|
|
retronecine + 2 L-isoleucine <=> senecionine
|
not assigned
|
–
|
|
KEGG:
R06726
|
|
|
|
Pseudoecgonine + ATP + CoA <=> Pseudoecgonyl-CoA + AMP
|
6.2.1
|
–
|
|
KEGG:
R06731
|
|
|
|
anabasine <=> Anatalline
|
not assigned
|
–
|
|
KEGG:
R06743
|
|
|
|
DELTA1-piperideine + acetoacetyl-CoA + H2O <=> Pelletierine + CoA + CO2
|
not assigned
|
–
|
|
KEGG:
R05129
|
|
|
|
senecionine + NADPH + O2 + H+ <=> senecionine_N-oxide + NADP+ + H2O
|
1.14.13.101
senecionine N-oxygenase
|
–
|
|
BRENDA:
BR48483
KEGG:
R07373
MetaCyc:
1.14.13.101-RXN
|
|
|
|
Tropine + (R)-phenyllactyl-CoA <=> Littorine + CoA
|
2.3.1
2.3.1.185
tropine acyltransferase
|
–
–
|
|
KEGG:
R08432
MetaCyc:
RXN-8254
|
|
|
|
1-Methylpyrrolinium <=> methyl_ecgonine
|
not assigned
|
–
|
|
KEGG:
R08429
|
|
|
|
methyl_ecgonine + H2O <=> Ecgonine + methanol
|
3.1.1
|
–
|
|
KEGG:
R06729
|
|
|
|
1-Methylpyrrolinium <=> Cuscohygrine
|
not assigned
|
–
|
|
KEGG:
R08427
|
|
|
|
methyl_ecgonine + benzoyl-CoA <=> cocaine + CoA
|
2.3.1
|
–
|
|
KEGG:
R08430
MetaCyc:
RXN-9201
|
|
|
|
17-Oxosparteine <=> lupanine
|
not assigned
|
–
|
|
KEGG:
R09049
MetaCyc:
RXN-8692
|
|
|
|
6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> H+ + Scopolamine + succinate + CO2 + H2O
|
1.14.11.11
hyoscyamine (6S)-dioxygenase
1.14.20.13
6beta-hydroxyhyoscyamine epoxidase
|
–
–
|
|
BRENDA:
BR40455
KEGG:
R03737
MetaCyc:
6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN
SABIO-RK:
3497
|
|
|
|
lupanine <=> 13-hydroxylupanine
|
not assigned
|
–
|
|
KEGG:
R09050
MetaCyc:
RXN-8693
|
|
|
|
H+ + DELTA1-piperideine-2-carboxylate + H2O <=> 6-Amino-2-oxohexanoate
|
not assigned
|
–
|
|
KEGG:
R04175
MetaCyc:
RXN-8172
|
|
|
|
anabasine + CO2 <=> DELTA1-piperideine + nicotinate
|
not assigned
|
–
|
|
KEGG:
R05128
|
|
|
|
Pelletierine <=> N-Methylpelletierine
|
not assigned
|
–
|
|
KEGG:
R05131
|
|
|
|
L-pipecolic_acid <=> 1-Indolizidinone
|
not assigned
|
–
|
|
KEGG:
R08415
|
|
|
|
cadaverine + pyruvate <=> H+ + 17-Oxosparteine + L-alanine + H2O
|
not assigned
|
–
|
|
KEGG:
R09048
MetaCyc:
RXN-8688
|
|
|
|
atropine + H2O <=> H+ + tropate + Tropine
|
3.1.1.10
tropinesterase
|
–
|
|
BRENDA:
BR15898;
BS415950
KEGG:
R03563;
R03564
MetaCyc:
TROPINESTERASE-RXN
|
|
|
|
Littorine <=> L-hyoscyamine
|
not assigned
|
–
|
|
KEGG:
R08434
MetaCyc:
RXN-8255
|
|
|
|
3,6-Dihydronicotinic_acid <=> 3,6-Dihydropyridine
|
not assigned
|
–
|
|
KEGG:
R09051
|
|
|
|
acetyl-CoA + pseudotropine <=> CoA + Acetylpseudotropine
|
2.3.1.186
pseudotropine acyltransferase
|
–
|
|
KEGG:
R06736
|
|
|
|
pseudotropine <=> calystegine_A3
|
not assigned
|
–
|
|
KEGG:
R06737
|
|
|
|
L-hyoscyamine + 2-oxoglutarate + O2 <=> 6beta-hydroxyhyoscyamine + succinate + CO2
