|
|
3,5,7,9,11,13,15,17,19-nonaoxoicosanoyl-[PKS-acp] <=> 6-[5-hydroxy-3-oxo-2-(3,5,7-trioxooctanoyl)phenyl]-3,5-dioxohexanoyl-[PKS-acp] + H2O
|
4.2.1
|
–
|
| |
MetaCyc:
RXN-17999
|
|
|
|
(4S)-2-acetyl-3,4,8,10,11,12-hexahydroxy-1,4-dihydrotetracen-1-one + O2 + NADPH + H+ <=> 4-demethylpremithracinone + H2O + NADP+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-13389
|
|
|
|
Premithramycinone + dTDP-D-boivinose <=> Premithramycin_A1 + dTDP + H+
|
2.4.1
|
–
|
| |
KEGG:
R06716
MetaCyc:
RXN-13375
|
|
|
|
3A-Deolivosylpremithramycin_B + dTDP-D-boivinose <=> Premithramycin_B + dTDP + H+
|
2.4.1
|
–
|
| |
KEGG:
R09352
MetaCyc:
RXN-13381
|
|
|
|
6-[5-hydroxy-3-oxo-2-(3,5,7-trioxooctanoyl)phenyl]-3,5-dioxohexanoyl-[PKS-acp] <=> 2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + H2O
|
not assigned
|
–
|
| |
MetaCyc:
RXN-18000
|
|
|
|
Premithramycin_A3 + dTDP-D-boivinose <=> 3A-Deolivosylpremithramycin_B + dTDP + H+
|
2.4.1
|
–
|
| |
KEGG:
R09351
MetaCyc:
RXN-13380
|
|
|
|
S-adenosyl-L-methionine + 4-demethylpremithracinone <=> Premithramycinone + S-adenosyl-L-homocysteine + H+
|
2.1.1
|
–
|
| |
MetaCyc:
RXN-13390
|
|
|
|
mithramycin + NADP+ <=> Mithramycin_DK + NADPH + H+
|
1.1.1
|
–
|
| |
MetaCyc:
RXN-13385
|
|
|
|
Premithramycin_A2' + dTDP-D-mycarose <=> Premithramycin_A3 + dTDP + H+
|
2.4.1
|
–
|
| |
KEGG:
R06718
MetaCyc:
RXN-13377
|
|
|
|
(2S)-2-hydroxy-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] <=> (4S)-2-acetyl-3,4,8,10,11,12-hexahydroxy-1,4-dihydrotetracen-1-one + polyketide-[acp] + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-13388
|
|
|
|
Premithramycin_B + O2 + NADPH + H+ <=> premithramycin_B_lactone + H2O + NADP+
|
1.14.13
|
–
|
| |
MetaCyc:
RXN-13382
|
|
|
|
2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + O2 <=> 2-oxo-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + H2O
|
1.13.99
|
–
|
| |
MetaCyc:
RXN-13386
|
|
|
|
S-adenosyl-L-methionine + Premithramycin_A3 <=> Premithramycin_A3 + S-adenosyl-L-homocysteine + H+
|
2.1.1
|
–
|
| |
KEGG:
R06719
MetaCyc:
RXN-13378
SABIO-RK:
6294
|
|
|
|
(2S)-2-hydroxy-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + NADP+ <=> 2-oxo-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + NADPH + H+
|
1.1.1
|
–
|
| |
MetaCyc:
RXN-13387
|
|
|
|
polyketide-[acp] + acetyl-CoA + malonyl-CoA + H+ <=> 3,5,7,9,11,13,15,17,19-nonaoxoicosanoyl-[PKS-acp] + CO2 + CoA
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-13383
|
|
|
|
premithramycin_B_lactone + H2O <=> Mithramycin_DK + CO2
|
not assigned
|
–
|
| |
MetaCyc:
RXN-13384
|
|
|
|
Premithramycin_A1 + dTDP-D-oliose <=> Premithramycin_A2' + dTDP + H+
|
2.4.1
|
–
|
| |
KEGG:
R06717
MetaCyc:
RXN-13376
|
|
