|
|
campesterol + NADP+ <=> H+ + crinosterol + NADPH
|
1.3.1
|
–
|
|
MetaCyc:
RXN-4242
|
|
|
|
4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD+ <=> avenastenone + NADH + CO2
|
1.1.1.418
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
KEGG:
R12376
MetaCyc:
RXN-11938
|
|
|
|
30-oxoobtusifoliol + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + H2O + oxidized_[NADPH-hemoprotein_reductase] + H+
|
1.14.14
|
–
|
|
MetaCyc:
RXN-19833
|
|
|
|
4alpha-formylergosta-7,24(241)-dien-3beta-ol + O2 + ferricytochrome_b5 + H+ <=> 3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + ferricytochrome_b5 + H2O
|
1.14.18.11
plant 4alpha-monomethylsterol monooxygenase
|
–
|
|
BRENDA:
BR52730
KEGG:
R12374
MetaCyc:
RXN-11932
|
|
|
|
4alpha-formyl-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.10
plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase
|
–
|
|
BRENDA:
BR52726
KEGG:
R12370
MetaCyc:
RXN-11927
|
|
|
|
24-methylene_cholesterol + NADP+ <=> 5-dehydroepisterol + NADPH + H+
|
1.3.1.21
7-dehydrocholesterol reductase
|
–
|
|
MetaCyc:
RXN-707
|
|
|
|
24(28)-methylene_cycloartanol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.10
plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase
|
–
|
|
BRENDA:
BR52724
KEGG:
R12368
MetaCyc:
RXN-11926
|
|
|
|
cycloeucalenol <=> obtusifoliol
|
5.5.1.9
cycloeucalenol cycloisomerase
|
–
|
|
BRENDA:
BR267
KEGG:
R03775
MetaCyc:
CYCLOEUCALENOL-CYCLOISOMERASE-RXN
|
|
|
|
cycloeucalenol + NADP+ <=> cycloeucalenone + NADPH + H+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
BRENDA:
BS188009
KEGG:
R12399
MetaCyc:
RXN-11929
|
|
|
|
30-hydroxyobtusifoliol + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 30-oxoobtusifoliol + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
not assigned
|
–
|
|
MetaCyc:
RXN-19832
|
|
|
|
24(28)-methylene_lophenol <=> 4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol
|
5.3.3.5
cholestenol Delta-isomerase
|
–
|
|
BRENDA:
BS418315
KEGG:
R07484
MetaCyc:
RXN-4161
|
|
|
|
24-methyldesmosterol + reduced_acceptor <=> ergosta-5-enol + acceptor
|
1.3
|
–
|
|
MetaCyc:
RXN-8353
|
|
|
|
H+ + Delta24-25-sitosterol + NADPH <=> sitosterol + NADP+
|
not assigned
|
–
|
|
MetaCyc:
RXN-4224
|
|
|
|
4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + H2O
|
not assigned
|
–
|
|
MetaCyc:
RXN-11936
|
|
|
|
H+ + 24-methyldesmosterol + NADPH <=> campesterol + NADP+
|
1.3
|
–
|
|
MetaCyc:
RXN-708
|
|
|
|
episterol + O2 + ferricytochrome_b5 + H+ <=> 5-dehydroepisterol + H2O + ferricytochrome_b5
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
|
BRENDA:
BS428606
KEGG:
R07491;
R07505
MetaCyc:
RXN3O-218
|
|
|
|
ergosta-5-enol + reduced_[NADPH-hemoprotein_reductase] + O2 <=> brassicasterol + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.19.41
sterol 22-desaturase
|
–
|
|
MetaCyc:
RXN-8352
|
|
|
|
24-ethylidenelophenol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + H2O
|
not assigned
|
–
|
|
MetaCyc:
RXN-11935
|
|
|
|
avenasterol + NADP+ <=> avenastenone + NADPH + H+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
BRENDA:
BS188006
KEGG:
R12401
MetaCyc:
RXN-11939
|
|
|
|
