|
|
2-methyl-4-amino-5-hydroxymethylpyrimidine_phosphate + ATP <=> 2-methyl-4-amino-5-hydroxymethylpyrimidine_diphosphate + ADP
|
2.7.1.49
hydroxymethylpyrimidine kinase
2.7.4.7
phosphooxymethylpyrimidine kinase
|
–
–
|
| |
BRENDA:
BR48075
KEGG:
R04509
MetaCyc:
PYRIMSYN3-RXN
|
|
|
|
1-deoxy-D-xylulose_5-phosphate + 2-iminoacetate + adenylyl-[ThiS] <=> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl_phosphate + [sulfur-carrier_protein_ThiS] + 2 H2O
|
2.8.1.10
thiazole synthase
|
–
|
| |
BRENDA:
BS416005
|
|
|
|
ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> H+ + ADP + 2-methyl-4-amino-5-hydroxymethylpyrimidine_phosphate
|
2.7.1.35
pyridoxal kinase
2.7.1.49
hydroxymethylpyrimidine kinase
2.7.4.7
phosphooxymethylpyrimidine kinase
|
–
–
–
|
| |
BRENDA:
BR47783
KEGG:
R03471
MetaCyc:
OHMETPYRKIN-RXN
SABIO-RK:
3265
|
|
|
|
2-(4-methyl-1,3-thiazol-5-yl)ethyl_phosphate + 2-methyl-4-amino-5-hydroxymethylpyrimidine_diphosphate + H+ <=> thiamine_phosphate + diphosphate
|
2.5.1.3
thiamine phosphate synthase
|
–
|
| |
BRENDA:
BR51526
KEGG:
R03223
MetaCyc:
THI-P-SYN-RXN
SABIO-RK:
3049
|
|
|
|
thiamine + ATP <=> H+ + thiamine_diphosphate + AMP
|
2.7.6.2
thiamine diphosphokinase
|
–
|
| |
BRENDA:
BR47855
KEGG:
R00619
MetaCyc:
THIAMIN-PYROPHOSPHOKINASE-RXN
|
|
|
|
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl_phosphate + 2-methyl-4-amino-5-hydroxymethylpyrimidine_diphosphate + H+ <=> thiamine_phosphate + CO2 + diphosphate
|
2.5.1.3
thiamine phosphate synthase
|
–
|
| |
BRENDA:
BR47665
KEGG:
R11312
MetaCyc:
RXN-12611
|
|
|
|
L-cysteine + [ThiI]-cysteine <=> L-alanine + [ThiI]-S-sulfanylcysteine
|
2.8.1.7
cysteine desulfurase
|
–
|
| |
BRENDA:
BS426551
|
|
|
|
S-adenosyl-L-methionine + L-tyrosine + NADPH <=> 2-iminoacetate + p-Cresol + 5''-deoxyadenosine + L-methionine + NADP+ + H+
|
4.1.99.19
2-iminoacetate synthase
|
–
|
| |
BRENDA:
BR49775
MetaCyc:
RXN-11319
|
|
|
|
NAD+ + glycine + [ADP-thiazole_synthase]-L-cysteine <=> nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole_synthase]-dehydroalanine + 3 H2O
|
2.4.2.60
cysteine-dependent adenosine diphosphate thiazole synthase
|
–
|
| |
BRENDA:
BR52385
|
|
|
|
ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole <=> H+ + ADP + 2-(4-methyl-1,3-thiazol-5-yl)ethyl_phosphate
|
2.7.1.50
hydroxyethylthiazole kinase
|
–
|
| |
BRENDA:
BR47785
KEGG:
R04448
MetaCyc:
THIAZOLSYN3-RXN
|
|
|
|
S-adenosyl-L-methionine + 5-amino-1-(5-phospho-D-ribosyl)imidazole <=> 2-methyl-4-amino-5-hydroxymethylpyrimidine_phosphate + 5''-deoxyadenosine + L-methionine + formate + CO + H+
|
4.1.99.17
phosphomethylpyrimidine synthase
|
–
|
| |
BRENDA:
BR49773
KEGG:
R03472
MetaCyc:
PYRIMSYN1-RXN
|
|
|
|
[ThiS] + ATP + H+ <=> adenylyl-[ThiS] + diphosphate
|
2.7.7.73
sulfur carrier protein ThiS adenylyltransferase
|
–
|
| |
BRENDA:
BR49425
MetaCyc:
RXN-9789
|
|
|
|
succinyl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + enzyme_N6-(S-succinyldihydrolipoyl)lysine
|
2.3.1.61
dihydrolipoyllysine-residue succinyltransferase
|
–
|
| |
BRENDA:
BR44062
KEGG:
R02570
|
|
|
|
H2O + thiamine <=> H+ + 4-methyl-5-(2-hydroxyethyl)-thiazole + 4-Amino-5-hydroxymethyl-2-methylpyrimidine
|
3.5.99.2
aminopyrimidine aminohydrolase
|
–
|
| |
BRENDA:
BR49840
KEGG:
R02133
MetaCyc:
THIAMINASE-RXN
|
|
|
|
thiamine_phosphate + ATP <=> thiamine_diphosphate + ADP
|
2.7.1.21
thymidine kinase
2.7.4.12
T2-induced deoxynucleotide kinase
2.7.4.13
(deoxy)nucleoside-phosphate kinase
2.7.4.16
thiamine-phosphate kinase
2.7.4.3
adenylate kinase
2.7.4.4
nucleoside-phosphate kinase
2.7.4.8
guanylate kinase
2.7.4.9
dTMP kinase
|
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR47844;
BR48076
KEGG:
R00617;
R02094
MetaCyc:
DTMPKI-RXN;
THI-P-KIN-RXN
SABIO-RK:
1007;
14622;
91
|
|
|
|
thiamine_phosphate + H2O <=> thiamine + phosphate
|
3.1.3.1
alkaline phosphatase
3.1.3.100
thiamine phosphate phosphatase
3.1.3.2
acid phosphatase
|
–
–
–
|
| |
BRENDA:
BR51620
KEGG:
R02135
MetaCyc:
RXNQT-4191
|
|
|
|
H+ + pyruvate + D-glyceraldehyde_3-phosphate <=> 1-deoxy-D-xylulose_5-phosphate + CO2
|
2.2.1.7
1-deoxy-D-xylulose-5-phosphate synthase
|
–
|
| |
BRENDA:
BR37092;
BS260856
KEGG:
R05636
MetaCyc:
DXS-RXN
|
|
