|
|
6-methylpretetramide + NADPH + O2 + H+ <=> 4-hydroxy-6-methylpretetramide + NADP+ + H2O
|
1.14.13.232
6-methylpretetramide 4-monooxygenase
|
–
|
| |
BRENDA:
BR51807
KEGG:
R05463
MetaCyc:
RXN-17981
|
|
|
|
S-adenosyl-L-methionine + anhydrotetracycline <=> anhydrotetracycline + S-adenosyl-L-homocysteine + H+
|
2.1.1.335
4-amino-anhydrotetracycline N4-methyltransferase
|
–
|
| |
BRENDA:
BR51856
KEGG:
R11521
MetaCyc:
RXN-17978
|
|
|
|
5a,11a-dehydrotetracycline + reduced_coenzyme_F420 <=> tetracycline + coenzyme_F420
|
1.3.98.4
5a,11a-dehydrotetracycline reductase
|
–
|
| |
BRENDA:
BR51789
KEGG:
R05459
MetaCyc:
RXN-17988
|
|
|
|
4-hydroxy-6-methylpretetramide + NADPH + O2 + H+ <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O
|
1.14.13.233
4-hydroxy-6-methylpretetramide 12a-monooxygenase
|
–
|
| |
BRENDA:
BR51808
KEGG:
R05462
MetaCyc:
RXN-17980
|
|
|
|
S-adenosyl-L-methionine + 4-amino-4-de(dimethylamino)anhydrotetracycline <=> anhydrotetracycline + S-adenosyl-L-homocysteine + H+
|
2.1.1.335
4-amino-anhydrotetracycline N4-methyltransferase
|
–
|
| |
BRENDA:
BR51855
KEGG:
R09191;
R11520
MetaCyc:
RXN-17977
|
|
|
|
5a,11a-dehydrooxytetracycline + reduced_coenzyme_F420 <=> oxytetracycline + coenzyme_F420
|
1.3.98.4
5a,11a-dehydrotetracycline reductase
|
–
|
| |
KEGG:
R09192
MetaCyc:
RXN-17975
|
|
|
|
aminated_amino_group_donor + 4-de(dimethylamino)-4-oxoanhydrotetracycline <=> deaminated_amino_group_donor + 4-amino-4-de(dimethylamino)anhydrotetracycline
|
2.6.1.M2
|
–
|
| |
MetaCyc:
RXN-17979
|
|
|
|
5a,11a-dehydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrooxytetracycline + H2O + NADP+
|
1.14.13.234
5a,11a-dehydrotetracycline 5-monooxygenase
|
–
|
| |
BRENDA:
BR51809
KEGG:
R09198
MetaCyc:
RXN-17976
|
|
|
|
anhydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrotetracycline + H2O + NADP+
|
1.14.13.38
anhydrotetracycline 6-monooxygenase
|
–
|
| |
BRENDA:
BR40419
KEGG:
R04060
MetaCyc:
ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN
|
|
