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cannabinoid biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
hexanoyl-CoA + malonyl-CoA + H+ <=> 3,5-dioxodecanoyl-CoA + CoA + CO2 not assigned

hexanoate + ATP + CoA <=> hexanoyl-CoA + AMP + diphosphate 6.2.1.1 acetate---CoA ligase
6.2.1.12 4-coumarate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.3 long-chain-fatty-acid---CoA ligase
6.2.1.44 3-(methylthio)propionyl---CoA ligase





3,5,7-trioxododecanoyl-CoA <=> CoA + 2,4-dihydroxy-6-pentylbenzoate + H+ 4.4.1.26 olivetolic acid cyclase

H+ + cannabidiolate <=> cannabidiol + CO2 not assigned

3,5-dioxodecanoyl-CoA + malonyl-CoA + H+ <=> 3,5,7-trioxododecanoyl-CoA + CoA + CO2 not assigned

H+ + DELTA9-tetrahydrocannabinolate <=> DELTA9-tetrahydrocannabinol + CO2 not assigned

geranyl_diphosphate + 2,4-dihydroxy-6-pentylbenzoate <=> cannabigerolate + diphosphate 2.5.1.102 geranyl-pyrophosphate---olivetolic acid geranyltransferase

cannabigerolate + acceptor <=> cannabichromenate + reduced_acceptor 1.21.99

cannabigerolate + O2 <=> DELTA9-tetrahydrocannabinolate + H2O2 1.21.3.7 tetrahydrocannabinolic acid synthase

H+ + cannabichromenate <=> cannabichromene + CO2 not assigned

cannabigerolate + O2 <=> cannabidiolate + H2O2 1.21.3.3 reticuline oxidase
1.21.3.8 cannabidiolic acid synthase


Visualization of the pathway