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protein N-glycosylation initial phase (eukaryotic)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
GDP-mannose + alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+ 2.4.1.131 GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

dolichyl_phosphate_D-mannose + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl_phosphate + H+ 2.4.1.259 dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP-mannose <=> alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + H+ + GDP 2.4.1.257 GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

UDP-glucose + dolichyl_phosphate <=> dolichyl_beta-D-glucosyl_phosphate + UDP 2.4.1.117 dolichyl-phosphate beta-glucosyltransferase

GDP-mannose + dolichyl_phosphate <=> dolichyl_phosphate_D-mannose + GDP 2.4.1.54 undecaprenyl-phosphate mannosyltransferase
2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase


N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-D-glucosamine <=> diphosphodolichyl-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine + H+ + UDP 2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

GDP-mannose + diphosphodolichyl-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine <=> beta-(1->4)-D-mannosylchitobiosyldiphosphodolichol + GDP + H+ 2.4.1
2.4.1.142 chitobiosyldiphosphodolichol beta-mannosyltransferase


dolichyl_phosphate_D-mannose + alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl_phosphate + H+ 2.4.1.261 dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol not assigned

dolichyl_phosphate_D-mannose + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl_phosphate + H+ 2.4.1.258 dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase

dolichyl_beta-D-glucosyl_phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl_phosphate + H+ 2.4.1.265 dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase

GDP-mannose + beta-(1->4)-D-mannosylchitobiosyldiphosphodolichol <=> alpha-D-Man-(1rarr3)-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H+ 2.4.1.132 GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase

dolichyl_phosphate_D-mannose <=> dolichyl_phosphate_D-mannose not assigned

dolichyl_beta-D-glucosyl_phosphate + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl_phosphate + H+ 2.4.1.267 dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase

dolichyl_phosphate_D-mannose + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Man-a-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl_phosphate + H+ 2.4.1.260 dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + [protein]-L-asparagine <=> dolichyl_diphosphate + Glc3Man9GlcNAc2-[protein] + H+ 2.4.99.18 dolichyl-diphosphooligosaccharide---protein glycotransferase

dolichyl_beta-D-glucosyl_phosphate <=> dolichyl_beta-D-glucosyl_phosphate not assigned

dolichyl_beta-D-glucosyl_phosphate + alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol <=> alpha-D-Glc-(1rarr2)-alpha-D-Glc-(1rarr3)-alpha-D-Glc-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr6)]-alpha-D-Man-(1rarr6)]-beta-D-Man-(1rarr4)-beta-D-GlcNAc-(1rarr4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl_phosphate + H+ 2.4.1.256 dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase

UDP-N-acetyl-D-glucosamine + dolichyl_phosphate <=> N-acetyl-D-glucosaminyl-diphosphodolichol + UMP 2.7.8.15 UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminephosphotransferase

Visualization of the pathway