|
|
17alpha-hydroxyprogesterone + 2 reduced_ferredoxin + O2 + 2 H+ <=> 21-deoxycortisol + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
| |
KEGG:
R03329
|
|
|
|
testosterone + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29315;
BS438469
KEGG:
R01838
MetaCyc:
1.1.1.51-RXN;
1.1.1.64-RXN
SABIO-RK:
1917
|
|
|
|
5alpha-androstane-3alpha,17beta-diol + NADP+ <=> 5alpha-dihydrotestosterone + NADPH + H+
|
1.1.1.105
all-trans-retinol dehydrogenase (NAD+)
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.3.1.20
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BS187692;
BS257212-a
KEGG:
R08963
MetaCyc:
RXN-12264
SABIO-RK:
7911
|
|
|
|
dehydroepiandrosterone + O2 + reduced_flavodoxin <=> 7alpha-hydroxydehydroepiandrosterone + flavin + H2O
|
1.14.14.23
cholesterol 7alpha-monooxygenase
|
–
|
| |
KEGG:
R08961
|
|
|
|
17alpha,20alpha-dihydroxycholesterol + 2 O2 + 4 H+ + 4 reduced_ferredoxin <=> 17alpha-hydroxypregnenolone + 4-Methylpentanal + 3 H2O + 4 oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
| |
KEGG:
R04676
|
|
|
|
Estrone_3-sulfate + H2O <=> estrone + sulfate + H+
|
3.1.6.1
arylsulfatase
3.1.6.2
steryl-sulfatase
3.1.6.8
cerebroside-sulfatase
|
–
–
–
|
| |
BRENDA:
BS398868
KEGG:
R03980
MetaCyc:
RXN-14263
|
|
|
|
corticosterone + NAD+ <=> 11-Dehydrocorticosterone + NADH
|
1.1.1
1.1.1.B40
|
–
–
|
| |
BRENDA:
BS370902
KEGG:
R03847
SABIO-RK:
3598
|
|
|
|
dehydroepiandrosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
–
|
| |
BRENDA:
BS403792
KEGG:
R01837
|
|
|
|
cortisol <=> 11beta-hydroxyandrost-4-ene-3,17-dione
|
not assigned
|
–
|
| |
KEGG:
R08995
|
|
|
|
3alpha,21-dihydroxy-5beta-pregnane-11,20-dione + NADP+ <=> 21-hydroxy-5beta-pregnane-3,11,20-trione + NADPH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
| |
KEGG:
R04843
|
|
|
|
estrone + H+ + O2 + NADH <=> 2-hydroxyestrone + NAD+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R02354
|
|
|
|
testosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29275
KEGG:
R01836
MetaCyc:
1.1.1.51-RXN_WOP;
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN
SABIO-RK:
1915
|
|
|
|
11beta-hydroxyprogesterone + reduced_flavodoxin + O2 <=> corticosterone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
| |
KEGG:
R03849
|
|
|
|
progesterone + NADH <=> 20alpha-hydroxyprogesterone + NAD+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
|
| |
BRENDA:
BS187276-a;
BS188322-a
KEGG:
R02207
SABIO-RK:
2179
|
|
|
|
4-androstene-3,17-dione + reduced_flavodoxin + O2 <=> 7alpha-hydroxy-4-androstene-3,17-dione + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R01842
|
|
|
|
19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced_flavodoxin <=> 19-oxoandrost-4-ene-3,17-dione + 2 H2O + flavin
|
1.14.14.14
aromatase
|
–
|
| |
BRENDA:
BR50748;
BS425315
KEGG:
R04759
|
|
|
|
11-Dehydrocorticosterone + NADPH <=> corticosterone + NADP+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.B40
|
–
–
|
| |
BRENDA:
BS370764
KEGG:
R03848
SABIO-RK:
3599
|
|
|
|
androst-4-ene-3,11,17-trione + NADPH <=> 11beta-hydroxyandrost-4-ene-3,17-dione + NADP+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
|
–
|
| |
BRENDA:
BS187260
KEGG:
R04758
|
|
