|
|
sphingomyelin + H2O <=> ceramide + phosphocholine + H+
|
3.1.4.12
sphingomyelin phosphodiesterase
3.1.4.3
phospholipase C
|
–
–
|
| |
BRENDA:
BR15953
KEGG:
R02541
MetaCyc:
SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
SABIO-RK:
2460
|
|
|
|
ceramide + phosphatidylcholine <=> sphingomyelin + diacylglycerol
|
2.7.8.27
sphingomyelin synthase
|
–
|
| |
BRENDA:
BR48769
KEGG:
R08969
MetaCyc:
2.7.8.27-RXN
|
|
|
|
acyl-CoA + phytosphingosine <=> CoA + phytoceramide
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
| |
KEGG:
R06527
|
|
|
|
digalactosylceramide + H2O <=> D-galactose + galactosylceramide
|
3.2.1.22
alpha-galactosidase
|
–
|
| |
BRENDA:
BS452754
KEGG:
R04019;
R06094
|
|
|
|
3''-phosphoadenylyl-sulfate + digalactosylceramide <=> Digalactosylceramide_sulfate + adenosine_3,5''-bisphosphate + H+
|
2.8.2.11
galactosylceramide sulfotransferase
|
–
|
| |
KEGG:
R05105;
R06122
MetaCyc:
RXN-18303
|
|
|
|
sphinganine_1-phosphate + H2O <=> sphinganine + phosphate
|
3.1.3
3.1.3.4
phosphatidate phosphatase
|
–
–
|
| |
BRENDA:
BS391833
KEGG:
R06520
MetaCyc:
DHS-PHOSPHATASE-RXN
SABIO-RK:
6096
|
|
|
|
acyl-CoA + sphingosylphosphorylcholine <=> CoA + sphingomyelin
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
| |
KEGG:
R02543
|
|
|
|
CMP-2-aminoethylphosphonate + ceramide <=> Ceramide_2-aminoethylphosphonate + CMP
|
2.7.8
|
–
|
| |
KEGG:
R04921
|
|
|
|
sphingosine + ATP <=> H+ + sphingosine_1-phosphate + ADP
|
2.7.1.91
sphingosine kinase
|
–
|
| |
BRENDA:
BR44314
KEGG:
R01926
MetaCyc:
RXN3DJ-11417
SABIO-RK:
1980
|
|
|
|
UDP-glucose + ceramide <=> beta-D-glucosyl-N-acylsphingosine + UDP + H+
|
2.4.1.80
ceramide glucosyltransferase
|
–
|
| |
BRENDA:
BR44252;
BS378013
KEGG:
R01497;
R06275
MetaCyc:
CERAMIDE-GLUCOSYLTRANSFERASE-RXN;
RXN-18272
|
|
|
|
beta-D-glucosyl-N-acylsphingosine + H2O <=> ceramide + D-glucose
|
3.2.1.104
steryl-beta-glucosidase
3.2.1.21
beta-glucosidase
3.2.1.45
glucosylceramidase
3.2.1.62
glycosylceramidase
|
–
–
–
–
|
| |
BRENDA:
BR16004;
BS140065
KEGG:
R01498
MetaCyc:
GLUCOSYLCERAMIDASE-RXN
SABIO-RK:
12280
|
|
|
|
CDP-choline + sphingosine <=> sphingosylphosphorylcholine + CMP + H+
|
2.7.8.10
sphingosine cholinephosphotransferase
|
–
|
| |
BRENDA:
BR47906
KEGG:
R01929
MetaCyc:
2.7.8.10-RXN
|
|
|
|
sphinganine + NADP+ <=> 3-dehydrosphinganine + NADPH + H+
|
1.1.1.102
3-dehydrosphinganine reductase
|
–
|
| |
BRENDA:
BR29168
KEGG:
R02978
MetaCyc:
3-DEHYDROSPHINGANINE-REDUCTASE-RXN;
RXN-20505
|
|
|
|
acyl-CoA + sphingosine <=> ceramide + CoA + H+
|
2.3.1.24
sphingosine N-acyltransferase
2.3.1.291
