|
|
phosphatidylinositol + dihydroceramide <=> inositol_phosphodihydroceramide + diacylglycerol
|
2.7.1
|
–
|
| |
MetaCyc:
RXN-7795
|
|
|
|
sphinganine + ATP <=> H+ + sphinganine_1-phosphate + ADP
|
2.7.1.91
sphingosine kinase
|
–
|
| |
BRENDA:
BS370403
KEGG:
R02976
MetaCyc:
SPHINGANINE-KINASE-RXN
SABIO-RK:
2830
|
|
|
|
dihydroceramide + O2 + ferricytochrome_b5 + H+ <=> (2''R)-2''-hydroxydihydroceramide + ferricytochrome_b5 + H2O
|
1.14.18.7
dihydroceramide fatty acyl 2-hydroxylase
|
–
|
| |
BRENDA:
BR51359
KEGG:
R11003
MetaCyc:
RXN-7796
|
|
|
|
(C18)-phytoceramide + O2 + ferricytochrome_b5 + H+ <=> (8E)-4-hydroxysphing-8-enine_ceramide + ferricytochrome_b5 + H2O
|
1.14.19.29
sphingolipid 8-(E/Z)-desaturase
|
–
|
| |
MetaCyc:
RXN-7798
|
|
|
|
beta-D-glucosyl-N-acylsphinganine + O2 + ferricytochrome_b5 + H+ <=> beta-D-glucosyl-N-acylsphingosine + ferricytochrome_b5 + H2O
|
1.14.19.17
sphingolipid 4-desaturase
|
–
|
| |
MetaCyc:
RXN-11341
|
|
|
|
UDP-glucose + dihydroceramide <=> beta-D-glucosyl-N-acylsphinganine + UDP + H+
|
2.4.1.80
ceramide glucosyltransferase
|
–
|
| |
BRENDA:
BS322984
MetaCyc:
RXN-7793
|
|
|
|
palmitoyl-CoA + L-serine + H+ <=> 3-dehydrosphinganine + CO2 + CoA
|
2.3.1.50
serine C-palmitoyltransferase
|
–
|
| |
BRENDA:
BR44052
KEGG:
R01281
MetaCyc:
SERINE-C-PALMITOYLTRANSFERASE-RXN
|
|
|
|
dihydroceramide + sterol_3-glucoside <=> beta-D-glucosyl-N-acylsphinganine + sterol
|
2.4.1
|
–
|
| |
MetaCyc:
RXN-7801
|
|
|
|
sphinganine + NADP+ <=> 3-dehydrosphinganine + NADPH + H+
|
1.1.1.102
3-dehydrosphinganine reductase
|
–
|
| |
BRENDA:
BR29168
KEGG:
R02978
MetaCyc:
3-DEHYDROSPHINGANINE-REDUCTASE-RXN;
RXN-20505
|
|
|
|
dihydroceramide + ATP <=> dihydroceramide_1-phosphate + ADP + H+
|
2.7.1.138
ceramide kinase
|
–
|
| |
MetaCyc:
RXN-7799
|
|
|
|
sphinganine + O2 + ferricytochrome_b5 + H+ <=> phytosphingosine + H2O + ferricytochrome_b5
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
| |
KEGG:
R06525
MetaCyc:
RXN3O-1380
|
|
|
|
acyl-CoA + sphinganine <=> dihydroceramide + CoA + H+
|
2.3.1.24
sphingosine N-acyltransferase
2.3.1.291
sphingoid base N-palmitoyltransferase
2.3.1.297
very-long-chain ceramide synthase
|
–
–
–
|
| |
BRENDA:
BS320738;
BS449519
KEGG:
R06517
MetaCyc:
RXN-7792
|
|
|
|
dihydroceramide + O2 + ferricytochrome_b5 + H+ <=> (C18)-phytoceramide + H2O + ferricytochrome_b5
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
| |
MetaCyc:
RXN-14250
|
|