|
|
2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-methoxyestrone + S-adenosyl-L-homocysteine
|
2.1.1.6
catechol O-methyltransferase
|
–
|
| |
KEGG:
R04762
|
|
|
|
17alpha,21-Dihydroxypregnenolone + 2 reduced_ferredoxin + O2 + 2 H+ <=> 11beta,17alpha,21-Trihydroxypregnenolone + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
| |
KEGG:
R04850
|
|
|
|
dehydroepiandrosterone_3-sulfate + H2O <=> dehydroepiandrosterone + sulfate + H+
|
3.1.6.1
arylsulfatase
3.1.6.2
steryl-sulfatase
3.1.6.8
cerebroside-sulfatase
|
–
–
–
|
| |
BRENDA:
BR15971
KEGG:
R03404
MetaCyc:
STERYL-SULFATASE-RXN
|
|
|
|
pregnenolone + reduced_flavodoxin + O2 <=> 21-hydroxypregnenolone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
| |
KEGG:
R03784
|
|
|
|
(20R,22R)-20,22-dihydroxy-cholesterol + O2 + reduced_adrenodoxin + H+ <=> pregnenolone + 4-Methylpentanal + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
| |
BRENDA:
BR50362
KEGG:
R03933
MetaCyc:
RXN66-339
|
|
|
|
Tetrahydrocorticosterone + NADP+ <=> 5beta-dihydrocorticosterone + NADPH + H+
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
| |
KEGG:
R04838
SABIO-RK:
4483
|
|
|
|
4-androstene-3,17-dione + reduced_ferredoxin + O2 <=> 11beta-hydroxyandrost-4-ene-3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
| |
BRENDA:
BS186775
KEGG:
R02725
|
|
|
|
17beta-estradiol + H+ + O2 + NADPH <=> 2-hydroxyestradiol + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R03090
SABIO-RK:
2930
|
|
|
|
17alpha-hydroxypregnenolone + NAD+ <=> 17alpha-hydroxyprogesterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
| |
KEGG:
R03327
|
|
|
|
3alpha,11beta,21-trihydroxy-20-oxo-5beta-pregnan-18-al + NADP+ <=> 11beta,21-dihydroxy-3,20-oxo-5beta-pregnan-18-al + NADPH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
| |
KEGG:
R04836
|
|
|
|
17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP+ <=> 17alpha-hydroxyprogesterone + NADPH + H+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
|
| |
BRENDA:
BR29214;
BS188323
KEGG:
R03325
MetaCyc:
1.1.1.149-RXN
SABIO-RK:
3135
|
|
|
|
pregnenolone + NADPH + H+ + O2 <=> 7alpha-hydroxypregnenolone + NADP+ + H2O
|
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
|
| |
KEGG:
R08943
|
|
|
|
17beta-estradiol + H+ + O2 + NADPH <=> estriol + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R03089
|
|
|
|
11-Dehydrocorticosterone <=> 21-hydroxy-5beta-pregnane-3,11,20-trione
|
not assigned
|
–
|
| |
KEGG:
R08994
|
|
|
|
17alpha-hydroxypregnenolone + reduced_flavodoxin + O2 <=> dehydroepiandrosterone + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
| |
BRENDA:
BR51745
KEGG:
R08517
|
|
|
|
5beta-Pregnan-3alpha-ol-20-one + NADH + H+ <=> 5beta-pregnane-3alpha,20alpha-diol + NAD+
|
1.1.1.112
indanol dehydrogenase
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
–
–
|
| |
BRENDA:
BS187023-a
KEGG:
R04847
|
|
|
|
androsterone + NADP+ <=> 5alpha-androstane-3,17-dione + NADPH + H+
|
1.1.1.105
all-trans-retinol dehydrogenase (NAD+)
1.1.1.112
indanol dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.21
aldose reductase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.20
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29252;
