|
|
lithocholic_acid + NAD+ <=> 3-oxo-5beta-cholan-24-oic_acid + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.52
3alpha-hydroxycholanate dehydrogenase (NAD+)
|
–
–
–
–
–
|
| |
BRENDA:
BR29316
KEGG:
R04139
MetaCyc:
1.1.1.52-RXN
SABIO-RK:
3860
|
|
|
|
7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD+ <=> 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
|
1.3.1.116
7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase
|
–
|
| |
BRENDA:
BR52900
KEGG:
R12111
MetaCyc:
RXN-17416
|
|
|
|
7beta-hydroxy-3-oxochol-4-enate <=> 3-oxochola-4,6-dien-24-oate + H2O
|
4.2.1.M3
|
–
|
| |
MetaCyc:
RXN-17419
|
|
|
|
3-oxochol-4-en-24-oate + NAD+ <=> 3-oxochola-4,6-dien-24-oate + NADH + H+
|
1.3.1.114
3-dehydro-bile acid Delta4,6-reductase
|
–
|
| |
MetaCyc:
RXN-21340
|
|
|
|
7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + cholic_acid <=> choloyl-CoA + 7beta-hydroxy-3-oxochol-4-enate
|
2.8.3.25
bile acid CoA-transferase
|
–
|
| |
MetaCyc:
RXN-21344
|
|
|
|
3-oxo-5beta-cholan-24-oic_acid + NAD+ <=> 3-oxochol-4-en-24-oate + NADH + H+
|
1.3.1.114
3-dehydro-bile acid Delta4,6-reductase
|
–
|
| |
MetaCyc:
RXN-21341
|
|
|
|
Ursodeoxycholoyl-CoA + NAD+ <=> 7beta-hydroxy-3-oxochol-24-oyl-CoA + NADH + H+
|
1.1.1.395
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase
|
–
|
| |
MetaCyc:
RXN-21343
|
|
|
|
ATP + ursodeoxycholate + CoA <=> AMP + diphosphate + Ursodeoxycholoyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
| |
MetaCyc:
RXN-21342
|
|
