|
|
(R)-3-(4-hydroxyphenyl)lactate + NADP+ <=> 4-hydroxyphenylpyruvate + NADPH + H+
|
1.1.1.110
aromatic 2-oxoacid reductase
1.1.1.237
hydroxyphenylpyruvate reductase
|
–
–
|
MK
|
|
BRENDA:
BR29263;
BS370805
KEGG:
R03339
MetaCyc:
1.1.1.222-RXN
|
|
|
|
(R)-3-(4-hydroxyphenyl)lactate + NAD+ <=> 4-hydroxyphenylpyruvate + NADH + H+
|
1.1.1.110
aromatic 2-oxoacid reductase
1.1.1.222
(R)-4-hydroxyphenyllactate dehydrogenase
1.1.1.237
hydroxyphenylpyruvate reductase
1.1.1.345
D-2-hydroxyacid dehydrogenase (NAD+)
1.1.1.37
malate dehydrogenase
1.1.1.96
diiodophenylpyruvate reductase
|
–
–
–
–
–
–
|
MK
|
|
BRENDA:
BR29263-a;
BS186997
KEGG:
R03337
MetaCyc:
1.1.1.222-RXN_WOP;
HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN
SABIO-RK:
3145
|
|
|
|
4-hydroxyphenylpyruvate + O2 <=> 4-hydroxyphenylacetate + CO2
|
1.2.3.13
4-hydroxyphenylpyruvate oxidase
|
–
|
BMK
|
|
BRENDA:
BR29429
KEGG:
R00042
MetaCyc:
1.2.3.13-RXN
|
|
|
|
prephenate + NAD+ <=> 4-hydroxyphenylpyruvate + CO2 + NADH
|
1.3.1.12
prephenate dehydrogenase
1.3.1.13
prephenate dehydrogenase (NADP+)
1.3.1.79
arogenate dehydrogenase [NAD(P)+]
|
–
–
–
|
BMK
|
|
BRENDA:
BR36797
KEGG:
R01728
MetaCyc:
PREPHENATEDEHYDROG-RXN
SABIO-RK:
1839
|
|
|
|
prephenate + NADP+ <=> 4-hydroxyphenylpyruvate + CO2 + NADPH
|
1.3.1.12
prephenate dehydrogenase
1.3.1.13
prephenate dehydrogenase (NADP+)
1.3.1.78
arogenate dehydrogenase (NADP+)
1.3.1.79
arogenate dehydrogenase [NAD(P)+]
|
–
–
–
–
|
K
|
|
BRENDA:
BR36798
KEGG:
R01730
MetaCyc:
PREPHENATE-DEHYDROGENASE-NADP+-RXN
SABIO-RK:
1840
|
|
|
|
4-hydroxyphenylpyruvate + O2 <=> CO2 + homogentisate
|
1.13.11.27
4-hydroxyphenylpyruvate dioxygenase
|
–
|
BMK
|
|
BRENDA:
BR37066
KEGG:
R02521
MetaCyc:
4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN
SABIO-RK:
2446
|
|
|
|
4-hydroxyphenylpyruvate + H+ <=> 4-hydroxyphenylacetaldehyde + CO2
|
4.1.1.72
branched-chain-2-oxoacid decarboxylase
4.1.1.74
indolepyruvate decarboxylase
4.1.1.80
4-hydroxyphenylpyruvate decarboxylase
|
–
–
–
|
BMK
|
|
BRENDA:
BR40592
KEGG:
R03341
MetaCyc:
4.1.1.80-RXN
|
|
|
|
L-tyrosine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.2
alanine transaminase
2.6.1.24
diiodotyrosine transaminase
2.6.1.27
tryptophan transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.49
dihydroxyphenylalanine transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
2.6.1.79
glutamate---prephenate aminotransferase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR47696
KEGG:
R00734
MetaCyc:
TYROSINE-AMINOTRANSFERASE-RXN
SABIO-RK:
1097
|
|
|
|
dimethylallyl_diphosphate + 4-hydroxyphenylpyruvate <=> diphosphate + 3-dimethylallyl-4-hydroxyphenylpyruvate
|
2.5.1.111
4-hydroxyphenylpyruvate 3-dimethylallyltransferase
|
–
|
MK
|
|
BRENDA:
BR50671
KEGG:
R06757
MetaCyc:
RXN-14631
|
|
|
|
(4-hydroxyphenyl)enolpyruvate <=> 4-hydroxyphenylpyruvate
