|
|
5-carboxy-2-methyl-3-oxopentanoyl-CoA + acetyl-CoA <=> 7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA + CoA
|
2.3.1.16
acetyl-CoA C-acyltransferase
|
–
|
|
MetaCyc:
RXN-19804
|
|
|
|
succinyl-CoA + propionyl-CoA <=> 5-carboxy-2-methyl-3-oxopentanoyl-CoA + CoA
|
2.3.1
|
–
|
|
MetaCyc:
RXN-19805
|
|
|
|
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + acetyl-CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + CoA
|
2.3.1.16
acetyl-CoA C-acyltransferase
|
–
|
|
MetaCyc:
RXN-12751
|
|
|
|
5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADP+ <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADPH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
MetaCyc:
RXN-12747
|
|
|
|
(3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA <=> (2E)-7-carboxy-4-methyl-5-oxohept-2-enoyl-CoA + H2O
|
4.2.1.119
enoyl-CoA hydratase 2
|
–
|
|
MetaCyc:
RXN-19802
|
|
|
|
(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> (S)-4-hydroxy-2-oxohexanoate
|
4.2.1.132
2-hydroxyhexa-2,4-dienoate hydratase
|
–
|
|
MetaCyc:
RXN-12734
|
|
|
|
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
|
6.2.1.41
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase
|
–
|
|
BRENDA:
BR51067
KEGG:
R10769
MetaCyc:
RXN-12746
|
|
|
|
propionaldehyde + CoA + NAD+ <=> propionyl-CoA + NADH + H+
|
1.2.1.10
acetaldehyde dehydrogenase (acetylating)
1.2.1.27
methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
1.2.1.57
butanal dehydrogenase
1.2.1.87
propanal dehydrogenase (CoA-propanoylating)
|
–
–
–
–
|
|
BRENDA:
BR50602
KEGG:
R09097
MetaCyc:
RXN-12736
SABIO-RK:
10853
|
|
|
|
(S)-4-hydroxy-2-oxohexanoate <=> pyruvate + propionaldehyde
|
4.1.3.43
4-hydroxy-2-oxohexanoate aldolase
|
–
|
|
BRENDA:
BR50714
MetaCyc:
RXN-12735
|
|
|
|
4-androstene-3,17-dione + acceptor <=> 1,4-androstadiene-3,17-dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
BRENDA:
BS258852
KEGG:
R09884
MetaCyc:
RXN-12714
|
|
|
|
(3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O <=> 9-carboxy-6-methyl-3,7-dioxononanoyl-CoA
|
4.1.99
|
–
|
|
MetaCyc:
RXN-19799
|
|
|
|
4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid + H2O <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+
|
3.7.1.17
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
|
–
|
|
BRENDA:
BR49990
KEGG:
R09883
MetaCyc:
RXN-12718
|
|
|
|
7-carboxy-4-methyl-5-oxoheptanoyl-CoA + acetyl-CoA <=> 9-carboxy-6-methyl-3,7-dioxononanoyl-CoA + CoA
|
2.3.1.16
acetyl-CoA C-acyltransferase
|
–
|
|
MetaCyc:
RXN-19800
|
|
|
|
(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NAD+ <=> (5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NADH + H+
|
1.1.1
|
–
|
|
MetaCyc:
RXN-19797
|
|
|
|
3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + O2 + FMNH2 <=> H+ + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + FMN
|
1.14.14.12
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
|
–
|
|
BRENDA:
BR49866
KEGG:
R09819
MetaCyc:
RXN-12717
|
|
|
|
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> H+ + 4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid
|
1.13.11.25
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
|
–
|
|
BRENDA:
BR40480
KEGG:
R04597
MetaCyc:
1.13.11.25-RXN
SABIO-RK:
4266
|
|
|
|
5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + acceptor <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + reduced_acceptor
|
1.3.99
|
–
|
|
MetaCyc:
RXN-12748
|
|
|
|
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + H2O
|
4.2.1
|
–
|
|
MetaCyc:
RXN-12749
|
|
|
|
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA + NAD+ <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + NADH + H+
|
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
|
–
|
|
MetaCyc:
RXN-12750
|
|
|
|
9alpha-hydroxy-1,4-androstadiene_3,17-dione <=> 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione
|
0.0.0.0
|
–
|
|
BRENDA:
BR52868
KEGG:
R09885
MetaCyc:
RXN-12715
|
|
|
|
(3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA + NAD+ <=> 7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA + NADH + H+
|
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
|
–
|
|
MetaCyc:
RXN-19803
|
|
|
|
1,4-androstadiene-3,17-dione + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 9alpha-hydroxy-1,4-androstadiene_3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
|
BRENDA:
BR49974
KEGG:
R09860
MetaCyc:
RXN-12691
|
|
|
|
7-carboxy-4-methyl-5-oxoheptanoyl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> (2E)-7-carboxy-4-methyl-5-oxohept-2-enoyl-CoA + reduced_flavodoxin
|
1.3.8
|
–
|
|
MetaCyc:
RXN-19801
|
|
|
|
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD+ <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NADH + H+
|
1.3.1
|
–
|
|
MetaCyc:
RXN-19796
|
|
|
|
(5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + H2O <=> (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H+
|
4.1.99
|
–
|
|
MetaCyc:
RXN-19798
|
|