|
|
D-lactate + a_quinone <=> pyruvate + a_quinol
|
1.1.5.12
D-lactate dehydrogenase (quinone)
|
–
|
| |
BRENDA:
BR51921
KEGG:
R11591
|
|
|
|
enzyme_N6-(dihydrolipoyl)lysine + NAD+ <=> [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine + NADH + H+
|
1.8.1.4
dihydrolipoyl dehydrogenase
|
–
|
| |
BRENDA:
BR36970
KEGG:
R03815;
R07618;
R08550
MetaCyc:
1.8.1.4-RXN;
RXN-7716
SABIO-RK:
9140
|
|
|
|
H+ + pyruvate + phosphate + O2 <=> acetyl_phosphate + CO2 + H2O2
|
1.2.3.3
pyruvate oxidase
|
–
|
| |
BRENDA:
BR36789
KEGG:
R00207
MetaCyc:
1.2.3.3-RXN
SABIO-RK:
167
|
|
|
|
NTP + pyruvate <=> NDP + phosphoenolpyruvate
|
2.7.1.40
pyruvate kinase
|
–
|
| |
KEGG:
R02320
|
|
|
|
D-lactate + NAD+ <=> pyruvate + NADH + H+
|
1.1.1.27
L-lactate dehydrogenase
1.1.1.28
D-lactate dehydrogenase
1.1.1.345
D-2-hydroxyacid dehydrogenase (NAD+)
|
–
–
–
|
| |
BRENDA:
BR29291
KEGG:
R00704
MetaCyc:
DLACTDEHYDROGNAD-RXN
SABIO-RK:
155
|
|
|
|
D-lactate + H+ <=> methylglyoxal + H2O
|
3.5.1.124
protein deglycase
4.2.1.130
D-lactate dehydratase
|
–
–
|
| |
BRENDA:
BR49777
KEGG:
R09796
MetaCyc:
GLYOXIII-RXN
|
|
|
|
D-Lactaldehyde + NAD+ + H2O <=> H+ + D-lactate + NADH
|
1.2.1.22
lactaldehyde dehydrogenase
1.2.1.23
2-oxoaldehyde dehydrogenase (NAD+)
1.2.1.3
aldehyde dehydrogenase (NAD+)
|
–
–
–
|
| |
BRENDA:
BS189164
KEGG:
R01735
MetaCyc:
LACTALDEHYDE-OXI-RXN
SABIO-RK:
548
|
|
|
|
(R)-2-hydroxyglutarate + pyruvate <=> 2-oxoglutarate + D-lactate
|
1.1.99.40
(R)-2-hydroxyglutarate---pyruvate transhydrogenase
|
–
|
| |
BRENDA:
BR51923
KEGG:
R11593
MetaCyc:
RXN-18432
|
|
|
|
pyruvate + H2O + ubiquinone <=> CO2 + ubiquinol + acetate
|
1.2.5.1
pyruvate dehydrogenase (quinone)
|
–
|
| |
BRENDA:
BR49235
KEGG:
R03145
MetaCyc:
RXN-11496
|
|
|
|
oxaloacetate + diphosphate <=> phosphate + CO2 + phosphoenolpyruvate
|
4.1.1.38
phosphoenolpyruvate carboxykinase (diphosphate)
|
–
|
| |
BRENDA:
BR3359
KEGG:
R00346
MetaCyc:
4.1.1.38-RXN
|
|
|
|
L-lactate + oxaloacetate <=> pyruvate + (S)-malate
|
1.1.99.7
lactate---malate transhydrogenase
|
–
|
| |
BRENDA:
BR29380;
BS451175
KEGG:
R01447
MetaCyc:
LACTATE-MALATE-TRANSHYDROGENASE-RXN
|
|
|
|
(S)-malate <=> fumarate + H2O
|
4.2.1.2
fumarate hydratase
4.2.1.34
(S)-2-methylmalate dehydratase
|
–
–
|
| |
BRENDA:
BR3389
KEGG:
R01082
MetaCyc:
FUMHYDR-RXN
SABIO-RK:
256
|
|
|
|
L-lactaldehyde + NAD+ + H2O <=> L-lactate + NADH + H+
|
1.2.1.22
lactaldehyde dehydrogenase
1.2.1.3
aldehyde dehydrogenase (NAD+)
|
–
–
|
| |
BRENDA:
BR29393
KEGG:
R01446
MetaCyc:
LACTALDDEHYDROG-RXN
SABIO-RK:
164
|
|
|
|
acetylene_dicarboxylate + H2O + H+ <=> pyruvate + CO2
|
4.1.1.78
acetylenedicarboxylate decarboxylase
|
–
|
| |
BRENDA:
BR48318
KEGG:
R00218
MetaCyc:
4.1.1.78-RXN
|
|
|
|
2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA
