|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol
|
5.4.99.17
squalene---hopene cyclase
5.4.99.7
lanosterol synthase
|
–
–
|
BMK
|
|
BRENDA:
BR254
KEGG:
R03199
MetaCyc:
LANOSTEROL-SYNTHASE-RXN
SABIO-RK:
3027
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> Cycloartenol
|
5.4.99.8
cycloartenol synthase
|
–
|
MK
|
|
BRENDA:
BR255
KEGG:
R03200
MetaCyc:
CYCLOARTENOL-SYNTHASE-RXN
|
|
|
|
(20S)-dammarenediol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O
|
4.2.1.125
dammarenediol II synthase
|
–
|
BMK
|
|
BRENDA:
BR48943
KEGG:
R09701
MetaCyc:
RXN-8885
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> beta-amyrin
|
5.4.99.34
germanicol synthase
5.4.99.39
beta-amyrin synthase
5.4.99.41
lupeol synthase
5.4.99.B2
|
–
–
–
–
|
BMK
|
|
BRENDA:
BR48944
KEGG:
R06469
MetaCyc:
RXN-7570
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lupeol
|
5.4.99.34
germanicol synthase
5.4.99.41
lupeol synthase
5.4.99.B2
|
–
–
–
|
MK
|
|
BRENDA:
BR48947
KEGG:
R06466
MetaCyc:
RXN-111
|
|
|
|
arabidiol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O
|
4.2.1.124
arabidiol synthase
|
–
|
MK
|
|
BRENDA:
BR49623
KEGG:
R09700
MetaCyc:
RXN-9684
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> thalianol
|
5.4.99.31
thalianol synthase
|
–
|
MK
|
|
BRENDA:
BR49626
KEGG:
R09709
MetaCyc:
RXN-9630
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> (17Z)-protosta-17(20),24-dien-3beta-ol
|
5.4.99.32
protostadienol synthase
|
–
|
K
|
|
BRENDA:
BR49627
KEGG:
R09689
MetaCyc:
RXN-12329
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> cucurbitadienol
|
5.4.99.33
cucurbitadienol synthase
|
–
|
K
|
|
BRENDA:
BR49628
KEGG:
R09688
MetaCyc:
RXN-12327
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> germanicol
|
5.4.99.34
germanicol synthase
|
–
|
MK
|
|
BRENDA:
BR49629
KEGG:
R09710
MetaCyc:
RXN-9915
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> taraxerol
|
5.4.99.35
taraxerol synthase
|
–
|
MK
|
|
BRENDA:
BR49630
KEGG:
R09476
MetaCyc:
RXN-9916
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> isomultiflorenol
|
5.4.99.36
isomultiflorenol synthase
|
–
|
MK
|
|
BRENDA:
BR49631
KEGG:
R09711
MetaCyc:
RXN-12103
|
|
|
|
lupan-3beta,20-diol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O
|
4.2.1.128
lupan-3beta,20-diol synthase
|
–
|
K
|
|
BRENDA:
BR49649
KEGG:
R09743
MetaCyc:
RXN-12338
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> camelliol_C
|
5.4.99.38
camelliol C synthase
|
–
|
K
|
|
BRENDA:
BR49651
KEGG:
R09713
MetaCyc:
RXN-12330
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> alpha-amyrin
|
5.4.99.40
alpha-amyrin synthase
5.4.99.B2
|
–
–
|
MK
|
|
BRENDA:
BR49652
KEGG:
R06471
MetaCyc:
RXN-8434
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> baruol
|
5.4.99.57
baruol synthase
|
–
|
MK
|
|
BRENDA:
BR49784
KEGG:
R09917
MetaCyc:
RXN-9685
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> shionone
|
5.4.99.46
shionone synthase
|
–
|
|
|
BRENDA:
BR49790
KEGG:
R09906
MetaCyc:
RXN-12841
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> parkeol
|
5.4.99.47
parkeol synthase
|
–
|
MK
|
|
BRENDA:
BR49791
KEGG:
R09907
MetaCyc:
RXN-12842
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> delta-amyrin
|
5.4.99.55
delta-amyrin synthase
|
–
|
M
|
|
BRENDA:
BR49792
KEGG:
R09915
MetaCyc:
RXN-12847
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> achilleol_B
|
5.4.99.48
achilleol B synthase
|
–
|
K
|
|
BRENDA:
BR49850
KEGG:
R09908
MetaCyc:
RXN-12843
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> glutinol
|
5.4.99.49
glutinol synthase
|
–
|
M
|
|
BRENDA:
BR49851
KEGG:
R09909
MetaCyc:
RXN-12099
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> friedelin
|
5.4.99.50
friedelin synthase
|
–
|
M
|
|
BRENDA:
BR49852
KEGG:
R09910
