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Porphyrin and chlorophyll metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
bacteriochlorophyllide_a <=> Bacteriochlorophyllide_b not assigned
 –
S-adenosyl-L-methionine + precorrin-5 + H2O <=> H+ + precorrin-6A + S-adenosyl-L-homocysteine + acetate 2.1.1.152 precorrin-6A synthase (deacetylating)
–
ATP + cob(I)alamin <=> tripolyphosphate + adenosylcobalamin 2.5.1.17 corrinoid adenosyltransferase
–
ATP + 15,173-seco-F430-173-acid <=> ADP + phosphate + coenzyme_F430 6.4.1.9 coenzyme F430 synthetase
–
heme + O2 + reduced_acceptor + H+ <=> biliverdin-IX-delta + Fe2+ + CO + acceptor + H2O 1.14.99.58 heme oxygenase (biliverdin-IX-beta and delta-forming)
–
protoporphyrinogen-IX + O2 <=> protoporphyrin_IX + H2O2 1.3.3.4 protoporphyrinogen oxidase
–
S-adenosyl-L-methionine + precorrin-3B <=> H+ + precorrin-4 + S-adenosyl-L-homocysteine 2.1.1.131 precorrin-3B C17-methyltransferase
–
alpha-ribazole_5''-phosphate + H2O <=> alpha-ribazole + phosphate 3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
–
–
heme_O <=> heme_a not assigned
 –
heme + H+ <=> protoporphyrin_IX + Fe2+ 4.99.1.1 protoporphyrin ferrochelatase
4.99.1.9 coproporphyrin ferrochelatase
–
–
precorrin-3A + O2 + NADH + H+ <=> precorrin-3B + H2O + NAD+ 1.14.13.83 precorrin-3B synthase
–
S-adenosyl-L-methionine + Coproporphyrinogen-III <=> protoporphyrinogen-IX + CO2 + L-methionine + 5''-deoxyadenosine 1.3.98.3 coproporphyrinogen dehydrogenase
–
divinyl_protochlorophyllide_a + 2 H+ <=> protochlorophyllide not assigned
 –
S-adenosyl-L-methionine + cobalt-precorrin-5B <=> cobalt-precorrin-6A + S-adenosyl-L-homocysteine 2.1.1.195 cobalt-precorrin-5B (C1)-methyltransferase
–
precorrin-2 + NAD+ <=> H+ + sirohydrochlorin + NADH 1.3.1.76 precorrin-2 dehydrogenase
–
heme + (2E,6E)-farnesyl_diphosphate + H2O <=> heme_O + diphosphate 2.5.1.141 heme o synthase
–
porphobilinogen + H2O <=> Hydroxymethylbilane + NH3 2.5.1.61 hydroxymethylbilane synthase
–
Fe2+ + H+ + O2 <=> Fe3+ + H2O 1.16.3.1 ferroxidase
1.16.3.3 manganese oxidase
–
–
Uroporphyrinogen_I + reduced_acceptor <=> uroporphyrin-I + acceptor + 6 H+ not assigned
 –
(3Z)-phycocyanobilin + oxidized_ferredoxin <=> Biliverdin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.5 phycocyanobilin:ferredoxin oxidoreductase
–
Coproporphyrinogen-III + O2 <=> coproporphyrin_III + H2O2 1.3.3.15 coproporphyrinogen III oxidase (coproporphyrin-forming)
1.3.3.4 protoporphyrinogen oxidase
–
–
pheophorbide_a + H2O + H+ <=> pyropheophorbide_a + methanol + CO2 3.1.1.82 pheophorbidase
–
S-adenosyl-L-methionine + a_3-vinyl_bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + a_bacteriochlorophyllide_c 2.1.1.333 bacteriochlorophyllide d C-20 methyltransferase
–
3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a <=> chlorophyllide_a + H2O 4.2.1.165 chlorophyllide a 31-hydratase
4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
–
7-hydroxychlorophyllide_a <=> chlorophyllide_a not assigned
 –
131-oxo-magnesium-protoporphyrin_IX_13-monomethyl_ester + O2 + NADPH <=> divinyl_protochlorophyllide_a + NADP+ + H2O 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