|
2.3.3.13
2-isopropylmalate synthase
2.3.3.17
methylthioalkylmalate synthase
|
–
–
|
| |
BRENDA:
BR47381;
BS353415;
BS375022;
BS438748
KEGG:
R01213
MetaCyc:
2-ISOPROPYLMALATESYN-RXN
SABIO-RK:
545
|
|
|
|
ATP + acetate <=> diphosphate + acetyl_adenylate
|
6.2.1.1
acetate---CoA ligase
|
–
|
| |
KEGG:
R00316
|
|
|
|
pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.2.7.1
pyruvate synthase
1.2.7.11
2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
|
–
–
–
|
| |
BRENDA:
BR29433
KEGG:
R01196
MetaCyc:
PYRUFLAVREDUCT-RXN
|
|
|
|
acetate + diphosphate <=> phosphate + acetyl_phosphate
|
2.7.2.12
acetate kinase (diphosphate)
|
–
|
| |
BRENDA:
BR47822
KEGG:
R00320
MetaCyc:
ACETATE-KINASE-PYROPHOSPHATE-RXN
|
|
|
|
oxaloacetate + ITP <=> CO2 + phosphoenolpyruvate + IDP
|
4.1.1.32
phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49
phosphoenolpyruvate carboxykinase (ATP)
|
–
–
|
| |
BRENDA:
BS1402
KEGG:
R00726
MetaCyc:
RXN-12481
SABIO-RK:
583
|
|
|
|
succinyl-CoA + acetate <=> succinate + acetyl-CoA
|
2.8.3.1
propionate CoA-transferase
2.8.3.18
succinyl-CoA:acetate CoA-transferase
2.8.3.8
acetate CoA-transferase
|
–
–
–
|
| |
BRENDA:
BR50544
KEGG:
R10343
MetaCyc:
RXN-8807
SABIO-RK:
14383
|
|
|
|
L-lactate <=> D-lactate
|
5.1.2.1
lactate racemase
5.1.2.2
mandelate racemase
|
–
–
|
| |
BRENDA:
BR178
KEGG:
R01450
MetaCyc:
LACTATE-RACEMASE-RXN
|
|
|
|
phosphate + acetyl-CoA <=> acetyl_phosphate + CoA
|
2.3.1.19
phosphate butyryltransferase
2.3.1.222
phosphate propanoyltransferase
2.3.1.8
phosphate acetyltransferase
|
–
–
–
|
| |
BRENDA:
BR44082
KEGG:
R00230
MetaCyc:
PHOSACETYLTRANS-RXN
SABIO-RK:
72
|
|
|
|
oxaloacetate + H+ + Na+ <=> pyruvate + CO2 + Na+
|
7.2.4.2
oxaloacetate decarboxylase (Na+ extruding)
|
–
|
| |
BRENDA:
BR52489
KEGG:
R12212
MetaCyc:
RXN-19736
|
|
|
|
acetyl-CoA + propionate <=> acetate + propionyl-CoA
|
2.8.3.1
propionate CoA-transferase
2.8.3.12
glutaconate CoA-transferase
2.8.3.14
5-hydroxypentanoate CoA-transferase
2.8.3.18
succinyl-CoA:acetate CoA-transferase
|
–
–
–
–
|
| |
BRENDA:
BR48124
KEGG:
R00928
MetaCyc:
PROPIONATE-COA-TRANSFERASE-RXN
SABIO-RK:
170
|
|
|
|
oxaloacetate + H+ <=> pyruvate + CO2
|
1.1.1.38
malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.40
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
4.1.1.112
oxaloacetate decarboxylase
4.1.1.32
phosphoenolpyruvate carboxykinase (GTP)
4.1.2.52
4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.16
4-hydroxy-2-oxoglutarate aldolase
4.1.3.17
4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.39
4-hydroxy-2-oxovalerate aldolase
4.1.3.42
(4S)-4-hydroxy-2-oxoglutarate aldolase
4.1.3.43
4-hydroxy-2-oxohexanoate aldolase
4.4.1.1
cystathionine gamma-lyase
7.2.4.2
oxaloacetate decarboxylase (Na+ extruding)
|
–
