|
|
3-hydroxypropanoyl-[acp] + malonyl-[acyl-carrier_protein] + NADPH + H+ <=> 9-hydroxynonanoyl-[acp] + CO2 + [acyl-carrier_protein] + NADP+ + H2O
|
2.3.1.M63
|
–
|
| |
MetaCyc:
RXN-19853
|
|
|
|
(5S,6S,7R,8R,10E,12R,13S)-3-(carboxymethyl)-3,5,6,7,13-pentahydroxy-8,12-dimethyltetradec-10-enoyl-[acp] <=> (2Z,5S,6S,7R,8R,10E,12R,13S)-3-(carboxymethyl)-5,6,7,13-tetrahydroxy-8,12-dimethyltetradeca-2,10-dienoyl-[acp] + H2O
|
4.2.1.M23
|
–
|
| |
MetaCyc:
RXN-19851
|
|
|
|
deoxymupirocin_P <=> deoxymupirocin_C + H2O
|
4.2.1.M24
|
–
|
| |
MetaCyc:
RXN-19875
|
|
|
|
(2Z,5S,6S,7R,8R,10E,12R,13S)-3-(carboxymethyl)-5,6,7,13-tetrahydroxy-8,12-dimethyltetradeca-2,10-dienoyl-[acp] + H+ <=> (2E,5S,6S,7R,8R,10E,12R,13S)-5,6,7,13-tetrahydroxy-3,8,12-trimethyltetradeca-2,10-dienoyl-[acp] + CO2
|
4.1.1.M16
|
–
|
| |
MetaCyc:
RXN-19852
|
|
|
|
S-adenosyl-L-methionine + soluble_holo-[acyl-carrier_protein] + acetyl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + NADPH + H+ <=> (3S,4R,6E,8R,9S)-3,9-dihydroxy-4,8-dimethyldec-6-enoyl-[acp] + CO2 + S-adenosyl-L-homocysteine + NADP+ + H2O + [acyl-carrier_protein]
|
2.3.1.M60
|
–
|
| |
MetaCyc:
RXN-19848
|
|
|
|
pseudomonic_acid_A + NADP+ <=> mupirocin_F1 + NADPH + H+
|
1.1.1.M51
|
–
|
| |
MetaCyc:
RXN-19861
|
|
|
|
pseudomonic_acid_C + NADP+ <=> deoxymupirocin_F + NADPH + H+
|
1.1.1.M51
|
–
|
| |
MetaCyc:
RXN-19871
|
|
|
|
ATP + deoxypseudomonate_B + [acyl-carrier_protein] <=> AMP + diphosphate + deoxypseudomonate_B-[mAcpE]
|
6.3.2.M13
|
–
|
| |
MetaCyc:
RXN-19873
|
|
|
|
malonyl-CoA + [acyl-carrier_protein] <=> CoA + malonyl-[acyl-carrier_protein]
|
2.3.1
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
2.3.1.85
fatty-acid synthase system
2.3.1.86
fatty-acyl-CoA synthase system
|
–
–
–
–
|
| |
BRENDA:
BR44039
KEGG:
R01626
MetaCyc:
MALONYL-COA-ACP-TRANSACYL-RXN
SABIO-RK:
1767
|
|
|
|
deoxypseudomonate_B-[mAcpE] + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> deoxymupirocin_P-[acp] + H2O + oxidized_ferredoxin
|
1.14.15.M8
|
–
|
| |
MetaCyc:
RXN-19867
|
|
|
|
(2E,5S,6S,7R,8R,10E,12R,13S)-5,6,7,13-tetrahydroxy-3,8,12-trimethyltetradeca-2,10-dienoyl-[acp] + O2 <=> (2E)-3-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxy-5-[(2E,4R,5S)-5-hydroxy-4-methylhex-2-en-1-yl]oxan-2-yl]but-2-enoyl-[acp] + H2O
|
1.13.12.M4
|
–
|
| |
MetaCyc:
RXN-19865
|
|
|
|
(5S,6S,7R,8R,10E,12R,13S)-5,6,7,13-tetrahydroxy-8,12-dimethyl-3-oxotetradec-10-enoyl-[acp] + acetyl-[acyl-carrier_protein] + H2O <=> (5S,6S,7R,8R,10E,12R,13S)-3-(carboxymethyl)-3,5,6,7,13-pentahydroxy-8,12-dimethyltetradec-10-enoyl-[acp] + [acyl-carrier_protein] + H+
|
2.3.1.M62
|
–
|
| |
MetaCyc:
RXN-19850
|
|
|
|
deoxymupirocin_F + NADP+ <=> deoxymupirocin_C + NADPH + H+
|
1.1.1.M50
|
–
|
| |
MetaCyc:
RXN-19870
|
|