MetaCyc:
RXN-12101
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> baccharis_oxide
|
5.4.99.51
baccharis oxide synthase
|
–
|
|
|
BRENDA:
BR49853
KEGG:
R09911
MetaCyc:
RXN-12844
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> alpha-seco-amyrin
|
5.4.99.52
alpha-seco-amyrin synthase
|
–
|
K
|
|
BRENDA:
BR49854
KEGG:
R09912
MetaCyc:
RXN-12845
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> marneral
|
5.4.99.53
marneral synthase
|
–
|
MK
|
|
BRENDA:
BR49855
KEGG:
R09913
MetaCyc:
RXN-9664
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> beta-seco-amyrin
|
5.4.99.54
beta-seco-amyrin synthase
|
–
|
K
|
|
BRENDA:
BR49856
KEGG:
R09914
MetaCyc:
RXN-12846
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> achilleol_A
|
5.4.99
5.4.99.7
lanosterol synthase
|
–
–
|
|
|
BRENDA:
BS427766
MetaCyc:
RXN-20254
|
|
|
|
squalene + reduced_flavodoxin + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + flavin + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
K
|
|
BRENDA:
BR40381
KEGG:
R02874
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> tirucalla-7,24-dien-3beta-ol
|
5.4.99.56
tirucalladienol synthase
|
–
|
K
|
|
BRENDA:
BR49858
KEGG:
R09916
|
|
|
|
squalene + NADPH + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS287895
SABIO-RK:
2736
|
|
|
|
squalene + reduced_acceptor + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + acceptor + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS375305;
BS394994
SABIO-RK:
2735
|
|
|
|
sterol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene
|
not assigned
|
–
|
|
|
KEGG:
R02116
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> Triterpenoid
|
not assigned
|
–
|
|
|
KEGG:
R03201
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> euphol
|
not assigned
|
–
|
|
|
KEGG:
R08376
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> cucurbitacin_E
|
not assigned
|
–
|
|
|
KEGG:
R08378
|
|
|
|
squalene + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + 2 ferricytochrome_b5 + H2O
|
1.14.19
|
–
|
K
|
|
KEGG:
R12355
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> multiflorenol
|
5.4.99
|
–
|
M
|
|
MetaCyc:
RXN-12102
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> tirucalla-7,24-diene-3beta-ol
|
5.4.99.56
tirucalladienol synthase
|
–
|
|
|
MetaCyc:
RXN-12326
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> isoarborinol
|
5.4.99
|
–
|
|
|
MetaCyc:
RXN-14392
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> bauerenol
|
5.4.99
|
–
|
|
|
MetaCyc:
RXNQT-4181
|
|
|
|
squalene + O2 + reduced_[NADPH-hemoprotein_reductase] <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.17
squalene monooxygenase
|
–
|
M
|
|
MetaCyc:
SQUALENE-MONOOXYGENASE-RXN
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + FAD + H2O <=> squalene + FADH2 + O2
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS451303
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + 1-Carba-1-deazaFAD + H2O <=> squalene + 1-carba-1-deaza-FADH2 + O2
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS451305
|
|
|
|
squalene + reduced_cytochrome_P450 + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + cytochrome_P450 + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS394996
|
|
|
|
squalene + electron_donor + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + oxidized_electron_donor + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS370237
|
|
|
|
squalene + reduced_NADPH-cytochrome_P450_reductase + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + oxidized_NADPH-cytochrome_P450_reductase + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS451304
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> astertarone_A
|
5.4.99.B40
|
–
|
|
|
BRENDA:
BR52661