3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + NAD+ <=> Episterone + NADH + CO2
|
1.1.1.418
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
KEGG:
R12375
MetaCyc:
RXN-11933
|
|
|
|
avenasterol + ferricytochrome_b5 + O2 + H+ <=> DELTA5,7-avenasterol + ferricytochrome_b5 + H2O
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
|
KEGG:
R07486
MetaCyc:
RXN-4209
|
|
|
|
24(28)-methylene_lophenol + O2 + ferricytochrome_b5 + H+ <=> 4alpha-(hydroxymethyl)ergosta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.11
plant 4alpha-monomethylsterol monooxygenase
|
–
|
|
BRENDA:
BR52728
KEGG:
R12372
MetaCyc:
RXN-11930
|
|
|
|
isofucosterol + NADP+ <=> DELTA5,7-avenasterol + NADPH + H+
|
1.3.1.21
7-dehydrocholesterol reductase
|
–
|
|
MetaCyc:
RXN-4210
|
|
|
|
S-adenosyl-L-methionine + Cycloartenol <=> H+ + S-adenosyl-L-homocysteine + 24(28)-methylene_cycloartanol
|
2.1.1.142
cycloartenol 24-C-methyltransferase
2.1.1.41
sterol 24-C-methyltransferase
|
–
–
|
|
BRENDA:
BS377685
KEGG:
R07481
MetaCyc:
RXN-4021
SABIO-RK:
12309
|
|
|
|
sitosterol + reduced_[NADPH-hemoprotein_reductase] + O2 <=> stigmasterol + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.19.41
sterol 22-desaturase
|
–
|
|
MetaCyc:
RXN-4243
|
|
|
|
4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD+ <=> cycloeucalenone + NADH + CO2
|
1.1.1.418
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
BRENDA:
BS446830
KEGG:
R12371
MetaCyc:
RXN-11928
|
|
|
|
4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol + NADP+ <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
|
1.3.1.70
Delta14-sterol reductase
|
–
|
|
BRENDA:
BS370809
KEGG:
R07483
MetaCyc:
RXN-4144
|
|
|
|
obtusifoliol + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 30-hydroxyobtusifoliol + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
not assigned
|
–
|
|
MetaCyc:
RXN-19831
|
|
|
|
S-adenosyl-L-methionine + 24(28)-methylene_lophenol <=> H+ + 24-ethylidenelophenol + S-adenosyl-L-homocysteine
|
2.1.1.142
cycloartenol 24-C-methyltransferase
2.1.1.143
24-methylenesterol C-methyltransferase
2.1.1.41
sterol 24-C-methyltransferase
|
–
–
–
|
|
BRENDA:
BR33800
KEGG:
R05776
MetaCyc:
2.1.1.143-RXN
SABIO-RK:
5368
|
|
|
|
4alpha-(hydroxymethyl)ergosta-7,24(241)-dien-3beta-ol + O2 + ferricytochrome_b5 + H+ <=> 4alpha-formylergosta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.11
plant 4alpha-monomethylsterol monooxygenase
|
–
|
|
BRENDA:
BR52729
KEGG:
R12373
MetaCyc:
RXN-11931
|
|
|
|
4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-formyl-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.10
plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase
|
–
|
|
BRENDA:
BR52725
KEGG:
R12369
MetaCyc:
RXN-11925
|
|
|
|
24-methylene_cholesterol <=> 24-methyldesmosterol
|
not assigned
|
–
|
|
MetaCyc:
RXN-4222
|
|
|
|
isofucosterol <=> Delta24-25-sitosterol
|
not assigned
|
–
|
|
MetaCyc:
RXN-4221
|
|
|
|
4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + H2O
|
not assigned
|
–
|
|
MetaCyc:
RXN-11937
|
|
|
|
Episterone + NADPH + H+ <=> episterol + NADP+
|
1.1.1
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
–
|
|
KEGG:
R12400
MetaCyc:
RXN-11934
|
|