|
|
Nonaketamide_tricyclic_intermediate <=> Pretetramid
|
not assigned
|
–
|
| |
KEGG:
R09196
|
|
|
|
S-adenosyl-L-methionine + 4-amino-4-de(dimethylamino)anhydrotetracycline <=> anhydrotetracycline + S-adenosyl-L-homocysteine + H+
|
2.1.1.335
4-amino-anhydrotetracycline N4-methyltransferase
|
–
|
| |
BRENDA:
BR51855
KEGG:
R09191;
R11520
MetaCyc:
RXN-17977
|
|
|
|
chlortetracycline + NADPH + H+ + O2 <=> 11a-Hydroxy-7-chlortetracycline + NADP+ + H2O
|
1.14.13.231
tetracycline 11a-monooxygenase
|
–
|
| |
KEGG:
R11526
|
|
|
|
ATP + malonyl-[acyl-carrier_protein] + L-glutamine + H2O <=> AMP + diphosphate + Malonamoyl-[acyl-carrier_protein] + L-glutamate
|
6.3.5
|
–
|
| |
KEGG:
R11515
|
|
|
|
4-hydroxy-6-methylpretetramide + NADPH + O2 + H+ <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O
|
1.14.13.233
4-hydroxy-6-methylpretetramide 12a-monooxygenase
|
–
|
| |
BRENDA:
BR51808
KEGG:
R05462
MetaCyc:
RXN-17980
|
|
|
|
5a,11a-dehydrooxytetracycline + reduced_coenzyme_F420 <=> oxytetracycline + coenzyme_F420
|
1.3.98.4
5a,11a-dehydrotetracycline reductase
|
–
|
| |
KEGG:
R09192
MetaCyc:
RXN-17975
|
|
|
|
tetracycline + O2 + Cl- + FADH2 <=> 7-chlorotetracycline + H2O + FAD + H+
|
1.14.19.49
tetracycline 7-halogenase
|
–
|
| |
BRENDA:
BR51837
KEGG:
R11478
MetaCyc:
RXN-17996
|
|
|
|
anhydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrotetracycline + H2O + NADP+
|
1.14.13.38
anhydrotetracycline 6-monooxygenase
|
–
|
| |
BRENDA:
BR40419
KEGG:
R04060
MetaCyc:
ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN
|
|
|
|
Nonaketamide_monocyclic_intermediate <=> Nonaketamide_tricyclic_intermediate
|
not assigned
|
–
|
| |
KEGG:
R09188
|
|
|
|
tetracycline + O2 + NADPH + H+ <=> 11a-hydroxytetracycline + H2O + NADP+
|
1.14.13.231
tetracycline 11a-monooxygenase
|
–
|
| |
BRENDA:
BR51805
KEGG:
R11449
MetaCyc:
RXN-17967
|
|
|
|
18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + NADPH + H+ <=> C-9_Reduced_nonaketamide + NADP+
|
1.1.1
|
–
|
| |
KEGG:
R06642
|
|
|
|
C-9_Reduced_nonaketamide <=> Nonaketamide_monocyclic_intermediate + 2 H2O
|
4.2.1
|
–
|
| |
KEGG:
R09187
|
|
|
|
4-de(dimethylamino)-4-oxoanhydrotetracycline <=> 4-amino-4-de(dimethylamino)anhydrotetracycline
|
not assigned
|
–
|
| |
KEGG:
R09197
|
|
|
|
6-methylpretetramide + NADPH + O2 + H+ <=> 4-hydroxy-6-methylpretetramide + NADP+ + H2O
|
1.14.13.232
6-methylpretetramide 4-monooxygenase
|
–
|
| |
BRENDA:
BR51807
KEGG:
R05463
MetaCyc:
RXN-17981
|
|
|
|
S-adenosyl-L-methionine + Pretetramid <=> S-adenosyl-L-homocysteine + 6-methylpretetramide + H+
|
2.1.1
2.1.1.M31
|
–
–
|
| |
KEGG:
R09189
MetaCyc:
RXN-17982
|
|
|
|
5a,11a-dehydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrooxytetracycline + H2O + NADP+
|
1.14.13.234
5a,11a-dehydrotetracycline 5-monooxygenase
|
–
|
| |
BRENDA:
BR51809
KEGG:
R09198
MetaCyc:
RXN-17976
|
|
|
|
6-methylpretetramide + 2 NADPH + 2 H+ + 2 O2 <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + 2 NADP+ + 2 H2O
|
1.14.13.232
6-methylpretetramide 4-monooxygenase
1.14.13.233
4-hydroxy-6-methylpretetramide 12a-monooxygenase
|
–
–
|
| |
KEGG:
R09190
|
|
|
|
oxytetracycline + NADPH + H+ + O2 <=> 11a-hydroxy-oxytetracycline + NADP+ + H2O
|
1.14.13.231
tetracycline 11a-monooxygenase
|
–
|
| |
KEGG:
R11525
|
|
|
|
5a,11a-dehydrotetracycline + reduced_coenzyme_F420 <=> tetracycline + coenzyme_F420
|
1.3.98.4
5a,11a-dehydrotetracycline reductase
|
–
|
| |
BRENDA:
BR51789
KEGG:
R05459
MetaCyc:
RXN-17988
|
|
|
|
Malonamoyl-[acyl-carrier_protein] + 8 malonyl-CoA <=> 18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + 8 CO2 + 8 CoA
|
2.3.1.260
tetracycline polyketide synthase
|
–
|
| |
KEGG:
R11516
|
|