sphingoid base N-palmitoyltransferase
|
–
–
|
| |
BRENDA:
BR44023
KEGG:
R01496
MetaCyc:
RXN-20352;
SPHINGOSINE-N-ACYLTRANSFERASE-RXN
|
|
|
|
ceramide_1-phosphate + H2O <=> ceramide + phosphate
|
3.1.3
3.1.3.4
phosphatidate phosphatase
|
–
–
|
| |
BRENDA:
BS381641
KEGG:
R06522
SABIO-RK:
6098
|
|
|
|
dihydroceramide + H2O <=> sphinganine + fatty_acid
|
3.5.1.23
ceramidase
|
–
|
| |
BRENDA:
BS413350
KEGG:
R06518
|
|
|
|
galactosylceramide + H2O <=> ceramide + D-galactose
|
3.2.1.123
endoglycosylceramidase
3.2.1.21
beta-glucosidase
3.2.1.46
galactosylceramidase
3.2.1.62
glycosylceramidase
|
–
–
–
–
|
| |
BRENDA:
BR19215;
BS140063
KEGG:
R03617
MetaCyc:
GALACTOSYLCERAMIDASE-RXN
SABIO-RK:
3399
|
|
|
|
palmitoyl-CoA + L-serine + H+ <=> 3-dehydrosphinganine + CO2 + CoA
|
2.3.1.50
serine C-palmitoyltransferase
|
–
|
| |
BRENDA:
BR44052
KEGG:
R01281
MetaCyc:
SERINE-C-PALMITOYLTRANSFERASE-RXN
|
|
|
|
UDP-galactose + galactosylceramide <=> digalactosylceramide + UDP + H+
|
2.4.1
2.4.1.241
digalactosyldiacylglycerol synthase
|
–
–
|
| |
KEGG:
R04016;
R06234
MetaCyc:
RXN-18302
|
|
|
|
cerebroside_3-sulfate + H2O <=> glucosylceramide + H+ + sulfate
|
3.1.6.1
arylsulfatase
3.1.6.3
glycosulfatase
3.1.6.8
cerebroside-sulfatase
|
–
–
–
|
| |
BRENDA:
BR15975;
BS93878
KEGG:
R04856;
R06280
MetaCyc:
CEREBROSIDE-SULFATASE-RXN
|
|
|
|
dihydroceramide + 2 ferricytochrome_b5 + O2 + 2 H+ <=> a_(4R)-4-hydroxysphinganine_ceramide + 2 ferricytochrome_b5 + H2O
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
| |
BRENDA:
BR50264
KEGG:
R06526
|
|
|
|
sphingosine_1-phosphate + H2O <=> sphingosine + phosphate
|
3.1.3
3.1.3.4
phosphatidate phosphatase
|
–
–
|
| |
BRENDA:
BS380760
KEGG:
R06521
MetaCyc:
RXN3DJ-25
|
|
|
|
galactosylceramide + N-acetylneuraminate <=> GM4 + H2O
|
3.2.1.18
exo-alpha-sialidase
|
–
|
| |
KEGG:
R04018
|
|
|
|
UDP-galactose + beta-D-glucosyl-N-acylsphingosine <=> lactosylceramide + H+ + UDP
|
2.4.1.274
glucosylceramide beta-1,4-galactosyltransferase
|
–
|
| |
BRENDA:
BR49761
KEGG:
R03354;
R06276
MetaCyc:
RXN-12119
|
|
|
|
sphinganine + ATP <=> H+ + sphinganine_1-phosphate + ADP
|
2.7.1.91
sphingosine kinase
|
–
|
| |
BRENDA:
BS370403
KEGG:
R02976
MetaCyc:
SPHINGANINE-KINASE-RXN
SABIO-RK:
2830
|
|
|
|
ceramide + CDP-choline <=> sphingomyelin + CMP + H+
|
2.7.8.3
ceramide cholinephosphotransferase
|
–
|
| |
BRENDA:
BR48093
KEGG:
R01891
MetaCyc:
CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN
|
|
|
|
UDP-galactose + sphingosine <=> H+ + galactosylsphingosine + UDP
|
2.4.1.23
sphingosine beta-galactosyltransferase
|
–
|
| |
BRENDA:
BR44204
