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tetracycline and oxytetracycline biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
6-methylpretetramide + NADPH + O2 + H+ <=> 4-hydroxy-6-methylpretetramide + NADP+ + H2O 1.14.13.232 6-methylpretetramide 4-monooxygenase

S-adenosyl-L-methionine + anhydrotetracycline <=> anhydrotetracycline + S-adenosyl-L-homocysteine + H+ 2.1.1.335 4-amino-anhydrotetracycline N4-methyltransferase

5a,11a-dehydrotetracycline + reduced_coenzyme_F420 <=> tetracycline + coenzyme_F420 1.3.98.4 5a,11a-dehydrotetracycline reductase

4-hydroxy-6-methylpretetramide + NADPH + O2 + H+ <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O 1.14.13.233 4-hydroxy-6-methylpretetramide 12a-monooxygenase

S-adenosyl-L-methionine + 4-amino-4-de(dimethylamino)anhydrotetracycline <=> anhydrotetracycline + S-adenosyl-L-homocysteine + H+ 2.1.1.335 4-amino-anhydrotetracycline N4-methyltransferase

5a,11a-dehydrooxytetracycline + reduced_coenzyme_F420 <=> oxytetracycline + coenzyme_F420 1.3.98.4 5a,11a-dehydrotetracycline reductase

aminated_amino_group_donor + 4-de(dimethylamino)-4-oxoanhydrotetracycline <=> deaminated_amino_group_donor + 4-amino-4-de(dimethylamino)anhydrotetracycline 2.6.1.M2

5a,11a-dehydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrooxytetracycline + H2O + NADP+ 1.14.13.234 5a,11a-dehydrotetracycline 5-monooxygenase

anhydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrotetracycline + H2O + NADP+ 1.14.13.38 anhydrotetracycline 6-monooxygenase

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