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR289
KEGG:
R00217
MetaCyc:
OXALODECARB-RXN
SABIO-RK:
149
|
|
|
|
ethanol + 2 ferricytochrome_c <=> acetaldehyde + 2 ferricytochrome_c
|
1.1.2.8
alcohol dehydrogenase (cytochrome c)
1.1.2.9
1-butanol dehydrogenase (cytochrome c)
|
–
–
|
| |
BRENDA:
BS424803
KEGG:
R05198
|
|
|
|
acetaldehyde + NADP+ + H2O <=> acetate + NADPH + H+
|
1.2.1
1.2.1.19
aminobutyraldehyde dehydrogenase
1.2.1.24
succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26
2,5-dioxovalerate dehydrogenase
1.2.1.3
aldehyde dehydrogenase (NAD+)
1.2.1.4
aldehyde dehydrogenase (NADP+)
1.2.1.5
aldehyde dehydrogenase [NAD(P)+]
1.2.1.8
betaine-aldehyde dehydrogenase
1.2.1.88
L-glutamate gamma-semialdehyde dehydrogenase
|
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BS231682
KEGG:
R00711
MetaCyc:
RXN0-3962
SABIO-RK:
541
|
|
|
|
(S)-malate + NADP+ <=> H+ + NADPH + oxaloacetate
|
1.1.1.299
malate dehydrogenase [NAD(P)+]
1.1.1.37
malate dehydrogenase
1.1.1.375
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.79
glyoxylate reductase (NADP+)
1.1.1.81
hydroxypyruvate reductase
1.1.1.82
malate dehydrogenase (NADP+)
|
–
–
–
–
–
–
|
| |
BRENDA:
BR29342;
BS188648
KEGG:
R00343
MetaCyc:
MALATE-DEHYDROGENASE-NADP+-RXN;
RXN-10813
SABIO-RK:
143
|
|
|
|
S-D-lactoylglutathione <=> methylglyoxal + glutathione
|
4.4.1.5
lactoylglutathione lyase
|
–
|
| |
BRENDA:
BR6441
KEGG:
R02530
MetaCyc:
GLYOXI-RXN
SABIO-RK:
177
|
|
|
|
ATP + acetyl-CoA + HCO3- <=> ADP + phosphate + malonyl-CoA + H+
|
6.4.1.2
acetyl-CoA carboxylase
6.4.1.3
propionyl-CoA carboxylase
6.4.1.4
methylcrotonoyl-CoA carboxylase
|
–
–
–
|
| |
BRENDA:
BR6444
KEGG:
R00742
MetaCyc:
ACETYL-COA-CARBOXYLTRANSFER-RXN
SABIO-RK:
542
|
|
|
|
S-D-lactoylglutathione + H2O <=> H+ + glutathione + D-lactate
|
3.1.2.6
hydroxyacylglutathione hydrolase
|
–
|
| |
BRENDA:
BS364477
KEGG:
R01736
MetaCyc:
GLYOXII-RXN
SABIO-RK:
283
|
|
|
|
acetyl-CoA + H2O + glyoxylate <=> H+ + (S)-malate + CoA
|
2.3.3.9
malate synthase
4.1.3.1
isocitrate lyase
|
–
–
|
| |
BRENDA:
BR47548;
BS381320
KEGG:
R00472
MetaCyc:
MALSYN-RXN
SABIO-RK:
152
|
|
|
|
(S)-malate + NADP+ <=> pyruvate + CO2 + NADPH
|
1.1.1.38
malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.39
malate dehydrogenase (decarboxylating)
1.1.1.40
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
–
–
|
| |
BRENDA:
BR29303;
BS355850
KEGG:
R00216
MetaCyc:
MALIC-NADP-RXN
|
|
|
|
acetyl_adenylate + CoA <=> AMP + acetyl-CoA
|
6.2.1.1
acetate---CoA ligase
|
–
|
| |
KEGG:
R00236
|
|
|
|
H+ + O2 + CoA + pyruvate <=> CO2 + H2O2 + acetyl-CoA
|
1.2.3.6
pyruvate oxidase (CoA-acetylating)
|
–
|
| |
BRENDA:
BR36790
KEGG:
R00211
MetaCyc:
PYRUVATE-OXIDASE-COA-ACETYLATING-RXN
|
|
|
|
L-lactaldehyde + NADP+ <=> methylglyoxal + NADPH + H+
