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Sesquiterpenoid and triterpenoid biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(+)-epi-isozizaene + O2 + NADPH + H+ <=> (5S)-albaflavenol + H2O + NADP+ 1.14.13.106 epi-isozizaene 5-monooxygenase
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(2E,6E)-farnesyl_diphosphate <=> (E)-2-epi-beta-caryophyllene + diphosphate 4.2.3.137 (E)-2-epi-beta-caryophyllene synthase
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(2E,6E)-farnesyl_diphosphate <=> (E)-beta-farnesene + diphosphate 4.2.3.47 beta-farnesene synthase
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(2E,6E)-farnesyl_diphosphate <=> (-)-vetispiradiene + diphosphate 4.2.3.21 vetispiradiene synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> parkeol 5.4.99.47 parkeol synthase
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beta-amyrin + reduced_flavodoxin + O2 <=> 24-hydroxy-beta-amyrin + flavin + H2O 1.14.14.134 beta-amyrin 24-hydroxylase
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5-epiaristolochene + 2 reduced_flavodoxin + 2 O2 <=> capsidiol + 2 flavin + 2 H2O 1.14.14.149 5-epiaristolochene 1,3-dihydroxylase
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(+)-beta-caryophyllene + H2O <=> (+)-caryolan-1-ol 4.2.1.138 (+)-caryolan-1-ol synthase
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(2E,6E)-farnesyl_diphosphate <=> (E,E)-germacrene_B + diphosphate 4.2.3.71 (E,E)-germacrene B synthase
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(2E,6E)-farnesol + NAD+ <=> (2E,6E)-farnesal + NADH + H+ 1.1.1.347 geraniol dehydrogenase (NAD+)
1.1.1.354 farnesol dehydrogenase (NAD+)
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> (17Z)-protosta-17(20),24-dien-3beta-ol 5.4.99.32 protostadienol synthase
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(2E,6E)-farnesol <=> farnesol 5.2.1.9 farnesol 2-isomerase
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(2E,6E)-farnesyl_diphosphate <=> (S)-beta-bisabolene + diphosphate 4.2.3.55 (S)-beta-bisabolene synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> alpha-amyrin 5.4.99.40 alpha-amyrin synthase
5.4.99.B2
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(2E,6E)-farnesyl_diphosphate <=> (E)-gamma-bisabolene + diphosphate 4.2.3.59 (E)-gamma-bisabolene synthase
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squalene <=> hop-22(29)-ene 5.4.99.17 squalene---hopene cyclase
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(2E,6E)-farnesyl_diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate 4.2.3.25 S-linalool synthase
4.2.3.26 R-linalool synthase
4.2.3.48 (3S,6E)-nerolidol synthase
4.2.3.49 (3R,6E)-nerolidol synthase
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(2E,6E)-farnesyl_diphosphate <=> (+)-beta-caryophyllene + diphosphate 4.2.3.89 (+)-beta-caryophyllene synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> taraxerol 5.4.99.35 taraxerol synthase
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(20S)-dammarenediol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O 4.2.1.125 dammarenediol II synthase
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(2E,6E)-farnesyl_diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate 4.2.3.25 S-linalool synthase
4.2.3.26 R-linalool synthase
4.2.3.48 (3S,6E)-nerolidol synthase
4.2.3.49 (3R,6E)-nerolidol synthase
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(2E,6E)-farnesyl_diphosphate <=> 8a-epi-alpha-selinene + diphosphate 4.2.3.198 alpha-selinene synthase
4.2.3.90 5-epi-alpha-selinene synthase
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(-)-vetispiradiene + reduced_flavodoxin + O2 <=> solavetivol + flavin + H2O 1.14.14.151 premnaspirodiene oxygenase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> beta-seco-amyrin 5.4.99.54 beta-seco-amyrin synthase
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(2E,6E)-farnesyl_diphosphate + H2O <=> 8-epi-cedrol + diphosphate 4.2.3.39 epi-cedrol synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lupeol 5.4.99.34 germanicol synthase
5.4.99.41 lupeol synthase
5.4.99.B2
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squalene + H2O <=> hopan-22-ol 4.2.1.129 squalene---hopanol cyclase
5.4.99.17 squalene---hopene cyclase
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(2E,6E)-farnesyl_diphosphate <=> germacrene_A + diphosphate 4.2.3.23 germacrene-A synthase
