3.2.a
|
–
–
–
|
|
|
BRENDA:
BS383075
MetaCyc:
3.6.3.11-RXN;
3.6.3.49-RXN
|
|
|
|
beta-hexachlorocyclohexane + H2O <=> pentachlorocyclohexanol + Cl- + H+
|
3.8.1.5
haloalkane dehalogenase
|
–
|
|
|
BRENDA:
BS384330
MetaCyc:
RXN-19740
|
|
|
|
S-adenosyl-L-methionine + Cl- <=> S-adenosyl-L-homocysteine + Chloromethane
|
2.1.1.165
methyl halide transferase
2.1.1.9
thiol S-methyltransferase
|
–
–
|
M
|
|
BRENDA:
BS390309
MetaCyc:
RXN-11267
|
|
|
|
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate + H2O <=> H+ + maleylacetate + Cl-
|
3.1.1.45
carboxymethylenebutenolidase
|
–
|
M
|
|
BRENDA:
BS398680
MetaCyc:
RXN-9913
|
|
|
|
hexachlorocyclohexane <=> gamma-pentachlorocyclohexene + Cl- + H+
|
4.5.1
4.5.1.B1
|
–
–
|
MK
|
|
BRENDA:
BS417024
KEGG:
R05386
MetaCyc:
LINA1-RXN
|
|
|
|
2,6-dichlorohydroquinone + O2 + H2O <=> H+ + 2-chloromaleylacetate + Cl-
|
1.13.11
1.13.11.66
hydroquinone 1,2-dioxygenase
|
–
–
|
MK
|
|
BRENDA:
BS419842
KEGG:
R05408
MetaCyc:
26DICHDIOX-RXN
|
|
|
|
glutathione + monochlorobimane <=> GS-bimane + Cl- + H+
|
2.5.1.18
glutathione transferase
|
–
|
|
|
BRENDA:
BS423867
MetaCyc:
RXN-19573
|
|
|
|
ethylene + Cl- + acceptor + H+ <=> vinyl_chloride + reduced_acceptor
|
1.21.99.5
tetrachloroethene reductive dehalogenase
1.21.99.M2
|
–
–
|
M
|
|
BRENDA:
BS442352
MetaCyc:
VCREDCHLOR-RXN
|
|
|
|
vinyl_chloride + Cl- + acceptor + H+ <=> cis-1,2-dichloroethene + reduced_acceptor
|
1.21.99.5
tetrachloroethene reductive dehalogenase
1.21.99.M1
|
–
–
|
M
|
|
BRENDA:
BS442357
MetaCyc:
DCEREDCHLOR-RXN
|
|
|
|
chloroform + reduced_acceptor <=> Dichloromethane + Cl- + acceptor + H+
|
1.21.99.5
tetrachloroethene reductive dehalogenase
|
–
|
M
|
|
BRENDA:
BS443286
MetaCyc:
R526-RXN
|
|
|
|
12-epi-hapalindole_C + 2-oxoglutarate + O2 + Cl- + H+ <=> 12-epi-hapalindole_E + succinate + CO2 + H2O
|
1.14.20.14
hapalindole-type alkaloid chlorinase
|
–
|
|
|
BRENDA:
BS444130
MetaCyc:
RXN-19284
|
|
|
|
ambiguine_C + 2-oxoglutarate + O2 + Cl- + H+ <=> ambiguine_B + succinate + CO2 + H2O
|
1.14.20.14
hapalindole-type alkaloid chlorinase
|
–
|
|
|
BRENDA:
BS444905
MetaCyc:
RXN-19287
|
|
|
|
ambiguine_H + 2-oxoglutarate + O2 + Cl- + H+ <=> ambiguine_A + succinate + CO2 + H2O
|
1.14.20.14
hapalindole-type alkaloid chlorinase
|
–
|
|
|
BRENDA:
BS444906
MetaCyc:
RXN-19286
|
|
|
|
ambiguine_I + 2-oxoglutarate + O2 + Cl- + H+ <=> ambiguine_E + succinate + CO2 + H2O
|
1.14.20.14
hapalindole-type alkaloid chlorinase
|
–
|
|
|
BRENDA:
BS444907
MetaCyc:
RXN-19289
|
|
|
|
ambiguine_L + 2-oxoglutarate + O2 + Cl- + H+ <=> ambiguine_K + succinate + CO2 + H2O