BS372395
KEGG:
R02477
MetaCyc:
1.1.1.209-RXN
SABIO-RK:
2409
|
|
|
|
2-hydroxyestradiol + S-adenosyl-L-methionine <=> 2-methoxyestradiol-17beta + S-adenosyl-L-homocysteine
|
2.1.1.6
catechol O-methyltransferase
|
–
|
| |
BRENDA:
BS395552
KEGG:
R04764
|
|
|
|
cortolone + NAD+ <=> 3alpha,17alpha,21-trihydroxy-5beta-pregnan-11,20-dione + NADH + H+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
| |
KEGG:
R04831
|
|
|
|
5alpha-pregnane-3alpha,20alpha-diol + NADP+ <=> 5alpha-pregnan-20alpha-ol-3-one + NADPH
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
|
–
–
|
| |
BRENDA:
BS187704
KEGG:
R08960
SABIO-RK:
13064
|
|
|
|
5alpha-dihydrotestosterone + NADP+ <=> testosterone + H+ + NADPH
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
–
|
| |
BRENDA:
BS258429
KEGG:
R02497
MetaCyc:
RXN66-343
SABIO-RK:
11551
|
|
|
|
5beta-Pregnan-3alpha-ol-20-one + NAD+ <=> 5beta-pregnane-3,20-dione + NADH
|
1.1.1.112
indanol dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
|
| |
BRENDA:
BS187016-a
KEGG:
R04845
SABIO-RK:
4490
|
|
|
|
20alpha-hydroxycholesterol + O2 + 2 reduced_ferredoxin + 2 H+ <=> (20R,22R)-20,22-dihydroxy-cholesterol + H2O + 2 oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
| |
KEGG:
R04854
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 11-deoxycorticosterone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
| |
BRENDA:
BS427511
KEGG:
R02213
|
|
|
|
16alpha-hydroxyandrost-4-ene-3,17-dione + H+ + NADH <=> 16alpha-hydroxy-dehydroepiandrosterone + NAD+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
| |
KEGG:
R04678
|
|
|
|
11beta-hydroxytestosterone + NADP+ <=> 11beta-hydroxyandrost-4-ene-3,17-dione + NADPH + H+
|
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
|
| |
KEGG:
R08980
|
|
|
|
cortol + NAD+ <=> tetrahydrocortisol + NADH + H+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
| |
KEGG:
R04834
|
|
|
|
dehydroepiandrosterone + H+ + O2 + NADPH <=> 16alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R03408
|
|
|
|
11beta-hydroxytestosterone + NAD+ <=> 11beta-hydroxyandrost-4-ene-3,17-dione + NADH
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
|
| |
BRENDA:
BS188499
KEGG:
R08945
|
|
|
|
19-oxotestosterone + O2 + reduced_flavodoxin <=> 17beta-estradiol + formate + H2O + flavin
|
1.14.14.14
aromatase
|
–
|
| |
BRENDA:
BR50745
KEGG:
R03087
|
|
|
|
cortisol + H+ + NADH <=> 11beta,17alpha,21-Trihydroxypregnenolone + NAD+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
| |
KEGG:
R02840
|
|
|
|
pregnenolone + reduced_flavodoxin + O2 <=> 17alpha-hydroxypregnenolone + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
| |
BRENDA:
BS427508
KEGG:
R03783
|
|
|
|
17alpha-hydroxypregnenolone + reduced_flavodoxin + O2 <=> 17alpha,21-Dihydroxypregnenolone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
| |
KEGG:
R04675
|
|
|
|
11-deoxycortisol + H+ + NADH <=> 17alpha,21-Dihydroxypregnenolone + NAD+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
| |
KEGG:
R04849
|
|
|
|
3''-phosphoadenylyl-sulfate + pregnenolone <=> adenosine_3,5''-bisphosphate + pregnenolone_sulfate + H+
|
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
–
|
| |