KEGG:
R01928
MetaCyc:
2.4.1.23-RXN
|
|
|
|
lactosylceramide + H2O <=> glucosylceramide + D-galactose
|
3.2.1.23
beta-galactosidase
|
–
|
| |
KEGG:
R03355
|
|
|
|
ceramide + H2O <=> sphingosine + fatty_acid
|
3.5.1.23
ceramidase
|
–
|
| |
BRENDA:
BR19241;
BS116225
KEGG:
R01493;
R01494
MetaCyc:
CERAMIDASE-RXN;
RXN-11375
SABIO-RK:
1667
|
|
|
|
ceramide + CDP-ethanolamine <=> a_ceramide_phosphoethanolamine + CMP + H+
|
2.7.8
|
–
|
| |
KEGG:
R01503
MetaCyc:
RXN-15020
|
|
|
|
dihydroceramide + O2 + ferricytochrome_b5 + H+ <=> ceramide + ferricytochrome_b5 + H2O
|
1.14.19.17
sphingolipid 4-desaturase
|
–
|
| |
BRENDA:
BR51368
KEGG:
R06519
MetaCyc:
RXN-16332
|
|
|
|
UDP-galactose + ceramide <=> galactosylceramide + UDP + H+
|
2.4.1.47
N-acylsphingosine galactosyltransferase
|
–
|
| |
BRENDA:
BR44227;
BS322811
KEGG:
R01500;
R06277
MetaCyc:
2.4.1.47-RXN
|
|
|
|
H2O + sphingomyelin <=> ceramide_1-phosphate + choline + H+
|
3.1.4.4
phospholipase D
3.1.4.41
sphingomyelin phosphodiesterase D
|
–
–
|
| |
BRENDA:
BR15963
KEGG:
R02542
MetaCyc:
SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN
|
|
|
|
3''-phosphoadenylyl-sulfate + galactosylceramide <=> cerebroside_3-sulfate + adenosine_3,5''-bisphosphate + H+
|
2.8.2.11
galactosylceramide sulfotransferase
|
–
|
| |
BRENDA:
BR48106;
BS360170;
BS436817
KEGG:
R04017;
R06279
MetaCyc:
GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN;
RXN-18301
|
|
|
|
acyl-CoA + sphinganine <=> dihydroceramide + CoA + H+
|
2.3.1.24
sphingosine N-acyltransferase
2.3.1.291
sphingoid base N-palmitoyltransferase
2.3.1.297
very-long-chain ceramide synthase
|
–
–
–
|
| |
BRENDA:
BS320738;
BS449519
KEGG:
R06517
MetaCyc:
RXN-7792
|
|
|
|
sphinganine_1-phosphate <=> hexadecanal + Phosphoethanolamine
|
4.1.2.27
sphinganine-1-phosphate aldolase
|
–
|
| |
BRENDA:
BR359
KEGG:
R02464
MetaCyc:
SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN
|
|
|
|
sphinganine + O2 + ferricytochrome_b5 + H+ <=> phytosphingosine + H2O + ferricytochrome_b5
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
| |
KEGG:
R06525
MetaCyc:
RXN3O-1380
|
|
|
|
ceramide + ATP <=> ceramide_1-phosphate + ADP + H+
|
2.7.1.138
ceramide kinase
|
–
|
| |
BRENDA:
BR47750
KEGG:
R01495
MetaCyc:
CERAMIDE-KINASE-RXN
SABIO-RK:
1668
|
|
|
|
sphingosine_1-phosphate <=> 2-trans-hexadecenal + Phosphoethanolamine
|
4.1.2
4.1.2.27
sphinganine-1-phosphate aldolase
4.3.2
|
–
–
–
|
| |
BRENDA:
BS416810
KEGG:
R06516
MetaCyc:
RXN3DJ-11230
|
|
|
|
phytoceramide + H2O <=> phytosphingosine + fatty_acid
|
3.5.1.23
ceramidase
|
–
|
| |
BRENDA:
BS413533
KEGG:
R06528
|
|