|
5.3.2.1
phenylpyruvate tautomerase
5.3.2.6
2-hydroxymuconate tautomerase
|
–
–
|
K
|
|
BRENDA:
BS1070
KEGG:
R03342
MetaCyc:
RXN-19491
SABIO-RK:
3150
|
|
|
|
O2 + 4-hydroxyphenylpyruvate <=> 4-hydroxymandelate + CO2
|
1.13.11.46
4-hydroxymandelate synthase
|
–
|
|
|
BRENDA:
BS186662
KEGG:
R05778
MetaCyc:
1.13.11.46-RXN
SABIO-RK:
5370
|
|
|
|
L-tyrosine + H2O + O2 <=> 4-hydroxyphenylpyruvate + NH3 + H2O2
|
1.4.3.11
L-glutamate oxidase
1.4.3.14
L-lysine oxidase
1.4.3.2
L-amino-acid oxidase
|
–
–
–
|
K
|
|
BRENDA:
BS258978
KEGG:
R00729
MetaCyc:
RXN-12487
SABIO-RK:
1092
|
|
|
|
L-tyrosine + pyruvate <=> 4-hydroxyphenylpyruvate + L-alanine
|
2.6.1.12
alanine---oxo-acid transaminase
2.6.1.44
alanine---glyoxylate transaminase
2.6.1.5
tyrosine transaminase
2.6.1.51
serine---pyruvate transaminase
2.6.1.58
phenylalanine(histidine) transaminase
|
–
–
–
–
–
|
BMK
|
|
BRENDA:
BS353950
KEGG:
R09254
MetaCyc:
RXN3O-4157
SABIO-RK:
9834
|
|
|
|
L-tyrosine + phenylpyruvate <=> 4-hydroxyphenylpyruvate + L-phenylalanine
|
2.6.1.28
tryptophan---phenylpyruvate transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.70
aspartate---phenylpyruvate transaminase
|
–
–
–
–
–
|
M
|
|
BRENDA:
BS356435
MetaCyc:
RXN-15200
|
|
|
|
4-hydroxyphenylpyruvate + O2 <=> (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + CO2
|
1.13.11.46
4-hydroxymandelate synthase
|
–
|
K
|
|
BRENDA:
BR29129
KEGG:
R06632
|
|
|
|
4-hydroxyphenylglyoxylate + L-tyrosine <=> L-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate
|
2.6.1.103
(S)-3,5-dihydroxyphenylglycine transaminase
2.6.1.B17
|
–
–
|
K
|
|
BRENDA:
BR52009
KEGG:
R06626
|
|
|
|
L-tyrosine + H2O + NAD+ <=> 4-hydroxyphenylpyruvate + NH3 + NADH
|
1.4.1.20
phenylalanine dehydrogenase
1.4.1.5
L-amino-acid dehydrogenase
|
–
–
|
K
|
|
BRENDA:
BS232337
KEGG:
R09830
SABIO-RK:
7284
|
|
|
|
D-tyrosine + H2O + O2 <=> 4-hydroxyphenylpyruvate + NH3 + H2O2
|
1.4.3.3
D-amino-acid oxidase
|
–
|
|
|
BRENDA:
BS259049
SABIO-RK:
9717
|
|
|
|
L-tyrosine + glyoxylate <=> 4-hydroxyphenylpyruvate + glycine
|
2.6.1.44
alanine---glyoxylate transaminase
2.6.1.51
serine---pyruvate transaminase
2.6.1.60
aromatic-amino-acid---glyoxylate transaminase
2.6.1.63
kynurenine---glyoxylate transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
–
–
–
–
–
|
|
|
BRENDA:
BS354013
SABIO-RK:
13948
|
|
|
|
4-hydroxyphenylpyruvate + ATP <=> atromentin + AMP + diphosphate
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-15606
|
|
|
|
4-hydroxyphenylpyruvate + acetyl-CoA + H2O <=> 2-(4-hydroxybenzyl)-malate + CoA + H+
|
2.3.3
|
–
|
M
|
|
MetaCyc:
RXN-16493
|
|
|
|
4-hydroxyphenylpyruvate + L-tyrosine <=> L-tyrosine + 4-hydroxyphenylpyruvate
|
2.6.1.57
aromatic-amino-acid transaminase
|
–
|
|
|
BRENDA:
BS379047
|
|
|
|
4-hydroxyphenylpyruvate + L-tryptophan <=> L-tyrosine + 3-Indole-2-oxopropanoate