–
bilirubin_diglucuronide + 2 H2O + 3 reduced_acceptor <=> D-Urobilinogen + 2 D-glucuronate + 3 acceptor 1
3.2.1.31 beta-glucuronidase
–
–
uroporphyrinogen_III + acceptor <=> uroporphyrinogen_III + 6 H+ + reduced_acceptor not assigned
 –
a_3-vinyl_bacteriochlorophyllide_d + (2E,6E)-farnesyl_diphosphate <=> Bacteriochlorophyll_d + diphosphate 2.5.1
–
heme + 3 reduced_flavodoxin + 3 O2 <=> Biliverdin + Fe2+ + CO + 3 flavin + 3 H2O 1.14.14.18 heme oxygenase (biliverdin-producing)
1.14.99.58 heme oxygenase (biliverdin-IX-beta and delta-forming)
–
–
heme <=> cytochrome_a not assigned
 –
12,18-didecarboxysiroheme <=> Fe-coproporphyrin_III not assigned
 –
nicotinic_acid_mononucleotide + 5,6-Dimethylbenzimidazole <=> alpha-ribazole_5''-phosphate + nicotinate + H+ 2.4.2.21 nicotinate-nucleotide---dimethylbenzimidazole phosphoribosyltransferase
2.4.2.55 nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
–
–
hydrogenobyrinic_acid_a,c-diamide + Co2+ + ATP + H2O <=> H+ + cob(II)yrinic_acid_a,c-diamide + ADP + phosphate 6.6.1.2 cobaltochelatase
–
adenosylcobyrinic_acid_a,c-diamide + L-glutamine + ATP + H2O <=> H+ + L-glutamate + adenosylcobyric_acid + ADP + phosphate 6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing)
–
D-Urobilinogen + 2 H+ <=> i-urobilinogen not assigned
 –
Bacteriochlorophyll_b + NADP+ <=> Geranylgeranyl_bacteriochlorophyllide_b + NADPH + H+ 1.3.1.111 geranylgeranyl-bacteriochlorophyllide a reductase
–
chlorophyll_a + oxidized_ferredoxin + H2O <=> 7-hydroxymethylchlorophyll_a + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.17.7.2 7-hydroxymethyl chlorophyll a reductase
–
sirohydrochlorin + Co2+ <=> cobalt-sirohydrochlorin + H+ 4.99.1.3 sirohydrochlorin cobaltochelatase
4.99.1.4 sirohydrochlorin ferrochelatase
–
–
reduced_transferrin + NAD+ <=> oxidized_transferrin + NADH + H+ 1.16.1.2 diferric-transferrin reductase
–
cobalt-precorrin-8 <=> cobyrinate + H+ 5.4.99.60 cobalt-precorrin-8 methylmutase
–
(S)-4-Amino-5-oxopentanoate <=> 5-aminolevulinate 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase
–
ATP + Ni-sirohydrochlorin_a,c-diamide + reduced_acceptor + H2O <=> ADP + phosphate + 15,173-seco-F430-173-acid + acceptor 6.3.3.7 Ni-sirohydrochlorin a,c-diamide reductive cyclase
–
bilirubin + coenzyme_F420-1 <=> Biliverdin + Reduced_coenzyme_F420-(gamma-Glu)n 1.3.98
–
heme + reduced_acceptor + O2 + H+ <=> 5-oxo-delta-bilirubin + Fe2+ + formaldehyde + acceptor + H2O 1.14.99.48 heme oxygenase (staphylobilin-producing)
–
8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide_d + H2O <=> 3-(1-hydroxyethyl)-pyrochlorophyllide_a 4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
S-adenosyl-L-methionine + cobalt-precorrin-7 <=> cobalt-precorrin-8 + S-adenosyl-L-homocysteine 2.1.1.289 cobalt-precorrin-7 (C5)-methyltransferase
–
S-adenosyl-L-methionine + 131-oxo-magnesium-protoporphyrin_IX_13-monomethyl_ester <=> divinyl_protochlorophyllide_a + 5''-deoxyadenosine + L-methionine + H+ 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
–
ATP + adenosylcobyric_acid + (R)-1-aminopropan-2-ol <=> H+ + ADP + phosphate + adenosylcobinamide 6.3.1.10 adenosylcobinamide-phosphate synthase
