|
|
5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
| |
KEGG:
R08759
|
|
|
|
5beta-cholestane-3alpha,7alpha-diol + reduced_flavodoxin + O2 <=> 5beta-cholestane-3alpha,7alpha,12alpha-triol + flavin + H2O
|
1.14.14.139
5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
|
–
|
| |
BRENDA:
BR48567
KEGG:
R07204
|
|
|
|
7alpha-hydroxycholesterol + NAD+ <=> 7alpha-hydroxy-4-cholesten-3-one + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.181
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
|
–
–
|
| |
BRENDA:
BR29239
KEGG:
R04263
MetaCyc:
1.1.1.181-RXN
SABIO-RK:
9288
|
|
|
|
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ <=> H+ + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA + NADH
|
1.1.1
|
–
|
| |
KEGG:
R04812
MetaCyc:
RXN-9799
|
|
|
|
cholesterol + reduced_acceptor + O2 <=> 25-hydroxycholesterol + acceptor + H2O
|
1.14.99.38
cholesterol 25-hydroxylase
|
–
|
| |
BRENDA:
BR48560;
BS375089
KEGG:
R07218
MetaCyc:
1.14.99.38-RXN
|
|
|
|
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced_adrenodoxin + H+ + O2 <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
| |
BRENDA:
BR50217;
BS288576
KEGG:
R04807
MetaCyc:
CHOLESTANETRIOL-26-MONOOXYGENASE-RXN
|
|
|
|
7alpha,25-Dihydroxycholesterol + NAD+ <=> 7alpha,25-dihydroxy-4-cholesten-3-one + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.181
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
|
–
–
|
| |
BRENDA:
BS257038
KEGG:
R08723
|
|
|
|
cholesterol + reduced_flavodoxin + O2 <=> 7alpha-hydroxycholesterol + flavin + H2O
|
1.14.14.23
cholesterol 7alpha-monooxygenase
|
–
|
| |
BRENDA:
BR29138
KEGG:
R01463
|
|
|
|
propionyl-CoA + chenodeoxycholoyl-CoA <=> CoA + 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA
|
2.3.1.176
propanoyl-CoA C-acyltransferase
|
–
|
| |
KEGG:
R04811
|
|
|
|
choloyl-CoA + glycine <=> H+ + glycocholate + CoA
|
2.3.1.65
bile acid-CoA:amino acid N-acyltransferase
|
–
|
| |
BRENDA:
BR44066
KEGG:
R03718
MetaCyc:
GLYCINE-N-CHOLOYLTRANSFERASE-RXN
SABIO-RK:
3479
|
|
|
|
7alpha,27-dihydroxy-4-cholesten-3-one + 2 O2 + 2 NADPH + 2 H+ <=> 7alpha-Hydroxy-3-oxo-4-cholestenoate + 2 NADP+ + 3 H2O
|
not assigned
|
–
|
| |
KEGG:
R08725
|
|
|
|
5-cholestene-26-oic_acid-3beta-ol + O2 + NADPH + H+ <=> 3beta,7alpha-dihydroxy-5-cholestenoic_acid + NADP+ + H2O
|
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
|
| |
KEGG:
R08727
|
|
|
|
5beta-cholestane-3alpha,7alpha-diol + reduced_adrenodoxin + O2 <=> 5beta-cholestane-3alpha,7alpha,26-triol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
| |
BRENDA:
BS386164
KEGG:
R04806
|
|
|
|
25-hydroxycholesterol + reduced_flavodoxin + O2 <=> 7alpha,25-Dihydroxycholesterol + flavin + H2O
|
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
|
| |
BRENDA:
BR48561
KEGG:
R07209
|
|
|
|
choloyl-CoA + H2O <=> H+ + cholic_acid + CoA
|
2.8.3.25
bile acid CoA-transferase
3.1.2.2
palmitoyl-CoA hydrolase
3.1.2.20
acyl-CoA hydrolase
3.1.2.27
choloyl-CoA hydrolase
|
–
–
–
–
|
| |
BRENDA:
BR48553
KEGG:
R07296
MetaCyc:
3.1.2.27-RXN
SABIO-RK:
8638
|
|
|
|
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + reduced_adrenodoxin + O2 + H+ <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic_acid + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
1.2.1.40
3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase
|
–
–
|
| |
BRENDA:
BR50219;
BS387400
KEGG:
R08761
MetaCyc:
1.2.1.40-RXN
|
|
|
|
taurochenodeoxycholate + H2O <=> chenodeoxycholic_acid + taurine
|
3.5.1.24
choloylglycine hydrolase
3.5.1.74
chenodeoxycholoyltaurine hydrolase
|
–
–
|
| |
BRENDA:
BR22711
KEGG:
R03977
MetaCyc:
CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN
|
|
|
|
chenodeoxycholoyl-CoA + glycine <=> H+ + glycochenodeoxycholic_acid + CoA
|
2.3.1.65
bile acid-CoA:amino acid N-acyltransferase
