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Histidine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
L-histidine <=> NH3 + Urocanate 4.3.1.3 histidine ammonia-lyase
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H2O + N-formimino-L-glutamate <=> L-glutamate + Formamide 3.5.3.8 formimidoylglutamase
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DL-5-(2-carboxyethyl)hydantoin + H2O <=> N-carbamoyl-L-glutamate not assigned
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3-(1H-imidazol-4-yl)propanoic_acid + acceptor <=> Urocanate + reduced_acceptor 1.3.99.33 urocanate reductase
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N-formyl-L-glutamate + H2O <=> L-glutamate + formate 3.5.1.68 N-formylglutamate deformylase
3.5.1.8 formylaspartate deformylase
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4,5-dihydro-4-oxo-5-imidazolepropanoate <=> Urocanate + H2O 4.2.1.49 urocanate hydratase
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D-erythro-1-(imidazol-4-yl)glycerol_3-phosphate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + H2O 4.2.1.19 imidazoleglycerol-phosphate dehydratase
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hercynine + gamma-Glu-L-Cys + O2 <=> S-(hercyn-2-yl)-gamma-L-glutamyl-L-cysteine_S-oxide + H2O 1.14.99.50 gamma-glutamyl hercynylcysteine S-oxide synthase
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L-Histidinol + NAD+ <=> H+ + L-histidinal + NADH 1.1.1.23 histidinol dehydrogenase
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L-Histidinol_phosphate + 2-oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + L-glutamate 2.6.1.9 histidinol-phosphate transaminase
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5-formimidoyltetrahydrofolate + L-glutamate <=> N-formimino-L-glutamate + tetrahydrofolate 2.1.2.5 glutamate formimidoyltransferase
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L-Histidinol_phosphate + H2O <=> L-Histidinol + phosphate 3.1.3.15 histidinol-phosphatase
3.1.3.2 acid phosphatase
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H2O + N-formimino-L-aspartate <=> NH3 + N-formyl-L-aspartate 3.5.3.13 formimidoylglutamate deiminase
3.5.3.5 formimidoylaspartate deiminase
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5'-phosphoribosylimidazoleacetate + H2O <=> (1-Ribosylimidazole)-4-acetate + phosphate not assigned
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H2O + N-formimino-L-glutamate <=> NH3 + N-formyl-L-glutamate 3.5.3.13 formimidoylglutamate deiminase
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H+ + L-histidine <=> CO2 + histamine 4.1.1.22 histidine decarboxylase
4.1.1.53 phenylalanine decarboxylase
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3-(1H-imidazol-4-yl)-2-oxopropanoate <=> 1H-imidazol-4-ylacetaldehyde + CO2 not assigned
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4,5-dihydro-4-oxo-5-imidazolepropanoate + H2O <=> formyl-isoglutamine 0.0.0.0
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hercynine + L-cysteine + O2 <=> S-(hercyn-2-yl)-L-cysteine_S-oxide + H2O 1.14.99.51 hercynylcysteine S-oxide synthase
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N-1-(5'-phosphoribosyl)-ATP + diphosphate <=> ATP + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.17 ATP phosphoribosyltransferase
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phosphoribulosylformimino-AICAR-phosphate + L-glutamine <=> H+ + L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol_3-phosphate + 5-aminoimidazole-4-carboxamide_ribonucleotide 2.4.2
4.3.1.B2
4.3.2.10 imidazole glycerol-phosphate synthase
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S-adenosyl-L-methionine + histamine <=> H+ + S-adenosyl-L-homocysteine + 1-Methylhistamine 2.1.1.8 histamine N-methyltransferase
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L-histidine + 2-oxoglutarate <=> L-glutamate + 3-(1H-imidazol-4-yl)-2-oxopropanoate 2.6.1.27 tryptophan transaminase
2.6.1.38 histidine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.9 histidinol-phosphate transaminase
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4,5-dihydro-4-oxo-5-imidazolepropanoate + H2O <=> N-formimino-L-glutamate 3.5.2.7 imidazolonepropionase
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ergothioneine <=> Thiourocanic_acid + trimethylamine not assigned
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acetyl-CoA + histamine <=> CoA + N-omega-acetylhistamine 2.3.1
2.3.1.5 arylamine N-acetyltransferase
2.3.1.57 diamine N-acetyltransferase
2.3.1.87 aralkylamine N-acetyltransferase
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L-histidine + S-adenosyl-L-methionine <=> 1-methylhistidine + S-adenosyl-L-homocysteine 2.1.1