–
myoglobin <=> Globin + heme not assigned
 –
Holocytochrome_c <=> apocytochrome_c + heme 4.4.1.17 holocytochrome-c synthase
4.4.1.B1
–
–
magnesium_protoporphyrin_monomethyl_ester + O2 + NADPH + H+ <=> 131-hydroxy-magnesium-protoporphyrin_IX_13-monomethyl_ester + NADP+ + H2O 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
–
S-adenosyl-L-methionine + Fe-coproporphyrin_III <=> heme + CO2 + 5''-deoxyadenosine + L-methionine 1.3.98.6 AdoMet-dependent heme synthase
–
S-adenosyl-L-methionine + magnesium_protoporphyrin_monomethyl_ester + H2O <=> 131-hydroxy-magnesium-protoporphyrin_IX_13-monomethyl_ester + 5''-deoxyadenosine + L-methionine + H+ 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
–
S-adenosyl-L-methionine + a_bacteriochlorophyllide_c + H2O <=> bacteriochlorophyllide_e + 5''-deoxyadenosine + L-methionine + H+ 1.17.98.2 bacteriochlorophyllide c C-71-hydroxylase
–
7-hydroxymethylchlorophyll_a + NAD+ <=> chlorophyll_b + NADH 1.1.1.294 chlorophyll(ide) b reductase
–
Ni-sirohydrochlorin + L-glutamine + ATP + H2O <=> Ni-sirohydrochlorin_a,c-diamide + L-glutamate + ADP + phosphate + H+ 6.3.5.12 Ni-sirohydrochlorin a,c-diamide synthase
–
NADPH + vitamin_B12 <=> NADP+ + cob(I)alamin + cyanide 1.16.1.6 cyanocobalamin reductase (cyanide-eliminating)
–
heme + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> Biliverdin + Fe2+ + CO + oxidized_ferredoxin + H2O 1.14.15.20 heme oxygenase (biliverdin-producing, ferredoxin)
–
O-phospho-L-threonine + H+ <=> (R)-1-aminopropan-2-yl_phosphate + CO2 4.1.1.81 threonine-phosphate decarboxylase
–
S-adenosyl-L-methionine + cobalt-sirohydrochlorin <=> H+ + S-adenosyl-L-homocysteine + cobalt-factor_III 2.1.1.151 cobalt-factor II C20-methyltransferase
–
7-hydroxychlorophyllide_a + O2 + NADPH + H+ <=> chlorophyllide_b + 2 H2O + NADP+ 1.14.13.122 chlorophyllide-a oxygenase
–
hemoglobin <=> Globin + heme not assigned
 –
cobyrinate + L-glutamine + ATP + H2O <=> cob(II)yrinic_acid_a,c-diamide + L-glutamate + ADP + phosphate + H+ 6.3.5.11 cobyrinate a,c-diamide synthase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
–
–
chlorophyllide_a + oxidized_ferredoxin + ADP + phosphate <=> protochlorophyllide + reduced_ferredoxin_[iron-sulfur]_cluster + ATP + H2O 1.3.7.15 chlorophyllide a reductase
1.3.7.7 ferredoxin:protochlorophyllide reductase (ATP-dependent)
–
–
cobalt-precorrin-5A + H2O <=> H+ + cobalt-precorrin-5B + acetaldehyde 3.7.1.12 cobalt-precorrin 5A hydrolase
–
chlorophyll_a + H+ <=> pheophytin_a + Mg2+ 4.99.1.10 magnesium dechelatase
–
a_bacteriochlorophyllide_c + (2E,6E)-farnesyl_diphosphate + H+ <=> bacteriochlorophyll_c + diphosphate 2.5.1
2.5.1.bl
–
–
S-adenosyl-L-methionine + 131-hydroxy-magnesium-protoporphyrin_IX_13-monomethyl_ester <=> 131-oxo-magnesium-protoporphyrin_IX_13-monomethyl_ester + 5''-deoxyadenosine + L-methionine + H+ 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
–
Fe-coproporphyrin_III + H2O2 + H+ <=> heme + CO2 + H2O 1.3.98.5 hydrogen peroxide-dependent heme synthase
–
H+ + adenosylcobinamide_phosphate + GTP <=> adenosylcobinamide-GDP + diphosphate 2.7.1.156 adenosylcobinamide kinase