BRENDA:
BS360202
KEGG:
R08978
MetaCyc:
RXN-20215
SABIO-RK:
15237
|
|
|
|
17beta-estradiol + NAD+ <=> estrone + NADH + H+
|
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.300
NADP-retinol dehydrogenase
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29326-a
KEGG:
R02352
MetaCyc:
ESTRADIOL-17-BETA-DEHYDROGENASE-RXN_WOP
SABIO-RK:
2300
|
|
|
|
17beta-estradiol + NADP+ <=> estrone + NADPH + H+
|
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29326
KEGG:
R02353
MetaCyc:
ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
SABIO-RK:
2301
|
|
|
|
4-androstene-3,17-dione + O2 + reduced_acceptor <=> testololactone + H2O + acceptor
|
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
|
| |
BRENDA:
BR40394;
BS375044
KEGG:
R01833
MetaCyc:
1.14.99.12-RXN
|
|
|
|
testosterone + O2 + reduced_flavodoxin <=> 19-hydroxytestosterone + H2O + flavin
|
1.14.14.14
aromatase
|
–
|
| |
BRENDA:
BR50743
KEGG:
R02501
|
|
|
|
UDP-glucuronate + 2-methoxyestrone <=> UDP + 2-methoxyestrone_beta-D-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS378071
KEGG:
R04353
|
|
|
|
19-oxoandrost-4-ene-3,17-dione + O2 + reduced_flavodoxin <=> estrone + formate + H2O + flavin
|
1.14.14.14
aromatase
|
–
|
| |
BRENDA:
BR50749;
BS425316
KEGG:
R02351
|
|
|
|
11-deoxycortisol + 2 reduced_ferredoxin + O2 + 2 H+ <=> cortisol + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
| |
KEGG:
R02843
|
|
|
|
3alpha,17alpha,21-trihydroxy-5beta-pregnan-11,20-dione + NADP+ <=> 17alpha,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADPH
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
–
|
| |
BRENDA:
BS257226
KEGG:
R04830
SABIO-RK:
11519
|
|
|
|
21-deoxycortisol + flavin + H2O <=> 11beta-hydroxyprogesterone + reduced_flavodoxin + O2
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
| |
KEGG:
R04852
|
|
|
|
5beta-pregnane-3,20-dione + NADP+ <=> progesterone + NADPH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
1.3.1.M16
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
–
–
–
–
|
| |
BRENDA:
BS389592
KEGG:
R02219
MetaCyc:
RXN-9726
SABIO-RK:
2191
|
|
|
|
7alpha,17beta-dihydroxyandrost-4-en-3-one + acceptor <=> 7alpha-hydroxy-4-androstene-3,17-dione + reduced_acceptor
|
not assigned
|
–
|
| |
KEGG:
R04760
|
|
|
|
pregnenolone + NAD+ <=> progesterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
–
|
| |
BRENDA:
BS383305
KEGG:
R02216
MetaCyc:
RXN-9722
SABIO-RK:
2188
|
|
|
|
cholesterol + O2 + reduced_adrenodoxin + H+ <=> (22R)-22-hydroxycholesterol + H2O + oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
| |
BRENDA:
BR50360
KEGG:
R02723
MetaCyc:
RXN-7875
|
|
|
|
5beta-Pregnan-3alpha-ol-20-one + NADP+ <=> 5beta-pregnane-3,20-dione + NADPH
|
1.1.1.112
indanol dehydrogenase
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.20
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BS187016
KEGG:
R04846
SABIO-RK:
4491
|
|
|
|
progesterone + NADPH <=> 20alpha-hydroxyprogesterone + NADP+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.189
prostaglandin-E2 9-reductase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BS187276;
BS188322
KEGG:
R02209
SABIO-RK:
2181
|
|
|
|