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4-oxoglutaramate + H2O <=> 2-oxoglutarate + NH3 0.0.0.0
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N-1-(5'-phosphoribosyl)-ATP + H2O <=> 1-(5-phosphoribosyl)-AMP + diphosphate + H+ 3.6.1.31 phosphoribosyl-ATP diphosphatase
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1-(5-phosphoribosyl)-AMP + H2O <=> N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide_ribonucleotide 3.5.4.19 phosphoribosyl-AMP cyclohydrolase
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S-(hercyn-2-yl)-L-cysteine_S-oxide + reduced_acceptor <=> ergothioneine + pyruvate + NH3 + acceptor 4.4.1.36 hercynylcysteine S-oxide lyase
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ATP + 1-methylhistidine + beta-Alanine <=> ADP + phosphate + anserine 6.3.2.11 carnosine synthase
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carnosine + H2O <=> beta-Alanine + L-histidine 3.4.11.25 beta-peptidyl aminopeptidase
3.4.13.18 cytosol nonspecific dipeptidase
3.4.13.20 beta-Ala-His dipeptidase
3.4.13.5 Xaa-methyl-His dipeptidase
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4,5-dihydro-4-oxo-5-imidazolepropanoate + H2O <=> 4-oxoglutaramate + formate + NH3 0.0.0.0
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histamine + H2O + O2 <=> 1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 1.4.3.10 putrescine oxidase
1.4.3.21 primary-amine oxidase
1.4.3.22 diamine oxidase
1.4.3.4 monoamine oxidase
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H2O + anserine <=> 1-methylhistidine + beta-Alanine 3.4.13.20 beta-Ala-His dipeptidase
3.4.13.5 Xaa-methyl-His dipeptidase
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S-adenosyl-L-methionine + L-histidine <=> hercynine + S-adenosyl-L-homocysteine + H+ 2.1.1.44 L-histidine Nalpha-methyltransferase
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S-(hercyn-2-yl)-gamma-L-glutamyl-L-cysteine_S-oxide + H2O <=> S-(hercyn-2-yl)-L-cysteine_S-oxide + L-glutamate 3.5.1.118 gamma-glutamyl hercynylcysteine S-oxide hydrolase
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N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide_ribonucleotide <=> phosphoribulosylformimino-AICAR-phosphate 5.3.1.16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
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1-Methylhistamine + H2O + O2 <=> 1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 1.4.3.22 diamine oxidase
1.4.3.4 monoamine oxidase
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beta-Alanine + L-histidine + ATP <=> H+ + carnosine + ADP + phosphate 6.3.2.11 carnosine synthase
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L-histidinal + NAD+ + H2O <=> H+ + L-histidine + NADH 1.1.1.23 histidinol dehydrogenase
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5-phospho-alpha-D-ribose_1-diphosphate + imidazoleacetate + ATP + H2O <=> phosphate + diphosphate + 5'-phosphoribosylimidazoleacetate + ADP + H+ 6.3.4.8 imidazoleacetate---phosphoribosyldiphosphate ligase
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1H-imidazol-4-ylacetaldehyde + H2O + NAD+ <=> imidazoleacetate + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
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4,5-dihydro-4-oxo-5-imidazolepropanoate + O2 + H2O <=> DL-5-(2-carboxyethyl)hydantoin + H2O2 1.14.13
1.17.3
1.17.3.2 xanthine oxidase
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imidazoleacetate + NADH + O2 <=> 5-hydroxy-4-imidazoleacetate + NAD+ + H2O 1.14.13.5 imidazoleacetate 4-monooxygenase
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H2O + N-formyl-L-aspartate <=> L-aspartate + formate 3.5.1.15 aspartoacylase
3.5.1.8 formylaspartate deformylase
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N-carbamoyl-L-glutamate + H2O <=> L-glutamate + CO2 + NH3 3.5.1.87 N-carbamoyl-L-amino-acid hydrolase
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N-formimino-L-aspartate <=> 5-hydroxy-4-imidazoleacetate + H2O 3.5.2
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1-methyl-1H-imidazol-4-ylacetaldehyde + NAD+ + H2O <=> Methylimidazoleacetic_acid + NADH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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S-adenosyl-L-methionine + carnosine <=> H+ + S-adenosyl-L-homocysteine + anserine 2.1.1.22 carnosine N-methyltransferase
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formyl-isoglutamine + H2O <=> L-isoglutamine not assigned
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3-(imidazol-5-yl)lactate + NAD+ <=> 3-(1H-imidazol-4-yl)-2-oxopropanoate + NADH + H+ 1.1.1.111 3-(imidazol-5-yl)lactate dehydrogenase
1.1.1.27 L-lactate dehydrogenase
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Visualization of the pathway