2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase
–
–
3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a <=> 3-deacetyl-3-vinylbacteriochlorophyllide_a + H2O 4.2.1.165 chlorophyllide a 31-hydratase
4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
–
ATP + cob(II)yrinic_acid_a,c-diamide <=> tripolyphosphate + adenosylcobyrinic_acid_a,c-diamide 2.5.1.17 corrinoid adenosyltransferase
–
S-adenosyl-L-methionine + cobalt-precorrin-4 <=> S-adenosyl-L-homocysteine + cobalt-precorrin-5A + H+ 2.1.1.271 cobalt-precorrin-4 methyltransferase
–
2 cob(II)yrinic_acid_a,c-diamide + FMNH2 <=> 2 cob(II)yrinic_acid_a,c-diamide + FMN + 2 H+ 1.16.8
–
adenosylcobinamide + GTP <=> adenosylcobinamide_phosphate + GDP + H+ 2.7.1.156 adenosylcobinamide kinase
–
H+ + precorrin-8X <=> Hydrogenobyrinate 5.4.99.61 precorrin-8X methylmutase
–
chlorophyll_b + H2O <=> phytol + chlorophyllide_b 3.1.1.14 chlorophyllase
–
12-Ethyl-8-isobutylbacteriochlorophyllide_d <=> 12-ethyl-8-isobutyl-3-vinyl-bacteriochlorophyllide_d + H2O 4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
ATP + adenosylcobyric_acid + (R)-1-aminopropan-2-yl_phosphate <=> ADP + adenosylcobinamide_phosphate + phosphate + H+ 6.3.1.10 adenosylcobinamide-phosphate synthase
–
S-adenosyl-L-methionine + precorrin-2 <=> H+ + S-adenosyl-L-homocysteine + precorrin-3A 2.1.1.130 precorrin-2 C20-methyltransferase
–
protoporphyrinogen-IX + 3 1,4-benzoquinone <=> protoporphyrin_IX + 3 hydroquinone 1.3.5.3 protoporphyrinogen IX dehydrogenase (quinone)
–
S-adenosyl-L-methionine + precorrin-4 <=> precorrin-5 + S-adenosyl-L-homocysteine + H+ 2.1.1.133 precorrin-4 C11-methyltransferase
2.1.1.271 cobalt-precorrin-4 methyltransferase
–
–
7-hydroxymethylchlorophyll_a + NADP+ <=> chlorophyll_b + NADPH 1.1.1.294 chlorophyll(ide) b reductase
–
divinyl_protochlorophyllide_a + NADPH <=> divinyl_chlorophyllide_a + NADP+ 1.3.1.33 protochlorophyllide reductase
–
Cobalamin <=> hydroxycobalamin not assigned
 –
Precorrin-6Y + NADP+ <=> precorrin-6A + NADPH + H+ 1.3.1.54 precorrin-6A reductase
–
S-adenosyl-L-methionine + 12-ethyl-8-propyl-3-vinyl-bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + 12-ethyl-8-isobutyl-3-vinyl-bacteriochlorophyllide_d + H+ 2.1.1.332 bacteriochlorophyllide d C-82-methyltransferase
–
(3Z)-phycocyanobilin <=> (3Z)-phycoerythrobilin not assigned
 –
2 i-urobilinogen + O2 <=> 2 i-urobilin + 2 H2O not assigned
 –
7-hydroxychlorophyllide_a + NADP+ <=> chlorophyllide_b + NADPH + H+ 1.1.1.294 chlorophyll(ide) b reductase
–
5-aminolevulinate <=> H+ + H2O + porphobilinogen 4.2.1.24 porphobilinogen synthase
–
S-adenosyl-L-methionine + magnesium_protoporphyrin_IX <=> S-adenosyl-L-homocysteine + magnesium_protoporphyrin_monomethyl_ester 2.1.1.11 magnesium protoporphyrin IX methyltransferase
–
siroheme + H+ <=> 12,18-didecarboxysiroheme + CO2 4.1.1.111 siroheme decarboxylase
–
Hydroxymethylbilane <=> uroporphyrinogen_III + H2O 4.2.1.75 uroporphyrinogen-III synthase
–
2 L-stercobilinogen + O2 <=> 2 L-Urobilin + 2 H2O not assigned
 –
5-COOH-porphyrinogen_I + acceptor <=> Coproporphyrin_I + reduced_acceptor + 6 H+ not assigned
