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apicidin F biosynthesis
| State Icon | Reaction | EC-Number | Confidence maximal confidence score from EnzymeDetector | |
|---|---|---|---|---|
| acetyl-CoA + malonyl-CoA <=> 2-oxooctanoate |
not assigned |
–
|
||
| S-adenosyl-L-methionine + 9-N-hydroxy-L-tryptophan <=> 9-N-methoxy-tryptophan + S-adenosyl-L-homocysteine + H+ |
2.1.1
|
–
|
||
| apicidin_F-[acp] <=> apicidin_F + [acyl-carrier_protein] |
6.3.2
|
–
|
||
| L-lysine <=> DELTA1-piperidine_6-carboxylate |
not assigned |
–
|
||
| L-2-amino-8-hydroxyoctanoate <=> L-2-aminooctanedioate |
not assigned |
–
|
||
| 2-oxooctanoate <=> L-2-amino-8-hydroxyoctanoate |
not assigned |
–
|
||
| D-pipecolyl-[acp] + L-2-aminooctanedioate + 9-N-methoxy-tryptophan + L-phenylalanine + ATP <=> apicidin_F-[acp] + AMP + diphosphate + H+ |
6.3.2
|
–
|
||
| L-pipecolic_acid + NADP+ <=> DELTA1-piperidine_6-carboxylate + NADPH + H+ |
1.5.1
1.5.1.2 pyrroline-5-carboxylate reductase |
–
– |
||
| L-pipecolic_acid + [acyl-carrier_protein] + ATP <=> D-pipecolyl-[acp] + AMP + diphosphate |
6.3.2
|
–
|
||
| L-tryptophan + O2 + NADPH + H+ <=> 9-N-hydroxy-L-tryptophan + NADP+ + H2O |
1.14.13
|
–
|
||