|
|
amorpha-4,11-diene + O2 + reduced_flavodoxin <=> artemisinic_alcohol + flavin + H2O
|
1.14.14.114
amorpha-4,11-diene 12-monooxygenase
|
–
|
| |
BRENDA:
BR50356
KEGG:
R10023
|
|
|
|
(2E,6E)-farnesyl_diphosphate <=> germacrene_A + diphosphate
|
4.2.3.23
germacrene-A synthase
4.2.3.9
aristolochene synthase
|
–
–
|
| |
BRENDA:
BR50766;
BS378383
KEGG:
R07649
MetaCyc:
RXN-11527
SABIO-RK:
15408
|
|
|
|
germacrene_A + O2 + reduced_flavodoxin <=> germacra-1(10),4,11(13)-trien-12-ol + flavin + H2O
|
1.14.14.95
germacrene A hydroxylase
|
–
|
| |
BRENDA:
BR52444
KEGG:
R09549
|
|
|
|
(2E,6E)-farnesyl_diphosphate <=> amorpha-4,11-diene + diphosphate
|
4.2.3.24
amorpha-4,11-diene synthase
|
–
|
| |
BRENDA:
BR48696
KEGG:
R07630
MetaCyc:
RXN-8046
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.170
8-epi-inunolide synthase
|
–
|
| |
BRENDA:
BR52568
KEGG:
R12273
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.168
germacrene A acid 8beta-hydroxylase
|
–
|
| |
BRENDA:
BR52563
KEGG:
R12266
|
|
|
|
8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.169
eupatolide synthase
|
–
|
| |
BRENDA:
BR52565
KEGG:
R12267
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.150
costunolide synthase
|
–
|
| |
BRENDA:
BR52441
KEGG:
R12131
|
|
|
|
germacra-1(10),4,11(13)-trien-12-al + O2 + reduced_flavodoxin <=> germacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.95
germacrene A hydroxylase
|
–
|
| |
BRENDA:
BR52446
KEGG:
R12130
|
|
|
|
artemisinate + O2 + H+ <=> (-)-arteannuin_B + H2O
|
0.0.0.0
|
–
|
| |
BRENDA:
BR53094
MetaCyc:
RXN-20257
|
|
|
|
artemisinic_alcohol + O2 + reduced_flavodoxin <=> artemisinic_aldehyde + flavin + 2 H2O
|
1.14.14.114
amorpha-4,11-diene 12-monooxygenase
|
–
|
| |
BRENDA:
BR50105
KEGG:
R10024
|
|
|
|
(11R)-dihydroartemisinic_aldehyde + NADP+ <=> artemisinic_aldehyde + NADPH + H+
|
1.3.1.74
2-alkenal reductase [NAD(P)+]
1.3.1.92
artemisinic aldehyde Delta11(13)-reductase
|
–
–
|
| |
BRENDA:
BR50092;
BS404367
KEGG:
R10075
MetaCyc:
RXN-8053
|
|
|
|
8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H+ <=> 8-epi-inunolide + H2O
|
1.14.14.170
8-epi-inunolide synthase
|
–
|
| |
BRENDA:
BR52569
KEGG:
R12274
MetaCyc:
RXN-20050
|
|
|
|
6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate + H+ <=> eupatolide + H2O
|
1.14.14.169
eupatolide synthase
|
–
|
| |
BRENDA:
BR52566
KEGG:
R12268
MetaCyc:
RXN-20053
|
|
|
|
6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H+ <=> (+)-costunolide + H2O
|
1.14.14.150
costunolide synthase
|
–
|
| |
BRENDA:
BR52442
KEGG:
R12132
MetaCyc:
RXN-15459
|
|
|
|
artemisinic_aldehyde + O2 + reduced_flavodoxin <=> artemisinate + flavin + H2O
|
1.14.14.114
amorpha-4,11-diene 12-monooxygenase
|
–
|
| |
BRENDA:
BR50106
KEGG:
R10025
|
|
|
|
germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced_flavodoxin <=> germacra-1(10),4,11(13)-trien-12-al + flavin + 2 H2O
|
1.14.14.95
germacrene A hydroxylase
|
–
|
| |
BRENDA:
BR52445
KEGG:
R12129
|
|