11beta,21-dihydroxy-3,20-oxo-5beta-pregnan-18-al + NADP+ <=> aldosterone + NADPH + H+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
| |
KEGG:
R03713
|
|
|
|
UDP-glucuronate + testosterone <=> UDP + epitestosterone_O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS402159
KEGG:
R02502
SABIO-RK:
2430
|
|
|
|
5beta-androstane-3alpha-ol-17-one + UDP-glucuronate <=> UDP + etiocholanone_O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS322190
KEGG:
R04352
|
|
|
|
estrone + H+ + O2 + NADPH <=> 16alpha-hydroxyestrone + NADP+ + H2O
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R02356
|
|
|
|
3''-phosphoadenylyl-sulfate + cholesterol <=> adenosine_3,5''-bisphosphate + Cholesterol_sulfate + H+
|
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
|
–
–
–
|
| |
BRENDA:
BS360219;
BS378388;
BS386092
KEGG:
R08977
MetaCyc:
RXN66-602
SABIO-RK:
15393
|
|
|
|
aldosterone <=> aldosterone
|
not assigned
|
–
|
| |
KEGG:
R08953
|
|
|
|
cortisol + NAD+ <=> cortisone + NADH
|
1.1.1
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.B40
|
–
–
–
–
|
| |
BRENDA:
BS370905
KEGG:
R02834
SABIO-RK:
2700
|
|
|
|
5beta-androstane-3alpha-ol-17-one + NAD+ <=> H+ + 5beta-androstane-3,17-dione + NADH
|
1.1.1.112
indanol dehydrogenase
1.1.1.152
3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29217
KEGG:
R04309
MetaCyc:
1.1.1.152-RXN
SABIO-RK:
4008
|
|
|
|
androsterone + UDP-glucuronate <=> Androsterone_glucuronide + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
KEGG:
R02478
|
|
|
|
21-hydroxypregnenolone + NAD+ <=> 11-deoxycorticosterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
| |
KEGG:
R04163
|
|
|
|
estriol + UDP-glucuronate <=> UDP + estriol-16_alpha-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS322189
KEGG:
R04683
|
|
|
|
3alpha,21-dihydroxy-5beta-pregnane-11,20-dione + NAD+ <=> 21-hydroxy-5beta-pregnane-3,11,20-trione + NADH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
| |
KEGG:
R04842
|
|
|
|
17beta-estradiol + H+ + O2 + NADH <=> 2-hydroxyestradiol + NAD+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R03088
|
|
|
|
Tetrahydrocorticosterone + NADP+ <=> 3alpha,21-dihydroxy-5beta-pregnane-11,20-dione + NADPH + H+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
|
–
|
| |
KEGG:
R04840
|
|
|
|
3''-Phosphoadenylyl_sulfate + 2-methoxyestrone <=> Adenosine_3'',5''-bisphosphate + 2-Methoxyestrone_3-sulfate
|
2.8.2.15
steroid sulfotransferase
|
–
|
| |
KEGG:
R00536
|
|
|
|
3''-phosphoadenylyl-sulfate + dehydroepiandrosterone <=> adenosine_3,5''-bisphosphate + dehydroepiandrosterone_3-sulfate + H+
|
2.8.2.1
aryl sulfotransferase
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.34
glycochenodeoxycholate sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
–
–
–
|
| |
BRENDA:
BS360111
KEGG:
R03405
MetaCyc:
RXN-20214
SABIO-RK:
9168
|
|
|
|
estriol + NADP+ <=> 16alpha-hydroxyestrone + NADPH + H+
|
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
|
| |
KEGG:
R04682
|
|
|
|
3alpha,20alpha,21-trihydroxy-5beta-pregnan-11-one + NAD+ <=> 3alpha,21-dihydroxy-5beta-pregnane-11,20-dione + NADH + H+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
| |
KEGG:
R04844
|
|
|
|
estriol + NAD+ <=> 16alpha-hydroxyestrone + NADH + H+