|
1.14.20.14
hapalindole-type alkaloid chlorinase
|
–
|
|
|
BRENDA:
BS444908
MetaCyc:
RXN-19288
|
|
|
|
glutathione + Dichloroacetate <=> 2-(glutathion-S-yl)-chloroacetate + Cl- + H+
|
2.5.1.18
glutathione transferase
|
–
|
|
|
BRENDA:
BS445444
MetaCyc:
RXN-19611
|
|
|
|
A + Cl- + H2O2 <=> RCl + 2 H2O
|
1.11.1.10
chloride peroxidase
1.11.1.B2
|
–
–
|
|
|
BRENDA:
BR33711
KEGG:
R00052
|
|
|
|
beta-chloro-L-alanine + H2O <=> pyruvate + Cl- + NH3
|
2.6.1.9
histidinol-phosphate transaminase
4.1.1.12
aspartate 4-decarboxylase
4.1.99.1
tryptophanase
4.1.99.2
tyrosine phenol-lyase
4.2.1.20
tryptophan synthase
4.4.1.1
cystathionine gamma-lyase
4.4.1.13
cysteine-S-conjugate beta-lyase
4.4.1.16
selenocysteine lyase
|
–
–
–
–
–
–
–
–
|
|
|
BRENDA:
BS1311
KEGG:
R01032
SABIO-RK:
1320
|
|
|
|
1,1-dichloro-2,2-bis(4-chlorophenyl)ethane <=> 1-chloro-2,2-bis(4-chlorophenyl)ethylene + Cl-
|
4.5.1
4.5.1.1
DDT-dehydrochlorinase
|
–
–
|
|
|
BRENDA:
BS19162
KEGG:
R05384
|
|
|
|
2-chloromaleylacetate + NADH <=> maleylacetate + Cl- + NAD+
|
1.3.1.32
maleylacetate reductase
|
–
|
K
|
|
BRENDA:
BS258484
KEGG:
R05355
|
|
|
|
2,5-dichloromaleylacetate + NADH <=> 2-chloro-3-oxohexanedioic_acid + NAD+ + Cl-
|
1.3.1.32
maleylacetate reductase
|
–
|
K
|
|
BRENDA:
BS258489
KEGG:
R06848
|
|
|
|
2,3,5-trichloromaleylacetate + NADH <=> 2,4-dichloro-3-oxohexanedioic_acid + NAD+ + Cl-
|
1.3.1.32
maleylacetate reductase
|
–
|
K
|
|
BRENDA:
BS258490
KEGG:
R09137
|
|
|
|
CH2BrCl + H2O <=> formaldehyde + Br- + Cl-
|
3.8.1.5
haloalkane dehalogenase
4.5.1.3
dichloromethane dehalogenase
|
–
–
|
|
|
BRENDA:
BS363526
KEGG:
R03523
|
|
|
|
2-amino-4-chloro-6-hydroxy-1,3,5-triazine + H2O <=> ammelide + Cl-
|
3.5.4.43
hydroxydechloroatrazine ethylaminohydrolase
3.8.1.8
atrazine chlorohydrolase
|
–
–
|
K
|
|
BRENDA:
BS383748
KEGG:
R06966
|
|
|
|
1,3,4,6-tetrachloro-1,4-cyclohexadiene + H2O <=> 2,4,5-trichloro-2,5-cyclohexadiene-1-ol + Cl-
|
3.8.1.5
haloalkane dehalogenase
|
–
|
K
|
|
BRENDA:
BS394607
KEGG:
R05369
|
|
|
|
cis-3-chloroacrylate <=> malonate_semialdehyde + Cl-
|
3.8.1
5.3.2.1
phenylpyruvate tautomerase
|
–
–
|
K
|
|
BRENDA:
BS416784
KEGG:
R05372
SABIO-RK:
4978
|
|
|
|
gamma-pentachlorocyclohexene <=> H+ + 1,3,4,6-tetrachloro-1,4-cyclohexadiene + Cl-
|
4.5.1
4.5.1.B1
|
–
–
|
MK
|
|
BRENDA:
BS417025
KEGG:
R05387
MetaCyc:
LINA2-RXN
|
|
|
|
trans-3-chloroacrylate <=> malonate_semialdehyde + Cl-
|
3.8.1
5.3.2.1
phenylpyruvate tautomerase
|
–
–
|
K
|
|
BRENDA:
BS417711
KEGG:
R05371
SABIO-RK:
4977
|
|
|
|
2,6-dichlorohydroquinone + H2O <=> 6-chlorohydroxyquinol + Cl-