|
1.1.1.156
glycerol 2-dehydrogenase (NADP+)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.21
aldose reductase
1.1.1.283
methylglyoxal reductase (NADPH)
1.1.1.71
alcohol dehydrogenase [NAD(P)+]
1.1.1.72
glycerol dehydrogenase (NADP+)
1.1.1.78
methylglyoxal reductase (NADH)
1.2.1.49
2-oxoaldehyde dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR48480;
BS139557
KEGG:
R02260
MetaCyc:
1.1.1.283-RXN
SABIO-RK:
550;
9214
|
|
|
|
phosphoenolpyruvate + CO2 <=> phosphate + oxaloacetate
|
4.1.1.31
phosphoenolpyruvate carboxylase
|
–
|
| |
BRENDA:
BS1399
KEGG:
R00345
SABIO-RK:
150
|
|
|
|
2-oxobutyrate + H2O + acetyl-CoA <=> (2R)-ethylmalate + CoA + H+
|
2.3.3.13
2-isopropylmalate synthase
2.3.3.6
2-ethylmalate synthase
|
–
–
|
| |
BRENDA:
BR44128
KEGG:
R00998
MetaCyc:
2-ETHYLMALATE-SYNTHASE-RXN
SABIO-RK:
543
|
|
|
|
acetaldehyde + acceptor + H2O <=> acetate + reduced_acceptor
|
1.1.99.20
alkan-1-ol dehydrogenase (acceptor)
1.2.5.2
aldehyde dehydrogenase (quinone)
1.2.99.6
carboxylate reductase
1.2.99.7
aldehyde dehydrogenase (FAD-independent)
|
–
–
–
–
|
| |
BRENDA:
BS257832
KEGG:
R00326
|
|
|
|
enol-oxaloacetate + H+ <=> pyruvate + CO2
|
4.1.1
|
–
|
| |
KEGG:
R00219
MetaCyc:
RXN-21383
|
|
|
|
(S)-malate + H+ <=> L-lactate + CO2
|
4.1.1.101
malolactic enzyme
|
–
|
| |
BRENDA:
BR51422
KEGG:
R11074
MetaCyc:
RXN-16819
SABIO-RK:
12493
|
|
|
|
acetyl_phosphate + H2O <=> acetate + phosphate
|
3.1.3.2
acid phosphatase
3.6.1.7
acylphosphatase
7.6.2.1
P-type phospholipid transporter
|
–
–
–
|
| |
BRENDA:
BS165360
KEGG:
R00317
SABIO-RK:
535
|
|
|
|
L-lactate + O2 <=> acetate + CO2 + H2O
|
1.13.12.4
lactate 2-monooxygenase
|
–
|
| |
BRENDA:
BR40547
KEGG:
R00319
MetaCyc:
RXN-19631
|
|
|
|
CoA + acetate + ATP <=> phosphate + acetyl-CoA + ADP
|
6.2.1.1
acetate---CoA ligase
6.2.1.13
acetate---CoA ligase (ADP-forming)
6.2.1.B11
|
–
–
–
|
| |
BRENDA:
BR64
KEGG:
R00229
MetaCyc:
ACETATE--COA-LIGASE-ADP-FORMING-RXN
SABIO-RK:
180
|
|
|
|
ethanol + 2 ferricytochrome_b5 <=> acetaldehyde + 2 ferricytochrome_b5
|
1.1.2.7
methanol dehydrogenase (cytochrome c)
|
–
|
| |
BRENDA:
BS449899
KEGG:
R09127
|
|
|
|
(S)-malate + FAD <=> oxaloacetate + FADH2
|
1.1.5.4
malate dehydrogenase (quinone)
|
–
|
| |
KEGG:
R01257
|
|
|
|
pyrroloquinoline_quinone + acetaldehyde + H2O <=> reduced_pyrroloquinoline_quinone + acetate
|
1.2.5.2
aldehyde dehydrogenase (quinone)
|
–
|
| |
KEGG:
R01019
|
|
|
|
an_alcohol + NADP+ <=> an_aldehyde + NADPH + H+
|
1.1.1.1
alcohol dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.191
indole-3-acetaldehyde reductase (NADPH)
1.1.1.195
cinnamyl-alcohol dehydrogenase
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.21
aldose reductase
1.1.1.215
gluconate 2-dehydrogenase
1.1.1.263
1,5-anhydro-D-fructose reductase