|
–
|
| |
BRENDA:
BS321175
KEGG:
R08744
MetaCyc:
RXN-9851
SABIO-RK:
10196
|
|
|
|
3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al + O2 + 2 H+ + 2 reduced_ferredoxin <=> 3alpha,7alpha-dihydroxy-5beta-cholestanate + H2O + 2 oxidized_ferredoxin
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
| |
KEGG:
R08760
|
|
|
|
7alpha-hydroxy-4-cholesten-3-one + ferricytochrome_b5 + H+ + O2 <=> 7alpha,12alpha-dihydroxy-4-cholesten-3-one + ferricytochrome_b5 + H2O
|
1.14.18.8
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
|
–
|
| |
KEGG:
R04826
MetaCyc:
1.14.13.95-RXN
|
|
|
|
5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol <=> 5beta-cyprinolsulfate
|
not assigned
|
–
|
| |
KEGG:
R04808
|
|
|
|
(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O <=> (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
|
4.2.1.107
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase
|
–
|
| |
KEGG:
R04809
MetaCyc:
RXN-9847
|
|
|
|
glycocholate + H2O <=> cholic_acid + glycine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
| |
BRENDA:
BR22684
KEGG:
R05835
MetaCyc:
CHOLOYLGLYCINE-HYDROLASE-RXN
SABIO-RK:
5426
|
|
|
|
choloyl-CoA + taurine <=> H+ + taurocholate + CoA
|
2.3.1.65
bile acid-CoA:amino acid N-acyltransferase
|
–
|
| |
BRENDA:
BS321166
KEGG:
R03720
MetaCyc:
RXN-9800
SABIO-RK:
3481
|
|
|
|
(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA + NAD+ <=> 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA + NADH + H+
|
1.1.1
|
–
|
| |
KEGG:
R04810
|
|
|
|
5beta-cholestane-3alpha,7alpha,12alpha-triol + NAD+ <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
| |
KEGG:
R04824
MetaCyc:
RXN-9796_WOP
|
|
|
|
3beta,7alpha-dihydroxy-5-cholestenoic_acid + NAD+ <=> 7alpha-Hydroxy-3-oxo-4-cholestenoate + NADH + H+
|
1.1.1.181
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
|
–
|
| |
KEGG:
R08728
|
|
|
|
7alpha,27-dihydroxycholesterol + NAD+ <=> 7alpha,27-dihydroxy-4-cholesten-3-one + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.181
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
|
–
–
|
| |
BRENDA:
BS257039
KEGG:
R08724
|
|
|
|
7alpha-hydroxy-4-cholesten-3-one + NADPH + H+ <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
| |
BRENDA:
BS396107
KEGG:
R04817
MetaCyc:
RXN-9840
SABIO-RK:
4465
|
|
|
|
chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholic_acid + CoA + H+
|
3.1.2.2
palmitoyl-CoA hydrolase
3.1.2.20
acyl-CoA hydrolase
3.1.2.27
choloyl-CoA hydrolase
|
–
–
–
|
| |
BRENDA:
BS360780
KEGG:
R03974
MetaCyc:
RXN-14289
SABIO-RK:
13309
|
|
|
|
glycochenodeoxycholic_acid + H2O <=> chenodeoxycholic_acid + glycine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
| |
BRENDA:
BS140405
KEGG:
R03975
MetaCyc:
RXN-17388
|
|
|
|
cholesterol + reduced_adrenodoxin + H+ + O2 <=> 27-Hydroxycholesterol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
| |
BRENDA:
BS386397
KEGG:
R08505
|
|
|
|
(24S)-cholest-5-ene-3beta,7alpha,24-triol + NAD+ <=> 7alpha,24-Dihydroxy-4-cholesten-3-one + NADH + H+
|
1.1.1.181
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
|
–
|
| |
KEGG:
R08721
|
|
|
|
27-Hydroxycholesterol + 2 O2 + 2 NADPH + 2 H+ <=> 5-cholestene-26-oic_acid-3beta-ol + 2 NADP+ + 3 H2O
|
not assigned
|
–
|
| |
KEGG:
R08726
|
|
|
|
ATP + chenodeoxycholic_acid + CoA <=> AMP + diphosphate + chenodeoxycholoyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
| |
BRENDA:
BS345
KEGG:
R08743
MetaCyc:
RXN-17398
|
|
|
|
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O
|
4.2.1.107
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase
4.2.1.119
enoyl-CoA hydratase 2
|
–
–
|
| |
BRENDA:
BR48550;
BS374955
KEGG:
R04813
MetaCyc:
4.2.1.107-RXN
|
|
|
|
7alpha,12alpha-dihydroxy-4-cholesten-3-one + NADPH + H+ <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