|
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
|
| |
KEGG:
R04681
|
|
|
|
tetrahydrocortisol + NAD+ <=> 11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
| |
KEGG:
R04832
|
|
|
|
androsterone + NAD+ <=> 5alpha-androstane-3,17-dione + NADH + H+
|
1.1.1.105
all-trans-retinol dehydrogenase (NAD+)
1.1.1.112
indanol dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29252-a;
BS186973
KEGG:
R02476
MetaCyc:
1.1.1.209-RXN_WOP
SABIO-RK:
2408
|
|
|
|
11-deoxycorticosterone + 2 reduced_ferredoxin + O2 + 2 H+ <=> corticosterone + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
| |
KEGG:
R03851
|
|
|
|
5beta-androstane-3,17-dione + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.3.1
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
–
|
| |
BRENDA:
BS258364
KEGG:
R01835
MetaCyc:
RXN-16513
SABIO-RK:
10858
|
|
|
|
3alpha,17alpha,21-trihydroxy-5beta-pregnan-11,20-dione + NAD+ <=> 17alpha,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
| |
KEGG:
R04829
SABIO-RK:
11522
|
|
|
|
2-methoxyestradiol-17beta + UDP-glucuronate <=> 2-Methoxy-estradiol-17beta_3-glucuronide + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
KEGG:
R04354
|
|
|
|
5alpha-Pregnan-3alpha,21-diol-20-one + NADP+ <=> 5alpha-pregnane-21-ol-3,20-dione + NADPH
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
|
–
–
|
| |
BRENDA:
BS187705
KEGG:
R08955
SABIO-RK:
11518;
11520;
13066
|
|
|
|
17beta-estradiol + UDP-glucuronate <=> beta-estradiol-3-glucuronide + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS322185
KEGG:
R03091
SABIO-RK:
2931
|
|
|
|
tetrahydrocortisol + NADP+ <=> 11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADPH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
| |
KEGG:
R04833
SABIO-RK:
4478
|
|
|
|
androstenediol + NAD+ <=> testosterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
| |
BRENDA:
BS404313
KEGG:
R02499
|
|
|
|
Cholesterol_sulfate + H2O <=> cholesterol + sulfate
|
3.1.6.2
steryl-sulfatase
|
–
|
| |
BRENDA:
BS370890
KEGG:
R08941
|
|
|
|
NADP+ + 17alpha-estradiol <=> NADPH + estrone + H+
|
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
|
| |
BRENDA:
BR29213
KEGG:
R02349
MetaCyc:
ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN
SABIO-RK:
2297
|
|
|
|
5alpha-pregnane-3beta-ol-20-one + NADP+ <=> H+ + 5alpha-dihydroprogesterone + NADPH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.278
3beta-hydroxy-5alpha-steroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR47593;
BS187716
KEGG:
R07138;
R08957
MetaCyc:
1.1.1.278-RXN;
RXN66-567
SABIO-RK:
13071
|
|
|
|
3''-Phosphoadenylyl_sulfate + 2-methoxyestradiol-17beta <=> Adenosine_3'',5''-bisphosphate + 2-Methoxyestradiol-17beta_3-sulfate
|
2.8.2.15
steroid sulfotransferase
|
–
|
| |
KEGG:
R00537
|
|
|
|
(22R)-22-hydroxycholesterol + O2 + reduced_adrenodoxin + H+ <=> (20R,22R)-20,22-dihydroxy-cholesterol + H2O + oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
| |
BRENDA:
BR50361
KEGG:
R04855
MetaCyc:
RXN66-338
|
|
|
|
androstenediol + NADP+ <=> dehydroepiandrosterone + NADPH
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
|
| |
BRENDA:
BS188301
KEGG:
R03407
SABIO-RK:
3210
|
|
|
|
