|
|
25-hydroxyvitamin_D3 + reduced_adrenodoxin + O2 + H+ <=> 1alpha,25-dihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.18
calcidiol 1-monooxygenase
|
–
|
|
BRENDA:
BR40512
KEGG:
R03610
MetaCyc:
CALCIDIOL-1-MONOOXYGENASE-RXN
|
|
|
|
3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + NAD+ <=> Episterone + NADH + CO2
|
1.1.1.418
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
KEGG:
R12375
MetaCyc:
RXN-11933
|
|
|
|
cholesteryl_ester + H2O <=> cholesterol + fatty_acid
|
3.1.1.13
sterol esterase
|
–
|
|
BRENDA:
BS363944
KEGG:
R01462
|
|
|
|
squalene + diphosphate + NADP+ <=> presqualene_diphosphate + NADPH + H+
|
1.3.1.96
Botryococcus squalene synthase
1.3.1.97
botryococcene synthase
2.5.1.21
squalene synthase
|
–
–
–
|
|
BRENDA:
BR48481
KEGG:
R02872
MetaCyc:
RXN-13724;
RXN66-281
|
|
|
|
lanosterol + reduced_flavodoxin + O2 <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + flavin + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
|
BRENDA:
BS186735
KEGG:
R05640
|
|
|
|
ergosta-5-enol + NADPH + H+ + O2 <=> brassicasterol + NADP+ + H2O
|
1.14.19.41
sterol 22-desaturase
|
–
|
|
BRENDA:
BS433222
KEGG:
R11097
|
|
|
|
5alpha-Cholest-7-en-3beta-ol <=> 5alpha-cholesta-8-en-3beta-ol
|
5.3.3.5
cholestenol Delta-isomerase
|
–
|
|
BRENDA:
BR3
KEGG:
R03353
MetaCyc:
RXN66-25
|
|
|
|
24,25-dihydrolanosterol + NADP+ <=> lanosterol + NADPH + H+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
|
BRENDA:
BS189402
KEGG:
R03689
MetaCyc:
RXN66-10
|
|
|
|
cycloeucalenol <=> obtusifoliol
|
5.5.1.9
cycloeucalenol cycloisomerase
|
–
|
|
BRENDA:
BR267
KEGG:
R03775
MetaCyc:
CYCLOEUCALENOL-CYCLOISOMERASE-RXN
|
|
|
|
S-adenosyl-L-methionine + Cycloartenol <=> H+ + S-adenosyl-L-homocysteine + 24(28)-methylene_cycloartanol
|
2.1.1.142
cycloartenol 24-C-methyltransferase
2.1.1.41
sterol 24-C-methyltransferase
|
–
–
|
|
BRENDA:
BS377685
KEGG:
R07481
MetaCyc:
RXN-4021
SABIO-RK:
12309
|
|
|
|
Cholesta-5,7,24-trienol + reduced_acceptor <=> 5alpha-cholesta-7,24-dien-3beta-ol + acceptor
|
not assigned
|
–
|
|
KEGG:
R04667
|
|
|
|
25-hydroxyvitamin_D3 + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 1alpha,25-dihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.22
vitamin D 1,25-hydroxylase
|
–
|
|
BRENDA:
BR51835
KEGG:
R11459
MetaCyc:
RXN-18215
|
|
|
|
vitamin_D3 + O2 + reduced_flavodoxin <=> 25-hydroxyvitamin_D3 + flavin + H2O
|
1.14.14.24
vitamin D 25-hydroxylase
|
–
|
|
BRENDA:
BR50107
KEGG:
R03611
|
|
|
|
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
|
1.3.1.70
Delta14-sterol reductase
|
–
|
|
BRENDA:
BR29447
KEGG:
R05639
MetaCyc:
RXN66-306
|
|
|
|
episterol + O2 + ferricytochrome_b5 + H+ <=> 5-dehydroepisterol + H2O + ferricytochrome_b5
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
|
BRENDA:
BS428606
KEGG:
R07491;
R07505
MetaCyc:
RXN3O-218
|
|
|
|
24-methylene_cholesterol + NADPH + H+ <=> ergosta-5-enol + NADP+
|
1.3.1
|
–
|
|
KEGG:
R11096
|
|
|
|
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> 3-dehydro-4-methylzymosterol + NADPH + CO2
|
1.1.1.170
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
BRENDA:
BS422640
KEGG:
R07494
MetaCyc:
RXN66-313