|
1.14.11.11
hyoscyamine (6S)-dioxygenase
|
–
|
|
BRENDA:
BR40457
KEGG:
R03812
MetaCyc:
HYOSCYAMINE-6-DIOXYGENASE-RXN
SABIO-RK:
8992
|
|
|
|
N-methylputrescine + O2 + H+ <=> 1-Methylpyrrolinium + H2O2 + NH3
|
1.4.3.21
primary-amine oxidase
|
–
|
|
KEGG:
R04027
|
|
|
|
5-Aminopentanal <=> DELTA1-piperideine
|
not assigned
|
–
|
|
KEGG:
R06741
|
|
|
|
cadaverine <=> sparteine
|
not assigned
|
–
|
|
KEGG:
R08419
|
|
|
|
sparteine <=> Cytisine
|
not assigned
|
–
|
|
KEGG:
R08420
|
|
|
|
L-lysine + H2O + O2 <=> 6-Amino-2-oxohexanoate + NH3 + H2O2
|
1.13.12.2
lysine 2-monooxygenase
1.4.3.14
L-lysine oxidase
1.4.3.2
L-amino-acid oxidase
1.4.3.25
L-arginine oxidase
|
–
–
–
–
|
|
BRENDA:
BR36876
KEGG:
R00447
MetaCyc:
L-LYSINE-OXIDASE-RXN
SABIO-RK:
887
|
|
|
|
phenylpyruvate + NADPH <=> D-phenyllactate + NADP+
|
1.1.1.110
aromatic 2-oxoacid reductase
1.1.1.237
hydroxyphenylpyruvate reductase
1.1.1.28
D-lactate dehydrogenase
1.1.1.79
glyoxylate reductase (NADP+)
|
–
–
–
–
|
|
BRENDA:
BS187840;
BS188652
KEGG:
R01371
SABIO-RK:
1573
|
|
|
|
piperidine + piperoyl-CoA <=> H+ + piperine + CoA
|
2.3.1.145
piperidine N-piperoyltransferase
|
–
|
|
BRENDA:
BR44006
KEGG:
R03994
MetaCyc:
PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN
|
|
|
|
Nicotine <=> Nornicotine
|
not assigned
|
–
|
|
KEGG:
R06738
|
|
|
|
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate <=> L-pipecolic_acid
|
not assigned
|
–
|
|
KEGG:
R08414
|
|
|
|
DELTA1-piperideine + trans-cinnamate + benzoyl-CoA <=> Lobelanine + CoA
|
not assigned
|
–
|
|
KEGG:
R08423
|
|
|
|
L-pipecolic_acid + NADP+ <=> DELTA1-piperideine-2-carboxylate + NADPH + H+
|
1.5.1.1
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.21
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
1.5.1.25
thiomorpholine-carboxylate dehydrogenase
1.5.1.49
1-pyrroline-2-carboxylate reductase [NAD(P)H]
|
–
–
–
–
|
|
BRENDA:
BR36897
KEGG:
R02203
MetaCyc:
RXN-19250;
RXN-8166
SABIO-RK:
2175
|
|
|
|
N-Methylpelletierine <=> Pseudopelletierine
|
not assigned
|
–
|
|
KEGG:
R08425
|
|
|
|
nicotinate <=> 3,6-Dihydronicotinic_acid
|
not assigned
|
–
|
|
KEGG:
R08426
|
|
|
|
(S)-2-amino-6-oxohexanoate <=> DELTA1-piperidine_6-carboxylate + H2O + H+
|
1.2.1.31
L-aminoadipate-semialdehyde dehydrogenase
1.4.1.18
lysine 6-dehydrogenase
|
–
–
|
|
BRENDA:
BS413149
KEGG:
R02317
MetaCyc:
RXN-8173
|
|
|
|
Tropine + NADP+ <=> tropinone + NADPH + H+
|
1.1.1.206
tropinone reductase I
1.1.1.236
tropinone reductase II
1.1.1.334
methylecgonone reductase
|
–
–
–
|
|
BRENDA:
BR33667;
BR33679;
BS230684;
BS230695
KEGG:
R02832;
R06734
MetaCyc:
TROPINE-DEHYDROGENASE-RXN;
TROPINONE-REDUCTASE-RXN
SABIO-RK:
2698;
2773
|
|
|
|