|
2.6.1.28
tryptophan---phenylpyruvate transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.99
L-tryptophan---pyruvate aminotransferase
|
–
–
–
|
|
|
BRENDA:
BS353555
|
|
|
|
L-leucine + 4-hydroxyphenylpyruvate <=> 4-methyl-2-oxopentanoate + L-tyrosine
|
2.6.1.42
branched-chain-amino-acid transaminase
|
–
|
|
|
BRENDA:
BS356515
|
|
|
|
D-tyrosine + H2O + FAD <=> 4-hydroxyphenylpyruvate + NH3 + FADH2
|
1.4.99.6
D-arginine dehydrogenase
|
–
|
|
|
BRENDA:
BS445424
|
|
|
|
DL-Tyr + H2O + O2 <=> 4-hydroxyphenylpyruvate + NH3 + H2O2
|
1.4.3.2
L-amino-acid oxidase
|
–
|
|
|
BRENDA:
BS441343
|
|
|
|
D-tyrosine + H2O + 2,6-dichlorophenolindophenol <=> 4-hydroxyphenylpyruvate + NH3 + reduced_2,6-dichlorophenolindophenol
|
1.4.99.6
D-arginine dehydrogenase
|
–
|
|
|
BRENDA:
BS260528
|
|
|
|
D-tyrosine + H2O + iodonitrotetrazolium_chloride <=> 4-hydroxyphenylpyruvate + NH3 + reduced_iodonitrotetrazolium_chloride
|
1.4.99.6
D-arginine dehydrogenase
|
–
|
|
|
BRENDA:
BS409180
|
|
|
|
L-tyrosine + H2O + 2 cytochrome_b <=> 4-hydroxyphenylpyruvate + NH3 + 2 reduced_cytochrome_b
|
1.4.99.B3
|
–
|
|
|
BRENDA:
BS439694
|
|
|
|
L-tyrosine + O2 <=> 4-hydroxyphenylpyruvate + NH3
|
1.13.12.15
3,4-dihydroxyphenylalanine oxidative deaminase
|
–
|
|
|
BRENDA:
BS397676
|
|
|
|
4-hydroxyphenylpyruvate + O2 <=> homogentisate + CO2 + 4-hydroxyphenylacetate
|
1.13.11.27
4-hydroxyphenylpyruvate dioxygenase
|
–
|
|
|
BRENDA:
BS424581
|
|
|
|
4-hydroxyphenylpyruvate + CoA + oxidized_ferredoxin <=> 4-hydroxyphenylacetyl-CoA + CO2 + reduced_ferredoxin
|
1.2.7.7
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
1.2.7.8
indolepyruvate ferredoxin oxidoreductase
|
–
–
|
|
|
BRENDA:
BS359423
|
|
|
|
4-hydroxyphenylpyruvate + CoA + 2 methyl_viologen <=> 4-hydroxyphenylacetyl-CoA + CO2 + 2 reduced_methyl_viologen + 2 H+
|
1.2.7.11
2-oxoacid oxidoreductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS422604
|
|
|
|
4-hydroxyphenylpyruvate + O2 <=> phenylpyruvate + H2O2
|
1.1.3.46
4-hydroxymandelate oxidase
|
–
|
|
|
BRENDA:
BS429757
|
|
|
|
4-hydroxymandelate + O2 <=> 4-hydroxyphenylpyruvate + H2O2
|
1.1.3.2
L-lactate oxidase
|
–
|
|
|
BRENDA:
BS442797
|
|
|
|
3-(4-hydroxyphenyl)lactate + 2,6-dichlorophenolindophenol <=> 4-hydroxyphenylpyruvate + reduced_2,6-dichlorophenolindophenol
|
1.1.3.15
(S)-2-hydroxy-acid oxidase
|
–
|
|
|
BRENDA:
BS257455
|
|
|
|
2-oxosuccinamic_acid + L-tyrosine <=> L-asparagine + 4-hydroxyphenylpyruvate
|
2.6.1.14
asparagine---oxo-acid transaminase
|
–
|
|
|
BRENDA:
BS354188
|
|
|
|
D-tyrosine + phenazine_methosulfate <=> 4-hydroxyphenylpyruvate + NH3 + reduced_phenazine_methosulfate
|
1.4.99.6
D-arginine dehydrogenase
|
–
|
|
|
BRENDA:
BS433618
|
|
|
|
4-hydroxyphenylpyruvate + NADH + H+ <=> 3-(4-hydroxyphenyl)lactate
|
1.1.1.37