17alpha-hydroxyprogesterone + reduced_flavodoxin + O2 <=> 11-deoxycortisol + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
| |
BRENDA:
BS427270
KEGG:
R03326
|
|
|
|
cholesterol + O2 + 2 H+ + 2 reduced_ferredoxin <=> 20alpha-hydroxycholesterol + H2O + 2 oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
| |
KEGG:
R01454
|
|
|
|
17alpha,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ <=> H+ + cortisone + NADPH
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
| |
BRENDA:
BR36811
KEGG:
R02893
MetaCyc:
CORTISONE-BETA-REDUCTASE-RXN
SABIO-RK:
2753
|
|
|
|
cortisol + NADP+ <=> cortisone + NADPH + H+
|
1.1.1
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.B40
|
–
–
–
|
| |
BRENDA:
BS370906
KEGG:
R02836
MetaCyc:
RXN-12085
SABIO-RK:
2701
|
|
|
|
3''-phosphoadenylyl-sulfate + estrone <=> adenosine_3,5''-bisphosphate + Estrone_3-sulfate + H+
|
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
–
|
| |
BRENDA:
BR48119
KEGG:
R02350
MetaCyc:
ESTRONE-SULFOTRANSFERASE-RXN
SABIO-RK:
2298
|
|
|
|
19-hydroxytestosterone + O2 + reduced_flavodoxin <=> 19-oxotestosterone + 2 H2O + flavin
|
1.14.14.14
aromatase
|
–
|
| |
BRENDA:
BR50744
KEGG:
R04761
|
|
|
|
progesterone + O2 + reduced_acceptor <=> 11alpha-hydroxyprogesterone + H2O + acceptor
|
1.14.99.14
progesterone 11alpha-monooxygenase
|
–
|
| |
BRENDA:
BR40393;
BS415731
KEGG:
R02214
MetaCyc:
PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN
|
|
|
|
5beta-pregnane-3,20-dione + acceptor <=> progesterone + reduced_acceptor
|
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
|
| |
KEGG:
R02215
|
|
|
|
androstenediol + NAD+ <=> dehydroepiandrosterone + NADH
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
|
| |
BRENDA:
BS188505
KEGG:
R03406
SABIO-RK:
3209
|
|
|
|
NAD+ + 17alpha-estradiol <=> NADH + estrone + H+
|
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
|
–
–
|
| |
BRENDA:
BR29213-a
KEGG:
R02347
MetaCyc:
ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN_WOP
|
|
|
|
cortisol + NADPH <=> 11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
| |
BRENDA:
BS388394
KEGG:
R02841
SABIO-RK:
2706
|
|
|
|
corticosterone + O2 + reduced_adrenodoxin + H+ <=> 18-hydroxycorticosterone + H2O + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
1.14.15.5
corticosterone 18-monooxygenase
|
–
–
|
| |
BRENDA:
BR40407;
BS186781
KEGG:
R03262
MetaCyc:
RXN66-360
|
|
|
|
17alpha-hydroxyprogesterone + reduced_flavodoxin + O2 <=> 4-androstene-3,17-dione + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
| |
BRENDA:
BR362
KEGG:
R08518
|
|
|
|
18-hydroxycorticosterone + reduced_adrenodoxin + H+ + O2 <=> H2O + aldosterone + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
1.14.15.5
corticosterone 18-monooxygenase
|
–
–
|
| |
BRENDA:
BS186783;
BS424454
KEGG:
R03263
MetaCyc:
RXN66-361
|
|
|
|
Tetrahydrocorticosterone + NAD+ <=> 5beta-dihydrocorticosterone + NADH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
| |
KEGG:
R04837
|
|
|
|
allopregnanolone + NADPH <=> 5alpha-pregnane-3alpha,20alpha-diol + NADP+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
|
–
|
| |
BRENDA:
BS372153
KEGG:
R08959
SABIO-RK:
10623
|
|
|
|
