|
|
(6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + NAD+ <=> (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + NADH + H+
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
|
| |
BRENDA:
BS455101
|
|
|
|
(6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + 2''-deoxyuridylate <=> dihydropteroylpentaglutamate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
| |
BRENDA:
BS319730
|
|
|
|
(6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + NADP+ <=> (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + NADPH + H+
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
|
| |
BRENDA:
BS455102
|
|
|
|
Tetrahydropteroylpentaglutamate + ketopantoate <=> (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + 2-oxoisovalerate + H2O
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
|
| |
BRENDA:
BS451906
|
|
|
|
(6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + reduced_acceptor <=> (+)-5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + oxidized_acceptor
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
| |
BRENDA:
BS287641
|
|
|
|
N,N-dimethylglycine + Tetrahydropteroylpentaglutamate + acceptor <=> sarcosine + (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + reduced_acceptor
|
1.5.8.4
dimethylglycine dehydrogenase
|
–
|
|
| |
BRENDA:
BS370178
|
|
|
|
ATP + 5,10-methylenetetrahydropteroyltetraglutamate + L-glutamate <=> ADP + phosphate + (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
| |
BRENDA:
BS475
|
|
|
|
(6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + glycine + H2O <=> 5-formyl-tetrahydropteroyl-pentaglutamate + L-serine
|
2.1.2.1
glycine hydroxymethyltransferase
|
–
|
|
| |
BRENDA:
BS387557
|
|
|
|
Tetrahydropteroylpentaglutamate + L-serine <=> (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + glycine + H2O
|
2.1.2.1
glycine hydroxymethyltransferase
|
–
|
|
| |
SABIO-RK:
15034
|
|