|
not assigned
|
–
|
K
|
|
KEGG:
R05445
MetaCyc:
DICHCYCLO-RXN
|
|
|
|
1,3,4,6-tetrachloro-1,4-cyclohexadiene <=> H+ + Cl- + 1,2,4-trichlorobenzene
|
not assigned
|
–
|
MK
|
|
KEGG:
R05483
MetaCyc:
LINABSPON-RXN
|
|
|
|
2,5-dichloro-p-quinol + glutathione <=> H+ + chlorohydroquinone + GSSG + Cl-
|
2.5.1
|
–
|
MK
|
|
KEGG:
R05269
MetaCyc:
LIND-RXN
|
|
|
|
deisopropylatrazine + H2O <=> H+ + 2-amino-6-(N-ethylamino)-4-hydroxy-1,3,5-triazine + Cl-
|
3.8.1
|
–
|
MK
|
|
KEGG:
R05572
MetaCyc:
R465-RXN
|
|
|
|
3,5-Dichloro-2-methylmuconolactone <=> 3-chloro-2-methyl-dienelactone + Cl- + H+
|
4.5.1
5.5.1.7
chloromuconate cycloisomerase
|
–
–
|
MK
|
|
KEGG:
R09217
MetaCyc:
RXN-10101
|
|
|
|
2,4,5-Trichlorophenol + O2 + FADH2 <=> 2,5-dichlorohydroquinone + Cl- + H2O + FAD + H+
|
1.14.14
|
–
|
MK
|
|
KEGG:
R05447
MetaCyc:
RXN-10134
|
|
|
|
2,5-dichloro-p-quinol + O2 + FADH2 <=> 5-chloro-2-hydroxy-[1,4]-benzoquinone + Cl- + H2O + FAD + H+
|
1.14.14
|
–
|
MK
|
|
KEGG:
R05446
MetaCyc:
RXN-10135
|
|
|
|
5-chloro-1,2,4-trihydroxybenzene <=> 2-hydroxy-1,4-benzoquinone + Cl- + H+
|
4.5.1
|
–
|
MK
|
|
KEGG:
R05388
MetaCyc:
RXN-10136
|
|
|
|
4-(2-amino-3-chlorophenyl)pyrrole + Cl- + O2 + FADH2 <=> aminopyrrolnitrin + H2O + FAD
|
1.14.19
|
–
|
MK
|
|
KEGG:
R11106
MetaCyc:
RXN-11793
|
|
|
|
Cl- + hydroquinone + GSSG + H+ <=> chlorohydroquinone + glutathione
|
2.5.1
|
–
|
K
|
|
KEGG:
R05267
MetaCyc:
RXN-12506
|
|
|
|
2,4-Dichloro-2,5-dihydro-5-oxofuran-2-acetate <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + Cl- + H+
|
not assigned
|
–
|
M
|
|
KEGG:
R10097
MetaCyc:
RXN-16227
|
|
|
|
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> cis-4-carboxymethylenebut-2-en-4-olide + Cl- + H+
|
not assigned
|
–
|
MK
|
|
KEGG:
R04500
MetaCyc:
RXN-9893
|
|
|
|
1-Chloropropane + H2O <=> 1-propanol + Cl-
|
3.8.1.5
haloalkane dehalogenase
|
–
|
|
|
BRENDA:
BS165582
SABIO-RK:
7251
|
|
|
|
1-Chlorobutane + H2O <=> 1-butanol + Cl-
|
3.8.1.5
haloalkane dehalogenase
|
–
|
|
|
BRENDA:
BS165585
SABIO-RK:
9969
|
|
|
|
1-Chlorohexane + H2O <=> 1-Hexanol + Cl-
|
3.8.1.5
haloalkane dehalogenase
|
–
|
|
|
BRENDA:
BS165595
SABIO-RK:
6851
|
|
|
|
Pentachlorophenol + NADPH + O2 <=> tetrachlorohydroquinone + NADP+ + Cl-
|
1.14.13.50
pentachlorophenol monooxygenase
|
–
|
|
|
BRENDA:
BS288303
SABIO-RK:
3718
|
|
|
|
beta-chloro-L-alanine + Sulfide <=> L-cysteine + Cl-
|
2.5.1.47
cysteine synthase
4.4.1.9
L-3-cyanoalanine synthase
|
–
–
|
|
|
BRENDA:
BS354309
SABIO-RK:
10508
|
|
|
|
1,2,3-trichloropropane + H2O <=> 2,3-dichloropropan-1-ol + Cl-
|
3.8.1.5
haloalkane dehalogenase
