|
|
5-carboxy-2-methyl-3-oxopentanoyl-CoA + acetyl-CoA <=> 7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA + CoA
|
2.3.1.16
acetyl-CoA C-acyltransferase
|
–
|
| |
MetaCyc:
RXN-19804
|
|
|
|
(5alpha)-androst-1-en-3,17-dione + H2O <=> 1-hydroxyandrostan-3,17-dione
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21464
|
|
|
|
succinyl-CoA + propionyl-CoA <=> 5-carboxy-2-methyl-3-oxopentanoyl-CoA + CoA
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-19805
|
|
|
|
1-hydroxyandrostan-3,17-dione + acceptor <=> androstan-1,3,17-trione + reduced_acceptor
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21465
|
|
|
|
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + H2O <=> 3aalpha-H-4alpha-carboxy-5-hydroxy-7abeta-methylhexahydro-1-indanone + acetyl-CoA + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21480
|
|
|
|
(5alpha)-androst-1-en-3,17-dione + acceptor <=> 1,4-androstadiene-3,17-dione + reduced_acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
| |
MetaCyc:
RXN-21463
|
|
|
|
5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADP+ <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADPH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
| |
MetaCyc:
RXN-12747
|
|
|
|
(3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA <=> (2E)-7-carboxy-4-methyl-5-oxohept-2-enoyl-CoA + H2O
|
4.2.1.119
enoyl-CoA hydratase 2
|
–
|
| |
MetaCyc:
RXN-19802
|
|
|
|
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
|
6.2.1.41
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase
|
–
|
| |
BRENDA:
BR51067
KEGG:
R10769
MetaCyc:
RXN-12746
|
|
|
|
1,17-dioxo-2,3-seco-androsta-4-en-3-oyl-CoA + H2O <=> 4-hydroxy-1,17-dioxo-2,3-seco-androstan-3-oyl-CoA
|
4.2.1
|
–
|
| |
MetaCyc:
RXN-21491
|
|
|
|
1,17-dioxo-2,3-seco-androstan-3-oyl-CoA + acceptor <=> 1,17-dioxo-2,3-seco-androsta-4-en-3-oyl-CoA + reduced_acceptor
|
1.3.99
|
–
|
| |
MetaCyc:
RXN-21490
|
|
|
|
4-androstene-3,17-dione + acceptor <=> 1,4-androstadiene-3,17-dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
| |
BRENDA:
BS258852
KEGG:
R09884
MetaCyc:
RXN-12714
|
|
|
|
(3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O <=> 9-carboxy-6-methyl-3,7-dioxononanoyl-CoA
|
4.1.99
|
–
|
| |
MetaCyc:
RXN-19799
|
|
|
|
2,5-seco-3,4-dinorandrost-1,5,17-trione <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21479
|
|
|
|
7-carboxy-4-methyl-5-oxoheptanoyl-CoA + acetyl-CoA <=> 9-carboxy-6-methyl-3,7-dioxononanoyl-CoA + CoA
|
2.3.1.16
acetyl-CoA C-acyltransferase
|
–
|
| |
MetaCyc:
RXN-19800
|
|
|
|
4-hydroxy-1,17-dioxo-2,3-seco-androstan-3-oyl-CoA <=> 2,5-seco-3,4-dinorandrost-1,5,17-trione + acetyl-CoA
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21492
|
|
|
|
(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NAD+ <=> (5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NADH + H+
|
1.1.1
|
–
|
| |
MetaCyc:
RXN-19797
|
|
|
|
3aalpha-H-4alpha-carboxy-5-hydroxy-7abeta-methylhexahydro-1-indanone + ATP + CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + AMP + diphosphate
|
6.2.1
|
–
|
| |
MetaCyc:
RXN-21481
|
|
|
|
androstan-1,3,17-trione + H2O <=> 1,17-dioxo-2,3-seco-androstan-3-oate + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21466
|
|
|
|
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + H2O
|
4.2.1
|
–
|
| |
MetaCyc:
RXN-12749
|
|
|
|
5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + acceptor <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + reduced_acceptor
|
1.3.99
|
–
|
| |
MetaCyc:
RXN-12748
|
|
|
|
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA + NAD+ <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + NADH + H+
|
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
|
–
|
| |
MetaCyc:
RXN-12750
|
|
|
|
(3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA + NAD+ <=> 7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA + NADH + H+
|
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
|
–
|
| |
MetaCyc:
RXN-19803
|
|
|
|
7-carboxy-4-methyl-5-oxoheptanoyl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> (2E)-7-carboxy-4-methyl-5-oxohept-2-enoyl-CoA + reduced_flavodoxin
|
1.3.8
|
–
|
| |
MetaCyc:
RXN-19801
|
|
|
|
1,17-dioxo-2,3-seco-androstan-3-oate + ATP + CoA <=> 1,17-dioxo-2,3-seco-androstan-3-oyl-CoA + AMP + diphosphate
|
6.2.1
|
–
|
| |
MetaCyc:
RXN-21477
|
|
|
|
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD+ <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NADH + H+
|
1.3.1
|
–
|
| |
MetaCyc:
RXN-19796
|
|
|
|
(5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + H2O <=> (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H+
|
4.1.99
|
–
|
| |
MetaCyc:
RXN-19798
|
|
