Copied!

Pathway Search



mithramycin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
3,5,7,9,11,13,15,17,19-nonaoxoicosanoyl-[PKS-acp] <=> 6-[5-hydroxy-3-oxo-2-(3,5,7-trioxooctanoyl)phenyl]-3,5-dioxohexanoyl-[PKS-acp] + H2O 4.2.1

(4S)-2-acetyl-3,4,8,10,11,12-hexahydroxy-1,4-dihydrotetracen-1-one + O2 + NADPH + H+ <=> 4-demethylpremithracinone + H2O + NADP+ not assigned

Premithramycinone + dTDP-D-boivinose <=> Premithramycin_A1 + dTDP + H+ 2.4.1

3A-Deolivosylpremithramycin_B + dTDP-D-boivinose <=> Premithramycin_B + dTDP + H+ 2.4.1

6-[5-hydroxy-3-oxo-2-(3,5,7-trioxooctanoyl)phenyl]-3,5-dioxohexanoyl-[PKS-acp] <=> 2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + H2O not assigned

Premithramycin_A3 + dTDP-D-boivinose <=> 3A-Deolivosylpremithramycin_B + dTDP + H+ 2.4.1

S-adenosyl-L-methionine + 4-demethylpremithracinone <=> Premithramycinone + S-adenosyl-L-homocysteine + H+ 2.1.1

mithramycin + NADP+ <=> Mithramycin_DK + NADPH + H+ 1.1.1

Premithramycin_A2' + dTDP-D-mycarose <=> Premithramycin_A3 + dTDP + H+ 2.4.1

(2S)-2-hydroxy-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] <=> (4S)-2-acetyl-3,4,8,10,11,12-hexahydroxy-1,4-dihydrotetracen-1-one + polyketide-[acp] + H+ not assigned

Premithramycin_B + O2 + NADPH + H+ <=> premithramycin_B_lactone + H2O + NADP+ 1.14.13

2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + O2 <=> 2-oxo-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + H2O 1.13.99

S-adenosyl-L-methionine + Premithramycin_A3 <=> Premithramycin_A3 + S-adenosyl-L-homocysteine + H+ 2.1.1

(2S)-2-hydroxy-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + NADP+ <=> 2-oxo-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + NADPH + H+ 1.1.1

polyketide-[acp] + acetyl-CoA + malonyl-CoA + H+ <=> 3,5,7,9,11,13,15,17,19-nonaoxoicosanoyl-[PKS-acp] + CO2 + CoA 2.3.1

premithramycin_B_lactone + H2O <=> Mithramycin_DK + CO2 not assigned

Premithramycin_A1 + dTDP-D-oliose <=> Premithramycin_A2' + dTDP + H+ 2.4.1

Visualization of the pathway