|
–
|
|
|
BRENDA:
BS371433
SABIO-RK:
7245
|
|
|
|
1,3-Dichloropropane + H2O <=> 3-Chloro-1-propanol + Cl-
|
3.8.1.5
haloalkane dehalogenase
|
–
|
|
|
BRENDA:
BS371449
SABIO-RK:
7249
|
|
|
|
chlorocyclohexane + H2O <=> Cyclohexanol + Cl-
|
3.8.1.5
haloalkane dehalogenase
|
–
|
|
|
BRENDA:
BS372696
SABIO-RK:
6853
|
|
|
|
2-chloro-4-(N-ethylamino)-6-hydroxy-1,3,5-triazine + H2O <=> 6-(ethylamino)-1,3,5-triazine-2,4-diol + Cl-
|
3.5.4.43
hydroxydechloroatrazine ethylaminohydrolase
3.8.1.8
atrazine chlorohydrolase
|
–
–
|
|
|
BRENDA:
BS395491
SABIO-RK:
12490
|
|
|
|
2-chloro-4-hydroxy-6-(N-isopropylamino)-1,3,5-triazine + H2O <=> N-isopropylammelide + Cl-
|
3.5.4.43
hydroxydechloroatrazine ethylaminohydrolase
3.8.1.8
atrazine chlorohydrolase
|
–
–
|
|
|
BRENDA:
BS395494
SABIO-RK:
12489
|
|
|
|
1,2-dichloro-4-nitrobenzene + glutathione <=> S-(2-chloro-4-nitro-phenyl)glutathione + Cl-
|
2.5.1.18
glutathione transferase
|
–
|
|
|
BRENDA:
BS407697
SABIO-RK:
12846
|
|
|
|
1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + H+ <=> 1-Chloro-2,2-bis(4''-chlorophenyl)ethylene + Cl-
|
not assigned
|
–
|
|
|
KEGG:
R05268
|
|
|
|
4-de(dimethylamino)-4-oxoanhydrotetracycline + FADH2 + Cl- + O2 + H+ <=> 4-Ketoanhydrochlortetracycline + FAD + 2 H2O
|
1.14.14
|
–
|
|
|
KEGG:
R05456
|
|
|
|
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane + Cl-
|
not assigned
|
–
|
|
|
KEGG:
R05476
|
|
|
|
1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene <=> 1-Chloro-2,2-bis(4''-chlorophenyl)ethylene + Cl-
|
1.97.1
|
–
|
|
|
KEGG:
R05497
|
|
|
|
5-chloro-2-hydroxymuconic-6-semialdehyde + H+ <=> 2-hydroxymuconate-6-semialdehyde + Cl-
|
1.97.1
|
–
|
K
|
|
KEGG:
R05504
|
|
|
|
2,4-Dichlorophenoxyacetic_acid + H+ + 2 e- <=> 4-Chlorophenoxyacetate + Cl-
|
1.97.1
|
–
|
K
|
|
KEGG:
R05505
|
|
|
|
beta-hexachlorocyclohexane <=> delta-3,4,5,6-Tetrachlorocyclohexene + 2 Cl-
|
not assigned
|
–
|
K
|
|
KEGG:
R05533
|
|
|
|
delta-3,4,5,6-Tetrachlorocyclohexene <=> 5,6-Dichloro-1,3-cyclohexadiene + 2 Cl-
|
not assigned
|
–
|
K
|
|
KEGG:
R05534
|
|
|
|
5,6-Dichloro-1,3-cyclohexadiene <=> chlorobenzene + Cl- + H+
|
not assigned
|
–
|
K
|
|
KEGG:
R05535
|
|
|
|
5,6-Dichloro-1,3-cyclohexadiene <=> Benzene + 2 Cl-
|
not assigned
|
–
|
K
|
|
KEGG:
R05536
|
|
|
|
(S)-beta-Tyrosyl-[pcp] + FADH2 + Cl- + O2 + H+ <=> (S)-3-Chloro-beta-tyrosyl-[pcp] + FAD + 2 H2O
|
1.14.19
|
–
|
K
|
|
KEGG:
R11368
|
|
|
|
(R)-2-Aza-beta-tyrosyl-[pcp] + FADH2 + Cl- + O2 + H+ <=> (R)-2-Aza-3-chloro-beta-tyrosyl-[pcp] + FAD + 2 H2O
|
1.14.19
|
–
|
K
|
|
KEGG:
R11393
|
|
|
|