progesterone + 2 reduced_ferredoxin + O2 + 2 H+ <=> 11beta-hydroxyprogesterone + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
| |
KEGG:
R02218
|
|
|
|
3alpha,11beta,21-trihydroxy-20-oxo-5beta-pregnan-18-al + NAD+ <=> 11beta,21-dihydroxy-3,20-oxo-5beta-pregnan-18-al + NADH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
| |
KEGG:
R04835
|
|
|
|
estrone + H+ + O2 + NADPH <=> 2-hydroxyestrone + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R02355
|
|
|
|
11-deoxycorticosterone + NADPH <=> 5alpha-pregnane-21-ol-3,20-dione + NADP+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
| |
BRENDA:
BS258532
KEGG:
R08954
|
|
|
|
estrone + UDP-glucuronate <=> UDP + estrone_3-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS322194
KEGG:
R02358
|
|
|
|
5alpha-androstane-3,17-dione + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
| |
KEGG:
R10242
SABIO-RK:
14506
|
|
|
|
5alpha-dihydroprogesterone + NADP+ <=> progesterone + NADPH + H+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
–
|
| |
BRENDA:
BS258427
KEGG:
R02208
MetaCyc:
PROGESTERONE-5-ALPHA-REDUCTASE-RXN
SABIO-RK:
2180
|
|
|
|
21-deoxycortisol + reduced_flavodoxin + O2 <=> cortisol + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
| |
KEGG:
R02838
|
|
|
|
20alpha-hydroxycholesterol + reduced_flavodoxin + O2 <=> 17alpha,20alpha-dihydroxycholesterol + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
| |
KEGG:
R04853
|
|
|
|
3''-phosphoadenylylsulfate + 17beta-estradiol <=> adenosine_3'',5''-bisphosphate + estradiol_3-sulfate
|
2.8.2.1
aryl sulfotransferase
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.3
amine sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
–
–
–
|
| |
BRENDA:
BS360260;
BS452476
KEGG:
R00535
SABIO-RK:
953
|
|
|
|
5alpha-pregnan-20alpha-ol-3-one + NADP+ <=> 5alpha-dihydroprogesterone + NADPH
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
–
|
| |
BRENDA:
BS372151
KEGG:
R08958
|
|
|
|
4-androstene-3,17-dione + O2 + reduced_flavodoxin <=> 19-hydroxyandrost-4-ene-3,17-dione + H2O + flavin
|
1.14.14.14
aromatase
|
–
|
| |
BRENDA:
BR50747;
BS425925
KEGG:
R01840
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 17alpha-hydroxyprogesterone + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
| |
BRENDA:
BS258003
KEGG:
R02211
|
|
|
|
O2 + reduced_acceptor + 17beta-estradiol <=> H2O + acceptor + 6beta-Hydroxyestradiol-17beta
|
1.14.99.11
estradiol 6beta-monooxygenase
|
–
|
| |
BRENDA:
BR40395
KEGG:
R03086
MetaCyc:
ESTRADIOL-6-BETA-MONOOXYGENASE-RXN
|
|
|
|
pregnenolone_sulfate + H2O <=> pregnenolone + sulfate
|
3.1.6.2
steryl-sulfatase
|
–
|
| |
BRENDA:
BS374416
KEGG:
R08942
|
|
|
|
testosterone + reduced_flavodoxin + O2 <=> 7alpha,17beta-dihydroxyandrost-4-en-3-one + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R02503
|
|
|
|
5beta-androstane-3,17-dione + NADPH <=> 5beta-androstane-3alpha-ol-17-one + NADP+
|
1.1.1.112
indanol dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
–
–
–
|
| |
BRENDA:
BS187024
KEGG:
R04310
SABIO-RK:
4009
|
|
|
|
testosterone + NADPH + H+ <=> 5beta-dihydrotestosterone + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
| |
BRENDA:
BS258366
KEGG:
R02498
SABIO-RK:
10859
|
|