1.1.1.265
3-methylbutanal reductase
1.1.1.283
methylglyoxal reductase (NADPH)
1.1.1.4
(R,R)-butanediol dehydrogenase
1.1.1.61
4-hydroxybutyrate dehydrogenase
1.1.1.71
alcohol dehydrogenase [NAD(P)+]
1.1.1.72
glycerol dehydrogenase (NADP+)
1.1.1.79
glyoxylate reductase (NADP+)
1.1.1.80
isopropanol dehydrogenase (NADP+)
1.1.1.91
aryl-alcohol dehydrogenase (NADP+)
1.1.1.97
3-hydroxybenzyl-alcohol dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29248;
BS139551
KEGG:
R00625;
R00746;
R07328
MetaCyc:
ALCOHOL-DEHYDROGENASE-NADP+-RXN;
ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN;
RXN-12484
SABIO-RK:
49
|
|
|
|
D-lactate + acceptor <=> pyruvate + reduced_acceptor
|
1.1.99.6
D-lactate dehydrogenase (acceptor)
|
–
|
| |
BRENDA:
BR29379
KEGG:
R00297
MetaCyc:
D-2-HYDROXY-ACID-DEHYDROGENASE-RXN
SABIO-RK:
791
|
|
|
|
methylglyoxal + NADP+ + H2O <=> H+ + pyruvate + NADPH
|
1.2.1.19
aminobutyraldehyde dehydrogenase
1.2.1.23
2-oxoaldehyde dehydrogenase (NAD+)
1.2.1.49
2-oxoaldehyde dehydrogenase (NADP+)
|
–
–
–
|
| |
BRENDA:
BS189258
KEGG:
R00205
MetaCyc:
RXN-8639
SABIO-RK:
521
|
|
|
|
acetyl-CoA <=> acetoacetyl-CoA + CoA
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155
acetyl-CoA C-myristoyltransferase
2.3.1.16
acetyl-CoA C-acyltransferase
2.3.1.38
[acyl-carrier-protein] S-acetyltransferase
2.3.1.9
acetyl-CoA C-acetyltransferase
|
–
–
–
–
–
|
| |
BRENDA:
BR44092
KEGG:
R00238
MetaCyc:
ACETYL-COA-ACETYLTRANSFER-RXN
SABIO-RK:
531
|
|
|
|
2-Oxopentanoate + acetyl-CoA + H2O <=> 2-hydroxy-2-propylsuccinic_acid + CoA
|
2.3.3.13
2-isopropylmalate synthase
4.1.3
|
–
–
|
| |
BRENDA:
BS353416
KEGG:
R05063
SABIO-RK:
9669
|
|
|
|
an_alcohol + NAD+ <=> an_aldehyde + NADH + H+
|
1.1.1.1
alcohol dehydrogenase
1.1.1.103
L-threonine 3-dehydrogenase
1.1.1.11
D-arabinitol 4-dehydrogenase
1.1.1.14
L-iditol 2-dehydrogenase
1.1.1.17
mannitol-1-phosphate 5-dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.192
long-chain-alcohol dehydrogenase
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.202
1,3-propanediol dehydrogenase
1.1.1.21
aldose reductase
1.1.1.244
methanol dehydrogenase
1.1.1.245
cyclohexanol dehydrogenase
1.1.1.284
S-(hydroxymethyl)glutathione dehydrogenase
1.1.1.306
S-(hydroxymethyl)mycothiol dehydrogenase
1.1.1.307
D-xylose reductase
1.1.1.6
glycerol dehydrogenase
1.1.1.71
alcohol dehydrogenase [NAD(P)+]
1.1.1.73
octanol dehydrogenase
1.1.1.77
lactaldehyde reductase
1.1.1.78
methylglyoxal reductase (NADH)
1.1.1.80
isopropanol dehydrogenase (NADP+)
1.1.1.B4
|
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29164;
BS139564;
BS405084
KEGG:
R00623;
R00754;
R07326
MetaCyc:
ALCOHOL-DEHYDROG-GENERIC-RXN;
ALCOHOL-DEHYDROG-RXN;
ALCOHOL-DEHYDROGENASE-NADP+-RXN_WOP
SABIO-RK:
597
|
|
|
|