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> protosta-17(20)Z,24-dien-3beta-ol + (20R)-protosta-13(17),24-dien-3beta-ol
|
5.4.99.32
protostadienol synthase
|
–
|
|
|
BRENDA:
BS415890
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + H2O <=> (3S,13R)-malabarica-17,21-dien-3,14-diol
|
4.2.1.124
arabidiol synthase
|
–
|
|
|
BRENDA:
BS415956
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> tirucalla-7,24-dien-3beta-ol + isotirucallol + (1S,4S,8beta,9beta,13alpha,14beta,17alpha,20S)-9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-5,24-dien-1-ol
|
5.4.99.56
tirucalladienol synthase
|
–
|
|
|
BRENDA:
BS415896
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> protosta-12,24-dien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427773
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> orysatinol
|
5.4.99.B41
|
–
|
|
|
BRENDA:
BR52662
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + H2O <=> 3beta-hydroxyhopene + 3beta-hydroxyhopanol
|
5.4.99.17
squalene---hopene cyclase
|
–
|
|
|
BRENDA:
BS444506
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> shionone + beta-amyrin + friedelin + dammara-20,24-dienol + 4-epishionone
|
5.4.99.46
shionone synthase
|
–
|
|
|
BRENDA:
BS425130
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lupeol + germanicol + beta-amyrin + taraxasterol + psi-taraxasterol + lupan-3beta,20-diol
|
5.4.99.41
lupeol synthase
|
–
|
|
|
BRENDA:
BS394124
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> alpha-amyrin + beta-amyrin
|
5.4.99.B2
|
–
|
|
|
BRENDA:
BS415939
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + H2O <=> (20S)-dammarenediol + hydroxydammarenone
|
4.2.1.125
dammarenediol II synthase
|
–
|
|
|
BRENDA:
BS394109
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + reduced_acceptor + O2 <=> (3S,22S)-2,3:22,23-dioxidosqualene + A + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS395092
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> (17Z)-protosta-17(20),24-dien-3beta-ol + (17Z)-protosta-13(17),24-dien-3beta-ol
|
5.4.99.32
protostadienol synthase
|
–
|
|
|
BRENDA:
BS415894
|
|
|
|
squalene + NADH + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS287895-a
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + NADPH + O2 <=> 2,3,22,23-dioxidosqualene + NADP+ + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS287903
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + achilleol_A + (13alphaH)-isomalabarica-14(26),17E,21-trien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427770
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + achilleol_A
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427769
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> Cycloartenol + lanosterol + parkeol
|
5.4.99.47
parkeol synthase
|
–
|
|
|
BRENDA:
BS415887
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + (13alphaH)-isomalabarica-14(26),17E,21-trien-3beta-ol + protosta-16,24-dien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427768
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + (13alphaH)-isomalabarica-14(26),17E,21-trien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427767
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> achilleol_A + protosta-12,24-dien-3beta-ol + lanosterol + parkeol
|
5.4.99.47
parkeol synthase
|
–
|
|
|
BRENDA:
BS415884
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> parkeol + lanosterol + lanost-24-ene-3beta,9alpha-diol
|
5.4.99.47
parkeol synthase
|
–
|
|
|
BRENDA:
BS415942
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + parkeol + 9beta-lanosta-7,24-dien-3beta-ol
|
5.4.99.7
lanosterol synthase
|
–
|
|
|
BRENDA:
BS427771
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol + parkeol
|
5.4.99.47
parkeol synthase
|
–
|
|
|
BRENDA:
BS415888
|
|