 –
H+ + glycine + succinyl-CoA <=> CO2 + CoA + 5-aminolevulinate 2.3.1.37 5-aminolevulinate synthase
–
chlorophyllide_a + H+ <=> pheophorbide_a + Mg2+ 4.99.1.10 magnesium dechelatase
–
chlorophyllide_a + NADP+ <=> divinyl_chlorophyllide_a + NADPH + H+ 1.3.1.75 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)
–
tRNAMet + L-glutamate + ATP <=> Glu-tRNAGln + diphosphate + AMP 6.1.1.17 glutamate---tRNA ligase
6.1.1.24 glutamate---tRNAGln ligase
–
–
(3Z)-phycocyanobilin + acceptor <=> (3Z)-phytochromobilin + reduced_acceptor + 2 H+ not assigned
 –
chlorophyllide_a + O2 + NADPH + H+ <=> 7-hydroxychlorophyllide_a + H2O + NADP+ 1.14.13.122 chlorophyllide-a oxygenase
–
chlorophyllide_a + H2O <=> 8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide_d + methanol + CO2 3.1.1.100 chlorophyllide a hydrolase
–
D-Urobilinogen + O2 <=> D-Urobilin + H2O not assigned
 –
ATP + protoporphyrin_IX + Mg2+ + H2O <=> H+ + magnesium_protoporphyrin_IX + phosphate + ADP 6.6.1.1 magnesium chelatase
–
protochlorophyllide + NADP+ <=> divinyl_protochlorophyllide_a + NADPH + H+ 1.3.1.75 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)
–
S-adenosyl-L-methionine + 8,12-diethyl-3-vinyl-bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + 12-ethyl-8-propyl-3-vinyl-bacteriochlorophyllide_d + H+ 2.1.1.332 bacteriochlorophyllide d C-82-methyltransferase
–
3,8-divinyl_chlorophyll_a <=> chlorophyll_a not assigned
 –
Hydrogenobyrinate + L-glutamine + ATP + H2O <=> H+ + L-glutamate + hydrogenobyrinic_acid_a,c-diamide + ADP + phosphate 6.3.5.11 cobyrinate a,c-diamide synthase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
–
–
pheophorbide_a + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> red_chlorophyll_catabolite + oxidized_ferredoxin 1.14.15.17 pheophorbide a oxygenase
–
(S)-4-Amino-5-oxopentanoate + NADP+ + tRNAMet <=> Glu-tRNAGln + NADPH + H+ 1.2.1.70 glutamyl-tRNA reductase
–
Fe-coproporphyrin_III + H+ <=> coproporphyrin_III + Fe2+ 4.99.1.9 coproporphyrin ferrochelatase
–
heme <=> catalase not assigned
 –
heme + O2 + reduced_acceptor + H+ <=> biliverdin_IXbeta + Fe2+ + CO + acceptor + H2O 1.14.99.58 heme oxygenase (biliverdin-IX-beta and delta-forming)
–
(3Z)-phycoerythrobilin + oxidized_ferredoxin <=> 15,16-dihydrobiliverdin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.3 phycoerythrobilin:ferredoxin oxidoreductase
–
Ni-sirohydrochlorin + H+ <=> sirohydrochlorin + Ni2+ 4.99.1.11 sirohydrochlorin nickelchelatase
–
Hydroxymethylbilane <=> Uroporphyrinogen_I + H2O not assigned
 –
protoporphyrinogen-IX + 3 acceptor <=> protoporphyrin_IX + 3 reduced_acceptor 1.3.99
–
(3Z)-phytochromobilin + oxidized_ferredoxin <=> Biliverdin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.4 phytochromobilin:ferredoxin oxidoreductase
–
adenosylcobinamide-GDP + alpha-ribazole <=> H+ + adenosylcobalamin + GMP 2.7.8.26 adenosylcobinamide-GDP ribazoletransferase
–
L-threonine + ATP <=> O-phospho-L-threonine + ADP + H+ 2.7.1.177 L-threonine kinase
–
(3Z)-phycoerythrobilin + oxidized_ferredoxin <=> Biliverdin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.6 phycoerythrobilin synthase