|
|
|
|
S-adenosyl-L-methionine + Zymosterol <=> H+ + S-adenosyl-L-homocysteine + fecosterol
|
2.1.1.142
cycloartenol 24-C-methyltransferase
2.1.1.143
24-methylenesterol C-methyltransferase
2.1.1.41
sterol 24-C-methyltransferase
|
–
–
–
|
|
BRENDA:
BR43897
KEGG:
R04427
MetaCyc:
RXN3O-178
SABIO-RK:
4114
|
|
|
|
24(28)-methylene_cycloartanol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.10
plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase
|
–
|
|
BRENDA:
BR52723
KEGG:
R12377
MetaCyc:
RXN-19720
|
|
|
|
acyl-CoA + cholesterol <=> CoA + cholesteryl_ester
|
2.3.1.26
sterol O-acyltransferase
|
–
|
|
BRENDA:
BS320749
KEGG:
R01461
|
|
|
|
squalene + reduced_flavodoxin + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + flavin + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
BRENDA:
BR40381
KEGG:
R02874
|
|
|
|
5alpha-Cholest-7-en-3beta-ol + ferricytochrome_b5 + O2 + H+ <=> 7-dehydrocholesterol + ferricytochrome_b5 + H2O
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
|
BRENDA:
BS258666;
BS432737
KEGG:
R07215
MetaCyc:
1.14.21.6-RXN
SABIO-RK:
14442
|
|
|
|
campesterol + NADP+ <=> 24-methylene_cholesterol + NADPH + H+
|
1.3.1
1.3.1.72
Delta24-sterol reductase
1.3.1.M20
|
–
–
–
|
|
BRENDA:
BS442167
KEGG:
R07493
MetaCyc:
RXN-20131
|
|
|
|
sitosterol + NADPH + H+ + O2 <=> stigmasterol + NADP+ + H2O
|
1.14.19.41
sterol 22-desaturase
|
–
|
|
BRENDA:
BS432714
KEGG:
R07489
|
|
|
|
25-hydroxyvitamin_D3 + reduced_adrenodoxin + H+ + O2 <=> secalciferol + oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
BRENDA:
BR49598
KEGG:
R09516
MetaCyc:
RXN-12069
|
|
|
|
ergosterol + light <=> vitamin_D2
|
not assigned
|
–
|
|
KEGG:
R03677
|
|
|
|
4alpha-methylzymosterol + NADP+ <=> H+ + 3-dehydro-4-methylzymosterol + NADPH
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
BRENDA:
BS422645
KEGG:
R07495
MetaCyc:
RXN66-314
|
|
|
|
squalene + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + 2 ferricytochrome_b5 + H2O
|
1.14.19
|
–
|
|
KEGG:
R12355
|
|
|
|
episterol + O2 + ferricytochrome_b5 + H+ <=> 5-dehydroepisterol + H2O + ferricytochrome_b5
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
|
BRENDA:
BS428606
KEGG:
R07491;
R07505
MetaCyc:
RXN3O-218
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> Cycloartenol
|
5.4.99.8
cycloartenol synthase
|
–
|
|
BRENDA:
BR255
KEGG:
R03200
MetaCyc:
CYCLOARTENOL-SYNTHASE-RXN
|
|
|
|
5alpha-cholesta-7,24-dien-3beta-ol <=> Zymosterol
|
5.3.3.5
cholestenol Delta-isomerase
|
–
|
|
BRENDA:
BS399747
KEGG:
R04804
MetaCyc:
RXN66-320
SABIO-RK:
4455
|
|
|
|
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+ <=> 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADPH + H+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
|
BRENDA:
BS189403
KEGG:
R07499
MetaCyc:
RXN-20119
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol
|
5.4.99.17
squalene---hopene cyclase
5.4.99.7
lanosterol synthase
|
–
–
|
|
BRENDA:
BR254
KEGG:
R03199
MetaCyc:
LANOSTEROL-SYNTHASE-RXN
SABIO-RK:
3027
|
|
|
|
24-ethylidenelophenol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.11
plant 4alpha-monomethylsterol monooxygenase
|
–
|
|
BRENDA:
BS446036
KEGG:
R12379
MetaCyc:
RXN-19723
|
|
|
|
cycloeucalenol + NADP+ <=> cycloeucalenone + NADPH + H+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
BRENDA:
BS188009
KEGG:
R12399
MetaCyc:
RXN-11929
|
|
|
|
Cholesta-5,7,24-trienol + NADPH + H+ <=> 7-dehydrocholesterol + NADP+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
|
BRENDA:
BS189404
KEGG:
R07507
|
|
|
|
avenasterol + NADP+ <=> avenastenone + NADPH + H+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
BRENDA:
BS188006
KEGG:
R12401
MetaCyc:
RXN-11939
|
|
|
|
5-dehydroepisterol + NADPH + H+ + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP+ + 2 H2O
|
1.14.19.41
sterol 22-desaturase
|
–
|
|
BRENDA:
BR51505;
BS432793
KEGG:
R07506
|
|
|
|
avenasterol + ferricytochrome_b5 + O2 + H+ <=> DELTA5,7-avenasterol + ferricytochrome_b5 + H2O
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
|
KEGG:
R07486
MetaCyc:
RXN-4209
|
|
|
|
sitosterol + NADP+ <=> isofucosterol + NADPH + H+
|
1.3.1
1.3.1.70
Delta14-sterol reductase
1.3.1.72
Delta24-sterol reductase
1.3.1.M20
|
–
–
–
–
|
|
BRENDA:
BS370997
KEGG:
R07488
MetaCyc:
RXN-20132
|
|
|
|
Zymosterol + NADPH <=> 5alpha-cholesta-8-en-3beta-ol + NADP+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
|
BRENDA:
BS189400
KEGG:
R07498
|
|
|
|
desmosterol + acceptor <=> Cholesta-5,7,24-trienol + reduced_acceptor
|
not assigned
|
–
|
|
KEGG:
R03724
|
|
|
|
diacylglycerol + cholesterol <=> monoacylglycerol + cholesteryl_ester
|
2.3.1.73
diacylglycerol---sterol O-acyltransferase
|
–
|
|
KEGG:
R02692
|
|
|
|
DELTA5,7-avenasterol <=> isofucosterol
|
1.3.1.21
7-dehydrocholesterol reductase
|
–
|
|
KEGG:
R07487
|
|
|
|
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + O2 + ferricytochrome_b5 + H+ <=> 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.9
4alpha-methylsterol monooxygenase
|
–
|
|
KEGG:
R07509
MetaCyc:
RXN-13712
|
|
|
|
lanosterol + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized_ferredoxin + H2O
|
1.14.15.36
sterol 14alpha-demethylase (ferredoxin)
|
–
|
|
KEGG:
R12323
MetaCyc:
RXN-20130
|
|
|
|
4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD+ <=> avenastenone + NADH + CO2
|
1.1.1.418
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
KEGG:
R12376
MetaCyc:
RXN-11938
|
|
|
|
(2E,6E)-farnesyl_diphosphate <=> presqualene_diphosphate + diphosphate
|
2.5.1.103
presqualene diphosphate synthase
2.5.1.21
squalene synthase
2.5.1.96
4,4'-diapophytoene synthase
|
–
–
–
|
|
BRENDA:
BR49808
KEGG:
R00702
MetaCyc:
RXN-12263
SABIO-RK:
1080
|
|
|
|
4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol + NADP+ <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
|
1.3.1.70
Delta14-sterol reductase
|
–
|
|
BRENDA:
BS370809
KEGG:
R07483
MetaCyc:
RXN-4144
|
|
|
|
cholesterol + NADP+ <=> 7-dehydrocholesterol + NADPH + H+
|
1.3.1.21
7-dehydrocholesterol reductase
|
–
|
|
BRENDA:
BR33764
KEGG:
R01456
MetaCyc:
RXN66-323
SABIO-RK:
1634
|
|
|
|
fecosterol <=> episterol
|
not assigned
|
–
|
|
KEGG:
R07497
MetaCyc:
RXN3O-203
|
|
|
|
4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD+ <=> cycloeucalenone + NADH + CO2
|
1.1.1.418