4.2.3.9 aristolochene synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> baruol 5.4.99.57 baruol synthase
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solavetivol + reduced_flavodoxin + O2 <=> solavetivone + flavin + 2 H2O 1.14.14.151 premnaspirodiene oxygenase
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germacrene_A + O2 + reduced_flavodoxin <=> germacra-1(10),4,11(13)-trien-12-ol + flavin + H2O 1.14.14.95 germacrene A hydroxylase
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squalene + reduced_flavodoxin + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + flavin + H2O 1.14.14.17 squalene monooxygenase
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(2E,6E)-farnesyl_diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate 4.2.3.46 alpha-farnesene synthase
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(2E,6E)-farnesyl_diphosphate <=> beta-selinene + diphosphate 4.2.3.66 beta-selinene cyclase
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2 delta-cadinene <=> gossypol not assigned
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(2E,6E)-farnesyl_diphosphate + H2O <=> diphosphate + (-)-patchoulol 4.2.3.70 patchoulol synthase
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(2E,6E)-farnesyl_diphosphate <=> (Z)-gamma-bisabolene + diphosphate 4.2.3.40 (Z)-gamma-bisabolene synthase
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(2E,6E)-farnesyl_diphosphate <=> trichodiene + diphosphate 4.2.3.6 trichodiene synthase
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aristolochene <=> PR-toxin not assigned
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squalene <=> dammara-20,24-diene 5.4.99.37 dammaradiene synthase
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(2E,6E)-farnesyl_diphosphate <=> (E)-alpha-bisabolene + diphosphate 4.2.3.38 alpha-bisabolene synthase
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(2E,6E)-farnesyl_diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate 3.1.7.6 farnesyl diphosphatase
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(2E,6E)-farnesyl_diphosphate <=> (7S)-germacrene_D + diphosphate 4.2.3.75 (-)-germacrene D synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> alpha-seco-amyrin 5.4.99.52 alpha-seco-amyrin synthase
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(2E,6E)-farnesyl_diphosphate + H2O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate 4.2.3.22 germacradienol synthase
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(2E,6E)-farnesyl_diphosphate <=> (E)-beta-caryophyllene + diphosphate 4.2.3.57 (-)-beta-caryophyllene synthase
4.2.3.89 (+)-beta-caryophyllene synthase
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(2E,6E)-farnesyl_diphosphate + H2O <=> avermitilol + diphosphate 4.2.3.96 avermitilol synthase
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(2E,6E)-farnesyl_diphosphate <=> germacrene_C + diphosphate 4.2.3.60 germacrene C synthase
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pentalenene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> pentalen-13-al + H2O + oxidized_ferredoxin 1.14.15.32 pentalenene oxygenase
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(2E,6E)-farnesyl_diphosphate <=> (+)-alpha-barbatene + diphosphate 4.2.3.69 (+)-alpha-barbatene synthase
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(2E,6E)-farnesyl_diphosphate <=> gamma-humulene + diphosphate 4.2.3.56 gamma-humulene synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> cucurbitadienol 5.4.99.33 cucurbitadienol synthase
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(2E,6E)-farnesyl_diphosphate <=> amorpha-4,11-diene + diphosphate 4.2.3.24 amorpha-4,11-diene synthase
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(2Z,6Z)-farnesyl_diphosphate <=> (+)-alpha-santalene + diphosphate 4.2.3.50 (+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
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(2E,6E)-farnesyl_diphosphate <=> (+)-epi-isozizaene + diphosphate 4.2.3.37 epi-isozizaene synthase
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(2E,6E)-farnesyl_diphosphate <=> pentalenene + diphosphate 4.2.3.7 pentalenene synthase
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(2E,6E)-farnesyl_diphosphate <=> (+)-delta-selinene + diphosphate 4.2.3.76 (+)-delta-selinene synthase
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(2E,6E)-farnesyl_diphosphate <=> 5-epiaristolochene + diphosphate 4.2.3.61 5-epiaristolochene synthase