S-adenosyl-L-methionine + putrescine <=> H+ + S-adenosyl-L-homocysteine + N-methylputrescine
|
2.1.1.53
putrescine N-methyltransferase
|
–
|
|
BRENDA:
BR43902
KEGG:
R01153
MetaCyc:
PUTRESCINE-N-METHYLTRANSFERASE-RXN
SABIO-RK:
1394
|
|
|
|
tigloyl-CoA + 13-hydroxylupanine <=> 13-tigloyloxylupanine + CoA
|
2.3.1.93
13-hydroxylupanine O-tigloyltransferase
|
–
|
|
BRENDA:
BR44096
KEGG:
R04205
MetaCyc:
RXN-8694
|
|
|
|
DELTA1-piperideine + trans-cinnamate <=> (-)-Sedamine
|
not assigned
|
–
|
|
KEGG:
R08422
|
|
|
|
DELTA1-piperideine <=> piperidine
|
not assigned
|
–
|
|
KEGG:
R09052
|
|
|
|
L-pipecolic_acid + NAD+ <=> DELTA1-piperideine-2-carboxylate + NADH + H+
|
1.5.1
1.5.1.1
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.21
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
1.5.1.49
1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.B5
|
–
–
–
–
–
|
|
BRENDA:
BR51216
KEGG:
R02201
MetaCyc:
RXN-14210;
RXN-8166_WOP
SABIO-RK:
2174
|
|
|
|
L-lysine + NAD+ + H2O <=> H+ + (S)-2-amino-6-oxohexanoate + NADH + NH3
|
1.4.1.18
lysine 6-dehydrogenase
|
–
|
|
BRENDA:
BR36866;
BS258926
KEGG:
R00446
MetaCyc:
RXN-8808
|
|
|
|
1-Indolizidinone <=> Slaframine
|
not assigned
|
–
|
|
KEGG:
R08417
|
|
|
|
cocaine + H2O <=> H+ + methyl_ecgonine + benzoate
|
3.1.1.1
carboxylesterase
3.1.1.8
cholinesterase
3.1.1.84
cocaine esterase
|
–
–
–
|
|
BRENDA:
BR49194;
BS402273
KEGG:
R06728
MetaCyc:
RXN-11192
|
|
|
|
Homospermidine <=> Trachelanthamidine
|
not assigned
|
–
|
|
KEGG:
R06724
|
|
|
|
L-phenylalanine + 2-oxoglutarate <=> phenylpyruvate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.24
diiodotyrosine transaminase
2.6.1.27
tryptophan transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.60
aromatic-amino-acid---glyoxylate transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
2.6.1.70
aspartate---phenylpyruvate transaminase
2.6.1.79
glutamate---prephenate aminotransferase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BS353519
KEGG:
R00694
MetaCyc:
RXN-10814
SABIO-RK:
1074
|
|
|
|
nicotinate + 3,6-Dihydropyridine <=> Anatabine + CO2
|
not assigned
|
–
|
|
KEGG:
R06779
|
|
|
|
cinnamoyl-CoA + D-phenyllactate <=> Cinnamic_acid + (R)-phenyllactyl-CoA
|
2.8.3.17
3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase
|
–
|
|
BRENDA:
BR47452
KEGG:
R07796
MetaCyc:
2.8.3.17-RXN
|
|
|
|
Lobelanine <=> lobeline
|
not assigned
|
–
|
|
KEGG:
R08424
|
|
|
|
D-phenyllactate + NAD+ <=> phenylpyruvate + NADH + H+
|
1.1.1.110
aromatic 2-oxoacid reductase
1.1.1.237
hydroxyphenylpyruvate reductase
1.1.1.26
glyoxylate reductase
1.1.1.27
L-lactate dehydrogenase
1.1.1.272
D-2-hydroxyacid dehydrogenase (NADP+)
1.1.1.28
D-lactate dehydrogenase
1.1.1.337