|
|
(2E)-3-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxy-5-[(2E,4R,5S)-5-hydroxy-4-methylhex-2-en-1-yl]oxan-2-yl]but-2-enoyl-[acp] + 9-hydroxynonanoyl-[acp] + H2O <=> deoxypseudomonate_B + [acyl-carrier_protein] + H+
|
2.3.1.M63
|
–
|
| |
MetaCyc:
RXN-19866
|
|
|
|
(3S,4R,6E,8R,9S)-3,9-dihydroxy-4,8-dimethyldec-6-enoyl-[acp] + malonyl-[acyl-carrier_protein] + NADPH + H+ <=> (5R,7S,8R,10E,12R,13S)-5,7,13-trihydroxy-8,12-dimethyl-3-oxotetradec-10-enoyl-[acp] + CO2 + [acyl-carrier_protein] + NADP+
|
2.3.1.M61
|
–
|
| |
MetaCyc:
RXN-19849
|
|
|
|
malonyl-[acyl-carrier_protein] + H+ <=> acetyl-[acyl-carrier_protein] + CO2
|
2.3.1.41
beta-ketoacyl-[acyl-carrier-protein] synthase I
4.1.1.87
malonyl-S-ACP decarboxylase
4.1.1.M15
|
–
–
–
|
| |
BRENDA:
BR48970
KEGG:
R09482
MetaCyc:
MALONYL-ACPDECARBOX-RXN
|
|
|
|
(5R,7S,8R,10E,12R,13S)-5,7,13-trihydroxy-8,12-dimethyl-3-oxotetradec-10-enoyl-[acp] + O2 + NADPH + H+ <=> (5S,6S,7R,8R,10E,12R,13S)-5,6,7,13-tetrahydroxy-8,12-dimethyl-3-oxotetradec-10-enoyl-[acp] + H2O + NADP+
|
1.14.13.M68
|
–
|
| |
MetaCyc:
RXN-19857
|
|
|
|
mupirocin_P <=> mupirocin_C1 + H2O
|
4.2.1.M24
|
–
|
| |
MetaCyc:
RXN-19862
|
|
|
|
(2E)-3-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxy-5-({3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl)oxan-2-yl]but-2-enoyl-[acp] + 9-hydroxynonanoyl-[acp] + H2O <=> pseudomonate_B + [acyl-carrier_protein] + H+
|
2.3.1.M63
|
–
|
| |
MetaCyc:
RXN-19860
|
|
|
|
mupirocin_P-[acp] + H2O <=> mupirocin_P + [acyl-carrier_protein] + H+
|
3.1.2.M5
|
–
|
| |
MetaCyc:
RXN-19864
|
|
|
|
(2E,5S,6S,7R,8R,10E,12R,13S)-5,6,7,13-tetrahydroxy-3,8,12-trimethyltetradeca-2,10-dienoyl-[acp] + O2 + NADPH + H+ <=> (2E,5S,6S,7R,8R)-5,6,7-trihydroxy-9-{3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}-3,8-dimethylnon-2-enoyl-[acp] + H2O + NADP+
|
1.14.13.M69
|
–
|
| |
MetaCyc:
RXN-19858
|
|
|
|
(2E,5S,6S,7R,8R)-5,6,7-trihydroxy-9-{3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}-3,8-dimethylnon-2-enoyl-[acp] + O2 <=> (2E)-3-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxy-5-({3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl)oxan-2-yl]but-2-enoyl-[acp] + H2O
|
1.13.12.M4
|
–
|
| |
MetaCyc:
RXN-19859
|
|
|
|
pseudomonate_B-[mAcpE] + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> mupirocin_P-[acp] + H2O + oxidized_ferredoxin
|
1.14.15.M8
|
–
|
| |
MetaCyc:
RXN-19863
|
|
|
|
ATP + pseudomonate_B + [acyl-carrier_protein] <=> AMP + diphosphate + pseudomonate_B-[mAcpE]
|
6.3.2.M13
|
–
|
| |
MetaCyc:
RXN-19872
|
|
|
|
mupirocin_F1 + NADP+ <=> mupirocin_C1 + NADPH + H+
|
1.1.1.M50
|
–
|
| |
MetaCyc:
RXN-19874
|
|
|
|
deoxymupirocin_P-[acp] + H2O <=> deoxymupirocin_P + [acyl-carrier_protein] + H+
|
3.1.2.M5
|
–
|
| |
MetaCyc:
RXN-19869
|
|
