|
|
11-deoxycorticosterone <=> 20-Hydroxy-3-oxopregn-4-en-21-al
|
5.3.1.21
corticosteroid side-chain-isomerase
|
–
|
|
|
BRENDA:
BR228
KEGG:
R04165
MetaCyc:
CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN
|
|
|
|
11-deoxycorticosterone + reduced_adrenodoxin + O2 + H+ <=> corticosterone + H2O + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
M
|
|
BRENDA:
BS186779;
BS424445
MetaCyc:
RXN66-359
|
|
|
|
11-deoxycorticosterone + reduced_ferredoxin + 2 H+ + 2 O2 <=> aldosterone + oxidized_ferredoxin + 2 H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS186777
KEGG:
R08949
|
|
|
|
11-deoxycorticosterone + NADPH <=> 5alpha-pregnane-21-ol-3,20-dione + NADP+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
K
|
|
BRENDA:
BS258532
KEGG:
R08954
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 11-deoxycorticosterone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
K
|
|
BRENDA:
BS427511
KEGG:
R02213
|
|
|
|
progesterone + NADPH + O2 <=> 11-deoxycorticosterone + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
1.14.14.16
steroid 21-monooxygenase
|
–
–
|
|
|
BRENDA:
BS186802
SABIO-RK:
7228
|
|
|
|
pregn-4-ene-3,20,21-trione + NADH <=> 11-deoxycorticosterone + NAD+
|
1.1.1.150
21-hydroxysteroid dehydrogenase (NAD+)
|
–
|
|
|
BRENDA:
BS187299
SABIO-RK:
11540
|
|
|
|
pregn-4-ene-3,20,21-trione + NADPH <=> 11-deoxycorticosterone + NADP+
|
1.1.1.151
21-hydroxysteroid dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS187307
SABIO-RK:
11546
|
|
|
|
11-deoxycorticosterone + 2 reduced_ferredoxin + O2 + 2 H+ <=> corticosterone + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
K
|
|
KEGG:
R03851
|
|
|
|
21-hydroxypregnenolone + NAD+ <=> 11-deoxycorticosterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
K
|
|
KEGG:
R04163
|
|
|
|
11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD+
|
1.1.1
|
–
|
|
|
MetaCyc:
RXN-15607
|
|
|
|
progesterone + reduced_adrenodoxin + O2 + H+ <=> 11-deoxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN66-358
|
|
|
|
corticosterone + reduced_ferredoxin + O2 <=> 11-deoxycorticosterone + adrenal_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS394807
|
|
|
|
progesterone + [reduced_NADPH-P450_reductase] + O2 <=> 11-deoxycorticosterone + [oxidized_NADPH-P450_reductase] + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS427514
|
|
|
|
11-deoxycorticosterone + reduced_flavodoxin + O2 <=> 15beta-hydroxy-11-deoxycorticosterone + flavin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS404982
|
|
|
|
11-deoxycorticosterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxy-11-deoxycorticosterone + 7beta,15beta-dihydroxy-11-deoxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS442714
|
|
|
|
11-deoxycorticosterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxy-11-deoxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS404979
|
|
|
|
11-deoxycorticosterone + reduced_megaredoxin + O2 <=> 15beta-hydroxy-11-deoxycorticosterone + oxidized_megaredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS404983
|
|
|
|
11-deoxycorticosterone + 2,6-dichlorophenolindophenol <=> 1,4-Pregnene-21-ol-3,20-dione + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS441275
|
|
|
|
11-deoxycorticosterone + 2,6-dichlorophenolindophenol <=> 1,4-pregnadiene-21-ol-3,20-dione + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS441274
|
|
|
|
11-deoxycorticosterone + UDP-glucuronate <=> UDP + 21-hydroxyprogesterone-21-O-alpha-D-glucuronate
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS386063
|
|
|
|
11-deoxycorticosterone + reduced_ferredoxin + O2 <=> 15beta-hydroxy-11-deoxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS404981
|
|
|
|
11-deoxycorticosterone + reduced_ferredoxin + O2 <=> 18-hydroxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS186778
|
|
|
|
progesterone + reduced_acceptor + O2 <=> 11-deoxycorticosterone + A + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS406463
|
|
|
|
progesterone + NADH + O2 <=> 11-deoxycorticosterone + NAD+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS186795
|
|
|
|
pregnenolone + NADH + O2 <=> 11-deoxycorticosterone + NAD+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS186799
|
|
|
|
11-deoxycorticosterone + NADH <=> 4-pregnen-20alpha,21-diol-3-one + NAD+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS383594-a
|
|
|
|
11-deoxycorticosterone + NADPH + O2 <=> 18-hydroxycorticosterone + NADP+ + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS375573
|
|
|
|
11-deoxycorticosterone + NADPH <=> 20,21-Dihydroxypregn-4-ene-3-one + NADP+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS188327
|
|
|
|
11-deoxycorticosterone + NADPH <=> pregnan-21-ol-3,20-dione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
|
|
BRENDA:
BS258424
|
|
|
|
11-deoxycorticosterone + NADPH <=> 4-pregnen-20alpha,21-diol-3-one + NADP+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS383594
|
|
|
|
11-deoxycorticosterone + NADPH <=> 21-trihydroxy-5beta-pregnane-3,20-dione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
|
|
BRENDA:
BS388393
|
|
|
|
3''-phosphoadenylylsulfate + 11-deoxycorticosterone <=> adenosine_3'',5''-bisphosphate + 11-deoxycorticosterone_sulfate
|
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
|
–
–
|
|
|
BRENDA:
BS360206
|
|
|
|
5beta-pregnane-21-ol-3,20-dione + acceptor <=> 11-deoxycorticosterone + reduced_acceptor
|
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
|
|
|
BRENDA:
BS258887
|
|
|
|
11-deoxycorticosterone + reduced_acceptor <=> 5alpha-pregnane-21-ol-3,20-dione + acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
|
|
BRENDA:
BS370928
|
|
|
|
11-deoxycorticosterone + acceptor <=> 1,4-Pregnene-21-ol-3,20-dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS258850
|
|
|
|
ATP + H2O + 11-deoxycorticosterone <=> ADP + phosphate + 11-deoxycorticosterone
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
|
BRENDA:
BS433452
|
|
|
|
11-deoxycorticosterone + NADPH <=> 5alpha-pregnane-21-ol-3,20-dione
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS260958
|
|