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diphthamide biosynthesis I (archaea)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
diphthine + NH3 + ATP <=> H+ + diphthamide-[translation_elongation_factor_2] + AMP + diphosphate 6.3.1.14 diphthine---ammonia ligase

S-adenosyl-L-methionine + L-histidine-[translation_elongation_factor_2] <=> 2-(3-carboxy-3-aminopropyl)-L-histidine-[translation_elongation_factor_2] + S-methyl-5''-thioadenosine + H+ 2.5.1.108 2-(3-amino-3-carboxypropyl)histidine synthase

S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine-[translation_elongation_factor_2] <=> diphthine + S-adenosyl-L-homocysteine + H+ 2.1.1.98 diphthine synthase

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