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superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
thiamine_phosphate + ATP <=> thiamine_diphosphate + ADP 2.7.1.21 thymidine kinase
2.7.4.12 T2-induced deoxynucleotide kinase
2.7.4.13 (deoxy)nucleoside-phosphate kinase
2.7.4.16 thiamine-phosphate kinase
2.7.4.3 adenylate kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.8 guanylate kinase
2.7.4.9 dTMP kinase








formate + CTP + H+ <=> dCTP + CO2 + H2O 1.1.98.6 ribonucleoside-triphosphate reductase (formate)

dUTP + H2O <=> H+ + dUMP + diphosphate 3.6.1
3.6.1.23 dUTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase




dUDP + oxidized_NrdH_glutaredoxin-like_protein + H2O <=> UDP + reduced_NrdH_glutaredoxin-like_protein 1.17.4.1 ribonucleoside-diphosphate reductase

dTDP + ATP <=> dTTP + ADP 2.7.4.6 nucleoside-diphosphate kinase

dCDP + ATP <=> dCTP + ADP 2.7.4.6 nucleoside-diphosphate kinase

H+ + H2O + dCTP <=> NH3 + dUTP 3.5.4.13 dCTP deaminase

dUDP + thioredoxin_disulfide + H2O <=> UDP + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)


dCDP + oxidized_NrdH_glutaredoxin-like_protein + H2O <=> CDP + reduced_NrdH_glutaredoxin-like_protein 1.17.4.1 ribonucleoside-diphosphate reductase

5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate 2.1.1.45 thymidylate synthase

dCDP + thioredoxin_disulfide + H2O <=> CDP + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)


formate + UTP + H+ <=> dUTP + CO2 + H2O 1.1.98.6 ribonucleoside-triphosphate reductase (formate)

dUDP + ATP <=> dUTP + ADP 2.7.4.6 nucleoside-diphosphate kinase

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