4.2.3.9 aristolochene synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> tirucalla-7,24-dien-3beta-ol 5.4.99.56 tirucalladienol synthase
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(2E,6E)-farnesyl_diphosphate <=> (+)-delta-Cadinene + diphosphate 4.2.3.13 (+)-delta-cadinene synthase
4.2.3.97 (-)-delta-cadinene synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> beta-amyrin 5.4.99.34 germanicol synthase
5.4.99.39 beta-amyrin synthase
5.4.99.41 lupeol synthase
5.4.99.B2
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(+)-epi-isozizaene + O2 + NADPH + H+ <=> (5R)-albaflavenol + H2O + NADP+ 1.14.13.106 epi-isozizaene 5-monooxygenase
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(5R)-albaflavenol + O2 + NADPH + H+ <=> albaflavenone + H2O + NADP+ 1.14.13.106 epi-isozizaene 5-monooxygenase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> camelliol_C 5.4.99.38 camelliol C synthase
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(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> geosmin + acetone 4.1.99.16 geosmin synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> isomultiflorenol 5.4.99.36 isomultiflorenol synthase
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germacra-1(10),4,11(13)-trien-12-ol + 2 O2 + 2 reduced_flavodoxin <=> germacra-1(10),4,11(13)-trien-12-oate + 2 flavin + 3 H2O 1.14.14.95 germacrene A hydroxylase
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lupan-3beta,20-diol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O 4.2.1.128 lupan-3beta,20-diol synthase
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(S)-beta-bisabolene <=> (S)-beta-macrocarpene 5.5.1.17 (S)-beta-macrocarpene synthase
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squalene + diphosphate + NADP+ <=> presqualene_diphosphate + NADPH + H+ 1.3.1.96 Botryococcus squalene synthase
1.3.1.97 botryococcene synthase
2.5.1.21 squalene synthase
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tetrahymanol <=> squalene + H2O 4.2.1.123 tetrahymanol synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> thalianol 5.4.99.31 thalianol synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> marneral 5.4.99.53 marneral synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> achilleol_B 5.4.99.48 achilleol B synthase
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(3S)-2,3-epoxy-2,3-dihydrosqualene <=> germanicol 5.4.99.34 germanicol synthase
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germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> (+)-costunolide + flavin + 2 H2O 1.14.14.150 costunolide synthase
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(2E,6E)-farnesyl_diphosphate <=> longifolene + diphosphate 4.2.3.58 longifolene synthase
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(2E,6E)-farnesyl_diphosphate <=> alpha-humulene + diphosphate 4.2.3.104 alpha-humulene synthase
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(2E,6E)-farnesyl_diphosphate <=> (+)-thujopsene + diphosphate 4.2.3.79 thujopsene synthase
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(2E,6E)-farnesyl_diphosphate <=> aristolochene + diphosphate 4.2.3.9 aristolochene synthase
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(2E,6E)-farnesyl_diphosphate <=> (+)-beta-chamigrene + diphosphate 4.2.3.78 beta-chamigrene synthase
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(5S)-albaflavenol + O2 + NADPH + H+ <=> albaflavenone + H2O + NADP+ 1.14.13.106 epi-isozizaene 5-monooxygenase
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(2E,6E)-farnesyl_diphosphate <=> presqualene_diphosphate + diphosphate 2.5.1.103 presqualene diphosphate synthase
2.5.1.21 squalene synthase
2.5.1.96 4,4'-diapophytoene synthase
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(2E,6E)-farnesyl_diphosphate <=> 7-epi-alpha-selinene + diphosphate 4.2.3.86 7-epi-alpha-selinene synthase
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trichodiene <=> Nivalenol not assigned
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(2E,6E)-farnesyl_diphosphate <=> valencene + diphosphate 4.2.3.73 valencene synthase
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arabidiol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O 4.2.1.124 arabidiol synthase
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Visualization of the pathway