malate dehydrogenase
|
–
|
|
|
BRENDA:
BS385490
|
|
|
|
L-kynurenine + 4-hydroxyphenylpyruvate <=> Kynurenic_acid + L-tyrosine
|
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
|
|
|
BRENDA:
BS423755
|
|
|
|
L-Histidinol_phosphate + 4-hydroxyphenylpyruvate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + L-tyrosine
|
2.6.1.9
histidinol-phosphate transaminase
|
–
|
|
|
BRENDA:
BS354122
|
|
|
|
L-tyrosine + 2-oxobutyrate <=> 4-hydroxyphenylpyruvate + 2-aminobutanoate
|
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
|
|
|
BRENDA:
BS377082
|
|
|
|
L-2-aminoadipate + 4-hydroxyphenylpyruvate <=> 2-oxoadipate + L-tyrosine
|
2.6.1.39
2-aminoadipate transaminase
|
–
|
|
|
BRENDA:
BS423709
|
|
|
|
L-tyrosine + 2-Oxopentanoate <=> 4-hydroxyphenylpyruvate + L-norvaline
|
2.6.1.5
tyrosine transaminase
|
–
|
|
|
BRENDA:
BS423790
|
|
|
|
L-tyrosine + 2-Oxohexanoate <=> 4-hydroxyphenylpyruvate + L-norleucine
|
2.6.1.5
tyrosine transaminase
|
–
|
|
|
BRENDA:
BS423789
|
|
|
|
prephenate + L-tyrosine <=> L-arogenate + 4-hydroxyphenylpyruvate
|
2.6.1.57
aromatic-amino-acid transaminase
|
–
|
|
|
BRENDA:
BS380218
|
|
|
|
enol-(p-hydroxyphenyl)pyruvate <=> 4-hydroxyphenylpyruvate
|
5.3.2.1
phenylpyruvate tautomerase
|
–
|
|
|
BRENDA:
BS368674
|
|
|
|
4-hydroxyphenylpyruvate <=> 4-hydroxyphenylpyruvate
|
4.1.1.84
D-dopachrome decarboxylase
5.3.2.1
phenylpyruvate tautomerase
|
–
–
|
|
|
BRENDA:
BS368696
|
|
|
|
L-phenylalanine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate
|
2.6.1.26
thyroid-hormone transaminase
|
–
|
|
|
BRENDA:
BS356402
|
|
|
|
D-tyrosine + H2O + methylene_blue <=> 4-hydroxyphenylpyruvate + NH3 + reduced_methylene_blue
|
1.4.99.6
D-arginine dehydrogenase
|
–
|
|
|
BRENDA:
BS260541
|
|
|
|
4-hydroxyphenylpyruvate + NADPH + NH3 <=> L-tyrosine + NADP+ + H2O
|
1.4.1.2
glutamate dehydrogenase
|
–
|
|
|
BRENDA:
BS389476
|
|
|
|
4-methylsulfanyl-2-oxobutanoate + L-tyrosine <=> L-methionine + 4-hydroxyphenylpyruvate
|
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.88
methionine transaminase
|
–
–
|
|
|
BRENDA:
BS353570
|
|
|
|
L-aspartate + 4-hydroxyphenylpyruvate <=> L-tyrosine + oxaloacetate
|
2.6.1.1
aspartate transaminase
2.6.1.27
tryptophan transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.70
aspartate---phenylpyruvate transaminase
2.6.1.78
aspartate---prephenate aminotransferase
|
–
–
–
–
–
–
|
|
|
BRENDA:
BS353586
|
|
|
|
L-glutamine + 4-hydroxyphenylpyruvate <=> 2-Oxoglutaramate + L-tyrosine
|
2.6.1.64
glutamine---phenylpyruvate transaminase
|
–
|
|
|
BRENDA:
BS356764
|
|
|
|
benzoylformate + L-tyrosine <=> L-phenylalanine + 4-hydroxyphenylpyruvate
|
2.6.1.B17
|
–
|
|
|
BRENDA:
BS437207
|
|
|
|
4-hydroxyphenylpyruvate + L-phenylalanine <=> L-glutamate + phenylpyruvate
|
2.6.1.5
tyrosine transaminase
|
–
|
|
|
BRENDA:
BS436905
|
|