|
|
H2O + (S)-3-hydroxy-3-methylglutaryl-CoA <=> H+ + 3-hydroxy-3-methylglutarate + CoA
|
3.1.2.2
palmitoyl-CoA hydrolase
3.1.2.20
acyl-CoA hydrolase
3.1.2.27
choloyl-CoA hydrolase
3.1.2.5
hydroxymethylglutaryl-CoA hydrolase
|
–
–
–
–
|
|
|
BRENDA:
BR10676;
BS360786
KEGG:
R02083
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN
SABIO-RK:
2093
|
|
|
|
NADP+ + CoA + (R)-mevalonate <=> H+ + NADPH + (S)-3-hydroxy-3-methylglutaryl-CoA
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88
hydroxymethylglutaryl-CoA reductase
1.1.1.B38
|
–
–
–
|
BMK
|
|
BRENDA:
BR29297;
BR50597;
BS188050;
BS451044
KEGG:
R02082
MetaCyc:
1.1.1.34-RXN
SABIO-RK:
2092
|
|
|
|
(R)-mevalonate + NAD+ + CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88
hydroxymethylglutaryl-CoA reductase
1.1.1.B38
|
–
–
–
|
BMK
|
|
BRENDA:
BR29347;
BR50597-a;
BS188686
KEGG:
R02081
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN
SABIO-RK:
6923
|
|
|
|
(S)-3-hydroxy-3-methylglutaryl-CoA <=> H2O + trans-3-methylglutaconyl-CoA
|
4.2.1.18
methylglutaconyl-CoA hydratase
|
–
|
BMK
|
|
BRENDA:
BR3388
KEGG:
R02085
MetaCyc:
METHYLGLUTACONYL-COA-HYDRATASE-RXN
SABIO-RK:
2095
|
|
|
|
(S)-3-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA
|
4.1.3.4
hydroxymethylglutaryl-CoA lyase
|
–
|
BMK
|
|
BRENDA:
BR395;
BS416230
KEGG:
R01360
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
SABIO-RK:
1564
|
|
|
|
acetoacetyl-CoA + H2O + acetyl-CoA <=> H+ + CoA + (S)-3-hydroxy-3-methylglutaryl-CoA
|
2.3.3.10
hydroxymethylglutaryl-CoA synthase
|
–
|
BMK
|
|
BRENDA:
BR44119
KEGG:
R01978
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
SABIO-RK:
2021
|
|
|
|
succinyl-CoA + 3-hydroxy-3-methylglutarate <=> succinate + (S)-3-hydroxy-3-methylglutaryl-CoA
|
2.8.3.13
succinate---hydroxymethylglutarate CoA-transferase
|
–
|
|
|
BRENDA:
BR47922;
BS358773
KEGG:
R02084
MetaCyc:
2.8.3.13-RXN
|
|
|
|
malonyl-CoA + 3-hydroxy-3-methylglutarate <=> malonate + (S)-3-hydroxy-3-methylglutaryl-CoA
|
2.8.3.13
succinate---hydroxymethylglutarate CoA-transferase
|
–
|
|
|
BRENDA:
BS358779
MetaCyc:
RXN-14051
|
|
|
|
(S)-3-hydroxy-3-methylglutaryl-CoA + NADPH <=> mevaldehyde + CoA + NADP+
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
|
–
|
|
|
BRENDA:
BS371412
|
|
|
|
(S)-3-hydroxy-3-methylglutaryl-CoA + NADPH <=> mevaldyl-CoA + NADP+
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
|
–
|
|
|
BRENDA:
BS370754
|
|