acetaldehyde + H2O + NAD+ <=> acetate + NADH + H+
|
1.17.1.4
xanthine dehydrogenase
1.2.1.10
acetaldehyde dehydrogenase (acetylating)
1.2.1.18
malonate-semialdehyde dehydrogenase (acetylating)
1.2.1.19
aminobutyraldehyde dehydrogenase
1.2.1.21
glycolaldehyde dehydrogenase
1.2.1.22
lactaldehyde dehydrogenase
1.2.1.24
succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26
2,5-dioxovalerate dehydrogenase
1.2.1.28
benzaldehyde dehydrogenase (NAD+)
1.2.1.3
aldehyde dehydrogenase (NAD+)
1.2.1.31
L-aminoadipate-semialdehyde dehydrogenase
1.2.1.32
aminomuconate-semialdehyde dehydrogenase
1.2.1.36
retinal dehydrogenase
1.2.1.39
phenylacetaldehyde dehydrogenase
1.2.1.41
glutamate-5-semialdehyde dehydrogenase
1.2.1.46
formaldehyde dehydrogenase
1.2.1.47
4-trimethylammoniobutyraldehyde dehydrogenase
1.2.1.48
long-chain-aldehyde dehydrogenase
1.2.1.5
aldehyde dehydrogenase [NAD(P)+]
1.2.1.65
salicylaldehyde dehydrogenase
1.2.1.69
fluoroacetaldehyde dehydrogenase
1.2.1.8
betaine-aldehyde dehydrogenase
1.2.1.85
2-hydroxymuconate-6-semialdehyde dehydrogenase
1.2.1.88
L-glutamate gamma-semialdehyde dehydrogenase
1.2.1.99
4-(gamma-glutamylamino)butanal dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BS189125
KEGG:
R00710
MetaCyc:
RXN66-3
|
|
|
|
L-lactate <=> formate + acetaldehyde
|
4.1.2.36
lactate aldolase
|
–
|
| |
BRENDA:
BR48322
KEGG:
R00753
MetaCyc:
LACTATE-ALDOLASE-RXN
|
|
|
|
pyruvate + phosphate + ATP <=> H+ + phosphoenolpyruvate + AMP + diphosphate
|
2.7.9.1
pyruvate, phosphate dikinase
|
–
|
| |
BRENDA:
BR48096
KEGG:
R00206
MetaCyc:
PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN
SABIO-RK:
147
|
|
|
|
2-hydroxyethyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_acetyltransferase]_S-acetyldihydrolipoyllysine + thiamine_diphosphate
|
1.2.4.1
pyruvate dehydrogenase (acetyl-transferring)
|
–
|
| |
KEGG:
R03270
|
|
|
|
acetaldehyde + CoA + NAD+ <=> acetyl-CoA + NADH + H+
|
1.2.1.10
acetaldehyde dehydrogenase (acetylating)
1.2.1.42
hexadecanal dehydrogenase (acylating)
1.2.1.57
butanal dehydrogenase
1.2.1.87
propanal dehydrogenase (CoA-propanoylating)
|
–
–
–
–
|
| |
BRENDA:
BR36771
KEGG:
R00228
MetaCyc:
ACETALD-DEHYDROG-RXN
SABIO-RK:
163
|
|
|
|
pyruvate + ATP <=> H+ + phosphoenolpyruvate + ADP
|
2.7.1.40
pyruvate kinase
|
–
|
| |
BRENDA:
BR47778
KEGG:
R00200
MetaCyc:
PEPDEPHOS-RXN
SABIO-RK:
9
|
|
|
|
(S)-malate + NAD+ <=> oxaloacetate + NADH + H+
|
1.1.1.28
D-lactate dehydrogenase
1.1.1.299
malate dehydrogenase [NAD(P)+]
1.1.1.337
L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37
malate dehydrogenase
1.1.1.375
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38
malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81
hydroxypyruvate reductase
1.1.1.82
malate dehydrogenase (NADP+)
1.1.1.85
