|
|
5-methyltetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + H+ + NADH
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
MK
|
|
BRENDA:
BR36896-a
KEGG:
R07168
MetaCyc:
1.5.1.20-RXN
SABIO-RK:
9210
|
|
|
|
5-methyltetrahydrofolate + oxidized_ferredoxin <=> 5,10-methylenetetrahydrofolate + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
–
|
BMK
|
|
BRENDA:
BR48613
KEGG:
R01217
MetaCyc:
RXN-5061
|
|
|
|
5-methyltetrahydrofolate + NADP+ <=> 5,10-methylenetetrahydrofolate + NADPH + H+
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
BK
|
|
BRENDA:
BR36896
KEGG:
R01224
SABIO-RK:
1453
|
|
|
|
L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate
|
2.1.1.13
methionine synthase
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
–
|
BMK
|
|
BRENDA:
BR40552
KEGG:
R00946
MetaCyc:
HOMOCYSMETB12-RXN
SABIO-RK:
1260
|
|
|
|
tetrahydrofolate + Trimethylsulfonium <=> H+ + Dimethylsulfide + 5-methyltetrahydrofolate
|
2.1.1.19
trimethylsulfonium---tetrahydrofolate N-methyltransferase
|
–
|
K
|
|
BRENDA:
BR43885
KEGG:
R02573
MetaCyc:
2.1.1.19-RXN
|
|
|
|
3-(methylthio)propanoate + 5-methyltetrahydrofolate + H+ <=> dimethylsulfoniopropionate + tetrahydrofolate
|
2.1.1.269
dimethylsulfoniopropionate demethylase
|
–
|
MK
|
|
BRENDA:
BR49172
KEGG:
R10333
MetaCyc:
RXN-9736
|
|
|
|
vanillic_acid + tetrahydrofolate <=> 3,4-dihydroxybenzoate + 5-methyltetrahydrofolate
|
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
|
MK
|
|
BRENDA:
BR52053
KEGG:
R10136
MetaCyc:
RXN-2
|
|
|
|
5-methoxygallic_acid + tetrahydrofolate <=> gallic_acid + 5-methyltetrahydrofolate
|
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
|
MK
|
|
BRENDA:
BR52054
KEGG:
R09271
MetaCyc:
RXN-10892
|
|
|
|
syringic_acid + tetrahydrofolate <=> 5-methoxygallic_acid + 5-methyltetrahydrofolate
|
2.1.1
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
–
|
MK
|
|
BRENDA:
BS438468
KEGG:
R09270
MetaCyc:
RXN-10890
|
|
|
|
5-methyltetrahydrofolate + H2O <=> 5-methylpteroate + L-glutamate
|
3.4.17.11
glutamate carboxypeptidase
|
–
|
|
|
BRENDA:
BS361739
SABIO-RK:
12931
|
|
|
|
5-methyltetrahydrofolate + corrinoid + H+ <=> methylcorrinoid_protein + tetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
K
|
|
KEGG:
R02289
|
|
|
|
serotonin + 5-methyltetrahydrofolate <=> 5-methoxytryptamine + tetrahydrofolate
|
2.1.1
|
–
|
K
|
|
KEGG:
R02912
|
|
|
|
tetrahydrofolate + acetyl-CoA <=> 5-methyltetrahydrofolate + CoA + CO
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
2.3.1.169
CO-methylating acetyl-CoA synthase
|
–
–
|
K
|
|
KEGG:
R10243
|
|
|
|
a_[methyl-Co(III)_corrinoid_Fe-S_protein] + tetrahydrofolate <=> [Co(I)_corrinoid_Fe-S_protein] + 5-methyltetrahydrofolate + H+
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
M
|
|
MetaCyc:
METHCOCLTH-RXN
|
|
|
|
5,10-methylenetetrahydropteroyl_mono-L-glutamate + H+ + e- <=> 5-methyltetrahydrofolate
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-15764
|
|
|
|
[methyl-Co(III)_glycine_betaine-specific_corrinoid_protein] + tetrahydrofolate <=> 5-methyltetrahydrofolate + [Co(I)_glycine_betaine-specific_corrinoid_protein] + H+
|
2.1.1.hi
|
–
|
M
|
|
MetaCyc:
RXN-21058
|
|
|
|
[methyl-Co(III)_proline_betaine-specific_corrinoid_protein] + tetrahydrofolate <=> 5-methyltetrahydrofolate + [Co(I)_proline_betaine-specific_corrinoid_protein] + H+
|
2.1.1.M73
|
–
|
M
|
|
MetaCyc:
RXN-21063
|
|
|
|
5-methyltetrahydrofolate + cob(I)alamin-[methionine_synthase] + H+ <=> tetrahydrofolate + methylcob(III)alamin-[methionine_synthase]
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-21539
|
|
|
|
5-methyltetrahydrofolate + NAD+ + reduced_ferredoxin_[iron-sulfur]_cluster <=> 5,10-methylenetetrahydrofolate + oxidized_ferredoxin + NADH
|
1.5.1.M4
|
–
|
M
|
|
MetaCyc:
RXN-21797
|
|
|
|
3-(methylthio)propanoate + tetrahydrofolate <=> 3-Mercaptopropionate + 5-methyltetrahydrofolate