(1H-pyrrole-2-carbonyl)-[peptidyl-carrier_protein] + FADH2 + Cl- + O2 <=> 5-Chloro-1H-pyrrole-2-carbonyl-[peptidyl-carrier_protein] + FAD + 2 H2O
|
1.14.19.56
1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase
|
–
|
|
|
KEGG:
R12021
|
|
|
|
5-Chloro-1H-pyrrole-2-carbonyl-[peptidyl-carrier_protein] + FADH2 + Cl- + O2 <=> 4,5-Dichloro-1H-pyrrole-2-carbonyl-[peptidyl-carrier_protein] + FAD + 2 H2O
|
1.14.19.56
1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase
|
–
|
|
|
KEGG:
R12022
|
|
|
|
(1H-pyrrole-2-carbonyl)-[peptidyl-carrier_protein] + 2 FADH2 + 2 Cl- + 2 O2 <=> 4,5-Dichloro-1H-pyrrole-2-carbonyl-[peptidyl-carrier_protein] + 2 FAD + 4 H2O
|
1.14.19.56
1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase
|
–
|
|
|
KEGG:
R12023
|
|
|
|
L-lysine + 2-oxoglutarate + O2 + Cl- + H+ <=> 4-Chloro-L-lysine + succinate + CO2 + H2O
|
1.14.20
|
–
|
K
|
|
KEGG:
R12407
|
|
|
|
2-Amino-4-chloro-4-pentenoic_acid <=> DL-propargylglycine + Cl- + H+
|
4.5.1
|
–
|
K
|
|
KEGG:
R12409
|
|
|
|
3-chloro-D-alanine + thioglycolic_acid <=> H+ + S-carboxymethyl-D-cysteine + Cl-
|
4.5.1.2
3-chloro-D-alanine dehydrochlorinase
|
–
|
|
|
MetaCyc:
ALADEHYDCHLORO-RXN
|
|
|
|
organic_molecule + Cl- + H2O2 + H+ <=> Cl- + H2O
|
1.11.1.10
chloride peroxidase
|
–
|
|
|
MetaCyc:
CHLORIDE-PEROXIDASE-RXN
|
|
|
|
1,3,4,6-tetrachloro-1,4-cyclohexadiene + H2O <=> (1S,4R)-2,4,5-trichloro-2,5-cyclohexadiene-1-diol + Cl- + H+
|
3.8.1.5
haloalkane dehalogenase
|
–
|
M
|
|
MetaCyc:
LINB1-RXN
|
|
|
|
(1S,4R)-2,4,5-trichloro-2,5-cyclohexadiene-1-diol + H2O <=> (1S,4S)-2,5-dichloro-2,5-cyclohexadiene-1,4-diol + Cl- + H+
|
3.8.1.5
haloalkane dehalogenase
|
–
|
M
|
|
MetaCyc:
LINB2-RXN
|
|
|
|
(1S,4R)-2,4,5-trichloro-2,5-cyclohexadiene-1-diol <=> H+ + 2,5-dichlorophenol + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
LINBBSPON-RXN
|
|
|
|
carbon_tetrachloride + reduced_putidaredoxin + H+ + O2 <=> chloroform + Cl- + A + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
R525-RXN
|
|
|
|
Dichloromethane + reduced_acceptor <=> Chloromethane + Cl- + acceptor + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
R527-RXN
|
|
|
|
5-chlorocarbonyl-4-hydroxy-penta-2,4-dienate + H2O <=> H+ + maleylacetate + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10077
|
|
|
|
cis-4-carboxymethylenebut-2-en-4-olide + Cl- + H+ <=> (+)-5-chloromuconolactone
|
5.5.1
|
–
|
M
|
|
MetaCyc:
RXN-10087
|
|
|
|
H+ + trans-3-methyldienelactone + Cl- <=> (4R,5R/4S,5S)-(+/-)-5-chloro-3-methylmuconolactone
|
5.5.1
|
–
|
|
|
MetaCyc:
RXN-10088
|
|
|
|