| |
BRENDA:
BS258371
KEGG:
R04823
MetaCyc:
RXN-9794
SABIO-RK:
4468
|
|
|
|
(25S)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA + acceptor <=> (24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + reduced_acceptor
|
1.17.99.3
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
|
–
|
| |
KEGG:
R08740
MetaCyc:
RXN-9846
|
|
|
|
ATP + (25R)-3alpha,7alpha-dihydroxy-5-beta-cholestanate + CoA <=> AMP + diphosphate + 3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA
|
6.2.1.28
3alpha,7alpha-dihydroxy-5beta-cholestanate---CoA ligase
6.2.1.7
cholate---CoA ligase
|
–
–
|
| |
BRENDA:
BR80;
BS273
KEGG:
R04507;
R08738
MetaCyc:
6.2.1.28-RXN
|
|
|
|
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic_acid + ATP + CoA <=> trihydroxycoprostanoyl-CoA + AMP + diphosphate
|
6.2.1.7
cholate---CoA ligase
|
–
|
| |
BRENDA:
BS363620
KEGG:
R04580;
R08733
MetaCyc:
6.2.1.29-RXN
SABIO-RK:
4251
|
|
|
|
choloyl-CoA + propionyl-CoA <=> CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA
|
2.3.1.16
acetyl-CoA C-acyltransferase
2.3.1.176
propanoyl-CoA C-acyltransferase
|
–
–
|
| |
BRENDA:
BR48555
KEGG:
R03719
MetaCyc:
2.3.1.176-RXN
SABIO-RK:
3480
|
|
|
|
(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> trihydroxycoprostanoyl-CoA
|
5.1.99.4
alpha-methylacyl-CoA racemase
|
–
|
| |
BRENDA:
BS390365
KEGG:
R08734
MetaCyc:
RXN-9797
SABIO-RK:
10542
|
|
|
|
5beta-cholestane-3alpha,7alpha-diol + NADP+ <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADPH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
| |
BRENDA:
BS422688
KEGG:
R04819
MetaCyc:
RXN-9841
SABIO-RK:
4467
|
|
|
|
5beta-cholestane-3alpha,7alpha-diol + NAD+ <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
| |
KEGG:
R04818
MetaCyc:
RXN-9841_WOP
SABIO-RK:
4466
|
|
|
|
(24S)-24-hydroxycholesterol + reduced_flavodoxin + O2 <=> (24S)-cholest-5-ene-3beta,7alpha,24-triol + flavin + H2O
|
1.14.14.26
24-hydroxycholesterol 7alpha-hydroxylase
|
–
|
| |
BRENDA:
BR48563
KEGG:
R07208
|
|
|
|
cholesterol + reduced_flavodoxin + O2 <=> (24S)-24-hydroxycholesterol + flavin + H2O
|
1.14.14.25
cholesterol 24-hydroxylase
|
–
|
| |
BRENDA:
BR48564
KEGG:
R07207
|
|
|
|
(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + acceptor <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + reduced_acceptor
|
1.17.99.3
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
1.3.99
|
–
–
|
| |
KEGG:
R08735
MetaCyc:
RXN-9798
|
|
|
|
chenodeoxycholoyl-CoA + taurine <=> H+ + taurochenodeoxycholate + CoA
|
2.3.1.65
bile acid-CoA:amino acid N-acyltransferase
|
–
|
| |
BRENDA:
BS321176
KEGG:
R08745
MetaCyc:
RXN-9852
SABIO-RK:
10188
|
|
|
|
ATP + cholic_acid + CoA <=> AMP + diphosphate + choloyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
| |
BRENDA:
BR90
KEGG:
R02794
MetaCyc:
CHOLATE--COA-LIGASE-RXN
|
|
|
|
5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADPH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
| |
BRENDA:
BS422687
KEGG:
R04825
MetaCyc:
RXN-9796
SABIO-RK:
4470
|
|
|
|
(25S)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA <=> 3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA
|
5.1.99.4
alpha-methylacyl-CoA racemase
|
–
|
| |
KEGG:
R08739
MetaCyc:
RXN-9845
|
|
|
|
taurocholate + H2O <=> cholic_acid + taurine
|
3.5.1.24
choloylglycine hydrolase
3.5.1.74
chenodeoxycholoyltaurine hydrolase
|
–
–
|
| |
BRENDA:
BS140404
KEGG:
R02797
MetaCyc:
RXN-17385
SABIO-RK:
2669
|
|
|
|
5beta-cholestane-3alpha,7alpha,26-triol <=> 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
| |
KEGG:
R08758
|
|
|
|
27-Hydroxycholesterol + reduced_flavodoxin + O2 <=> 7alpha,27-dihydroxycholesterol + flavin + H2O
|
1.14.14.23
cholesterol 7alpha-monooxygenase
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
–
|
| |
KEGG:
R07372
|
|