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
BRENDA:
BS446830
KEGG:
R12371
MetaCyc:
RXN-11928
|
|
|
|
24(28)-methylene_lophenol + O2 + ferricytochrome_b5 + H+ <=> 3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + ferricytochrome_b5 + H2O
|
1.14.18.11
plant 4alpha-monomethylsterol monooxygenase
|
–
|
|
BRENDA:
BR52727
KEGG:
R12378
MetaCyc:
RXN-19724
|
|
|
|
Zymosterol + NADP+ <=> H+ + zymosterone + NADPH
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
|
|
BRENDA:
BS374946
KEGG:
R12405
MetaCyc:
RXN66-319
|
|
|
|
obtusifoliol + reduced_flavodoxin + O2 <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + flavin + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
|
BRENDA:
BS186733
KEGG:
R05731
|
|
|
|
1alpha,25-dihydroxyvitamin_D3 + reduced_adrenodoxin + O2 + H+ <=> 1alpha,24R,25-trihydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.16
vitamin D3 24-hydroxylase
|
–
|
|
BRENDA:
BR49597
KEGG:
R09515
MetaCyc:
RXN-9830
|
|
|
|
4alpha-methylzymosterol + O2 + ferricytochrome_b5 + H+ <=> 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome_b5 + H2O
|
1.14.18.9
4alpha-methylsterol monooxygenase
|
–
|
|
KEGG:
R12403
MetaCyc:
RXN-13709
|
|
|
|
ergosterol + NADP+ <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
|
1.3.1.71
Delta24(241)-sterol reductase
1.3.1.72
Delta24-sterol reductase
|
–
–
|
|
BRENDA:
BR36833;
BS370945
KEGG:
R05641
MetaCyc:
1.3.1.71-RXN
|
|
|
|
vitamin_D3 + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 25-hydroxyvitamin_D3 + oxidized_ferredoxin + H2O
|
1.14.15.22
vitamin D 1,25-hydroxylase
|
–
|
|
BRENDA:
BR51834
KEGG:
R11458
MetaCyc:
RXN-18214
|
|
|
|
4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> zymosterone + NADPH + CO2
|
1.1.1.170
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
|
BRENDA:
BS422642
KEGG:
R12404
MetaCyc:
RXN66-318
|
|
|
|
5-dehydroepisterol <=> 24-methylene_cholesterol
|
1.3.1.21
7-dehydrocholesterol reductase
|
–
|
|
KEGG:
R07492
|
|
|
|
Episterone + NADPH + H+ <=> episterol + NADP+
|
1.1.1
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
–
|
|
KEGG:
R12400
MetaCyc:
RXN-11934
|
|
|
|
S-adenosyl-L-methionine + 24(28)-methylene_lophenol <=> H+ + 24-ethylidenelophenol + S-adenosyl-L-homocysteine
|
2.1.1.142
cycloartenol 24-C-methyltransferase
2.1.1.143
24-methylenesterol C-methyltransferase
2.1.1.41
sterol 24-C-methyltransferase
|
–
–
–
|
|
BRENDA:
BR33800
KEGG:
R05776
MetaCyc:
2.1.1.143-RXN
SABIO-RK:
5368
|
|
|
|
5alpha-Cholest-7-en-3beta-ol + NADP+ <=> 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
|
BRENDA:
BR29448
KEGG:
R05703
MetaCyc:
RXN66-321
|
|
|
|
cholesterol + NAD+ <=> 7-dehydrocholesterol + NADH + H+
|
1.3.1.21
7-dehydrocholesterol reductase
|
–
|
|
KEGG:
R01451
|
|
|
|
7-dehydrocholesterol + light <=> vitamin_D3
|
not assigned
|
–
|
|
KEGG:
R03311
|
|
|
|
cholesterol + NADP+ <=> desmosterol + NADPH + H+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
|
BRENDA:
BS189401
KEGG:
R01457
MetaCyc:
RXN66-28
|
|
|
|
24(28)-methylene_lophenol <=> 4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol
|
5.3.3.5
cholestenol Delta-isomerase
|
–
|
|
BRENDA:
BS418315
KEGG:
R07484
MetaCyc:
RXN-4161
|
|