3-chlorophenol + Cl- + acceptor <=> 2,5-dichlorophenol + reduced_acceptor
|
1.21.99.M3
|
–
|
|
|
MetaCyc:
RXN-10111
|
|
|
|
4-hydroxyphenylacetate + Cl- + acceptor + H+ <=> 3-chloro-4-hydroxyphenylacetate + reduced_acceptor
|
1.21.99.M3
|
–
|
|
|
MetaCyc:
RXN-10112
|
|
|
|
phenol + Cl- + acceptor + H+ <=> 2-chlorophenol + reduced_acceptor
|
1.21.99.M3
|
–
|
|
|
MetaCyc:
RXN-10113
|
|
|
|
2-chlorophenol + Cl- + acceptor <=> 2,6-dichlorophenol + reduced_acceptor
|
1.21.99.M3
|
–
|
|
|
MetaCyc:
RXN-10114
|
|
|
|
3-chlorophenol + Cl- + acceptor + H+ <=> 2,3-dichlorophenol + reduced_acceptor
|
1.21.99.M3
|
–
|
|
|
MetaCyc:
RXN-10115
|
|
|
|
4-Chlorophenol + Cl- + acceptor + H+ <=> 2,4-Dichlorophenol + reduced_acceptor
|
1.21.99.M3
|
–
|
|
|
MetaCyc:
RXN-10116
|
|
|
|
5-chlorocarbonyl-2-hydroxy-penta-2,4-dienate + H2O <=> 2-hydroxy-2,4-hexadienedioate + H+ + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10420
|
|
|
|
3-chlorobenzoate-cis-3,4-diol <=> 3,4-dihydroxybenzoate + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10424
|
|
|
|
6-chloro-2-hydroxy-4-carboxymuconate-6-semialdehyde <=> H+ + 2-Pyrone-4,6-dicarboxylate + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10426
|
|
|
|
3,4-dichlorobenzoate-cis-4,5-diol <=> H+ + 5-chloroprotocatechuate + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10428
|
|
|
|
3-chlorobenzoate + H2O <=> H+ + 3-hydroxybenzoate + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10448
|
|
|
|
vinyl_chloride + Cl- + acceptor + H+ <=> trans-dichloroethylene + reduced_acceptor
|
1.21.99
|
–
|
|
|
MetaCyc:
RXN-10752
|
|
|
|
organic_molecule + HOCl <=> Cl- + H2O
|
1.11.2
|
–
|
|
|
MetaCyc:
RXN-11817
|
|
|
|
sulochrin + Cl- + O2 + FADH2 <=> dihydrogeodin + H2O + FAD
|
1.14.19
|
–
|
M
|
|
MetaCyc:
RXN-13552
|
|
|
|
8-demethylnovobiocic_acid + Cl- + FADH2 + O2 <=> Chlorobiocate + FAD + H2O
|
1.14.14
|
–
|
|
|
MetaCyc:
RXN-14684
|
|
|
|
2-chloro-2-hydroxypropanoate <=> pyruvate + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-15142
|
|
|
|
(S)-beta-tyrosyl-[SgcC2] + Cl- + O2 + FADH2 <=> (S)-3-chloro-beta-tyrosyl-[SgcC2] + H2O + FAD
|
1.14.14
|
–
|
|
|
MetaCyc:
RXN-15397
|
|
|
|
3-chloro-D-alanine <=> 2-aminoacrylate + Cl- + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-15584
|
|
|
|
griseophenone_C + Cl- + FADH2 + O2 <=> griseophenone_B + FAD + H2O
|
1.14.19
|
–
|
M
|
|
MetaCyc:
RXN-16536
|
|
|
|
3,6-dichloro-3a-methyl-dihydro-3H-furo[3,2-b]furan-2,5-dione <=> trans-2-chloro-3-methyldienelactone + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17087
|
|
|
|