|
2.1.1
|
–
|
M
|
|
MetaCyc:
RXN-9738
|
|
|
|
5,10-methylenetetrahydrofolate + FADH2 <=> 5-methyltetrahydrofolate + FAD
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
–
|
|
|
BRENDA:
BS370225
|
|
|
|
hydroxycobalamin + 5-methyltetrahydrofolate <=> methylcobalamin + tetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
|
|
BRENDA:
BS420788
|
|
|
|
2-(dimethylsulfonio)propanoate + tetrahydrofolate <=> 2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate
|
2.1.1.269
dimethylsulfoniopropionate demethylase
|
–
|
|
|
BRENDA:
BS403406
|
|
|
|
2-(dimethylsulfonio)propanoate + tetrahydrofolate <=> 3-(methylthio)propanoate + 5-methyltetrahydrofolate
|
2.1.1.269
dimethylsulfoniopropionate demethylase
|
–
|
|
|
BRENDA:
BS453913
|
|
|
|
a_[methyl-Co(III)_corrinoid_Fe-S_protein] + tetrahydrofolate <=> [Co(I)_corrinoid_Fe-S_protein] + 5-methyltetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
B
|
|
BRENDA:
BR50170
|
|
|
|
[Co(I)_corrinoid_Fe-S_protein] + 5-methyltetrahydrofolate <=> a_[methyl-Co(III)_corrinoid_Fe-S_protein] + tetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
|
|
BRENDA:
BS421717
|
|
|
|
5,10-methylenetetrahydrofolate + reduced_ferredoxin <=> 5-methyltetrahydrofolate + Ferredoxin
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS375953
|
|
|
|
5-methyltetrahydrofolate + oxidized_menadione <=> 5,10-methylenetetrahydrofolate + menadiol
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
BRENDA:
BS259231
|
|
|
|
5-methyltetrahydrofolate + rubredoxin <=> 5,10-methylenetetrahydrofolate + reduced_rubredoxin
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS376004
|
|
|
|
5-methyltetrahydrofolate + menadione <=> 5,10-methylenetetrahydrofolate + reduced_menadiol
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS376003
|
|
|
|
S-adenosyl-L-methionine + tetrahydrofolate <=> 5-methyltetrahydrofolate + S-adenosyl-L-homocysteine
|
2.1.1.13
methionine synthase
|
–
|
|
|
BRENDA:
BS289528
|
|
|
|
5-methyltetrahydrofolate_glutamate + H2O <=> 5-methyltetrahydrofolate + L-glutamate
|
3.4.19.9
folate gamma-glutamyl hydrolase
|
–
|
|
|
BRENDA:
BS431428
|
|
|
|
5-methyltetrahydrofolate_heptaglutamate + 7 H2O <=> 5-methyltetrahydrofolate + 7 L-glutamate
|
3.4.19.9
folate gamma-glutamyl hydrolase
|
–
|
|
|
BRENDA:
BS431429
|
|
|
|
5-methyltetrahydrofolate + Oxidized_benzyl_viologen <=> 5,10-methylenetetrahydrofolate + reduced_benzyl_viologen
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS376001
|
|
|
|
5-methyltetrahydrofolate + 2-mercaptoethanol <=> S-Methyl-2-mercaptoethanol + tetrahydrofolate
|
2.1.1.13
methionine synthase
|
–
|
|
|
BRENDA:
BS289525
|
|
|
|
syringic_acid + 2 tetrahydrofolate <=> 3,4-dihydroxybenzoate + 2 5-methyltetrahydrofolate
|
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
|
|
|
BRENDA:
BS439920
|
|
|
|
5-Methyltetrahydrofolate_hexaglutamate + 6 H2O <=> 5-methyltetrahydrofolate + 6 L-glutamate
|
3.4.19.9
folate gamma-glutamyl hydrolase
|
–
|
|
|
BRENDA:
BS431430
|
|
|
|
5,10-methylenetetrahydrofolate + acceptor <=> 5-methyltetrahydrofolate + reduced_acceptor
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
BRENDA:
BS395977
|
|
|
|
5,10-methylenetetrahydrofolate + reduced_acceptor <=> 5-methyltetrahydrofolate + oxidized_acceptor
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
BRENDA:
BS287640
|
|
|
|
Cobalamin + 5-methyltetrahydrofolate <=> methylcobalamin + tetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
|
|
BRENDA:
BS428493
|
|
|
|
ATP + 5-methyltetrahydrofolate + L-glutamate <=> ADP + phosphate + (6S)-5-methyl-5,6,7,8-tetrahydropteroyl-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS369046
|
|
|
|
5-methyltetrahydrofolate + menadione <=> menadiol + 5,10-methylenetetrahydrofolate
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
SABIO-RK:
12848
|
|