3-isopropylmalate dehydrogenase
1.1.1.95
phosphoglycerate dehydrogenase
1.1.1.96
diiodophenylpyruvate reductase
|
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29300;
BS188027
KEGG:
R00342
MetaCyc:
MALATE-DEH-RXN;
RXN-10813_WOP
|
|
|
|
acetyl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + enzyme_N6-(S-acetyldihydrolipoyl)lysine
|
2.3.1.12
dihydrolipoyllysine-residue acetyltransferase
|
–
|
| |
BRENDA:
BR43982
KEGG:
R02569
|
|
|
|
acetylene_dicarboxylate + H2O <=> enol-oxaloacetate
|
4.1.1.78
acetylenedicarboxylate decarboxylase
|
–
|
| |
KEGG:
R04177
MetaCyc:
RXN-21382
|
|
|
|
H2O + acetyl-CoA <=> H+ + acetate + CoA
|
2.3.1.16
acetyl-CoA C-acyltransferase
2.3.1.226
carboxymethylproline synthase
2.3.1.31
homoserine O-acetyltransferase
2.3.3.10
hydroxymethylglutaryl-CoA synthase
2.3.3.13
2-isopropylmalate synthase
3.1.2.1
acetyl-CoA hydrolase
3.1.2.17
(S)-methylmalonyl-CoA hydrolase
3.1.2.18
ADP-dependent short-chain-acyl-CoA hydrolase
3.1.2.20
acyl-CoA hydrolase
3.1.2.23
4-hydroxybenzoyl-CoA thioesterase
3.1.2.25
phenylacetyl-CoA hydrolase
3.1.2.29
fluoroacetyl-CoA thioesterase
|
–
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR11726
KEGG:
R00227
MetaCyc:
ACETYL-COA-HYDROLASE-RXN
SABIO-RK:
171
|
|
|
|
pyruvate + CoA + flavin + H+ <=> acetyl-CoA + CO2 + reduced_flavodoxin
|
1.2.7
1.2.7.1
pyruvate synthase
|
–
–
|
| |
KEGG:
R10866
MetaCyc:
PYFLAVOXRE-RXN
|
|
|
|
H2O + pyruvate + ATP <=> H+ + phosphate + phosphoenolpyruvate + AMP
|
2.7.1.40
pyruvate kinase
2.7.9.2
pyruvate, water dikinase
|
–
–
|
| |
BRENDA:
BR48097
KEGG:
R00199
MetaCyc:
PEPSYNTH-RXN
SABIO-RK:
148
|
|
|
|
L-lactate + NAD+ <=> pyruvate + NADH + H+
|
1.1.1.27
L-lactate dehydrogenase
1.1.1.337
L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37
malate dehydrogenase
1.1.1.375
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38
malate dehydrogenase (oxaloacetate-decarboxylating)
|
–
–
–
–
–
|
| |
BRENDA:
BR29287
KEGG:
R00703
MetaCyc:
L-LACTATE-DEHYDROGENASE-RXN
|
|
|
|
ethanol + ubiquinone <=> acetaldehyde + ubiquinol
|
1.1.5.5
alcohol dehydrogenase (quinone)
|
–
|
| |
BRENDA:
BR49059
KEGG:
R09479
MetaCyc:
RXN-11039
|
|
|
|
succinate + a_quinone <=> fumarate + a_quinol
|
1.3.5.1
succinate dehydrogenase
1.3.5.4
fumarate reductase (quinol)
|
–
–
|
| |
BRENDA:
BR49374
KEGG:
R02164
|
|
|
|
formate + acetyl-CoA <=> pyruvate + CoA
|
2.3.1.54
formate C-acetyltransferase
|
–
|
| |
BRENDA:
BR44056
KEGG:
R00212
MetaCyc:
PYRUVFORMLY-RXN
SABIO-RK:
146
|
|
|
|
D-lactate + ferricytochrome_b5 <=> pyruvate + ferricytochrome_b5 + H+
|
1.1.2.5
D-lactate dehydrogenase (cytochrome c-553)
|
–
|
| |
BRENDA:
BR36727
KEGG:
R00198
MetaCyc:
1.1.2.5-RXN
|
|
|
|
oxaloacetate + GTP <=> CO2 + phosphoenolpyruvate + GDP
|
4.1.1.32
phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49
phosphoenolpyruvate carboxykinase (ATP)
|
–
–
|
| |
BRENDA:
BR291
KEGG:
R00431
MetaCyc:
4.1.1.32-RXN
SABIO-RK:
106
|
|
|
|
L-lactate + 2 ferricytochrome_c <=> pyruvate + 2 ferricytochrome_c + 2 H+
|
1.1.2.3
L-lactate dehydrogenase (cytochrome)
|
–
|
| |
BRENDA:
BR33683
KEGG:
R00196
SABIO-RK:
188
|
|
|
|
D-lactate + 2 ferricytochrome_c <=> pyruvate + 2 ferricytochrome_c + 2 H+
|
1.1.2.4
D-lactate dehydrogenase (cytochrome)
|
–
|
| |
BRENDA:
BR36726
KEGG:
R00197
|
|
|
|
methylglyoxal + NAD+ + H2O <=> H+ + pyruvate + NADH
|
1.2.1.19
aminobutyraldehyde dehydrogenase
1.2.1.22
lactaldehyde dehydrogenase
1.2.1.23
2-oxoaldehyde dehydrogenase (NAD+)
1.2.1.3
aldehyde dehydrogenase (NAD+)
1.2.1.46
formaldehyde dehydrogenase
1.2.1.8
betaine-aldehyde dehydrogenase
|
–
–
–
–
–
–
|
| |
BRENDA:
BS189163
KEGG:
R00203
MetaCyc:
METHYL-GLYOXAL-DEHYDROG-RXN
SABIO-RK:
520
|
|
|
|
2-oxoglutarate + H2O + acetyl-CoA <=> H+ + (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
|
2.3.3.14
homocitrate synthase
|
–
|
| |
BRENDA:
BR44122;
BS321812
KEGG:
R00271
MetaCyc:
HOMOCITRATE-SYNTHASE-RXN
SABIO-RK:
532
|
|
|
|
D-Lactaldehyde + NAD+ <=> methylglyoxal + NADH + H+
|
1.1.1.78
methylglyoxal reductase (NADH)
1.1.1.79
glyoxylate reductase (NADP+)
|
–
–
|
| |
BRENDA:
BR22616
KEGG:
R02527
MetaCyc:
D-LACTALDEHYDE-DEHYDROGENASE-RXN
|
|
|
|
(S)-malate + NAD+ <=> pyruvate + CO2 + NADH
|
1.1.1.38
malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.39
malate dehydrogenase (decarboxylating)
1.1.1.40
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1.1.1.85
3-isopropylmalate dehydrogenase
1.3.1.7
meso-tartrate dehydrogenase
|
–
–
–
–
–
|
| |
BRENDA:
BR29301;
BS188113
KEGG:
R00214
MetaCyc:
1.1.1.39-RXN;
RXN-19748
SABIO-RK:
141
|
|
|
|
H+ + pyruvate + thiamine_diphosphate <=> 2-hydroxyethyl-ThPP + CO2
|
1.2.4.1
pyruvate dehydrogenase (acetyl-transferring)
2.2.1.6
acetolactate synthase
4.1.1.1
pyruvate decarboxylase
|
–
–
–
|
| |
KEGG:
R00014
MetaCyc:
RXN-12583
SABIO-RK:
6479
|
|
|
|
oxaloacetate + ATP <=> CO2 + phosphoenolpyruvate + ADP
|
4.1.1.31
phosphoenolpyruvate carboxylase
4.1.1.38
phosphoenolpyruvate carboxykinase (diphosphate)
4.1.1.49
phosphoenolpyruvate carboxykinase (ATP)
|
–
–
–
|
| |
BRENDA:
BR308
KEGG:
R00341
MetaCyc:
PEPCARBOXYKIN-RXN
SABIO-RK:
151
|
|
|
|
pyruvate + HCO3- + ATP <=> H+ + oxaloacetate + ADP + phosphate
|
6.4.1.1
pyruvate carboxylase
|
–
|
| |
BRENDA:
BR153
KEGG:
R00344
MetaCyc:
PYRUVATE-CARBOXYLASE-RXN
SABIO-RK:
105
|
|
|
|
ATP + acetate <=> ADP + acetyl_phosphate
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
2.7.2.1
acetate kinase
2.7.2.15
propionate kinase
2.7.2.2
carbamate kinase
|
–
–
–
–
|
| |
BRENDA:
BR47820
KEGG:
R00315
MetaCyc:
ACETATEKIN-RXN
SABIO-RK:
71
|
|