L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.345
D-2-hydroxyacid dehydrogenase (NAD+)
1.1.1.37
malate dehydrogenase
1.1.1.79
glyoxylate reductase (NADP+)
1.1.1.96
diiodophenylpyruvate reductase
43380
|
–
–
–
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR52504;
BS186998
KEGG:
R01370
MetaCyc:
RXN-10816
SABIO-RK:
9871
|
|
|
|
L-lysine + H+ <=> cadaverine + CO2
|
4.1.1.17
ornithine decarboxylase
4.1.1.18
lysine decarboxylase
4.1.1.19
arginine decarboxylase
4.1.1.50
adenosylmethionine decarboxylase
4.1.1.86
diaminobutyrate decarboxylase
4.1.1.B12
|
–
–
–
–
–
–
|
|
BRENDA:
BR6435
KEGG:
R00462
MetaCyc:
LYSDECARBOX-RXN
SABIO-RK:
899
|
|
|
|
DELTA1-piperideine + Pelletierine <=> L-(+)-Anaferine
|
not assigned
|
–
|
|
KEGG:
R05130
|
|
|
|
acetyl-CoA + Tropine <=> CoA + 3-acetyl-tropine
|
2.3.1.185
tropine acyltransferase
2.3.1.186
pseudotropine acyltransferase
|
–
–
|
|
BRENDA:
BS451941
KEGG:
R06735
|
|
|
|
1-Indolizidinone <=> swainsonine
|
not assigned
|
–
|
|
KEGG:
R08416
|
|
|
|
Tropine + NADP+ <=> tropinone + NADPH + H+
|
1.1.1.206
tropinone reductase I
1.1.1.236
tropinone reductase II
1.1.1.334
methylecgonone reductase
|
–
–
–
|
|
BRENDA:
BR33667;
BR33679;
BS230684;
BS230695
KEGG:
R02832;
R06734
MetaCyc:
TROPINE-DEHYDROGENASE-RXN;
TROPINONE-REDUCTASE-RXN
SABIO-RK:
2698;
2773
|
|
|
|
cadaverine + H2O + O2 <=> 5-Aminopentanal + NH3 + H2O2
|
1.4.3.10
putrescine oxidase
1.4.3.13
protein-lysine 6-oxidase
1.4.3.21
primary-amine oxidase
1.4.3.22
diamine oxidase
|
–
–
–
–
|
|
BRENDA:
BS259111
KEGG:
R06740
MetaCyc:
RXN-11784
SABIO-RK:
6315
|
|
|
|
Trachelanthamidine <=> retronecine
|
not assigned
|
–
|
|
KEGG:
R06725
|
|
|
|
putrescine <=> Homospermidine + NH3
|
2.5.1.44
homospermidine synthase
|
–
|
|
BRENDA:
BR29481
KEGG:
R00018
MetaCyc:
2.5.1.44-RXN
|
|
|
|
Ecgonine <=> Pseudoecgonine
|
5.1
|
–
|
|
KEGG:
R06730
|
|
|
|
Nicotine + CO2 + H+ <=> 1-Methylpyrrolinium + nicotinate
|
not assigned
|
–
|
|
KEGG:
R02861
|
|
|
|
L-phenylalanine <=> tropate
|
not assigned
|
–
|
|
KEGG:
R06744
|
|
|
|
Hygrine <=> tropinone
|
not assigned
|
–
|
|
KEGG:
R06733
|
|
|
|
1-Methylpyrrolinium <=> Hygrine
|
not assigned
|
–
|
|
KEGG:
R06732
|
|
|
|
L-phenylalanine + pyruvate <=> phenylpyruvate + L-alanine
|
2.6.1.12
alanine---oxo-acid transaminase
2.6.1.15
glutamine---pyruvate transaminase
2.6.1.44
alanine---glyoxylate transaminase
2.6.1.51
serine---pyruvate transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.58
phenylalanine(histidine) transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
|
–
–
–
–
–
–
–
|
|
BRENDA:
BR47420
KEGG:
R00692
MetaCyc:
2.6.1.58-RXN
SABIO-RK:
1072
|
|
|
|
cadaverine <=> 13-hydroxylupanine
|
not assigned
|
–
|
|
KEGG:
R08418
|
|