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reductive TCA cycle II

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
cis-aconitate + H2O <=> isocitrate 4.2.1.3 aconitate hydratase

citrate + CoA + ATP <=> (3S)-citryl-CoA + ADP + phosphate 6.2.1.18 citrate---CoA ligase

(S)-malate <=> fumarate + H2O 4.2.1.2 fumarate hydratase
4.2.1.34 (S)-2-methylmalate dehydratase


succinate + CoA + ATP <=> succinyl-CoA + ADP + phosphate 6.2.1.13 acetate---CoA ligase (ADP-forming)
6.2.1.4 succinate---CoA ligase (GDP-forming)
6.2.1.5 succinate---CoA ligase (ADP-forming)



pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.1 pyruvate synthase
1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)



(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase











isocitrate + NAD+ <=> oxalosuccinate + NADH + H+ 1.1.1

menaquinol + fumarate <=> menaquinone + succinate 1.3.5.1 succinate dehydrogenase
1.3.5.4 fumarate reductase (quinol)


citrate <=> cis-aconitate + H2O 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3 aconitate hydratase


ATP + 2-oxoglutarate + CO2 + H2O <=> oxalosuccinate + ADP + phosphate + H+ 6.4.1.7 2-oxoglutarate carboxylase

2-oxoglutarate + CoA + oxidized_ferredoxin <=> succinyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.3 2-oxoglutarate synthase


(3S)-citryl-CoA <=> oxaloacetate + acetyl-CoA 4.1.3.34 citryl-CoA lyase

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