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icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + NAD+ <=> (2E,11Z,14Z,17Z)-icosatetraenoyl-CoA + NADH + H+ 1.3.1.93 very-long-chain enoyl-CoA reductase
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(3R,11Z,14Z,17Z)-3-hydroxyicosatrienoyl-CoA + NADP+ <=> (11Z,14Z,17Z)-3-oxoicosatrienoyl-CoA + NADPH + H+ 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase
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(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + glycerolipid <=> [glycerolipid]-(11Z,14Z,17Z)-icosatrienoate + CoA 2.3.1
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(3R,11Z,14Z,17Z)-3-hydroxyicosatrienoyl-CoA <=> (2E,11Z,14Z,17Z)-icosatetraenoyl-CoA + H2O 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
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malonyl-CoA + linolenoyl-CoA + H+ <=> (11Z,14Z,17Z)-3-oxoicosatrienoyl-CoA + CoA + CO2 2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase
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[glycerolipid]-(11Z,14Z,17Z)-icosatrienoate + O2 + ferricytochrome_b5 + H+ <=> [glycerolipid]-(8Z,11Z,14Z,17Z)-icosatetraenoate + H2O + ferricytochrome_b5 1.14.19.4 acyl-lipid (11-3)-desaturase
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[glycerolipid]-(8Z,11Z,14Z,17Z)-icosatetraenoate + O2 + ferricytochrome_b5 + H+ <=> [glycerolipid]-(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + H2O + ferricytochrome_b5 1.14.19.30 acyl-lipid (8-3)-desaturase
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