–
S-adenosyl-L-methionine + 8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + 8,12-diethyl-3-vinyl-bacteriochlorophyllide_d + H+ 2.1.1.331 bacteriochlorophyllide d C-121-methyltransferase
–
15,16-dihydrobiliverdin + oxidized_ferredoxin <=> Biliverdin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.2 15,16-dihydrobiliverdin:ferredoxin oxidoreductase
1.3.7.6 phycoerythrobilin synthase
–
–
131-hydroxy-magnesium-protoporphyrin_IX_13-monomethyl_ester + NADPH + H+ + O2 <=> 131-oxo-magnesium-protoporphyrin_IX_13-monomethyl_ester + NADP+ + H2O 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
–
NADP+ + bilirubin <=> Biliverdin + NADPH + H+ 1.3.1.24 biliverdin reductase
–
cobalt-precorrin-6B + NAD+ <=> cobalt-precorrin-6A + NADH 1.3.1.106 cobalt-precorrin-6A reductase
–
Bacteriochlorophyllide_b + geranylgeranyl_diphosphate + H+ <=> Geranylgeranyl_bacteriochlorophyllide_b + diphosphate 2.5.1.133 bacteriochlorophyll a synthase
–
H2O + Chlorophyll <=> chlorophyllide_a + phytol 3.1.1.14 chlorophyllase
–
hemoglobin + O2 <=> Oxyhemoglobin not assigned
 –
adenosylcobinamide + ATP <=> H+ + adenosylcobinamide_phosphate + ADP 2.7.1.156 adenosylcobinamide kinase
–
sirohydrochlorin + Fe2+ <=> H+ + siroheme 4.99.1.3 sirohydrochlorin cobaltochelatase
4.99.1.4 sirohydrochlorin ferrochelatase
–
–
i-urobilinogen + 4 H+ <=> L-stercobilinogen not assigned
 –
S-adenosyl-L-methionine + uroporphyrinogen_III <=> S-adenosyl-L-homocysteine + precorrin-2 + H+ 2.1.1.107 uroporphyrinogen-III C-methyltransferase
–
2 ATP + 2 cob(II)yrinic_acid_a,c-diamide + reduced_flavodoxin <=> 2 tripolyphosphate + 2 adenosylcobyrinic_acid_a,c-diamide + flavin 2.5.1.17 corrinoid adenosyltransferase
–
7-hydroxychlorophyllide_a + NAD+ <=> chlorophyllide_b + NADH + H+ 1.1.1.294 chlorophyll(ide) b reductase
–
S-adenosyl-L-methionine + Precorrin-6Y <=> precorrin-8X + S-adenosyl-L-homocysteine + CO2 + H+ 2.1.1.132 precorrin-6B C5,15-methyltransferase (decarboxylating)
–
bilirubin + O2 <=> Biliverdin + H2O 1.3.3.5 bilirubin oxidase
–
NAD+ + bilirubin <=> Biliverdin + NADH + H+ 1.3.1.24 biliverdin reductase
–
3-deacetyl-3-vinylbacteriochlorophyllide_a + ADP + phosphate + oxidized_ferredoxin <=> chlorophyllide_a + ATP + H2O + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.15 chlorophyllide a reductase
–
Coproporphyrinogen-III + O2 + H+ <=> protoporphyrinogen-IX + CO2 + H2O 1.3.3.3 coproporphyrinogen oxidase
–
heme <=> Peroxidase not assigned
 –
2 UDP-glucuronate + bilirubin <=> 2 UDP + bilirubin_diglucuronide 2.4.1.17 glucuronosyltransferase
–
uroporphyrinogen_III + H+ <=> Coproporphyrinogen-III + CO2 4.1.1.37 uroporphyrinogen decarboxylase
–
8,12-diethyl-3-vinyl-bacteriochlorophyllide_d + H2O <=> 8,12-Diethylbacteriochlorophyllide_d 4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
cob(I)inamide + ATP <=> adenosylcobinamide + tripolyphosphate 2.5.1.17 corrinoid adenosyltransferase
–
primary_fluorescent_chlorophyll_catabolite + oxidized_ferredoxin <=> red_chlorophyll_catabolite + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.12 red chlorophyll catabolite reductase
–