2-chloro-2-(2-chloro-4-methyl-5-oxofuran-2-yl)acetate <=> cis-5-chloro-2-methyldienelactone + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17088
|
|
|
|
2-(2,4-dichloro-5-oxofuran-2-yl)propanoate <=> 2-Chloro-5-methyl-cis-dienelactone + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17090
|
|
|
|
2-(2-chloro-4-methyl-5-oxofuran-2-yl)acetate <=> cis-4-carboxymethylenebut-2-methyl-2-en-4-olide + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17091
|
|
|
|
2-chloro-2-(2-chloro-5-oxofuran-2-yl)acetate <=> 5-chloro-trans-dienelactone + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17092
|
|
|
|
2-chloro-2-(2,4-dichloro-5-oxofuran-2-yl)acetate <=> 2,5-Dichloro-carboxymethylenebut-2-en-4-olide + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17093
|
|
|
|
2-Chloro-2-hydroxyethyl-CoM <=> 2-(2-oxoethylthio)ethanesulfonate + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17586
|
|
|
|
vinyl_chloride + Cl- + acceptor + H+ <=> 1,1-dichloroethylene + reduced_acceptor
|
1.21.99.M1
|
–
|
|
|
MetaCyc:
RXN-17953
|
|
|
|
2-chloro-2-(4-chloro-5-oxo-2H-furan-2-yl)acetate <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18361
|
|
|
|
5-chloro-3-oxoadipate <=> maleylacetate + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18362
|
|
|
|
2,5-dichloro-3-oxoadipate <=> 5-chloromaleylacetate + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18363
|
|
|
|
tetrachlorohydroquinone + glutathione + H+ <=> 2-(glutathione-S-yl)-trichloro-p-hydroquinone + Cl-
|
2.5.1.18
glutathione transferase
|
–
|
M
|
|
MetaCyc:
RXN-18405
|
|
|
|
2,3,5-trichlorohydroquinone + glutathione <=> 3-(glutathione-S-yl)-2,6-dichloro-p-hydroquinone + Cl-
|
2.5.1.18
glutathione transferase
|
–
|
M
|
|
MetaCyc:
RXN-18407
|
|
|
|
melleolide_F + Cl- + FADH2 + O2 <=> 6''-chloromelleolide_F + FAD + H2O
|
1.14.19
|
–
|
M
|
|
MetaCyc:
RXN-18831
|
|
|
|
1H-pyrrole-2-carbonyl-[PltL_prolyl-carrier_protein] + Cl- + O2 + FADH2 <=> 4,5-dichloro-1H-pyrrole-2-carbonyl-[PltL_prolyl-carrier_protein] + H2O + FAD
|
1.14.19.56
1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase
|
–
|
|
|
MetaCyc:
RXN-19067
|
|
|
|
1H-pyrrole-2-carbonyl-[PltL_prolyl-carrier_protein] + Cl- + O2 + FADH2 <=> 5-chloro-1H-pyrrole-2-carbonyl-[PltL_prolyl-carrier_protein] + H2O + FAD
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-19081
|
|
|
|
5-chloro-1H-pyrrole-2-carbonyl-[PltL_prolyl-carrier_protein] + Cl- + O2 + FADH2 <=> 4,5-dichloro-1H-pyrrole-2-carbonyl-[PltL_prolyl-carrier_protein] + H2O + FAD
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-19082
|
|
|
|
ambiguine_J + 2-oxoglutarate + O2 + Cl- + H+ <=> ambiguine_D + succinate + CO2 + H2O
