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Riboflavin metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one_4-phosphate <=> H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine + phosphate + H2O 2.5.1.78 6,7-dimethyl-8-ribityllumazine synthase
2.5.1.9 riboflavin synthase


FMN + H2O <=> riboflavin + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.102 FMN hydrolase
3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
3.1.3.2 acid phosphatase
3.1.3.8 3-phytase





riboflavin + CTP <=> H+ + FMN + CDP 2.7.1.161 CTP-dependent riboflavin kinase

H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + riboflavin 2.5.1.9 riboflavin synthase

2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> H+ + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + formate 3.5.1.102 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase

FMNH2 + NAD+ <=> FMN + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.4 rubredoxin---NAD(P)+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)










5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+ <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+ 1.1.1.193 5-amino-6-(5-phosphoribosylamino)uracil reductase

FADH2 + NAD+ <=> FAD + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.2 ferredoxin---NADP+ reductase
1.18.1.4 rubredoxin---NAD(P)+ reductase
1.3.1.116 7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
1.5.1.45 FAD reductase [NAD(P)H]
1.6.99.3 NADH dehydrogenase
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)












FMNH2 + NADP+ <=> FMN + NADPH + H+ 1.18.1.2 ferredoxin---NADP+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
1.5.1.45 FAD reductase [NAD(P)H]









2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone_5'-phosphate + NADP+ <=> 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + NADPH + H+ 1.1.1.302 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase

reduced_riboflavin + NADP+ <=> H+ + riboflavin + NADPH 1.5.1.30 flavin reductase (NADPH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.41 riboflavin reductase [NAD(P)H]



FMN + ATP + H+ <=> FAD + diphosphate 2.7.7.2 FAD synthase

GTP + H2O <=> H+ + 2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + phosphate 3.5.4.29 GTP cyclohydrolase IIa

H2O + GTP <=> H+ + diphosphate + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + formate 3.5.4.25 GTP cyclohydrolase II

2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone_5'-phosphate + NAD+ <=> 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + NADH + H+ 1.1.1.302 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase

D-ribulose_5-phosphate <=> H+ + formate + L-3,4-dihydroxybutan-2-one_4-phosphate 4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase

H+ + 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone_5'-phosphate + H2O <=> 5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NH3 3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase

6,7-dimethyl-8-(1'-D-ribityl)lumazine <=> 7-Hydroxy-6-methyl-8-ribityllumazine not assigned

H2O + FAD <=> H+ + FMN + AMP 3.6.1.18 FAD diphosphatase
3.6.1.9 nucleotide diphosphatase


H+ + H2O + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH3 3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase

reduced_riboflavin + NAD+ <=> riboflavin + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.41 riboflavin reductase [NAD(P)H]






riboflavin + alpha-D-glucose_1-phosphate <=> FMN + D-glucose 2.7.1.42 riboflavin phosphotransferase

FADH2 + NADP+ <=> FAD + NADPH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.2 ferredoxin---NADP+ reductase
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.45 FAD reductase [NAD(P)H]







H+ + H2O + riboflavin <=> lumichrome + ribitol 3.5.99.1 riboflavinase

5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + H2O <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + phosphate 3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase

FMNH2 + O2 <=> 5,6-Dimethylbenzimidazole + D-erythrose_4-phosphate + H2O 1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase

riboflavin + ATP <=> FMN + ADP + H+ 2.7.1.161 CTP-dependent riboflavin kinase
2.7.1.26 riboflavin kinase


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