12-Ethyl-8-propylbacteriochlorophyllide_d <=> 12-ethyl-8-propyl-3-vinyl-bacteriochlorophyllide_d + H2O 4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
2 cob(I)alamin + NAD+ <=> 2 Cobalamin + NADH + H+ 1.16.1.3 aquacobalamin reductase
1.16.1.4 cob(II)alamin reductase
–
–
3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a + NAD+ <=> bacteriochlorophyllide_a + NADH + H+ 1.1.1.396 bacteriochlorophyllide a dehydrogenase
–
phytyl_diphosphate + chlorophyllide_a <=> bacteriopheophytin_a + Mg2+ + diphosphate not assigned
 –
3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a + ADP + oxidized_ferredoxin + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a + ATP + reduced_ferredoxin_[iron-sulfur]_cluster + H2O + H+ 1.3.7.15 chlorophyllide a reductase
–
S-adenosyl-L-methionine + cobalt-factor_III + reduced_acceptor <=> S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor 2.1.1.272 cobalt-factor III methyltransferase
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adenosylcobinamide + H2O <=> (R)-1-aminopropan-2-ol + adenosylcobyric_acid 3.5.1.90 adenosylcobinamide hydrolase
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chlorophyllide_b + phytyl_diphosphate + H+ <=> chlorophyll_b + diphosphate 2.5.1.62 chlorophyll synthase
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bacteriochlorophyllide_a + geranylgeranyl_diphosphate + H+ <=> geranylgeranyl-bacteriochlorophyllide_a + diphosphate 2.5.1.133 bacteriochlorophyll a synthase
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Uroporphyrinogen_I + H+ <=> 5-COOH-porphyrinogen_I + CO2 4.1.1.37 uroporphyrinogen decarboxylase
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chlorophyllide_a + phytyl_diphosphate + H+ <=> chlorophyll_a + diphosphate 2.5.1.62 chlorophyll synthase
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protochlorophyllide + oxidized_ferredoxin <=> divinyl_protochlorophyllide_a + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.1.75 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)
1.3.7.13 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin)
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S-adenosyl-L-methionine + cobalt-precorrin-6B + H+ <=> cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO2 2.1.1.196 cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]
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divinyl_chlorophyllide_a <=> 3,8-divinyl_chlorophyll_a not assigned
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pyruvate + 5-aminolevulinate <=> L-alanine + 4,5-Dioxopentanoate 2.6.1.40 (R)-3-amino-2-methylpropionate---pyruvate transaminase
2.6.1.43 aminolevulinate transaminase
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bacteriochlorophyll_a + NADP+ <=> geranylgeranyl-bacteriochlorophyllide_a + NADPH + H+ 1.3.1.111 geranylgeranyl-bacteriochlorophyllide a reductase
1.3.1.83 geranylgeranyl diphosphate reductase
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chlorophyllide_a + NADP+ <=> protochlorophyllide + NADPH + H+ 1.3.1.33 protochlorophyllide reductase
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Visualization of the pathway