|
1.14.20.14
hapalindole-type alkaloid chlorinase
|
–
|
|
|
MetaCyc:
RXN-19290
|
|
|
|
glutathione + fenclorim <=> 4-(glutathion-S-yl)-fenclorim + Cl- + H+
|
2.5.1.18
glutathione transferase
|
–
|
|
|
MetaCyc:
RXN-19600
|
|
|
|
Dichloroacetate + H2O <=> glyoxylate + Cl- + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-19609
|
|
|
|
2-(glutathion-S-yl)-chloroacetate + H2O <=> glyoxylate + glutathione + Cl- + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-19612
|
|
|
|
3-chlorocatechol + H2O + O2 <=> 2-hydroxy-2,4-hexadienedioate + Cl- + H+
|
1.13.11.M11
|
–
|
|
|
MetaCyc:
RXN-19956
|
|
|
|
naphthomycin_E + FADH2 + Cl- + O2 <=> naphthomycin_A + FAD + H2O
|
1.14.19.M25
|
–
|
M
|
|
MetaCyc:
RXN-20303
|
|
|
|
ochratoxin_B + Cl- + H+ + acceptor <=> ochratoxin_A + reduced_acceptor
|
1.21.99.M6
|
–
|
M
|
|
MetaCyc:
RXN-21095
|
|
|
|
trichloromethanethiol <=> H+ + thiophosgene + Cl-
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-8397
|
|
|
|
thiophosgene + Sulfide <=> H+ + carbon_disulfide + Cl-
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-8398
|
|
|
|
carbon_tetrachloride + reduced_acceptor <=> trichloromethyl_radical + Cl- + acceptor + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-8401
|
|
|
|
trichloromethyl_radical + reduced_acceptor <=> dichlorocarbene + Cl- + acceptor + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-8406
|
|
|
|
dichlorocarbene + H2O <=> H+ + CO + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-8407
|
|
|
|
dichlorocarbene + H2O <=> H+ + formate + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-8408
|
|
|
|
Chloromethane + reduced_acceptor <=> methane + Cl- + acceptor + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-8410
|
|
|
|
trichloroacetate + O2 + NADPH <=> oxalate + Cl- + NADP+ + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9150
|
|
|
|
Dichloroacetate + NADP+ + Cl- + H+ <=> Trichloroethylene + NADPH + O2
|
1.21.1
|
–
|
M
|
|
MetaCyc:
RXN-9151
|
|
|
|
Dichloroacetate + O2 + NADPH <=> oxalate + Cl- + NADP+ + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9152
|
|
|
|
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> protoanemonin + Cl- + CO2
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9869
|
|
|
|
(1R,2S)-1,3,4,6-tetrachlorocyclohexa-3,5-diene-1,2-diol <=> H+ + 3,4,6-trichlorocatechol + Cl-
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9876
|
|
|
|
2-(2-chloro-4-methyl-5-oxofuran-2-yl)acetate <=> cis-4-carboxymethylenebut-2-methyl-2-en-4-olide + Cl- + H+
|
not assigned
|
–
|
M
|